Head and neck cancer trials in Australia

In Australia 42 Also abroad 942

42 trials · From ClinicalTrials.gov, checked 11 November 2026. Ask the study team whether a trial fits you.

Phase 1Taking people
A Study of LY4052031 in Participants With Advanced or Metastatic Urothelial Cancer or Other Solid Tumors
Where
Darlinghurst, Nedlands
Age
18 years and over
People
460 worldwide
Run by
Eli Lilly and Company
See details and how to joinNCT06465069 · EU 2024-512927-36-00
Phase 3Taking people
A Study of Amivantamab in Addition to Standard of Care Agents (SOC) Compared With SOC Alone in Participants With Recurrent/Metastatic Head and Neck Cancer
Where
Clayton, Liverpool, Melbourne, Murdoch, St Leonards
Age
18 years and over
People
600 worldwide
Run by
Janssen Research & Development, LLC
See details and how to joinNCT07276399 · EU 2025-521917-24-00
Early phase 1Taking people
177Lu-anti-PD-L1 sdAb in Metastatic Solid Tumors
Where
Adelaide, Gosford, Kingswood, Murdoch, Southport, Wollongong
Age
18 years and over
People
30
Run by
Radiopharm Theranostics, Ltd
See details and how to joinNCT06305962
Phase 2/3Taking people
FORTIFI-HN01: A Study of Ficerafusp Alfa (BCA101) or Placebo in Combination With Pembrolizumab in First-Line PD-L1-pos, R or M HNSCC
Where
Camperdown, Heidelberg, Kingswood, Murdoch, North Melbourne, Southport, Tugun, Waratah
Age
18 years and over
People
650 worldwide
Run by
Bicara Therapeutics
See details and how to joinNCT06788990 · EU 2024-519654-37-00
Phase 2Taking people
DB-1311 in Combination With BNT327 or DB-1305 in Advanced/Metastatic Solid Tumors
Where
Adelaide, Benowa, Birtinya, North Sydney
Age
18 years and over
People
750 worldwide
Run by
DualityBio Inc.
See details and how to joinNCT06953089 · EU 2025-523895-22-00
Phase 1/2Taking people
SumMET: Study of [225Ac]Ac-FL-261 in Participants With Solid Tumors Overexpressing c-MET
Where
Nedlands
Age
18 years and over
People
208 worldwide
Run by
Full-Life Technologies UK Limited
See details and how to joinNCT07873450
Phase 1Taking people
A Study of MGC026 in Participants With Advanced Solid Tumors
Where
Auchenflower, Heidelberg, Kurralta Park
Age
18 years and over
People
394 worldwide
Run by
MacroGenics
See details and how to joinNCT06242470
Phase 2/3Taking people
Ordastobart (INBRX-106) Add-on to Pembrolizumab in 1L HPV+ PD-L1+ R/M OPSCC (HexAgon-HN)
Where
Adelaide
Age
18 years and over
People
450 worldwide
Run by
Inhibrx Biosciences, Inc
See details and how to joinNCT06295731
Phase 2Taking people
A Study of HER3-DXd in Subjects With Locally Advanced or Metastatic Solid Tumors
Where
Camperdown, Chermside, Clayton, Hobart, Hyde Park
Age
18 years and over
People
740 worldwide
Run by
Daiichi Sankyo
See details and how to joinNCT06172478 · EU 2023-507641-29-00
Phase 1/2Taking people
A Study to Evaluate the Efficacy and Safety of Ifinatamab Deruxtecan (I-DXd) in Subjects With Recurrent or Metastatic Solid Tumors (IDeate-PanTumor02)
Where
Blacktown, Mount Kuring-Gai, St Leonards, Subiaco, Woolloongabba
Age
18 years and over
People
680 worldwide
Run by
Daiichi Sankyo
See details and how to joinNCT06330064 · EU 2023-509632-26-00
Phase 2Taking people
A Study to See if Giving Fianlimab and Cemiplimab Together is Better Than Cemiplimab Alone at Treating Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma
Where
Bundaberg, Cairns, Hervey Bay, Melbourne
Age
18 years and over
People
120 worldwide
Run by
Regeneron Pharmaceuticals
See details and how to joinNCT06769698 · EU 2024-517620-19-00
Phase 1/2Taking people
A Phase 1/2a Study of DB-1311/BNT324 in Advanced/Metastatic Solid Tumors
Where
Birtinya, Blacktown, Brisbane, Camperdown, Concord, Gold Coast, Nedlands, New Lambton Heights, Sydney, Waratah
Age
18 years and over
