Head and neck cancer trials in United States

In United States 386 Also abroad 940

386 trials · From ClinicalTrials.gov, checked 12 November 2026. Ask the study team whether a trial fits you.

Phase 1Taking people
A Phase 1 of CTX-8371 in Patients With Advanced Malignancies
Where
Athens, Birmingham, Boston, Buffalo, Fort Wayne, Margate, Nashville, Orlando, Palo Alto, Sarasota, Spokane
Age
18 years and over
People
85
Run by
Compass Therapeutics
See details and how to joinNCT06150664
Phase 1Taking people
A Study of LY4052031 in Participants With Advanced or Metastatic Urothelial Cancer or Other Solid Tumors
Where
Atlanta, Boston, Chicago, Cleveland, Denver, Duarte, Grand Rapids, Houston, Indianapolis, La Jolla, Los Angeles, Nashville, New York, Salt Lake City, San Antonio, St Louis, St. Petersburg, West Valley City
Age
18 years and over
People
460 worldwide
Run by
Eli Lilly and Company
See details and how to joinNCT06465069 · EU 2024-512927-36-00
Early phase 1Taking people
PET/CT Assessment of Radiation-Induced Vascular Complications in Head and Neck Cancer
Where
Atlanta
Age
18 years and over
People
20
Run by
Emory University
See details and how to joinNCT06914999
Phase 3Taking people
High-dose Prophylactic Gabapentin (HOPE) vs. Placebo to Prevent Opioid Use for Oral Mucositis Pain During Concurrent Chemoradiation for Head and Neck Cancer
Where
Albert Lea, Ames, Anaconda, Antigo, Augusta, Aurora, Bakersfield, Barrington, Bath, Bellevue, Bemidji, Billings, Bismarck, Bloomington, Boise, Boone, Bozeman, Bridgeport, Brunswick, Buffalo, Burlington, Canton, Cape Girardeau, Carthage, Cedar Rapids, Cherry Hill, Cheyenne, Chicago, Clive, Coeur d'Alene, Colorado Springs, Columbus, Council Bluffs, Crystal Lake, Cudahy, Damariscotta, Danville, Decatur, Denver, Des Moines, Dickson City, Dixon, Downers Grove, Dublin, Eau Claire, Effingham, Elgin, Erie, Eureka, Fargo, Farmington, Farrell, Forest Hills, Fort Dodge, Fremont, Fresno, Fruitland, Galesburg, Germantown, Gilbert, Grafton, Great Falls, Green Bay, Greensburg, Greer, Harrisburg, Hazel Crest, Honolulu, Jefferson, Jefferson Hills, Joplin, Kalispell, Kearney, Kenosha, Kewanee, La Crosse, Lafayette, Lake Success, Lakewood, Lewisburg, Libertyville, Little Rock, Lone Tree, Los Angeles, Macomb, Mankato, Marinette, Marshalltown, Martinsburg, Mattoon, Mechanicsburg, Medford, Menomonee Falls, Meridian, Milwaukee, Missoula, Modesto, Moline, Monroeville, Morgantown, Mount Vernon, Nampa, Newport News, New York, Normal, Oak Creek, Oakland, Oak Lawn, O'Fallon, Oklahoma City, Omaha, Oshkosh, Ottawa, Palos Heights, Parkersburg, Park Ridge, Pekin, Peoria, Peru, Philadelphia, Phoenix, Pittsburgh, Portland, Post Falls, Pottsville, Princeton, Racine, Rego Park, Rhinelander, Rochester, Roseville, Sacramento, Saint Cloud, Salt Lake City, Sandpoint, Sanford, San Francisco, San Jose, San Leandro, San Rafael, Santa Clara, Santa Rosa, Scarborough, Scottsdale, Seneca, Sewell, Sheboygan, Sioux Falls, South Jordan, South Portland, South San Francisco, Spartanburg, Springfield, Stevens Point, St Louis, Stony Brook, Summit, Surprise, Tempe, The Bronx, Two Rivers, Urbana, Vallejo, Walnut Creek, Washington, Wausau, Wauwatosa, West Allis, West Bend, Wexford, Wheeling, Wilkes-Barre, Willow Grove, Wisconsin Rapids
Age
18 years and over
People
228
Run by
Alliance for Clinical Trials in Oncology
See details and how to joinNCT06992427
No phaseTaking people
Distance-Based Exercise to Preserve Function and Prevent Disability
Where
Boston, Butler, Cranberry Township, Dublin, Fremont, Fresno, Indiana, Kernersville, Mechanicsville, Midlothian, Modesto, Mount Airy, New Castle, Oakland, Pittsburgh, Richmond, Sacramento, San Francisco, San Jose, San Rafael, Santa Clara, Santa Rosa, Seneca, Vallejo, Walnut Creek, Winston-Salem
Age
18 years and over
People
104
Run by
Alliance for Clinical Trials in Oncology
See details and how to joinNCT07059884
No phaseTaking people
Feasibility of Cough Skill Training in Individuals With Head and Neck Cancer
Where
Boston
Age
18 years and over
People
10
Run by
Boston University Charles River Campus
See details and how to joinNCT07756684
No phaseTaking people
Biomarkers in Patients With Respiratory Tract Dysplasia or Lung Cancer, Head and Neck Cancer, or Aerodigestive Tract Cancer and in Normal Volunteers
Where
Aurora
Age
21 years to 90 years
People
700
Run by
University of Colorado, Denver
See details and how to joinNCT00900419
Phase 3Taking people
JNJ-90301900 (NBTXR3) Activated by Radiotherapy With or Without Cetuximab in LA-HNSCC
Where
Atlanta, Birmingham, Boston, Chapel Hill, Charlotte, Charlottesville, Cincinnati, Duarte, Jacksonville, Laguna Hills, La Jolla, Lexington, Los Angeles, Newport Beach, New York, Norfolk, Oklahoma City, Orlando, Philadelphia, Portland, San Francisco, Santa Fe, Staten Island, Tampa, The Bronx, Washington D.C.
