Heart failure trials in Japan

In Japan 25 Also abroad 1265

25 trials · From ClinicalTrials.gov, checked 11 November 2026. Ask the study team whether a trial fits you.

Phase 2Taking people
The Clinical Trial of Tamibarotene for Patients With HFpEF (RELIEF Trial)
Where
Nagoya, Ōbu, Tokyo, Tsu
Age
26 years and over
People
90
Run by
Nagoya University
See details and how to joinNCT07855692
No phaseTaking people
Product Performance Report: Evaluate Long-term Reliability & Performance of Medtronic Marketed Cardiac Therapy Products
Where
Ageo, Bunkyō City, Gifu, Hidaka, Hiroshima, Kagoshima, Kamakura, Kawasaki, Kitakyushu, Koshigaya, Kumamoto, Kyoto, Minatoku, Mitaka, Nagoya, Niigata, Okayama, Ōsaka-sayama, Sapporo, Shinagawa-ku, Shizuoka, Suita, Tokyo, Toyoake, Tsukuba, Urasoe, Yamagata, Yokohama
People
20,000 worldwide
Run by
Medtronic
See details and how to joinNCT00271180
Phase 1Taking people
A Study of LY3971297 in Participants With Heart Failure
Where
Kobe, Kyoto, Suita-Shi, Tsuchiura-shi
Age
18 years to 65 years
People
90 worldwide
Run by
Eli Lilly and Company
See details and how to joinNCT07547540 · EU 2026-525663-40-00
No phaseTaking people
ELEVATE-HFpEF Clinical Study
Where
Chiba, Kitakyushu, Suita
Age
40 years and over
People
700 worldwide
Run by
Medtronic Cardiac Rhythm and Heart Failure
See details and how to joinNCT06678841
Phase 3Taking people
Maridebart Cafraglutide in Heart Failure With Preserved or Mildly Reduced Ejection Fraction and Obesity
Where
Chiba, Fujinomiya-shi, Fukuoka, Hachioji-shi, Hamamatsu, Higashiyamato-shi, Himeji-Shi, Kagoshima, Kanazawa, Kitaazumi-gun, Kitakyushu-shi, Kumamoto, Kyoto, Niigata, Ōita, Sagamihara-shi, Sapporo, Shinagawa-ku, Suginami-ku, Suita-shi, Takamatsu, Takarazuka-shi, Toyoake-shi, Yonago-shi
Age
18 years to 99 years
People
5,056 worldwide
Run by
Amgen
See details and how to joinNCT07037459
Phase 3Taking people
A Study to Test Whether Vicadrostat in Combination With Empagliflozin Helps People With Heart Failure
Where
Aichi, Kasugai, Azumino-shi, Chiba, Chiba, Chūōku, Fujisawa-shi, Fukuoka, Kitakyushu, Hachioji-shi, Hamada-Shi, Higashiibaraki-gun, Himeji-Shi, Hiratsuka-shi, Hokkaido, Sapporo, Hokkaido, Tomakomai, Hyogo, Amagasaki, Ikeda-cho, Kitaazumi, Ishikawa, Kanazawa, Iwakuni-shi, Kamakura-shi, Kanagawa, Miura-gun, Kanagawa, Yokohama, Kanonji-shi, Kawanishi-shi, Kishiwada-shi, Kobe, Kumamoto, Matsumoto-shi, Matsuyama, Mito, Nakano-shi, Ōita, Okayama, Okayama, Okinawa, Naha, Okinawa, Urasoe, Osaka, Osaka, Osaka, Saga, Saitama-shi, Sendai, Suita-shi, Tachikawa-shi, Takamatsu, Tokushima, Tokyo, Ome, Tomakomai-shi
Age
18 years and over
People
6,712 worldwide
Run by
Boehringer Ingelheim
See details and how to joinNCT06424288 · EU 2023-509706-30-00
Phase 3Taking people
A Study to Test Whether Vicadrostat (BI 690517) in Combination With Empagliflozin Helps People With Heart Failure and a Weak Pumping Function of the Left Side of the Heart
Where
