Heart failure trials in Canada

In Canada 80 Also abroad 1266

66 of 80 trials · From ClinicalTrials.gov, checked 12 November 2026. Ask the study team whether a trial fits you.

Phase 2/3Taking people
Efficacy, Safety, and Pharmacokinetics of Vericiguat in Pediatric Participants With Heart Failure Due to Left Ventricular Systolic Dysfunction (MK-1242-036)
Where
Edmonton, Sherbrooke, Toronto
Age
29 days to 17 years
People
342 worldwide
Run by
Merck Sharp & Dohme LLC
See details and how to joinNCT05714085 · EU 2022-501238-52-00
Phase 2Taking people
Reversing Microvascular Dysfunction in Heart Failure With Preserved Ejection Fraction
Where
Montreal
Age
40 years and over
People
64
Run by
Montreal Heart Institute
See details and how to joinNCT06217120
Phase 4Not yet taking people in Canada
DESAL-HEART: Hypertonic Saline Added to a Pre-declared Furosemide Dose in Acute Heart Failure
Where
Edmonton
Age
18 years and over
People
60
Run by
University of Alberta
See details and how to joinNCT07927127
No phaseNot yet taking people in Canada
Ketone Ester for Treatment Of Acute Heart Failure
Where
Edmonton
Age
18 years and over
People
60
Run by
University of Alberta
See details and how to joinNCT07434466
No phaseTaking people
Multidisciplinary Approach for High Risk Patients Leading to Early Diagnosis of Canadians in Heart Failure
Where
Montreal, Sherbrooke, Vancouver
Age
40 years and over
People
1,360
Run by
Cardiology Research UBC
See details and how to joinNCT05859048
No phaseTaking people
LEFT ATRIAL MONITORING IN PATIENTS BEFORE AND AFTER MITRAL SURGERY - LAMBDA STUDY
Where
Ottawa
Age
18 years and over
People
50
Run by
Ottawa Heart Institute Research Corporation
See details and how to joinNCT06547788
Phase 3Taking people
Study With Omecamtiv Mecarbil (CK-1827452) to Treat Chronic Heart Failure With Severely Reduced Ejection Fraction
Where
Edmonton, Kelowna, Kingston, London, Montreal, Oakville, Sherbrooke, Surrey, Terrebonne, Toronto, Vancouver, Victoria, Winnipeg
Age
18 years to 85 years
People
1,800 worldwide
Run by
Cytokinetics
See details and how to joinNCT06736574 · EU 2024-519219-32-00
No phaseTaking people
ELEVATE-HFpEF Clinical Study
Where
Calgary, Vancouver
Age
40 years and over
People
700 worldwide
Run by
Medtronic Cardiac Rhythm and Heart Failure
See details and how to joinNCT06678841
Phase 3Taking people
Maridebart Cafraglutide in Heart Failure With Preserved or Mildly Reduced Ejection Fraction and Obesity
Where
Brampton, Cambridge, Chicoutimi, Edmonton, Montreal, Newmarket, North York, Peterborough, Sarnia, Scarborough Village, Sherbrooke, Stoney Creek, Thunder Bay, Toronto, Trois-Rivières, Waterloo, Winchester, Winnipeg
Age
18 years to 99 years
People
5,056 worldwide
Run by
Amgen
See details and how to joinNCT07037459
Phase 3Taking people
A Study to Test Whether Vicadrostat in Combination With Empagliflozin Helps People With Heart Failure
Where
Cambridge, Edmonton, Greater Sudbury, Greenfield Park, Hamilton, Kitchener, Mississauga, Montreal, Oakville, Oshawa, Peterborough, Saint-Jean-sur-Richelieu, Sarnia, Stoney Creek, Toronto, Trois-Rivières
Age
18 years and over
People
6,712 worldwide
Run by
Boehringer Ingelheim
See details and how to joinNCT06424288 · EU 2023-509706-30-00
Phase 3Taking people
A Study to Test Whether Vicadrostat (BI 690517) in Combination With Empagliflozin Helps People With Heart Failure and a Weak Pumping Function of the Left Side of the Heart
Where
Brossard, Cambridge, Greater Sudbury, Hamilton, Kitchener, Mississauga, Oakville, Oshawa, Peterborough, Québec, Sarnia, Sherbrooke, Trois-Rivières, Waterloo
Age
18 years and over
People
4,200 worldwide
Run by
Boehringer Ingelheim
See details and how to joinNCT06935370 · EU 2024-519525-38-00
Phase 3Taking people
A Study to Learn More About How Safe Finerenone is, When it is Taken for a Longer Time With Standard Treatment, in Children and Young Adults With Heart Failure and Left Ventricular Systolic Dysfunction
Where
Edmonton, London, Montreal, Saskatoon, Toronto, Vancouver
Age
Up to 18 years
People
117 worldwide
Run by
Bayer
See details and how to joinNCT07192952 · EU 2024-519830-22-00
No phaseTaking people
Renal Denervation in Patients With Atrial Fibrillation and Hypertension
Where
London
Age
18 years and over
People
10
Run by
Pavel Antiperovitch
See details and how to joinNCT07893821
Phase 2Taking people
