Glioblastoma: open trials in United States

• NCT05432804

  Testing the Addition of an Anti-cancer Drug, Selinexor, to the Usual Chemotherapy Treatment (Temozolomide) for Brain Tumors That Have Returned After Previous Treatment

  Trial Treatment · Phase 1/2 · National Cancer Institute (NCI)

  Emory University Hospital/Winship Cancer Institute, Atlanta · Emory University Hospital Midtown, Atlanta · UCHealth University of Colorado Hospital, Aurora · Roswell Park Cancer Institute, Buffalo · University of Virginia Cancer Center, Charlottesville · University of Chicago Comprehensive Cancer Center, Chicago · University of Cincinnati Cancer Center-UC Medical Center, Cincinnati · Cleveland Clinic Foundation, Cleveland · Ohio State University Comprehensive Cancer Center, Columbus · UM Sylvester Comprehensive Cancer Center at Coral Gables, Coral Gables · UM Sylvester Comprehensive Cancer Center at Deerfield Beach, Deerfield Beach · City of Hope Comprehensive Cancer Center, Duarte · UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care, Irvine · Mayo Clinic in Florida, Jacksonville · UC San Diego Moores Cancer Center, La Jolla · University of Kentucky/Markey Cancer Center, Lexington · Cooperman Barnabas Medical Center, Livingston · Los Angeles General Medical Center, Los Angeles · Keck Medicine of USC Koreatown, Los Angeles · USC / Norris Comprehensive Cancer Center, Los Angeles · University of Wisconsin Carbone Cancer Center - Eastpark Medical Center, Madison · University of Wisconsin Carbone Cancer Center - University Hospital, Madison · University of Miami Miller School of Medicine-Sylvester Cancer Center, Miami · Rutgers New Jersey Medical School, Newark · Rutgers Cancer Institute of New Jersey, New Brunswick · Laura and Isaac Perlmutter Cancer Center at NYU Langone, New York · NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center, New York · University of Oklahoma Health Sciences Center, Oklahoma City · UC Irvine Health- Chao Family Comprehensive Cancer Center, Orange · University of Chicago Medicine-Orland Park, Orland Park · Mayo Clinic Hospital in Arizona, Phoenix · UPMC Hillman Cancer Center, Pittsburgh · VCU Massey Comprehensive Cancer Center, Richmond · Mayo Clinic in Rochester, Rochester · University of California Davis Comprehensive Cancer Center, Sacramento · Huntsman Cancer Institute/University of Utah, Salt Lake City · Moffitt Cancer Center, Tampa · University of Cincinnati Cancer Center-West Chester, West Chester · Wake Forest University Health Sciences, Winston-Salem

  Registry updated 2026-11-06

• NCT05969860

  At-Home Cancer Directed Therapy Versus in Clinic for the Treatment of Patients With Advanced Cancer

  Trial Treatment · Phase 2 · Mayo Clinic

  Altru Cancer Center, Grand Forks · Mayo Clinic in Florida, Jacksonville

  Registry updated 2026-11-06

• NCT06161519

  PLX038 in Primary Central Nervous System Tumors Containing MYC or MYCN Amplifications

  Trial Treatment · Phase 1/2 · National Cancer Institute (NCI)

  National Institutes of Health Clinical Center, Bethesda

  Registry updated 2026-11-06

• NCT07195591

  Beginning Radiation Immediately With GammaTile at GBM Excision Versus Standard of Care

  Trial Treatment · Phase 3 · GT Medical Technologies, Inc.

  Emory Winship Cancer Institute, Atlanta · Johns Hopkins University, Baltimore · Medical University of South Carolina, Charleston · Rush University Medical Center, Chicago · University of Missouri, Columbia · The Ohio State University, Columbus · Inova Schar Cancer Institute, Fairfax · East Carolina University, Greenville · Houston Methodist, Houston · Dartmouth Hitchcock Medical Center, Lebanon · Advent Health - Colorado, Littleton · Keck Medicine of USC, Los Angeles · Norton Cancer Institute - Brownsboro, Louisville · Jersey Shore University Medical Center | Hackensack, Neptune City · Advent Health, Orlando · Allegheny Health Network, Pittsburgh · Brown University Health, Providence · Sutter Health, San Francisco · HonorHealth Scottsdale Osborn Medical Center, Scottsdale · Westchester Medical Center, Valhalla

  Registry updated 2026-11-06

• NCT00083512

  Collection of Blood and Urine Samples in Patients Receiving Radiation Therapy for Glioblastoma Multiforme

  Research · National Cancer Institute (NCI)

  National Institutes of Health Clinical Center, Bethesda

  Registry updated 2026-11-05

• NCT06641908

  Anti-GD2 ADC M3554 in Advanced Solid Tumors

  Trial Treatment · Phase 1 · EMD Serono Research & Development Institute, Inc.

