Heart failure trials in United Kingdom

In United Kingdom 95 Also abroad 1265

95 trials · From ClinicalTrials.gov, checked 11 November 2026. Ask the study team whether a trial fits you.

Phase 3Taking people
A Study to Investigate CV Outcomes With Elecoglipron Compared With Placebo in Adult Participants With HFpEF or HFmrEF
Where
Ashton-under-Lyne, Basildon, Belfast, Birmingham, Brighton, Bristol, Cardiff, Clydebank, Dundee, Glasgow, Kings Lynn, Leeds, London, Sandbach, Southampton, Woodbridge
Age
18 years and over
People
6,950 worldwide
Run by
AstraZeneca
See details and how to joinNCT07761117 · EU 2026-526304-79-00
Phase 4Taking people
Acalabrutinib Monotherapy vs Investigator's Choice of Treatment in Patients With CL Leukaemia and Heart Failure
Where
Bournemouth, Oxford, Plymouth, Romford, Stockton, Sutton Coldfield
Age
18 years to 130 years
People
60 worldwide
Run by
AstraZeneca
See details and how to joinNCT06651970
Phase 3Taking people
A Study to Determine the Efficacy and Safety of Finerenone on Morbidity and Mortality Among Hospitalized Heart Failure Patients
Where
Ashford, Ashington, Brighton, Cardiff, Chester, Darlington, Dudley, Durham, Glasgow, Leeds, Liverpool, London, Manchester, Plymouth, Portadown, Southampton, Swindon
Age
18 years and over
People
5,200 worldwide
Run by
Colorado Prevention Center
See details and how to joinNCT06008197
Phase 3Taking people
A Study to Determine the Efficacy and Safety of Finerenone and SGLT2i in Combination in Hospitalized Patients With Heart Failure (CONFIRMATION-HF)
Where
Bournemouth, Bristol, Glasgow, London
Age
18 years and over
People
1,500 worldwide
Run by
Colorado Prevention Center
See details and how to joinNCT06024746
No phaseTaking people
Novel Technologies to Improve Echocardiographic Estimates of Left Ventricular Filling Pressure in Heart Failure Combined With Atrial Fibrillation
Where
Birmingham, London
Age
18 years and over
People
400 worldwide
Run by
Oslo University Hospital
See details and how to joinNCT07436299
Phase 1Taking people
A Research Study on the Effects of NNC0537-1482 in Participants With Heart Failure
Where
London
Age
40 years to 75 years
People
36
Run by
Novo Nordisk A/S
See details and how to joinNCT07218627
No phaseTaking people
Cardiomyopathies and Heart Muscle Diseases: Cardiac Imaging in the Evaluation of Myocardial Fibrosis Transition
Where
Edinburgh
Age
30 years to 90 years
People
290
Run by
University of Edinburgh
See details and how to joinNCT06409585
No phaseTaking people
A Prospective Registry Study to Assess Real-world Patient Characteristics, Treatment Patterns, and Longitudinal Outcomes in Patients Receiving Mavacamten and Other Treatments for Symptomatic Obstructive Hypertrophic Cardiomyopathy (Obstructive-HCM)
Where
Birmingham, Cardiff, Leeds, Liverpool, London, Manchester
Age
18 years and over
People
1,700 worldwide
Run by
Bristol-Myers Squibb
See details and how to joinNCT05489705
Phase 3Taking people
A Research Study to Look at How Well NNC0487-0111 Works Compared to Placebo in People With Heart Failure and Obesity
Where
Airdrie, Barnet, Belfast, Bridgend, Bristol, Chesterfield, Chichester, Coventry, Craigavon, Dorchester, Dundee, Eastbourne, Harrow, Inverness, Isleworth, Kirkcaldy, Leicester, Lincoln, Liverpool, London, Middlesbrough, Newcastle upon Tyne, North Shields, Norwich, Nuneaton, Oldham, Plymouth, Rhyl, Stevenage, Sunderland, Taunton, Tooting, Torquay, Truro, Wakefield, Worcester
Age
18 years and over
People
5,610 worldwide
Run by
Novo Nordisk A/S
See details and how to joinNCT07567001 · EU 2025-523717-29-00
No phaseTaking people
Monitoring Oedema in Heart Failure to Improve Function and Reduce Hospitalisation Risk
Where
Ashford, Aylesbury, Belfast, Bridgend, Croydon, Glasgow, Hardwick, Hull, Lincoln, London, Manchester, Milton Keynes, Nottingham, Patrington, Plymouth, Pont-y-clun, Walsall, Welwyn Garden City
Age
18 years and over
People
300
Run by
Heartfelt Technologies
See details and how to joinNCT07067658
No phaseTaking people
Early Detection and IntervenTion in Heart Failure
Where
Edinburgh
Age
65 years and over
People
18,000 worldwide
Run by
University Hospital, Basel, Switzerland
See details and how to joinNCT07731490
Phase 3Taking people
Study to Evaluate Safety, Tolerability and Efficacy of Inclisiran in Children With Homozygous Familial Hypercholesterolemia
Where
Southampton
Age
2 years to 11 years
People
9 worldwide
Run by
Novartis Pharmaceuticals
See details and how to joinNCT06597006
No phaseTaking people
