Head and neck cancer trials in Canada
58 trials · From ClinicalTrials.gov, checked 11 November 2026. Ask the study team whether a trial fits you.
- Phase 1Taking peopleA Study to Learn About the Study Medicine Called PF-08046876 in People With Advanced Solid Tumors
- Where
- Montreal, Toronto
- Age
- 18 years and over
- People
- 540 worldwide
- Run by
- Pfizer
See details and how to joinNCT07090499 · EU 2025-521729-33-00 - Phase 3Taking peopleJNJ-90301900 (NBTXR3) Activated by Radiotherapy With or Without Cetuximab in LA-HNSCC
- Where
- Toronto
- Age
- 60 years and over
- People
- 500 worldwide
- Run by
- Johnson & Johnson Enterprise Innovation Inc.
See details and how to joinNCT04892173 · EU 2024-520386-31-00 - No phaseTaking peopleHN-BIO 02: A Phase II Randomized Study of the Effects of Delayed Elective Radiotherapy on Head and Neck MRI and Immune Response Biomarkers
- Where
- Toronto
- Age
- 18 years and over
- People
- 40
- Run by
- University Health Network, Toronto
See details and how to joinNCT06487403 - Phase 2/3Taking peopleFORTIFI-HN01: A Study of Ficerafusp Alfa (BCA101) or Placebo in Combination With Pembrolizumab in First-Line PD-L1-pos, R or M HNSCC
- Where
- Montreal, Toronto, Vancouver
- Age
- 18 years and over
- People
- 650 worldwide
- Run by
- Bicara Therapeutics
See details and how to joinNCT06788990 · EU 2024-519654-37-00 - Phase 2Taking peopleA Study of HER3-DXd in Subjects With Locally Advanced or Metastatic Solid Tumors
- Where
- Edmonton, Toronto, Vancouver
- Age
- 18 years and over
- People
- 740 worldwide
- Run by
- Daiichi Sankyo
See details and how to joinNCT06172478 · EU 2023-507641-29-00 - Phase 2Not yet taking people in CanadaOptimizing Response to Immunotherapy With Online Adaptive Pulsed Radiotherapy in Incurable Head and Neck Cancers
- Where
- Toronto
- Age
- 18 years and over
- People
- 48
- Run by
- University Health Network, Toronto
See details and how to joinNCT07888816 - Phase 1Taking peopleAnti-Ly6E Exatecan ADC M7437 in Advanced Solid Tumors
- Where
- Toronto, Vancouver
- Age
- 18 years and over
- People
- 138 worldwide
- Run by
- EMD Serono Research & Development Institute, Inc.
See details and how to joinNCT07360314 · EU 2025-523232-39-00 - Phase 3Not yet taking people in CanadaSALI-10 Probiotic to Reduce Osteoradionecrosis and Dental Toxicity Following Radiation Therapy for Head and Neck Cancer
- Where
- Toronto
- Age
- 18 years and over
- People
- 288
- Run by
- University Health Network, Toronto
See details and how to joinNCT07883005 - Phase 3Taking peoplePalliative Steroeotactic Body Radiotherapy vs Palliative Standard Radiotherapy in Patients With Advanced Head and Neck Cancer
- Where
- Calgary, Edmonton, Hamilton, Montreal, Ottawa, Québec, Toronto, Vancouver, Winnipeg
- Age
- 18 years and over
- People
- 196
- Run by
- Canadian Cancer Trials Group
See details and how to joinNCT06641791 - Phase 3Taking peopleA Study to Evaluate CRB-701 Compared to Investigator's Choice Therapy in Previously Treated Oropharyngeal Squamous Cell Carcinoma
- Where
- Edmonton, London, Montreal, Ottawa, Regina
- Age
- 18 years and over
- People
- 260 worldwide
- Run by
- Corbus Pharmaceuticals Inc.
