Fatty liver disease (MASLD/MASH): open trials in Germany

23 open trials have a site in Germany. Registry data; only the trial team decides who can take part.

NCT06215716
A Study Evaluating Efruxifermin in Subjects With Non-Cirrhotic Nonalcoholic Steatohepatitis (NASH)/Metabolic Dysfunction-Associated Steatohepatitis (MASH) and Fibrosis
Trial Treatment · Phase 3 · Akero Therapeutics, Inc
Berlin · Frankfurt am Main · Homburg · Leipzig · Lübeck · Mainz · Würzburg
Registry updated 2026-11-06
NCT07850063
ELEVATE-LIVER: A Study to Test Whether Survodutide Helps Improve Heart Structure and Function in People With Overweight or Obesity and Fatty Liver Disease
Trial Treatment · Phase 3 · Boehringer Ingelheim
Zentrum für Klinische Studien Bad Homburg, Bad Homburg · Universitätsklinikum Erlangen, Erlangen · Universitätsklinikum Freiburg, Freiburg im Breisgau · Eugastro GmbH, Leipzig · Universitätsmedizin der Johannes Gutenberg-Universität Mainz, Mainz
Registry updated 2026-10-30
NCT06632444
LIVERAGE™: A Study to Test Whether Survodutide Helps People With a Liver Disease Called NASH/MASH Who Have Moderate or Advanced Liver Fibrosis
Trial Treatment · Phase 3 · Boehringer Ingelheim
Charite Universitaetsmedizin Berlin KöR, Berlin · Universitaetsklinikum Knappschaftskrankenhaus Bochum GmbH, Bochum · University Hospital Cologne AöR, Cologne · Technische Universitaet Dresden, Dresden · Universitaetsklinikum Erlangen AöR, Erlangen · Goethe University Frankfurt, Frankfurt Am Main · Universitaetsklinikum Heidelberg AöR, Heidelberg · Universitaet Des Saarlandes, Homburg · Klinikum Landshut AdoeR der Stadt Landshut, Landshut · Eugastro GmbH, Leipzig · Universitaetsklinikum Schleswig-Holstein AöR, Luebeck · Otto Von Guericke Universitaet Magdeburg, Magdeburg · Universitaetsmedizin der Johannes Gutenberg-Universitaet Mainz KöR, Mainz · Heidelberg University, Mannheim · Universitaetsklinikum Muenster AöR, Muenster · Universitaetsklinikum Tuebingen AöR, Tuebingen · St. Josefs-Hospital Wiesbaden GmbH, Wiesbaden · Universitaetsklinikum Wuerzburg AöR, Wuerzburg
Registry updated 2026-10-28
NCT06632457
LIVERAGE™ - Cirrhosis: A Study to Test Whether Survodutide Helps People With a Liver Disease Called NASH/MASH Who Have Cirrhosis
Trial Treatment · Phase 3 · Boehringer Ingelheim
Charite Universitaetsmedizin Berlin KöR, Berlin · Universitaetsklinikum Knappschaftskrankenhaus Bochum GmbH, Bochum · University Hospital Cologne AöR, Cologne · Technische Universitaet Dresden, Dresden · Goethe University Frankfurt, Frankfurt Am Main · Universitaetsklinikum Heidelberg AöR, Heidelberg · Universitaet Des Saarlandes, Homburg · Klinikum Landshut AdoeR der Stadt Landshut, Landshut · Universitaetsklinikum Schleswig-Holstein AöR, Luebeck · Otto Von Guericke Universitaet Magdeburg, Magdeburg · Universitaetsmedizin der Johannes Gutenberg-Universitaet Mainz KöR, Mainz · Heidelberg University, Mannheim · Universitaetsklinikum Muenster AöR, Muenster · St. Josefs-Hospital Wiesbaden GmbH, Wiesbaden · Universitaetsklinikum Wuerzburg AöR, Wuerzburg
Registry updated 2026-10-28
2024-512895-36-00
A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study Evaluating the Safety and Efficacy of Efruxifermin in Subjects with Compensated Cirrhosis Due to Nonalcoholic Steatohepatitis (NASH)/Metabolic Dysfunction-Associated Steatohepatitis (MASH)
Trial Treatment · Phase 3 · Akero Therapeutics Inc.