The Early Valve Replacement in Severe ASYmptomatic Aortic Stenosis Study
Where
Aberdeen, Aintree, Ashington, Ayr, Barnsley, Basildon, Basingstoke, Birmingham, Blackpool, Bodelwyddan, Brighton, Carlisle, Chesterfield, Coventry, Darlington, Doncaster, Dorchester, Dudley, Dundee, Durham, Edinburgh, Exeter, Gateshead, Glasgow, Gloucester, High Wycombe, Huddersfield, Inverness, Isleworth, Keighley, Kettering, Kilmarnock, Leeds, Leicester, Lincoln, Liverpool, London, Maidstone, Manchester, Middlesbrough, Newcastle upon Tyne, Norwich, Nottingham, Nuneaton, Paisley, Plymouth, Poole, Portsmouth, Scunthorpe, Sheffield, Southampton, Stirling, Stockport, Stockton-on-Tees, Sunderland, Swansea, Taunton, Torquay, Truro, Wakefield, Walsall, Warwick, Watford, West Bromwich, Wolverhampton, Worcester, Yeovil
Age
18 years and over
People
2,104 worldwide
Run by
University of Leicester
See details and how to joinNCT04204915
Phase 3Taking people
A Study to Evaluate Finerenone on Clinical Efficacy and Safety in Patients With Heart Failure Who Are Intolerant or Not Eligible for Treatment With Steroidal Mineralocorticoid Receptor Antagonists
Where
Bristol, Glasgow, London, Southampton
Age
18 years and over
People
2,600 worldwide
Run by
Colorado Prevention Center
See details and how to joinNCT06033950
Phase 4Taking people
The STOP-MED CTRCD Trial
Where
Liverpool, London
Age
18 years and over
People
335 worldwide
Run by
Dinesh Thavendiranathan
See details and how to joinNCT06183437
No phaseTaking people
Physiological Versus Right Ventricular Outcome Trial Evaluated for Bradycardia Treatment Upgrades
Where
Cambridge, Chichester, Coventry, Croydon, Leicester, London, Oxford, Southampton, Swindon, Worthing
Age
18 years and over
People
155
Run by
Imperial College London
See details and how to joinNCT06052475
No phaseTaking people
RCT of Implantable Defibrillators in Patients With Non Ischemic Cardiomyopathy, Scar and Severe Systolic Heart Failure
Where
Aberdeen, Ashington, Basildon, Blackpool, Bournemouth, Brighton, Camberley, Canterbury, Cardiff, Chichester, Coventry, Darlington, Edinburgh, Exeter, Gorleston-on-Sea, Hardwick, High Wycombe, Hull, Leeds, Leicester, Liverpool, London, Maidstone, Manchester, Middlesbrough, Newcastle, Nottingham, Oxford, Plymouth, Portsmouth, Redhill, Scarborough, Sheffield, Southampton, Swansea, Taunton, Tooting, Wakefield, Wolverhampton, Worcester
Age
18 years and over
People
2,504
Run by
University Hospital Southampton NHS Foundation Trust
See details and how to joinNCT05568069
No phaseTaking people
Heart Failure Carer Support Programme: Implementation Testing in the UK.
Where
Belfast, Craigavon, Glasgow, London
Age
18 years and over
People
360
Run by
Queen's University, Belfast
See details and how to joinNCT07373041
No phaseTaking people
Strategy for EArly Recognition of Cancer, COPD & Heart Failure in the Emergency Department
Where
Glasgow
Age
18 years and over
People
17,000
Run by
NHS Greater Glasgow and Clyde
See details and how to joinNCT07391280
No phaseTaking people
Reduction of Mitral Regurgitation With the SATURN Trans-Septal Transcatheter Mitral Valve Replacement (TMVR) System in Patients With Severe Symptomatic Mitral Regurgitation
Where
Brighton
Age
65 years and over
People
30 worldwide
Run by
InnovHeart
See details and how to joinNCT06414265
No phaseTaking people
Study to Collect High-Resolution ECG Data and Patient Insights on Heart Failure Care
Where
London
Age
45 years to 80 years
People
1,000
Run by
Richmond Research Institute
See details and how to joinNCT06809686
Phase 3Taking people
Study to Evaluate Efficacy and Safety of Inclisiran in Children With Heterozygous Familial Hypercholesterolemia
Where
London, West Midlands
Age
6 years to 11 years
People
60 worldwide
Run by
Novartis Pharmaceuticals
See details and how to joinNCT06597019
No phaseTaking people
Utilising AI Analysis of Sounds To prEdict heaRt failurE decOmpensation
Where
Cambridge
Age
18 years and over
People
250
Run by
Cambridge University Hospitals NHS Foundation Trust
See details and how to joinNCT06555757
Phase 2Taking people
Coronary Artery Stents in Heart Failure With Preserved Ejection Fraction
Where
London
Age
18 years and over
People
350
Run by
King's College London
See details and how to joinNCT07560436
No phaseTaking people
Manganese-enhanced Magnetic Resonance Imaging (MEMRI) in Heart Failure With Preserved Ejection Fraction
Where
Leicester
Age
18 years and over
People
60
Run by
University of Leicester
See details and how to joinNCT06652763