Heart failure trials in Czechia

In Czechia 44 Also abroad 1265

44 trials · From ClinicalTrials.gov and EU CTIS (euclinicaltrials.eu), checked 11 November 2026. Ask the study team whether a trial fits you.

No phaseTaking people
Endovascular Ablation of the Right Greater Splanchnic Nerve in Subjects With Reduced Ejection Fraction
Where
Prague
Age
40 years and over
People
50 worldwide
Run by
Axon Therapies, Inc.
See details and how to joinNCT07403058
No phaseTaking people
Trial to Evaluate Safety And Effectiveness of Mechanical Circulatory Support in Patients With Advancing Heart Failure
Where
Prague
Age
18 years and over
People
850 worldwide
Run by
Abbott Medical Devices
See details and how to joinNCT06526195
No phaseTaking people
Product Performance Report: Evaluate Long-term Reliability & Performance of Medtronic Marketed Cardiac Therapy Products
Where
Prague
People
20,000 worldwide
Run by
Medtronic
See details and how to joinNCT00271180
No phaseTaking people
ELEVATE-HFpEF Clinical Study
Where
Prague
Age
40 years and over
People
700 worldwide
Run by
Medtronic Cardiac Rhythm and Heart Failure
See details and how to joinNCT06678841
Phase 3Taking people
Maridebart Cafraglutide in Heart Failure With Preserved or Mildly Reduced Ejection Fraction and Obesity
Where
Brandýs nad Labem, Brno, Broumov, Bruntál, Chlumec nad Cidlinou, Chomutov, Havirov - Mesto, Holešov, Hradec Králové, Jaroměř, Liberec, Mělník, Náchod, Olomouc, Ostrava, Pardubice, Prague, Praha 5 - Smichov, Přerov, Prostějov, Slaný, Trutnov, Uherské Hradiště, Ústí nad Labem
Age
18 years to 99 years
People
5,056 worldwide
Run by
Amgen
See details and how to joinNCT07037459
Phase 3Taking people
A Study to Test Whether Vicadrostat in Combination With Empagliflozin Helps People With Heart Failure
Where
Bílovec, Brandýs nad Labem, Brno, Brno-Stred, Brno-Zidenice, Chrudim IV, Havlickuv Brod, Horni Predmesti, Litovel, Mariánské Lázně, Prague, Prague 1, Prague 4, Pulecny, Smiřice, Uherské Hradiště, Zlín
Age
18 years and over
People
6,712 worldwide
Run by
Boehringer Ingelheim
See details and how to joinNCT06424288 · EU 2023-509706-30-00
Phase 3Taking people
A Study to Test Whether Vicadrostat (BI 690517) in Combination With Empagliflozin Helps People With Heart Failure and a Weak Pumping Function of the Left Side of the Heart
Where
Bílovec, Brandýs nad Labem, Brno-Stred, Chrudim IV, Horni Predmesti, Jaroměř, Litovel, Louny, Mariánské Lázně, Nova Ulice, Prague, Prague 1, Slaný, Uherské Hradiště
Age
18 years and over
People
4,200 worldwide
Run by
Boehringer Ingelheim
See details and how to joinNCT06935370 · EU 2024-519525-38-00
Phase 3Taking people
Maridebart Cafraglutide in Heart Failure With Preserved or Mildly Reduced Ejection Fraction and Obesity (MARITIME-HF)
Where
Brandýs nad Labem, Brno, Brno-Královo Pole, Brno-Stred, Brno-Zidenice, Broumov, Bruntal, Chlumec nad Cidlinou, Chomutov, Havířov, Holesov, Horni Brana, Horni Predmesti, Hradec Králové, Jaroměř, Liberec, Melnik, Moravska Ostrava A Privoz, Náchod, Olomouc, Ostrava, Pardubice, Pardubice I, Prague, Prague 1, Prague 2, Prerov I-Mesto, Prostějov, Slaný, Uherske Hradiste, Uherské Hradiště, Usti nad Labem, Ústí nad Labem, Valasske Mezirici
Age
18 years and over
People
2,787 worldwide
Run by
Amgen Inc.