Age
60 years and over
People
500 worldwide
Run by
Johnson & Johnson Enterprise Innovation Inc.
See details and how to joinNCT04892173 · EU 2024-520386-31-00
Phase 1/2Taking people
A Study of Amivantamab Alone or in Addition to Other Treatment Agents in Participants With Head and Neck Cancer
Where
Ann Arbor, Aurora, Baltimore, Boston, Chapel Hill, Charlottesville, Chicago, Cleveland, Detroit, Fairfax, La Jolla, New Brunswick, New Haven, Salt Lake City, St Louis
Age
18 years and over
People
287 worldwide
Run by
Janssen Research & Development, LLC
See details and how to joinNCT06385080 · EU 2023-508418-40-00
Phase 1Taking people
A Study of JNJ-90301900 in Combination With Chemoradiation Therapy in Participants With Locally Advanced Head and Neck Squamous Cell Carcinoma
Where
Atlanta, Birmingham, Boston, Chapel Hill, Duarte, Jacksonville, La Jolla, Philadelphia, Tampa, The Bronx
Age
18 years to 74 years
People
45 worldwide
Run by
Johnson & Johnson Enterprise Innovation Inc.
See details and how to joinNCT07219212 · EU 2025-522914-22-00
Phase 3Taking people
A Study of Amivantamab in Addition to Standard of Care Agents (SOC) Compared With SOC Alone in Participants With Recurrent/Metastatic Head and Neck Cancer
Where
Ann Arbor, Atlanta, Baltimore, Boston, Chandler, Charlottesville, Chicago, Cincinnati, Columbus, Dallas, Detroit, Fairfax, Fort Myers, Fredericksburg, Fullerton, Hartford, Hershey, Houston, Knoxville, La Jolla, Lexington, Lincoln, Los Angeles, Macon, Miami, Mineola, Murrieta, Nashville, New Brunswick, New Haven, New York, O'Fallon, Orlando, Philadelphia, Portland, Sacramento, Salt Lake City, San Francisco, Stanford, St Louis, St. Petersburg, The Bronx, Tucson, Tyler, Waco, West Palm Beach, Wilson
Age
18 years and over
People
600 worldwide
Run by
Janssen Research & Development, LLC
See details and how to joinNCT07276399 · EU 2025-521917-24-00
Phase 1/2Not yet taking people in United States
Ficerafusp Alfa, Pembrolizumab, and Stereotactic Body Radiotherapy (SBRT) for Head and Neck Squamous Cell Carcinoma (HNSCC)
Where
St Louis
Age
18 years and over
People
45
Run by
Washington University School of Medicine
See details and how to joinNCT07552558
Phase 1/2Taking people
A Study of Bispecific Antibody MCLA-158 in Patients With Advanced Solid Tumors
Where
Atlanta, Boston, Cleveland, Columbus, Dallas, Detroit, Fort Myers, Gainesville, Georgetown, Houston, Ithaca, La Jolla, Lone Tree, Los Angeles, Maumee, Memphis, Nashville, New York, Oklahoma City, Orlando, Philadelphia, Roanoke, Salt Lake City, San Diego, Spokane, St Louis, Syracuse, Tyler
Age
18 years and over
People
560 worldwide
Run by
Genmab
See details and how to joinNCT03526835 · EU 2024-513627-16-01
Phase 2Taking people
Lymphoscintigraphy Directed Elective Neck Radiation for p16+ Favorable Risk Oropharynx Cancer
Where
Philadelphia
Age
18 years and over
People
22
Run by
Fox Chase Cancer Center
See details and how to joinNCT05800574
Phase 1Taking people
A Study of [225Ac]Ac-AKY-2519 in Patients With B7-H3 Expressing Solid Tumors
Where
Houston, Miami
Age
18 years and over
People
152
Run by
Aktis Oncology, Inc.