  Dana-Farber Cancer Institute, Boston · The University of Texas MD Anderson Cancer Center, Houston · Memorial Sloan-Kettering Cancer Center (MSKCC) - New York - Memorial Sloan Kettering Cancer Center (CC)- Westc, New York

  Registry updated 2026-11-05

• NCT05139056

  Multiple Intracerebral Doses of Neural Stem Cell-Based Virotherapy (NSC-CRAd-S-pk7) for the Treatment of Recurrent High-Grade Gliomas

  Trial Treatment · Phase 1 · City of Hope Medical Center

  Northwestern University, Chicago · City of Hope Medical Center, Duarte · Standford University, Stanford · Wake Forest University, Winston-Salem

  Registry updated 2026-11-04

• NCT07464925

  A Phase 1 Safety and Dose Finding Study of GLIX1 in Adults With Recurrent or Progressive High-grade Glioma

  Trial Treatment · Phase 1 · Tetragon Biosciences Ltd

  Northwestern Medicine, Chicago · NYU Langone Health, New York · Stanford University, Palo Alto · Moffitt Cancer Center, Tampa

  Registry updated 2026-11-04

• NCT07628647

  Living Well With Brain Cancer: A Group-Based Intervention to Promote Whole-Person Well-Being

  Trial Treatment · University of Colorado, Denver

  University of Colorado Anschutz, Aurora · University Hospitals Cleveland Medical Center*, Cleveland

  Registry updated 2026-11-03

• NCT03970447

  A Trial to Evaluate Multiple Regimens in Newly Diagnosed and Recurrent Glioblastoma

  Trial Treatment · Phase 2/3 · Global Coalition for Adaptive Research

  Piedmont Atlanta Hospital, Atlanta · Winship Cancer Institute of Emory University, Atlanta · University of Colorado Denver, Aurora · Texas Oncology - Austin, Austin · University of Alabama at Birmingham, Birmingham · Dana-Farber Cancer Institute, Boston · Massachusetts General Hospital, Boston · Medical University of South Carolina - Hollings Cancer Center, Charleston · University of Virginia Health, Charlottesville · Cleveland Clinic, Cleveland · University Hospitals Cleveland Medical Center*, Cleveland · Ohio State University Cancer Center, Columbus · University of Texas Southwestern Medical Center, Dallas · Henry Ford Health System, Detroit · Duke University Medical Center, Durham · University of Texas - MD Anderson Cancer Center, Houston · University of Mississippi Medical Center, Jackson · Mayo Clinic Cancer Center, Jacksonville · University of California San Diego, La Jolla · Cedars Sinai - Samuel Oschin Comprehensive Cancer Institute, Los Angeles · University of California, Los Angeles, Los Angeles · Sylvester Comprehensive Cancer Center*, Miami · Froedtert Hospital/Medical College of Wisconsin, Milwaukee · Allina Health Systems/Abbott Northwestern Hospital, Minneapolis · Yale Cancer Center / Smilow Cancer Hospital*, New Haven · LSU Health Sciences Center - New Orleans, New Orleans · Memorial Sloan-Kettering Cancer Center, New York · Icahn School of Medicine at Mount Sinai, New York · Perlmutter Cancer Center, NYU Langone Health, New York · Columbia University Medical Center, New York · St. Joseph Hospital, Orange · University of Pennsylvania - Perelman Center for Advanced Medicine, Philadelphia · Allegheny General Hospital, Pittsburgh · University of Pittsburgh Medical Center - Hillman Cancer Center, Pittsburgh · Mayo Clinic Cancer Center - Rochester, Rochester · University of Utah - Huntsman Cancer Institute, Salt Lake City · University of California San Francisco, San Francisco · University of Washington Medical Center, Seattle · Stanford Cancer Center, Stanford · Washington University School of Medicine - Siteman Cancer Center, St Louis · Moffitt Cancer Center, Tampa · Comprehensive Cancer Center of Wake Forest*, Winston-Salem

  Registry updated 2026-11-02

• NCT05106296

  Chemo-immunotherapy Using Ibrutinib Plus Indoximod for Patients With Pediatric Brain Cancer

  Trial Treatment · Phase 1 · Theodore S. Johnson

  Augusta University, Georgia Cancer Center, Augusta

  Registry updated 2026-11-02

• NCT07326566

  Study of Silevertinib With Temozolomide for the Treatment of Newly Diagnosed GBM With Unmethylated MGMT and EGFRvIII

  Trial Treatment · Phase 2 · Black Diamond Therapeutics, Inc.