See details and how to join2024-516654-22-00 · EU 2024-516654-22-00
Phase 3Taking people
A Study to Learn More About How Safe Finerenone is, When it is Taken for a Longer Time With Standard Treatment, in Children and Young Adults With Heart Failure and Left Ventricular Systolic Dysfunction
Where
Brno, Prague
Age
Up to 18 years
People
117 worldwide
Run by
Bayer
See details and how to joinNCT07192952 · EU 2024-519830-22-00
Phase 2Taking people
A Study to Learn About the Study Medicine Called PF-07328948 in Adults With Heart Failure (BRANCH-HF)
Where
Brno, Brno-Královo Pole, Hradec Králové, Jaroměř, Krnov, Ostrava, Prerov
Age
18 years to 79 years
People
620 worldwide
Run by
Pfizer
See details and how to joinNCT06991257 · EU 2024-518438-94-00
No phaseTaking people
BIO|STREAM.CSP Study
Where
Olomouc, Prague
Age
18 years and over
People
1,000 worldwide
Run by
Biotronik SE & Co. KG
See details and how to joinNCT07393009
Phase 3Taking people
Phase III Study Investigating Heart Failure and Cardiovascular Death With Baxdrostat in Combination With Dapagliflozin
Where
Benešov, Brandýs nad Labem, Brno-Stred, Chlumec nad Cidlinou, Hodonin, Humpolec, Jaroměř, Jesenice, Krnov, Mariánské Lázně, Moravska Ostrava A Privoz, Olomouc, Plzeň 3, Police nad Metuji, Prague, Praha
Age
40 years and over
People
11,300 worldwide
Run by
AstraZeneca
See details and how to joinNCT06677060 · EU 2024-514506-32-00
Phase 3Taking people
CLEOPATTRA: A Research Study to Look at the Effects of Treatment With a Medicine Called Coramitug (NNC6019-0001) in People With Heart Failure Due to Transthyretin Amyloid (ATTR) Amyloidosis
Where
Brno, Broumov, Olomouc, Ostrava - Poruba, Prague, Uherské Hradiště
Age
18 years and over
People
1,280 worldwide
Run by
Novo Nordisk A/S
See details and how to joinNCT07207811
Phase 3Taking people
A Study to Learn More About How Well Finerenone Works, How Safe it is, and How it Moves Into, Through, and Out of the Body Compared to Placebo When Taken With Standard Treatment in Children With Heart Failure and Left Ventricular Systolic Dysfunction
Where
Brno, Prague
Age
6 months to 17 years
People
111 worldwide
Run by
Bayer
See details and how to joinNCT07188805 · EU 2024-519829-38-00
Phase 3Taking people
Study to Evaluate the Effect of Balcinrenone/Dapagliflozin in Patients With Heart Failure and Impaired Kidney Function
Where
Brno, Broumov, Česká Lípa, Jaroměř, Louny, Ostrava, Pilsen, Plzen - Bory, Prague, Přerov, Slaný, Svitavy, Ustí Nad Labem, Zlín
Age
18 years to 130 years
People
3,850 worldwide
Run by
AstraZeneca
See details and how to joinNCT06307652 · EU 2023-508162-15-00
Phase 3Taking people
Multi-center Trial of Ferric Derisomaltose Versus no Intravenous Iron in Iron-deficient Subjects With Symptomatic Chronic Heart Failure
Where
Brandýs nad Labem, Brno, Brno-Stred, Brno-Zidenice, Chlumec Nad Cidlinou Iv, Ostrava, Plzen 3, Prague, Uherské Hradiště, Znojmo
Age
18 years and over
People
1,900 worldwide
Run by
Pharmacosmos A/S
See details and how to joinNCT06929806 · EU 2024-519059-28-00
Phase 3Taking people
A Study to Investigate CV Outcomes With Elecoglipron Compared With Placebo in Adult Participants With HFpEF or HFmrEF