People
862 worldwide
Run by
DualityBio Inc.
See details and how to joinNCT05914116
Phase 1/2Taking people
Intratumoral N17350 in Advanced Solid Tumors
Where
Melbourne, Newcastle, Westmead
Age
18 years and over
People
275 worldwide
Run by
Onchilles Pharma Inc
See details and how to joinNCT07339176
Phase 1Taking people
Study to Assess Adverse Events and Change in Disease Activity in Adult Participants With Select Advanced Solid Tumor Indications Receiving Intravenous (IV) ABBV-400
Where
Camperdown, Heidelberg
Age
18 years and over
People
325 worldwide
Run by
AbbVie
See details and how to joinNCT06084481 · EU 2023-506227-29-00
Phase 1/2Taking people
A Study to Investigate Safety of AZD6750 in Adult Participants With Select Advanced or Metastatic Solid Tumors
Where
East Melbourne
Age
18 years and over
People
120 worldwide
Run by
AstraZeneca
See details and how to joinNCT07115043
Phase 1Taking people
Study of Safety and Tolerability of BCA101 Monotherapy and in Combination Therapy in Patients With EGFR-driven Advanced Solid Tumors
Where
Camperdown, Heidelberg, Melbourne, Waratah
Age
18 years and over
People
473 worldwide
Run by
Bicara Therapeutics
See details and how to joinNCT04429542
Phase 1/2Taking people
The Evaluation of PC14586 in Patients With Advanced Solid Tumors Harboring a TP53 Y220C Mutation (PYNNACLE)
Where
Bedford Park, Camperdown, Clayton, Nedlands, South Brisbane
Age
12 years and over
People
300 worldwide
Run by
PMV Pharmaceuticals, Inc
See details and how to joinNCT04585750
Phase 1Taking people
Study of Zanzalintinib in Combination With Immuno-Oncology or Other Agents in Participants With Solid Tumors
Where
Albury, Birtinya, Brisbane, Saint Leonards, Sydney
Age
18 years and over
People
1,394 worldwide
Run by
Exelixis
See details and how to joinNCT05176483 · EU 2023-510061-10-00
Phase 1Taking people
A Study of KIVU-107 in Participants With Locally Advanced or Metastatic Solid Tumors
Where
Adelaide, Brisbane, Camperdown, Geelong, Sydney
Age
18 years and over
People
76 worldwide
Run by
Kivu Bioscience Inc.
See details and how to joinNCT07229313
Phase 1/2Taking people
Study of AU-007, A Monoclonal Antibody That Binds to IL-2 and Inhibits IL-2Rα Binding, in Patients With Unresectable Locally Advanced or Metastatic Cancer
Where
Bedford Park, Clayton, Frankston, Heidelberg, Melbourne, Miranda, Saint Albans
Age
18 years and over
People
159 worldwide
Run by
Aulos Bioscience, Inc.
See details and how to joinNCT05267626
Phase 1/2Taking people
SL-28 for Advanced Solid Tumours
Where
Adelaide, Gold Coast, Sydney
Age
18 years and over
People
60
Run by
Second Life Therapeutics
See details and how to joinNCT07341737
Phase 2Taking people
Study of Volrustomig as Monotherapy or in Combination With Anti- Cancer Agents in Participants With Advanced/Metastatic Solid Tumors
Where
Clayton, Nedlands
Age
18 years to 64 years
People
257 worldwide
Run by
AstraZeneca
See details and how to joinNCT06535607 · EU 2025-523947-36-00
Phase 1Taking people
ADCE-T02, a Tissue Factor Targeted Antibody-Drug Conjugate, in Patients With Selected Advanced Solid Tumours
Where
Bedford Park, Frankston, Macquarie Park, Malvern, Melbourne, Nedlands, Randwick
Age
18 years and over
People
210 worldwide
Run by
Adcendo ApS
See details and how to joinNCT06597721
Phase 2Taking people
Adaptive RadioTherapy for OroPharynx Cancer
Where
Melbourne
Age
18 years and over
People
120 worldwide
Run by
Centre hospitalier de l'Université de Montréal (CHUM)
See details and how to joinNCT04901234
Phase 1Taking people
A First-in-Human Study of HH160 in Participants With Advanced or Metastatic Solid Tumors
Where
Southport, Waratah
Age
18 years to 75 years
People
299 worldwide
Run by
Huahui Health
See details and how to joinNCT07623369