Familial hypercholesterolaemia: open trials in United Kingdom

10 open trials have a site in United Kingdom. Registry data; only the trial team decides who can take part.

NCT06451770
Phase 1b Study of VERVE-201 in Patients With Refractory Hyperlipidemia
Trial Treatment · Phase 1 · Verve Therapeutics, Inc.
Clinical Study Center, Liverpool · Clinical Study Center, London · Clinical Study Center 2, Manchester · Clinical Study Center, Manchester
Registry updated 2026-10-23
NCT07058077
A Study of Enlicitide Decanoate (MK-0616, an Oral PCSK9 Inhibitor) in Children and Adolescents With Heterozygous Familial Hypercholesterolemia (MK-0616-029)
Trial Treatment · Phase 2/3 · Merck Sharp & Dohme LLC
Birmingham Childrens Hospital (Site 1501), Birmingham · Sheffield Childrens Hospital (Site 1503), Sheffield · Southampton General Hospital (Site 1502), Southampton
Registry updated 2026-10-07
NCT05682378
Long-term Safety and Tolerability of Inclisiran in Participants With HeFH or HoFH Who Have Completed the Pediatric ORION-16, ORION-13, ORION-20, or ORION-19 Studies
Trial Treatment · Phase 3 · Novartis Pharmaceuticals
Middlesex
Registry updated 2026-09-18
NCT07491172
A Safety and Tolerability Trial Evaluating CTX310 in Participants With Refractory Dyslipidemias
Trial Treatment · Phase 1 · CRISPR Therapeutics AG
Royal Papworth Hospital, Cambridge · Richmond Pharmacology, London
Registry updated 2026-09-18
NCT06164730
A Study of VERVE-102 in Patients With Familial Hypercholesterolemia or Premature Coronary Artery Disease
Trial Treatment · Phase 1 · Verve Therapeutics, Inc.
Clinical Study Center, Birmingham · Clinical Study Center, Cambridge · Clinical Study Center, Edinburgh · Clinical Study Center, London · Clinical Study Center, Manchester · Clinical Study Center, Nottingham
Registry updated 2026-09-02
NCT06597006
Study to Evaluate Safety, Tolerability and Efficacy of Inclisiran in Children With Homozygous Familial Hypercholesterolemia
Trial Treatment · Phase 3 · Novartis Pharmaceuticals
Southampton
Registry updated 2026-07-24
NCT07614958
Phase 3 Clinical Study Evaluating Efficacy, Safety, and Tolerability of Obicetrapib Vs Bempedoic Acid to Treat Dyslipidemia in Adults With Primary Non-familial Hypercholesterolemia or Mixed Dyslipidemia at High to Very High Cardiovascular Risk, During a Treatment Period of Approximately 84 Days
Trial Treatment · Phase 3 · A. Menarini International Licensing S.A.
FutureMeds North Tees, Stockton-on-Tees
Registry updated 2026-06-09
NCT06597019
Study to Evaluate Efficacy and Safety of Inclisiran in Children With Heterozygous Familial Hypercholesterolemia
Trial Treatment · Phase 3 · Novartis Pharmaceuticals
London · West Midlands
Registry updated 2026-05-15
NCT06112327
Long-term Follow-up of Participants Dosed With an Investigational Gene Editing Therapy for Cardiovascular Disease
Research · Verve Therapeutics, Inc.
Clinical Study Center, London
Registry updated 2026-04-08
NCT04272697
EAS Familial Hypercholesterolaemia Studies Collaboration
Research · Imperial College London
School of Public Health, Imperial College London, London
Registry updated 2026-03-04

All Familial hypercholesterolaemia trials and the map

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