  University of Michigan, Ann Arbor · Piedmont Oncology Research, Atlanta · Johns Hopkins Sidney Kimmel Cancer Center - Baltimore, Baltimore · University of Alabama at Birmingham O'Neal Comprehensive Cancer Center, Birmingham · Massachusetts General Hospital, Boston · Beth Israel Deaconess Medical Center, Boston · Dana-Farber Cancer Institute, Boston · Cleveland Clinic Taussig Cancer Center, Cleveland · Ohio State University, Columbus · Henry Ford Cancer- Detroit, Detroit · Inova Schar Cancer Institute, Fairfax · Prisma Health, Greenville · John Theurer Cancer Center at Hackensack University Medical Center, Hackensack · UT MD Anderson Cancer Center, Houston · UCSD Moores Cancer Center, La Jolla · Northwell Health Center for Advanced Medicine - Brain Tumor Center, Lake Success · Cedars-Sinai Medical Center, Los Angeles · University of Wisconsin Carbone Cancer Center, Madison · Miami Cancer Institute, Miami · Atrium Health Levine Cancer Institute, Minneapolis · Rutgers Cancer Institute, New Brunswick · Yale Cancer Center, New Haven · Columbia University Irving Medical Center, New York · University of Nebraska Medical Center, Omaha · UC Irvine Health, Orange · Stanford University, Palo Alto · Thomas Jefferson University, Sidney Kimmel Comprehensive Cancer Center, Philadelphia · UPMC Hillman Cancer Center, Pittsburgh · VCU Massey Comprehensive Cancer Center, Richmond · Huntsman Cancer Institute/University of Utah, Salt Lake City · Maine Health Cancer Care and Blood Disorders - Scarborough, Scarborough · Highlands Oncology Group, Springdale · Washington University School of Medicine - Siteman Cancer Center, St Louis · Atlantic Health, Summit · Moffitt Cancer Center, Tampa · Montefiore Medical Center, The Bronx · Johns Hopkins Sibley Memorial Hospital, Washington D.C. · Atrium Health Wake Forest Baptist, Winston-Salem

  Registry updated 2026-11-02

• NCT04573140

  A Study of RNA-lipid Particle (RNA-LP) Vaccines for Newly Diagnosed Pediatric High-Grade Gliomas (pHGG) and Adult Glioblastoma (GBM)

  Trial Treatment · Phase 1 · University of Florida

  UF Health, Gainesville · Children's National Hospital, Washington D.C.

  Registry updated 2026-10-30

• NCT05303467

  A Feasibility Study to Evaluate the Safety of the TheraSphere Glioblastoma (GBM) Device in Patients With Recurrent GBM

  Trial Treatment · Phase 1 · Boston Scientific Corporation

  Johns Hopkins Interventional Radiology Center, Baltimore · University of Alabama Birmingham, Birmingham · Northwestern Univerity, Chicago · MD Anderson Cancer Center, Houston · Mayo Jacksonville, Jacksonville · Lenox Hill Hospital, New York · University of California San Diego, San Diego · University of California San Francisco, San Francisco · Washington University School of Medicine, St Louis

  Registry updated 2026-10-30

• NCT06946680

  IL-8 Receptor-modified CD70 CAR T Cell Therapy in CD70+ Newly Diagnosed and Recurrent Pediatric High-grade Glioma (pHGG) and Newly Diagnosed Diffuse Intrinsic Pontine Glioma (ndDIPG)

  Trial Treatment · Phase 1 · University of Florida

  University of Florida Health Children's Hospital, Gainesville

  Registry updated 2026-10-30

• NCT07301268

  GI-102 Alone or With Pembrolizumab Before Surgery for Treatment of Recurrent or Progressive IDH Wildtype Glioblastoma and IDH Mutated Grade 4 Astrocytoma

  Trial Treatment · Phase 2 · Mayo Clinic

  Mayo Clinic in Rochester, Rochester

  Registry updated 2026-10-30

• NCT07775534

  Tear Fluid for the Detection of Tumor-associated Extracellular Vesicles in Glioblastoma Patients

