Fatty liver disease (MASLD/MASH) trials in United States

In United States 100 Also abroad 369

100 trials · From ClinicalTrials.gov, checked 15 November 2026. Ask the study team whether a trial fits you.

No phaseNot yet taking people in United States
AGED Diagnostics Clinical Validation Study
Where
Bethesda
Age
18 years to 75 years
People
500
Run by
Active Genomes Expressed Diagnostics, Corp
See details and how to joinNCT07867574
No phaseTaking people
Blood Collection Biorepository for Liver Disease Research
Where
Buffalo
Age
7 years and over
People
1,000
Run by
State University of New York at Buffalo
See details and how to joinNCT03025074
Phase 3Taking people
A Master Protocol of Multiple Agents in Adults With Metabolic Dysfunction-Associated Steatotic Liver Disease (SYNERGY-Outcomes)
Where
Akron, Albuquerque, Aurora, Austin, Baltimore, Bastrop, Beavercreek, Bellaire, Bellevue, Brooklyn, Brownsville, Buffalo, Canoga Park, Chandler, Charleston, Chattanooga, Chevy Chase, Chicago, Clermont, Clinton Township, Columbia, Cordova, Dalton, Daytona Beach, Delray Beach, Denison, DeSoto, Doral, Durham, Edinburg, El Dorado, Englewood, Farmers Branch, Flourtown, Flowood, Forney, Fort Myers, Fort Worth, Fountain Valley, Freehold, Fresno, Gainesville, Gilbert, Hamden, Hollywood, Houston, Indianapolis, Inverness, Jacksonville, Jupiter, Kansas City, Lady Lake, La Jolla, Lake Forest, Lakewood Rch, Lancaster, Largo, Las Vegas, Lenexa, Lexington, Long Beach, Los Angeles, Marietta, Marrero, McAllen, Mesquite, Miami, Miami Lakes, Minneapolis, Monroe, Morehead City, Morristown, Murrieta, Naples, New Albany, New Bedford, Newburgh, New Iberia, New York, Norfolk, North Little Rock, Ogden, Orange, Orlando, Pasadena, Pennington, Peoria, Philadelphia, Port Orange, Providence, Richmond, Ridgewood, Riverside, Riverview, Roanoke, San Antonio, San Diego, Sandy City, San Francisco, Seattle, Shavano Park, Shreveport, South Bend, Southfield, Southlake, St. Petersburg, Sugar Land, Sun City, Tacoma, Tamarac, Topeka, Troy, Tucson, Tuscaloosa, Union City, University Park, Warren Township, Weslaco, West Des Moines, Westlake, West Monroe, Wylie, Wyomissing, Yonkers
Age
18 years and over
People
4,500 worldwide
Run by
Eli Lilly and Company
See details and how to joinNCT07165028 · EU 2025-522674-36-00
Phase 2Taking people
A Phase 2a Study of ALN-PNP With and Without a GLP1R Agonist in Adult Patients With Homozygous PNPLA3-Related MASLD
Where
Austin, Coronado, Georgetown, Jupiter, Metairie, Miami, Pasadena, San Antonio, Tucson
Age
18 years to 75 years
People
204
Run by
Regeneron Pharmaceuticals
See details and how to joinNCT07527910
Phase 2Taking people
Liver Cirrhosis Network Rosuvastatin Efficacy and Safety for Cirrhosis in the United States
Where
Ann Arbor, Cleveland, Durham, La Jolla, Los Angeles, Miami, New York, Richmond, Rochester, San Francisco
Age
18 years to 75 years
People
260
Run by
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
See details and how to joinNCT05832229
Phase 3Taking people
Phase 3 Study of the Efficacy, Safety, and Clinical Outcomes of Pemvidutide in MASH
Where
Fountain Valley, Fresno, Gardena, Long Beach, Miami, North Little Rock, Ocala, Springboro, Westlake
Age
18 years to 75 years
People
1,800
Run by
Altimmune, Inc.
See details and how to joinNCT07795164
Phase 2Taking people
Impact of Soymilk on Liver Disease Severity of Children With Non-alcoholic Fatty Liver Disease (NAFLD)
Where
Cincinnati
Age
5 years to 16 years
People
44
Run by
Marialena Mouzaki
See details and how to joinNCT06133101
Phase 3Taking people
A Clinical Study to Investigate the Safety and Tolerability of Efimosfermin Alfa Injection in Participants With Known or Suspected F2- or F3-stage MASH
Where
Akron, Arcadia, Austin, Boynton Beach, Brownsville, Cape Coral, Chattanooga, Clermont, Covina, Dallas, DeSoto, Doral, East Syracuse, Fort Myers, Hialeah, Homestead, Inverness, Jacksonville, Jersey City, Kissimmee, Lakeland, Los Angeles, Maitland, Manassas, Marrero, Miami, Miami Lakes, Morehead City, New York, Ocala, Palmetto Bay, Richmond, San Antonio, San Diego, Santa Maria, Sarasota, Seabrook, Seattle, Springboro, Springfield, St Louis, Sugar Land, Tomball, Topeka, Van Nuys, Waco, West Jordan