Where
Benešov, Boskovice, Brno-Stred, Broumov, Cesky Krumlov, Hradec Králové, Hustopece u Brna, Jaroměř, Klatovy IV, Liberec I-Stare Mesto, Louny, Prague, Teplice, Vsetin
Age
18 years and over
People
6,950 worldwide
Run by
AstraZeneca
See details and how to joinNCT07761117 · EU 2026-526304-79-00
Phase 4Taking people
Acalabrutinib Monotherapy vs Investigator's Choice of Treatment in Patients With CL Leukaemia and Heart Failure
Where
Brno, Hradec Králové, Prague
Age
18 years to 130 years
People
60 worldwide
Run by
AstraZeneca
See details and how to joinNCT06651970
Phase 2/3Taking people
Randomized Evaluation of Istaroxime for Stabilization in Acute Heart Failure-Cardiogenic Shock
Where
Konska, Olomouc, Prague
Age
18 years to 80 years
People
600 worldwide
Run by
Seismic Pharmaceuticals Operations LLC
See details and how to joinNCT07583446 · EU 2026-527261-29-00
Phase 1/2Taking people
A Phase 1b/2a Trial to Evaluate Invobenitug Also Known as Procizumab (PCZ; AK1967) in Critical Cardiovascular Care.
Where
Plzen 23, Prague
Age
18 years to 80 years
People
90 worldwide
Run by
4TEEN4 Pharmaceuticals GmbH
See details and how to joinNCT06832722 · EU 2024-518450-16-00
Phase 2Not yet taking people in Czechia
A Study to Evaluate the Safety and Efficacy of AC01 Compared to Placebo in Participants With Chronic Heart Failure
Where
Brandýs nad Labem, Brno, Broumov, Klatovy IV, Louny, Mlada Boleslav III, Pardubice I
Age
18 years to 85 years
People
400 worldwide
Run by
AnaCardio AB
See details and how to joinNCT07584967 · EU 2025-524469-25-00
Phase 3Taking people
A Study to Determine the Efficacy and Safety of Finerenone on Morbidity and Mortality Among Hospitalized Heart Failure Patients
Where
Brno, Chlumec nad Cidlinou, Pilsen, Prague, Roudnice nad Labem
Age
18 years and over
People
5,200 worldwide
Run by
Colorado Prevention Center
See details and how to joinNCT06008197
No phaseEnrolling by invitation
Snapshot Study on Patients With Heart Failure
Where
Brno, Broumov, České Budějovice, Havířov, Hradec Králové, Jaroměř, Motol, Náchod, Ostrava, Pardubice, Pilsen, Prague
Age
18 years and over
People
4,000 worldwide
Run by
European Society of Cardiology
See details and how to joinNCT06469814
Phase 2Not yet taking people in Czechia
A Phase 2, randomized, double-blind, placebo-controlled trial to evaluate the efficacy, safety, and tolerability of CRD-4730 in patients with heart failure with reduced ejection fraction (HFREF) (CALIBRATE-HF)
Where
Brno-Stred, Hradec Králové, Jaroměř, Louny, Pardubice I, Prague, Prague 2
Age
18 years and over
People
369 worldwide
Run by
Cardurion Pharmaceuticals Inc.
See details and how to join2025-525033-31-00 · EU 2025-525033-31-00
No phaseTaking people
A Prospective Registry Study to Assess Real-world Patient Characteristics, Treatment Patterns, and Longitudinal Outcomes in Patients Receiving Mavacamten and Other Treatments for Symptomatic Obstructive Hypertrophic Cardiomyopathy (Obstructive-HCM)
Where
Olomouc, Prague
Age
18 years and over
People
1,700 worldwide
Run by
Bristol-Myers Squibb
See details and how to joinNCT05489705