Glioblastoma trials in Germany

In Germany 26 Also abroad 424

26 trials · From ClinicalTrials.gov and EU CTIS (euclinicaltrials.eu), checked 11 November 2026. Ask the study team whether a trial fits you.

Phase 1Not yet taking people in Germany
Synergism of dendritic cell vaccination and anti-PD-L1 immune check-point blockade to sensitize recurrent glioblastoma to anti-tumoral immunity
Where
Duesseldorf, Duisburg
Age
18 years and over
People
6
Run by
Heinrich-Heine-Universitaet Duesseldorf
See details and how to join2026-525397-19-00 · EU 2026-525397-19-00
Phase 2/3Taking people
A Trial to Evaluate Multiple Regimens in Newly Diagnosed and Recurrent Glioblastoma
Where
Bonn, Cologne, Frankfurt Am Main, Heidelberg, Mannheim, Regensburg, Tuebingen
Age
18 years and over
People
2,250 worldwide
Run by
Global Coalition for Adaptive Research
See details and how to joinNCT03970447 · EU 2024-511452-40-00
Phase 2Not yet taking people in Germany
IDH1-vac in Patients With Newly Diagnosed IDH1R132H-positive High-grade Astrocytomas
Where
Berlin, Bonn, Cologne, Dresden, Erlangen, Essen, Frankfurt, Heidelberg, Mannheim, Regensburg, Tübingen, Ulm, Würzburg
Age
18 years to 70 years
People
216
Run by
German Cancer Research Center
See details and how to joinNCT07888647 · EU 2026-526308-64-00
No phaseNot yet taking people in Germany
An Optimization Study Evaluating Safety and Efficacy of the Y-90 Glioblastoma (GBM) Device in Patients With Recurrent GBM
Where
Tübingen
Age
18 years and over
People
30 worldwide
Run by
Boston Scientific Corporation
See details and how to joinNCT07867886
Phase 2Taking people
Phase I/II trial of meclofenamate in progressive MGMT-methylated glioblastoma under temozolomide second-line therapy (MecMeth/ NOA-24)
Where
Bochum, Bonn, Cologne, Dresden, Erfurt, Essen, Frankfurt Am Main, Freiburg im Breisgau, Heidelberg, Leipzig, München, Münster, Regensburg, Rostock, Tübingen
Age
18 years and over
People
72
Run by
Rheinische Friedrich-Wilhelms-Universitaet Bonn
See details and how to join2024-511264-89-00 · EU 2024-511264-89-00
No phaseTaking people
Targeted Pediatric High-Grade Glioma Therapy
Where
Heidelberg
Age
12 months to 39 years
People
350 worldwide
Run by
Nationwide Children's Hospital
See details and how to joinNCT05839379
Phase 2Taking people
Study of Olutasidenib and Temozolomide in HGG
Where
Heidelberg
Age
12 years to 39 years
People
60 worldwide
Run by
Rigel Pharmaceuticals
See details and how to joinNCT06161974
No phaseTaking people
Mental Health and Suicidality in Glioblastoma Patients in Germany
Where
Berlin, Bochum, Essen, Hamburg, Heidelberg, Münster
Age
18 years and over
People
180
Run by
University Hospital, Essen
See details and how to joinNCT07409584
No phaseTaking people
Prognostic Potential of Olfactory Function in Glioblastoma: a Prospective Observational Study
Where
Essen, Münster
Age
18 years and over
People
128
Run by
Sied Kebir
See details and how to joinNCT06954636
Early phase 1Taking people
Lorlatinib for Newly-Diagnosed High-Grade Glioma With ROS or ALK Fusion
Where
Heidelberg
Age
1 year to 21 years
People
15 worldwide
Run by
Nationwide Children's Hospital
See details and how to joinNCT06333899
Phase 1/2Taking people
Radiodynamic Therapy (RDT) With Gliolan in Patients With First Recurrence of Brain Tumor
Where
Muenster
Age
18 years to 75 years
People
34
Run by
Universität Münster
See details and how to joinNCT05590689 · EU 2024-517651-12-00
Phase 1Not yet taking people in Germany
An open-label dose escalation study to estimate maximum tolerated dose (MTD), identify dose-limiting toxicities (DLTs) and study pharmacokinetics following a single dose of intracranially administered temozolomide-based SI-053 as an add-on to the current standard of care (SoC), in adult patients with newly diagnosed glioblastoma (GBM).