See details and how to joinNCT07887971
Phase 1/2Taking people
CR-002 in Adult Participants With Locally Advanced or Metastatic Solid Tumors
Where
Austin, Dallas, Fairfax
Age
18 years and over
People
219
Run by
Crescent Biopharma, Inc.
See details and how to joinNCT07909031 · EU 2026-527289-54-00
Phase 2/3Taking people
FORTIFI-HN01: A Study of Ficerafusp Alfa (BCA101) or Placebo in Combination With Pembrolizumab in First-Line PD-L1-pos, R or M HNSCC
Where
Ann Arbor, Aurora, Baltimore, Birmingham, Boston, Canton, Charleston, Charlottesville, Chicago, Cincinnati, Cleveland, Durham, Edmonds, Hackensack, Houston, Iowa City, Jacksonville, La Jolla, Lexington, Los Angeles, Louisville, Madison, Maplewood, Milwaukee, Nashville, Newark, New York, Palm Bay, Phoenix, Pittsburgh, Portland, Providence, Richmond, Rochester, Sacramento, San Francisco, Seattle, Stanford, St Louis, Tampa, Vancouver, Waco, Westwood
Age
18 years and over
People
650 worldwide
Run by
Bicara Therapeutics
See details and how to joinNCT06788990 · EU 2024-519654-37-00
Phase 2Taking people
DB-1311 in Combination With BNT327 or DB-1305 in Advanced/Metastatic Solid Tumors
Where
Anderson, Atlanta, Bethesda, Charleston, Florida City, Houston, Lincoln, Los Angeles, New York, Portland, Puyallup, Spokane, Virginia Beach, Wheat Ridge
Age
18 years and over
People
750 worldwide
Run by
DualityBio Inc.
See details and how to joinNCT06953089 · EU 2025-523895-22-00
Phase 1Taking people
Testing the Addition of an Anti-Cancer Drug, Camonsertib, to Radiation Therapy for Recurrent Head and Neck Squamous Cell Carcinoma
Where
Duarte, Irvine, Lexington, Pittsburgh
Age
18 years and over
People
39
Run by
National Cancer Institute (NCI)
See details and how to joinNCT07156227
Phase 1/2Taking people
SumMET: Study of [225Ac]Ac-FL-261 in Participants With Solid Tumors Overexpressing c-MET
Where
Minneapolis
Age
18 years and over
People
208 worldwide
Run by
Full-Life Technologies UK Limited
See details and how to joinNCT07873450
Phase 1/2Taking people
E7 T-cell Receptor (TCR) -T Cell Induction Therapy for Locoregionally Advanced HPV-associated Cancers
Where
New Brunswick
Age
18 years and over
People
15
Run by
Christian Hinrichs
See details and how to joinNCT05639972
Phase 2Taking people
E7 TCR-T Cell Immunotherapy for Human Papillomavirus (HPV) Associated Cancers
Where
Bethesda, New Brunswick
Age
18 years and over
People
20
Run by
Christian Hinrichs
See details and how to joinNCT05686226
Phase 1Taking people
A Study of MGC026 in Participants With Advanced Solid Tumors
Where
Grand Rapids, Houston, Lake Success, Los Angeles, Portland, West Valley City
Age
18 years and over
People
394 worldwide
Run by
MacroGenics
See details and how to joinNCT06242470
Phase 2/3Taking people
Ordastobart (INBRX-106) Add-on to Pembrolizumab in 1L HPV+ PD-L1+ R/M OPSCC (HexAgon-HN)
Where
Billings, Boston, Chapel Hill, Chicago, Corpus Christi, Detroit, Duarte, Gainesville, Las Vegas, Los Angeles, Louisville, Miami, Newark, Oklahoma City, Omaha, Orange City, Pittsburgh, Portland, Richmond, Sacramento, San Diego, Santa Fe, Santa Monica, St Louis, Weston
Age
18 years and over
People
450 worldwide
Run by
Inhibrx Biosciences, Inc
See details and how to joinNCT06295731
Phase 1/2Taking people
Lead-212 PSV359 Therapy for Patients With Solid Tumors
Where
Cleveland, Columbus, Dallas, Houston, Kansas City, Lexington, Los Angeles, Madison, Miami, New York, Omaha, Pittsburgh, Rochester, St Louis
Age
18 years to 90 years
People
112
Run by
Perspective Therapeutics
See details and how to joinNCT06710756