  Trial Treatment · City of Hope Medical Center

  City of Hope Medical Center, Duarte

  Registry updated 2026-10-30

• NCT05765812

  A Study of Zedoresertib (Debio 0123) in Combination With Temozolomide in Adult Participants With Recurrent or Progressive Glioblastoma and of Zedoresertib (Debio 0123) in Combination With Temozolomide and Radiotherapy in Adult Participants With Newly Diagnosed Glioblastoma

  Trial Treatment · Phase 1/2 · Debiopharm International SA

  Northwestern Memorial Hospital, Chicago · Baylor Scott & White Research Institute, Dallas · The University of Texas MD Anderson Cancer Center, Houston · David H. Koch Center for Cancer Care at Memorial Sloan Kettering Cancer Center, New York · New York University Langone Medical Center, New York · Huntsman Cancer Institute, Salt Lake City · South Texas Accelerated Research Therapeutics (START), San Antonio · Fred Hutchinson Cancer Research Center, Seattle

  Registry updated 2026-10-28

• NCT06914128

  A Study of PRMT5 Inhibitor BAY 3713372 in Participants With MTAP-deleted Solid Tumors

  Trial Treatment · Phase 1/2 · Bayer

  UCHealth Cancer Center - Anschutz Medical Campus - University of Colorado Cancer Center, Aurora · UAB O'Neal Comprehensive Cancer Center - The Kirklin Clinic of UAB Hospital, Birmingham · Massachusetts General Hospital - Neurology, Boston · Dana-Farber Cancer Institute - Oncology Department, Boston · Sarah Cannon Research Institute at HCA HealthONE Presbyterian St. Luke's, Denver · City of Hope - Duarte Cancer Center, Duarte · START | Midwest, Grand Rapids · NEXT Dallas - Oncology Department, Irving · UCLA Health Bowyer Oncology Center, Los Angeles · Froedtert Hospital - Clinical Cancer Center, Milwaukee · SCRI Oncology Partners, Nashville · Memorial Sloan Kettering Cancer Center New York - Main Campus, New York · Icahn School of Medicine at Mount Sinai - Oncology, New York · Sarah Cannon Research Institute at Florida Cancer Specialists- Lake Nona, Orlando · START | San Antonio, San Antonio · UCSF Helen Diller Medical Center at Parnassus Heights - Neurology, San Francisco · Stanford University Medical Center - Neurology, Stanford

  Registry updated 2026-10-28

• NCT07852975

  GLAD-KE GLioma Biomarker and Safety Assessment During Dietary Ketone Elevation Subtitle: A Surgical Biomarker Discovery Study of Ketogenic Therapy in Recurrent Glioma

  Trial Treatment · Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

  Oncology- Broadway, Baltimore

  Registry updated 2026-10-28

• NCT06896110

  Intrathecal Azacitidine and Nivolumab in Patients With Recurrent High-grade Glioma

  Trial Treatment · Phase 1 · Andrew P. Groves

  Holden Comprehensive Cancer Center, Iowa City

  Registry updated 2026-10-27

• NCT07708961

  Temozolomide, With or Without WSD0922-FU, for the Treatment of EGFR-Mutant, IDH-Wildtype Glioblastoma

  Trial Treatment · Phase 2 · Mayo Clinic

  Mayo Clinic in Florida, Jacksonville · Mayo Clinic in Rochester, Rochester · Mayo Clinic in Arizona, Scottsdale

  Registry updated 2026-10-26

• NCT04541082

  Phase I Study of Oral ONC206 in Recurrent and Rare Primary Central Nervous System Neoplasms

  Trial Treatment · Phase 1 · Jazz Pharmaceuticals

  National Institutes of Health, Bethesda

  Registry updated 2026-10-23

• NCT07346144

  Study of an AAV Mediated Dual-Payload Gene Therapy in Patients With High Grade Glioma

  Trial Treatment · Phase 1/2 · Trogenix ltd

  Ohio State University Hospital, Columbus

  Registry updated 2026-10-23

• NCT07544992

  Locoregional Administration of Genetically Engineered Cells (EGFR/IL13Rα2 Pool-CAR T Cells) for the Treatment of Recurrent or Progressive High-Grade Gliomas

  Trial Treatment · Phase 1 · City of Hope Medical Center

  City of Hope Medical Center, Duarte

  Registry updated 2026-10-23

All Glioblastoma trials and the map

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