Charite Universitaetsmedizin Berlin KöR, Berlin · Medizinische Hochschule Hannover, Hanover · Universitaet Des Saarlandes, Homburg · Universitaet Leipzig, Leipzig · Eugastro GmbH, Leipzig · Universitaetsklinikum Schleswig-Holstein AöR, Luebeck
Registry updated 2026-10-23
NCT06318169
A Study Evaluating the Efficacy and Safety of Pegozafermin in Participants With MASH and Fibrosis (ENLIGHTEN-Fibrosis)
Trial Treatment · Phase 3 · Hoffmann-La Roche
Klinikum Chemnitz gGmbH, Chemnitz · Goethe University Frankfurt, Frankfurt Am Main · Medical Center- University of Freiburg, Freiburg im Breisgau · Medizinische Hochschule Hannover, Hanover · Universitaet Des Saarlandes, Homburg · Universitaet Muenster, Muenster
Registry updated 2026-10-23
NCT06419374
A Study to Evaluate the Efficacy and Safety of Pegozafermin in Participants With Compensated Cirrhosis Due to MASH
Trial Treatment · Phase 3 · Hoffmann-La Roche
Klinikum Chemnitz gGmbH, Chemnitz · Goethe University Frankfurt, Frankfurt Am Main · Medical Center- University of Freiburg, Freiburg im Breisgau · Medizinische Hochschule Hannover, Hanover · Universitaet Des Saarlandes, Homburg · Universitaet Muenster, Muenster
Registry updated 2026-10-23
NCT07877272
Endohepatology-Based Reclassification of Treatment Indication in High-Risk MASLD
Research · University Hospital Muenster
University hospital Muenster, Münster
Registry updated 2026-10-20
2026-525755-82-00
A pivotal clinical study to investigate the safety and efficacy of efimosfermin compared with placebo in adult participants with compensated cirrhosis due to Metabolic dysfunction-associated steatohepatitis (MASH)
Trial Treatment · Phase 3 · Glaxosmithkline Research & Development Limited
Epimed Gesellschaft fuer epidemiologische und klinische Forschung in der Medizin mbH, Berlin · University Medical Center Hamburg-Eppendorf, Hamburg · Universitaetsklinikum Heidelberg AöR, Heidelberg · Universitaet Des Saarlandes, Homburg · Eugastro GmbH, Leipzig · Universitaetsmedizin der Johannes Gutenberg-Universitaet Mainz KöR, Mainz · Universitaet Muenster, Muenster
Registry updated 2026-10-19
2026-525757-37-00
A study to investigate safety and efficacy of efimosfermin compared with placebo in adult participants with compensated cirrhosis (stage F4 fibrosis) due to MASH (NEBULA-2)
Trial Treatment · Phase 3 · Glaxosmithkline Research & Development Limited
University Medical Center Hamburg-Eppendorf, Hamburg · Universitaetsklinikum Heidelberg AöR, Heidelberg · Universitaet Des Saarlandes, Homburg · Eugastro GmbH, Leipzig · Universitaetsmedizin der Johannes Gutenberg-Universitaet Mainz KöR, Mainz · Universitaet Muenster, Muenster
Registry updated 2026-10-19
NCT06528314
A Study Evaluating Efruxifermin in Subjects With Compensated Cirrhosis Due to NASH/MASH
Trial Treatment · Phase 3 · Akero Therapeutics, Inc
Berlin · Frankfurt am Main · Homburg · Leipzig · Lübeck
Registry updated 2026-10-13
NCT07165028
A Master Protocol of Multiple Agents in Adults With Metabolic Dysfunction-Associated Steatotic Liver Disease (SYNERGY-Outcomes)
Trial Treatment · Phase 3 · Eli Lilly and Company
Herz - und Diabeteszentrum Nordrhein - Westfalen, Bad Oeynhausen, Bad Oeynhausen · Charité Campus Virchow-Klinikum, Berlin · Universitätsklinikum Brandenburg an der Havel, Brandenburg · Universitaetsklinikum Carl Gustav Carus, Technischen Universitaet Dresden, Dresden · Deutsches Diabetes-Zentrum (DDZ), Düsseldorf · Universitätsklinikum Frankfurt Goethe-Universität, Frankfurt · Medizinische Hochschule Hannover, Hanover · Universitaetsklinikum Heidelberg, Heidelberg · Universitaetsklinikum des Saarlandes, Homburg · Eugastro GmbH, Leipzig · Universitatsklinikum Leipzig, Leipzig · Universitätsmedizin Johannes Gutenberg Universität Mainz, Mainz · Ruppiner Kliniken, Neuruppin
Registry updated 2026-10-08
NCT07221188