Where
Aachen, Cologne, Hamburg
Age
18 years to 64 years
People
27 worldwide
Run by
Double Bond Pharmaceutical AB
See details and how to joinNCT04967690 · EU 2024-515128-35-00
Phase 3Taking people
Lomustine With and Without Reirradiation for First Progression of Glioblastoma: a Randomized Phase III Study
Where
Bochum, Cologne, Essen, Heidelberg, Jena, Munich, Tuebingen
Age
18 years and over
People
411 worldwide
Run by
European Organisation for Research and Treatment of Cancer - EORTC
See details and how to joinNCT05904119 · EU 2023-505267-36-00
No phaseTaking people
Low-Intensity Oscillatory Magnetic Therapy in Patients With Newly Diagnosed Glioblastoma Multiforme (GBM) - An Exposure-time Escalation Pilot Trial
Where
Bonn, Leipzig, Lünen, Mannheim, München, Stuttgart
Age
18 years and over
People
30
Run by
BioTex, Inc.
See details and how to joinNCT06533163
Phase 2Taking people
Study of Ribociclib and Everolimus in HGG and DIPG or Ribociclib and Temozolomide in DHG, H3G34-mutant
Where
Heidelberg
Age
12 months to 39 years
People
120 worldwide
Run by
Nationwide Children's Hospital
See details and how to joinNCT05843253
No phaseTaking people
Glioblastoma Radiotherapy Using IMRT or Proton Beams
Where
Heidelberg, Marburg, Stuttgart
Age
18 years and over
People
326
Run by
University Hospital Heidelberg
See details and how to joinNCT04752280
Phase 1Taking people
Intracranial Injection of NK-92/5.28.z Cells in Combination With Intravenous Ezabenlimab in Patients With Recurrent HER2-positive Glioblastoma
Where
Frankfurt Am Main, Heidelberg, Mainz, Mannheim
Age
18 years and over
People
42
Run by
Johann Wolfgang Goethe University Hospital
See details and how to joinNCT03383978 · EU 2024-511988-29-01
Phase 2Taking people
Surgery for Recurrent Glioblastoma
Where
Erfurt, Münster
Age
18 years and over
People
120 worldwide
Run by
Insel Gruppe AG, University Hospital Bern
See details and how to joinNCT02394626
Phase 3Taking people
Anterior Temporal Lobectomy in Temporal Glioblastoma
Where
Bonn
Age
18 years to 74 years
People
178
Run by
University Hospital, Bonn
See details and how to joinNCT07021339
No phaseTaking people
Amplitude Modulated Radiofrequency Electromagnetic Field Treatment Combined With Radiochemotherapy and Maintenance Chemotherapy in Patients With Glioblastoma (Brain-RF)
Where
Berlin
Age
18 years to 70 years
People
26
Run by
Charite University, Berlin, Germany
See details and how to joinNCT06140875
No phaseTaking people
The RECSUR-study: Resection Versus Best Oncological Treatment for Recurrent Glioblastoma (ENCRAM 2302)
Where
Heidelberg, Munich
Age
18 years to 90 years
People
464 worldwide
Run by
Jasper Gerritsen
See details and how to joinNCT06283927
No phaseTaking people
The SUPRAMAX Study: Supramaximal Resection Versus Maximal Resection for High-Grade Glioma Patients (ENCRAM 2201)
Where
Heidelberg, Munich
Age
18 years to 90 years
People
784 worldwide
Run by
Jasper Gerritsen
See details and how to joinNCT06118723
No phaseTaking people
The RECMAP-study: Resection With or Without Intraoperative Mapping for Recurrent Glioblastoma
Where
Heidelberg, Munich
Age
Up to 90 years
People
225 worldwide
Run by
Erasmus Medical Center
See details and how to joinNCT06273176
No phaseTaking people
The RESBIOP-study: Resection Versus Biopsy in High-grade Glioma Patients (ENCRAM 2202)
Where
Heidelberg, Munich
Age
18 years to 90 years
People
564 worldwide
Run by
Jasper Gerritsen
See details and how to joinNCT06146725
No phaseTaking people
The PALSUR-study: Palliative Care Versus Surgery in High-grade Glioma Patients (ENCRAM 2203)
Where
Heidelberg, Munich
Age
18 years to 90 years
People
1,015 worldwide
Run by
Jasper Gerritsen
See details and how to joinNCT06146738