Epilepsy: open trials in United States

• NCT06038929

  Effect of Vagal Nerve Stimulation on Gastric Motor Functions

  Trial Treatment · Mayo Clinic

  University of Minnesota, Minneapolis · Mayo Clinic in Rochester, Rochester

  Registry updated 2026-10-02

• NCT06798896

  RENAISSANCE 2: SPN-817 Phase 2, Double-Blind, Placebo-Controlled Study in Adults With Focal Onset Seizures

  Trial Treatment · Phase 2 · Supernus Pharmaceuticals, Inc.

  Albany Medical Center, Albany · Dent Neurologic Institute, Amherst · Asheville Neurology Specialists, Asheville · Johns Hopkins University, Baltimore · Mid-Atlantic Epilepsy and Sleep Center, Bethesda · Onsite Clinical Solutions, LLC, Charlotte · Neurology Institute Epilepsy Center of Cleveland Clinic, Cleveland · Neurocare Of Louisiana, Covington · Wayne State University - Detroit Medical Center, Detroit · Advanced Neurology Epilepsy and Sleep Center/ANESC Research, El Paso · Stryde Research, Frisco · Northwest Florida Clinical Research Group, LLC, Gulf Breeze · Northeast Regional Epilepsy Group - Hackensack, Hackensack · UT Health Houston, Houston · Ilumina Medical Research, Kissimmee · Clinical Trials Inc., Little Rock · Clinical Research Institute, Los Angeles · University of Louisville Physicians, Louisville · Medstar Health Research Institute, McLean · Visionary Investigators Network, Miami · University of Miami, Miami · Access Community Clinical Trials, Mission Hills · Vanderbilt University Medical Center, Nashville · Hackensack Meridian Health Jersey Shore University Medical Center, Neptune City · Yale University, New Haven · Ochsner Clinic Foundation, New Orleans · Northwell Health - Lenox Hill, New York · University of California Irvine, Orange · Research Institute of Orlando LLC, Orlando · Thomas Jefferson University, Philadelphia · Xenoscience, Phoenix · Banner-University Medical Center Phoenix, Phoenix · Medsol Clinical Research Center, Port Charlotte · Cleveland Clinic Florida Martin Health, Port Saint Lucie · University of Rochester Medical Center, Rochester · Southern Illinois University School of Medicine, Springfield · Center for Neurosciences, Tucson · University of Arizona College of Medicine - Tucson, Tucson · Focus Clinical Research, West Hills

  Registry updated 2026-10-01

• NCT07228338

  Cholinergic Enhancement of Theta

  Trial Treatment · Early phase 1 · University of Texas Southwestern Medical Center

  University of Texas Southwestern Medical Center, Dallas

  Registry updated 2026-09-29

• NCT07847918

  A Fully Remote Feasibility Trial of Phenylbutyrate for SLC6A1-Related Disorders

  Trial Treatment · Phase 2 · Scripps Translational Science Institute

  Scripps Research Translational Institute, San Diego

  Registry updated 2026-09-29

• NCT03233399

  Modulating Movement Intention Via Cortical Stimulation

  Trial Treatment · NYU Langone Health

  New York University School of Medicine, New York

  Registry updated 2026-09-25

• NCT07012148

  Optimizing Therapy in Epilepsy Using Seizure Forecasts Via EEG and Wearables

  Trial Treatment · Early phase 1 · Mayo Clinic

  Mayo Clinic, Jacksonville · Mayo Clinic in Rochester, Rochester · Mayo Clinic, Scottsdale

  Registry updated 2026-09-25

• NCT02216500

  Ketogenic Therapy Effects on Electrical and Metabolic Abnormalities in Epilepsy

  Trial Treatment · University of Florida

  University of Florida, Gainesville

  Registry updated 2026-09-17

• NCT04500119

  Neuronal Mechanisms of Human Episodic Memory

  Trial Treatment · Cedars-Sinai Medical Center

  Cedars-Sinai Medical Center, Los Angeles

  Registry updated 2026-09-17

• NCT07821697

  Translational Recording and Characterization of Epilepsy Signals Using Subgaleal EEG During Standard-of-care SEEG Monitoring

  Trial Treatment · Early phase 1 · Adraxe Corp.

  University of Minnisota, Minneapolis

  Registry updated 2026-09-16

• NCT07822178

  Neural Mechanisms of Social Attribution From Faces

  Trial Treatment · Cedars-Sinai Medical Center

  Cedars-Sinai Medical Center, Los Angeles · Stanford University, Palo Alto

  Registry updated 2026-09-16

• NCT07823465

  RNS System for Drug-Resistant Focal Epilepsy in Adolescents: A Real-World Study

  Research · NeuroPace

  OM1's Central Site (Virtual Site), Waltham

  Registry updated 2026-09-16

• NCT06388707

  A Safety, Tolerability, and Preliminary Efficacy of Low-intensity Focused Ultrasound Neuromodulation in Patients With Drug-resistant Epilepsy

  Trial Treatment · Phase 1/2 · NaviFUS Corporation

  Brigham and Women's Hospital, Boston · University of Virginia School of Medicine, Charlottesville · Stanford University, School of Medicine, Palo Alto

  Registry updated 2026-09-15

• NCT06534502

  Study of the Pharmacokinetics, Safety, and Tolerability of ZONISADE in Children 1 Month to 17 Years of Age With Partial-onset Seizures