A Study to Learn About the Study Medicine Called PF-07328948 in Adults With Heart Failure (BRANCH-HF)
Where
Chicoutimi, Greater Sudbury, Halifax, Québec, Richmond, Sarnia, Shebrooke, Sherbrooke, Terrebonne, Toronto, Trois-Rivières, Winchester
Age
18 years to 79 years
People
620 worldwide
Run by
Pfizer
See details and how to joinNCT06991257 · EU 2024-518438-94-00
Phase 3Taking people
Phase III Study Investigating Heart Failure and Cardiovascular Death With Baxdrostat in Combination With Dapagliflozin
Where
Abbotsford British Columbia, Calgary, Cambridge, Guelph, Halifax, Hamilton, Laval, Lévis, Markham, Mirabel, Moncton, Montreal, Newmarket, North York, Oakville, Ottawa, Québec, Regina, Saint-Charles-Borromée, Saint John, Sarnia, Scarborough Village, Sherbrooke, Sherwood Park, St. John's, Sydney, Terrebonne, Toronto, Trois-Rivières
Age
40 years and over
People
11,300 worldwide
Run by
AstraZeneca
See details and how to joinNCT06677060 · EU 2024-514506-32-00
Phase 3Taking people
CLEOPATTRA: A Research Study to Look at the Effects of Treatment With a Medicine Called Coramitug (NNC6019-0001) in People With Heart Failure Due to Transthyretin Amyloid (ATTR) Amyloidosis
Where
Calgary, Greater Sudbury, Halifax, Hamilton, Kitchener, London, Mississauga, Ottawa, Québec, Rimouski, Scarborough Village, Toronto, Vancouver
Age
18 years and over
People
1,280 worldwide
Run by
Novo Nordisk A/S
See details and how to joinNCT07207811
No phaseTaking people
Treating Atrial Fibrillation in Heart Failure With Preserved Ejection Fraction: Ablation or Medication
Where
Halifax, Hamilton, London, Montreal
Age
18 years and over
People
84
Run by
Nova Scotia Health Authority
See details and how to joinNCT07272902
No phaseTaking people
The Canadian CABG or PCI in Patients With Ischemic Cardiomyopathy Trial (STICH3C)
Where
Calgary, Edmonton, Halifax, Hamilton, London, Montreal, Newmarket, New Westminster, Ottawa, Québec, Toronto, Vancouver, Winnipeg
Age
18 years and over
People
754 worldwide
Run by
Sunnybrook Health Sciences Centre
See details and how to joinNCT05427370
No phaseEnrolling by invitation
Implementation of Acute Heart Failure Checklist
Where
Ottawa
Age
18 years and over
People
5,040
Run by
Ottawa Hospital Research Institute
See details and how to joinNCT07727304
Phase 2Taking people
Feasibility Trial for a Right Ventricular Failure Platform Trial
Where
Calgary, Edmonton, London, Ottawa, Vancouver
Age
18 years and over
People
30
Run by
University of Alberta
See details and how to joinNCT06570473
Phase 3Taking people
A Study to Learn More About How Well Finerenone Works, How Safe it is, and How it Moves Into, Through, and Out of the Body Compared to Placebo When Taken With Standard Treatment in Children With Heart Failure and Left Ventricular Systolic Dysfunction
Where
Edmonton, London, Montreal, Saskatoon, Toronto, Vancouver
Age
6 months to 17 years
People
111 worldwide
Run by
Bayer
See details and how to joinNCT07188805 · EU 2024-519829-38-00
Phase 3Taking people
Study to Evaluate the Effect of Balcinrenone/Dapagliflozin in Patients With Heart Failure and Impaired Kidney Function
Where
Cambridge, Chicoutimi, Greenfield Park, Hamilton, London, Montreal, Newmarket, New Westminster, North Vancouver, North York, Oakville, Oshawa, Ottawa, Peterborough, Saint-Jean-sur-Richelieu, Sydney, Thunder Bay, Toronto, Trois-Rivières, Vancouver, Waterloo, Winnipeg
Age
18 years to 130 years
People
3,850 worldwide
Run by
AstraZeneca
See details and how to joinNCT06307652 · EU 2023-508162-15-00
No phaseTaking people
Alleviant ALLAY-HFrEF Study
Where
Montreal, Newmarket, Québec
Age
18 years and over
People
350 worldwide
Run by
Alleviant Medical, Inc.
See details and how to joinNCT06812533
No phaseTaking people
Surgical Ablation of AF Efficacy Trial
Where
Hamilton
Age
18 years and over
People
2,000
Run by
Population Health Research Institute
See details and how to joinNCT05434819
Phase 2Taking people
A Research Study Comparing Different Doses of CDR132L With Placebo on the Structure and Function of the Heart in People With Heart Failure With Preserved Ejection Fraction and Left Ventricular Hypertrophy
Where
Brampton, Hamilton, Mississauga, Ottawa, Québec, Toronto, Vancouver, Winchester
Age
40 years to 84 years
People
200 worldwide
Run by
Novo Nordisk A/S
See details and how to joinNCT06979362 · EU 2024-515796-35-00