See details and how to joinNCT07768189 · EU 2026-527123-94-00 - Phase 1Taking peopleStudy of Safety and Tolerability of BCA101 Monotherapy and in Combination Therapy in Patients With EGFR-driven Advanced Solid Tumors
- Where
- Montreal, Toronto
- Age
- 18 years and over
- People
- 473 worldwide
- Run by
- Bicara Therapeutics
See details and how to joinNCT04429542 - Phase 2Taking peopleMolecular Residual Disease Interception in Locoregionally-Advanced High Risk HPV+ and HPV- HNSCC
- Where
- Toronto
- Age
- 18 years and over
- People
- 102
- Run by
- University Health Network, Toronto
See details and how to joinNCT05414032 - Phase 2Taking peopleA Comprehensive Multiomic Biomarker Evaluation Across Two Single-arm Cohorts to Elucidate Mechanisms of Response and Resistance in Recurrent/Metastatic (R/M) Head and Neck Squamous Cell Carcinoma (HNSCC)
- Where
- Toronto
- Age
- 18 years and over
- People
- 30
- Run by
- University Health Network, Toronto
See details and how to joinNCT07408063 - Phase 3Taking peopleA Global Study of Volrustomig (MEDI5752) for Participants With Unresected Locally Advanced Head and Neck Squamous Cell Carcinoma Following Definitive Concurrent Chemoradiotherapy
- Where
- Calgary, Chicoutimi, Edmonton, Kelowna, Kingston, London, Montreal, Regina, Toronto
- Age
- 18 years to 130 years
- People
- 1,145 worldwide
- Run by
- AstraZeneca
See details and how to joinNCT06129864 - No phaseTaking peopleLiquid Biopsy Evaluation and Repository Development at Princess Margaret
- Where
- Toronto
- Age
- 18 years and over
- People
- 2,500
- Run by
- University Health Network, Toronto
See details and how to joinNCT03702309 - No phaseTaking peopleVirtual Rehabilitation for Cancer Survivors
- Where
- Toronto
- Age
- 18 years and over
- People
- 388
- Run by
- University Health Network, Toronto
See details and how to joinNCT05898789 - Phase 1Taking peopleTesting the Addition of Ipatasertib to Usual Chemotherapy and Radiation for Head and Neck Cancer
- Where
- Toronto
- Age
- 18 years and over
- People
- 46 worldwide
- Run by
- National Cancer Institute (NCI)
See details and how to joinNCT05172245 - Phase 2Taking peopleInvestigating the Effects of Atezolizumab in People Whose Tumour DNA or RNA Indicates Possible Sensitivity
- Where
- Toronto, Vancouver
- Age
- 18 years and over
- People
- 50
- Run by
- British Columbia Cancer Agency
See details and how to joinNCT04273061 - Phase 2Taking peopleStudy of Volrustomig as Monotherapy or in Combination With Anti- Cancer Agents in Participants With Advanced/Metastatic Solid Tumors
- Where
- Edmonton, Montreal
- Age
- 18 years to 64 years
- People
- 257 worldwide
- Run by
- AstraZeneca
See details and how to joinNCT06535607 · EU 2025-523947-36-00 - Phase 1/2Taking peopleFirst in Human Study of TUB-030 in Patients With Advanced Solid Tumors
- Where
- Toronto
- Age
- 18 years and over
- People
- 250 worldwide
- Run by
- Gilead Sciences
See details and how to joinNCT06657222 · EU 2025-522517-35-00 - No phaseTaking peopleEvaluating Treatment Strategies for p53 Mutant Oral Cancer and Oral Cancer Precursors
- Where
- Vancouver
- Age
- 18 years and over
- People
- 636
- Run by
- University of British Columbia
See details and how to joinNCT07090070 - Phase 3Taking peopleStereotactic Boost and Short-course Radiation Therapy for Oropharynx Cancer
- Where
- London, Montreal
- Age
- 18 years and over
- People
- 360
- Run by
- Centre hospitalier de l'Université de Montréal (CHUM)
See details and how to joinNCT04178174 - Phase 2Taking peopleAdaptive RadioTherapy for OroPharynx Cancer
- Where
- Montreal
- Age
- 18 years and over
- People
- 120 worldwide
- Run by
- Centre hospitalier de l'Université de Montréal (CHUM)
See details and how to joinNCT04901234 - No phaseTaking peopleStudy of High-Precision Evaluation of Molecular ResiduaL Disease Through a PlatfOrm for Cancer TracKing and Interception (SHERLOCK)
- Where
- Toronto
- Age
- 18 years and over
- People
- 7,000
- Run by
- University Health Network, Toronto
See details and how to joinNCT07524114 - Phase 1Taking peopleA Study to Assess the Adverse Events, Change in Disease Activity, and How Oral ABBV-711 Tablets Move Through the Body as a Monotherapy and in Combination With Intravenously Infused Budigalimab (ABBV-181), in Adults With Advanced Squamous Tumors
- Where
- Montreal, Toronto
- Age
- 18 years and over
- People
- 220 worldwide
- Run by
- AbbVie
See details and how to joinNCT07241039 · EU 2025-521607-48-00