Age
18 years to 75 years
People
1,250 worldwide
Run by
GlaxoSmithKline
See details and how to joinNCT07221188 · EU 2025-523674-16-00
No phaseNot yet taking people in United States
Digital Behavioral Therapy to Reduce Diabetes and Liver Disease Risk
Where
Jamaica
Age
18 years and over
People
180
Run by
SIPPA Solutions INC
See details and how to joinNCT07032311
Phase 2Taking people
Study of Resmetirom in Children and Adolescents With MASH
Where
Indianapolis
Age
6 years to 17 years
People
61
Run by
Madrigal Pharmaceuticals, Inc.
See details and how to joinNCT07763015
Early phase 1Taking people
Effect of Tirzepatide on Markers of MASLD in Patients With Obesity
Where
Albuquerque
Age
18 years to 75 years
People
8
Run by
University of New Mexico
See details and how to joinNCT06934642
Phase 1/2Taking people
A Study of VV-14303 for the Treatment of Metabolic Dysfunction-associated Steatohepatitis (MASH)
Where
Chandler, Lady Lake
Age
18 years to 75 years
People
56 worldwide
Run by
Kriya Therapeutics, Inc.
See details and how to joinNCT07732400
Phase 1/2Taking people
Phase 1/2 Study of OPK-88006 in Healthy and Presumed MASH Participants
Where
Miami
Age
18 years to 75 years
People
30
Run by
OPKO Health, Inc.
See details and how to joinNCT07512427
Phase 2Taking people
Study to Evaluate Resmetirom in Post-Liver Transplant Patients With MASH
Where
Aurora, Charlottesville, Chicago, Dallas, Houston, La Jolla, Los Angeles, Manhasset, Murray, Nashville, New York, Omaha, Rochester, San Francisco, Washington D.C.
Age
18 years to 75 years
People
120 worldwide
Run by
Madrigal Pharmaceuticals, Inc.
See details and how to joinNCT07335601
Phase 1Taking people
Human Models of Selective Insulin Resistance: Alpelisib, Part I
Where
New York
Age
18 years to 70 years
People
32
Run by
Columbia University
See details and how to joinNCT06354088
Early phase 1Taking people
NeuroFLiPP: Parametric PET of Neuroinflammation in Fatty Liver Disease
Where
Sacramento
Age
18 years and over
People
12
Run by
University of California, Davis
See details and how to joinNCT06453915
Phase 4Taking people
Quantifying Hepatic Mitochondrial Fluxes in Humans
Where
San Antonio
Age
18 years to 80 years
People
60
Run by
The University of Texas Health Science Center at San Antonio
See details and how to joinNCT05305287
No phaseTaking people
InAdvance: Surveillance, Prevention, and Interception in a Population at Risk for Cancer
Where
Boston
People
5,000
Run by
Dana-Farber Cancer Institute
See details and how to joinNCT05463796
No phaseNot yet taking people in United States
Screening Cardiometabolic Opportunities Using Transformative Echocardiography Artificial Intelligence (SCOUT Echo-AI)
Where
Boston, Chicago, Los Angeles, Palo Alto, Pleasanton
Age
18 years and over
People
2,000
Run by
Kaiser Permanente
See details and how to joinNCT07216859
No phaseTaking people
Harnessing Macrophage Lysosomal Lipid Metabolism in Obesity
Where
Columbia
Age
18 years to 70 years
People
60
Run by
Bettina Mittendorfer
See details and how to joinNCT06335771
No phaseTaking people
Harnessing Macrophage Lysosomal Lipid Metabolism in Obesity (ATM)
Where
Columbia
Age
18 years to 70 years
People
60
Run by
Bettina Mittendorfer
See details and how to joinNCT06571474
No phaseTaking people
Effects of Peanut Consumption on Adults With Metabolic Associated Fatty Liver Disease
Where
Detroit
Age
30 years to 70 years
People
125
Run by
Henry Ford Health System
See details and how to joinNCT07646197
Phase 4Taking people
Fibrosis Lessens After Metabolic Surgery
Where
Cleveland, Indianapolis, Phoenix, Rochester
Age
18 years to 75 years
People
120 worldwide
Run by
The Cleveland Clinic
See details and how to joinNCT06374875
No phaseTaking people
Pathogenesis of Pediatric Nonalcoholic Fatty Liver Disease (NAFLD)
Where
New Haven
Age
12 years to 18 years
People
260
Run by
Yale University
See details and how to joinNCT04634643
Phase 2Taking people
A Study to Evaluate the Use of Resmetirom in Participants With MASLD and HIV
Where
Baltimore, Birmingham, Durham, Houston, Indianapolis, La Jolla, New York, Richmond, San Francisco, West Palm Beach
Age
18 years and over
People
120
Run by
Naga P. Chalasani
See details and how to joinNCT07143968