A Clinical Study to Investigate the Safety and Tolerability of Efimosfermin Alfa Injection in Participants With Known or Suspected F2- or F3-stage MASH
Trial Treatment · Phase 3 · GlaxoSmithKline
Epimed Gesellschaft fuer epidemiologische und klinische Forschung in der Medizin mbH, Berlin · Charite Universitaetsmedizin Berlin KöR, Berlin · University Medical Center Hamburg-Eppendorf, Hamburg · Universitaetsklinikum Heidelberg AöR, Heidelberg · Universitaet Des Saarlandes, Homburg · Universitaet Leipzig, Leipzig · Eugastro GmbH, Leipzig · Universitaetsmedizin der Johannes Gutenberg-Universitaet Mainz KöR, Mainz · Universitaet Muenster, Muenster
Registry updated 2026-09-17
NCT06814990
Acquisition of Cardiac Function Parameters in MRI and Echocardiography in Patients With Ethyltoxic Liver Cirrhosis and Transjugular Intrahepatic Portosystemic Shunt (TIPSS) Placement
Trial Treatment · Stephanie Gräger
Jena University Hospital, Jena
Registry updated 2026-08-04
NCT06819917
Identification of Liver Fibrosis Biomarkers
Research · Roche Diagnostics GmbH
Universitätsmedizin der Johannes Gutenberg-Universität Mainz, Mainz
Registry updated 2026-05-27
NCT07530809
Time-restricted Feeding in MASLD
Trial Treatment · Universität des Saarlandes
Department of Internal Medicine II, Saarland University Medical Center, Saarland University,, Homburg
Registry updated 2026-04-15
2023-505141-48-00
A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study Evaluating the Safety and Efficacy of Efruxifermin in Subjects with Non-Cirrhotic Nonalcoholic Steatohepatitis (NASH)/Metabolic Dysfunction-Associated Steatohepatitis (MASH) and Fibrosis
Trial Treatment · Phase 3 · Akero Therapeutics Inc.
Epimed Gesellschaft fuer epidemiologische und klinische Forschung in der Medizin mbH, Berlin · Charite Universitaetsmedizin Berlin KöR, Berlin · Goethe University Frankfurt, Frankfurt Am Main · Universitaet Des Saarlandes, Homburg · Velocity Clinical Research Germany GmbH, Leipzig · Eugastro GmbH, Leipzig · Universitaet Leipzig, Leipzig · Universitaetsklinikum Schleswig-Holstein AöR, Luebeck · Universitaetsmedizin Der Johannes Gutenberg-Universitaet Mainz Koerperschaft Des Offentlichen Rechts, Mainz · Universitaetsklinikum Wuerzburg AöR, Wuerzburg
Registry updated 2026-01-22
NCT06907563
Long-term Follow-up to Determine Outcome in Liver Disease (LOVE Study)
Research · Universität des Saarlandes
University Medical Center Saarland, Department of Internal Medicine II, Homburg
Registry updated 2025-04-02
NCT05651724
Global Research Initiative for Patients Screening on MASH
Research · Julius Clinical
Universitätsklinikum des Saarlandes, Homburg · Universitätsmedizin Mainz, Mainz
Registry updated 2024-08-01
NCT06396871
Deep Phenotyping of Peripheral Blood Cells and Circulating Factors in Metabolic Diseases
Research · Technische Universität Dresden
University Study Center for Metabolic Diseases, Dresden
Registry updated 2024-05-02
NCT04066608
Prevalence of Advanced Fibrosis in Patients Living With HIV
Research · Johannes Gutenberg University Mainz
University Medical Center of the Johannes Gutenberg University, Mainz · University Medical Center of the Johannes Gutenber Univeristy, Mainz
Registry updated 2023-12-28
NCT05046483
Metabolic Phenotyping and Follow-Up of Patients With and Without Diabetes After New Onset of STEMI
Research · German Diabetes Center
German Diabetes Center, Düsseldorf
Registry updated 2023-08-22
NCT04442334
The European NAFLD Registry
Research · Newcastle University
UNIVERSITÄTSKLINIKUM der RWTH Aachen, Aachen · Charite - University Hospital Berlin, Berlin · Universitätsklinikum Freiburg, Freiburg im Breisgau · Universitätsmedizin der Johannes Gutenberg-Universität Mainz, Mainz · Universitätsklinikums Würzburg, Würzburg
Registry updated 2023-01-06

All Fatty liver disease (MASLD/MASH) trials and the map

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