  Trial Treatment · Phase 4 · Azurity Pharmaceuticals

  Le Bonheur Children's Hospital, Memphis · Wake Forest University School of Medicine, Winston-Salem

  Registry updated 2026-09-15

• NCT07454785

  Neuronal Mechanisms of Learning and Utilizing Abstract Representations

  Trial Treatment · Cedars-Sinai Medical Center

  Cedars-Sinai Medical Center, Los Angeles

  Registry updated 2026-09-15

• NCT07775872

  Prospective Natural History Study of POLG Disease

  Research · The POLG Foundation

  Akron Children's Hospital, Akron · Children's Hospital Colorado, Aurora · Baylor Hospital, Dallas · UTHealth Houston, Houston · Columbia University Irving Medical Center, New York · Children's Hospital of Philadelphia-Philadelphia, Philadelphia · University of California San Diego, San Diego

  Registry updated 2026-09-15

• NCT07088835

  SeizEAR Safety Study

  Trial Treatment · Icahn School of Medicine at Mount Sinai

  Icahn School of Medicine at Mount Sinai, New York

  Registry updated 2026-09-14

• NCT07301346

  EASEE® System Pivotal Study for the United States of America

  Trial Treatment · Precisis US, Inc.

  Columbia University Irving Medical Center/New York Presbyterian Hospital, New York

  Registry updated 2026-08-28

• NCT07451093

  Epileptiform Potential of Fully Immersive Virtual Reality

  Trial Treatment · Dartmouth-Hitchcock Medical Center

  Dartmouth Hitchcock Medical Center, Lebanon

  Registry updated 2026-08-27

• NCT00575081

  Physiological Brain Atlas Development

  Research · Vanderbilt University Medical Center

  Vanderbilt Univeristy, Nashville

  Registry updated 2026-08-26

• NCT05096273

  Retraining and Control Therapy (ReACT): Sense of Control and Symptom Expectations as Targets of a Treatment for PNES

  Trial Treatment · University of Alabama at Birmingham

  Sparks Center Office of Psychiatric Research, Birmingham

  Registry updated 2026-08-26

• NCT06063850

  AMT-260 Gene Therapy Study in Adults With Unilateral Refractory Mesial Temporal Lobe Epilepsy

  Trial Treatment · Phase 1/2 · UniQure Biopharma B.V.

  Baylor Scott & White Medical Center, Austin · Johns Hopkins School of Medicine, Baltimore · Midatlantic Epilepsy and Sleep Center, Bethesda · University of Alabama at Birmingham, Birmingham · Massachusetts General Hospital, Boston · Cleveland Clinic, Cleveland · Ohio State University, Columbus · Corewell Health, Grand Rapids · Northeast Regional Epilepsy Group, Hackensack · Mayo Clinic Florida, Jacksonville · Kansas University Medical Center, Kansas City · Dartmouth Hitchcock Medical Center, Lebanon · Medical College of Wisconsin, Milwaukee · Robert Wood Johnson Hospital, New Brunswick · Stanford University, Palo Alto · Hospital of the University of Pennsylvania, Philadelphia · Mayo Clinic - Arizona, Phoenix · Allegheny Health Network, Pittsburgh

  Registry updated 2026-08-24

• NCT07775976

  Cor360: Clinician-Facing Broad-Spectrum Cardiac Phenotyping and Risk Assessment Using COR® Wearable ECG to Inform Outcomes-Oriented Care Pathways

  Research · Peerbridge Health, Inc

  Peerbridge Health, Inc., Nashville · Peerbridge Health, Inc., Pasadena

  Registry updated 2026-08-21

• NCT06092346

  A Natural History Study Seeks to Understand the Clinical, Genomic, Pharmacological, Laboratory, and Dietary Determinates of Pyrimidine and Purine Metabolism Disorders

  Research · National Human Genome Research Institute (NHGRI)

  National Institutes of Health Clinical Center, Bethesda

  Registry updated 2026-08-19

• NCT06252532

  Causal Role of Top-Down Theta Oscillations in Prioritization

  Trial Treatment · University of North Carolina, Chapel Hill

  University of North Carolina at Chapel Hill, Chapel Hill

  Registry updated 2026-08-19

• NCT07281027

  COMparison Between Anakinra and Tocilizumab in NORSE - "COMBAT-NORSE"

  Trial Treatment · Phase 3 · Yale University

  Children's Hospital Colorado, Aurora · Mass General (MGH), Boston · Boston Children's Hospital, Boston · Beth Israel Deaconess, Boston · University of Chicago, Chicago · University of Cincinnati, Cincinnati · Cleveland Clinic, Cleveland · UT Southwestern Medical Center, Dallas · Northwestern University, Evanston · University of Florida, Gainesville · Baylor/Texas Children's, Houston · University of Nebraska, Lincoln · University of Wisconsin, Madison · Medical College of Wisconsin, Milwaukee · Yale New Haven Hospital, New Haven · New York University, New York · Columbia University, New York · Mount Sinai (NY), New York · University of Pennsylvania, Philadelphia · Children's Hospital Philadelphia (CHOP), Philadelphia · Barrow Institute, Phoenix · Oregon Health and Science University, Portland · Mayo Clinic, Rochester · Seattle Children's Hospital, Seattle · Children's National (DC), Washington D.C.

  Registry updated 2026-08-19

All Epilepsy trials and the map

This page is not medical advice. Talk to your doctor before contacting a trial.

Report an error