Amagasaki-shi, Asahi-shi, Fujisawa-shi, Fukuoka, Fukuoka, Chikushino, Gunma, Maebashi, Hachioji-shi, Hamada-Shi, Hamamatsu, Himeji-Shi, Hiratsuka-shi, Hitachi-Naka, Ishikawa, Kanazawa, Iwakuni-shi, Kamakura-shi, Kanagawa, Miura-gun, Kanonji-shi, Kasama-Shi, Kasugai-shi, Kawaguchi-shi, Kawasaki-shi, Kishiwada-shi, Kobe, Kumamoto, Kure, Matsudo-shi, Matsumoto-shi, Matsuyama, Meguro-Ku, Mito, Miyagi, Sendai, Nagasaki, Nagasaki, Nagoya, Nakano-shi, Nara, Kashihara, Okayama, Okayama, Ome-shi, Omura-shi, Osaka, Saitama, Saitama, SakaiShi, Sapporo, Sendai, Shimonoseki-shi, Suita-shi, Suita-Shi, Tachikawa-shi, Takasaki-shi, Tanabe-shi, Tokushima, Tomakomai-shi, Toyota-shi, Ueda-shi
Age
18 years and over
People
4,200 worldwide
Run by
Boehringer Ingelheim
See details and how to joinNCT06935370 · EU 2024-519525-38-00
Phase 2Taking people
A Study to Learn About the Study Medicine Called PF-07328948 in Adults With Heart Failure (BRANCH-HF)
Where
Iwakuni, Kasugai, Kishiwada, Kodaira-shi, Koga, Matsudo, Meguro-Ku, Nagasaki, Sagamihara, Sapporo, Sendai, Suginami, tabashi City, Toshimaku, Tsu, Wako, Yokohama
Age
18 years to 79 years
People
620 worldwide
Run by
Pfizer
See details and how to joinNCT06991257 · EU 2024-518438-94-00
Phase 1/2Taking people
Endocardial Delivery for Myocardial Regeneration Using Allogeneic iPSC-derived Cardiomyocyte Spheroids for HF With Systolic Dysfunction (EMERALD Study)
Where
Kawasaki, Matsumoto, Shinagawa Ku, Shinjuku-ku, Tsukuba
Age
20 years to 80 years
People
14
Run by
Heartseed Inc.
See details and how to joinNCT07347197
Phase 3Taking people
Phase III Study Investigating Heart Failure and Cardiovascular Death With Baxdrostat in Combination With Dapagliflozin
Where
Amagasaki-shi, Asahikawa-shi, Azumino-shi, Chūōku, Fukui-shi, Hakusan-shi, Himeji, Izumo-shi, Kakegawa-shi, Kamakura-shi, Kanazawa, Kawaguchi-shi, Kishiwada-shi, Kita-ku, Kyoto, Matsudo-shi, Meguro-ku, Mito, Miyazaki, Nagano, Ogaki-shi, Ōita, Ōmihachiman, Osaka, Saitama-shi, Sendai, Shizuoka, Suita-shi, tabashi City, Takamatsu, Takatsuki-shi, Toyota-Shi, Tsuchiura-shi, Ueda-shi, Uwajima-shi, Yanagawa-shi, Yokkaichi-shi, Yokohama
Age
40 years and over
People
11,300 worldwide
Run by
AstraZeneca
See details and how to joinNCT06677060 · EU 2024-514506-32-00
Phase 3Taking people
CLEOPATTRA: A Research Study to Look at the Effects of Treatment With a Medicine Called Coramitug (NNC6019-0001) in People With Heart Failure Due to Transthyretin Amyloid (ATTR) Amyloidosis
Where
Amagasaki, Bunkyo-ku, Fukuoka, Himeji, Kanagawa, Kashihara, Kitakyushu, Kobe, Kumamoto, Kurume-shi, Kyoto, Matsumoto, Nagasaki, Nagoya, Nankoku-shi, Osaka, Sapporo, Suita, Tokyo, Toyama, Tsu, Uwajima-shi, Yamaguchi Prefecture, Yokohama
Age
18 years and over
People
1,280 worldwide
Run by
Novo Nordisk A/S
See details and how to joinNCT07207811
Phase 2Taking people
Dose-finding Study of YMI024 to Assess Efficacy, Safety, and Tolerability in Adults With Stable Coronary Artery Disease and Elevated hsCRP
Where
Kamakura, Kasugai, Matsubara, Matsudo
Age
18 years to 80 years
People
180 worldwide
Run by
Novartis Pharmaceuticals
See details and how to joinNCT07830719 · EU 2026-525974-21-00
Phase 3Taking people
Study to Evaluate the Effect of Balcinrenone/Dapagliflozin in Patients With Heart Failure and Impaired Kidney Function
Where
Beppu-shi, Bunkyō City, Fujisawa-shi, Fukui-shi, Fukuoka, Fukutsu-shi, Hakusan-shi, Higashiibaraki-gun, Himeji, Iwakuni-shi, Kanazawa, Kanonji-shi, Kasugai-shi, Kasuga-shi, Kawaguchi, Kawanishi-shi, Kishiwada-shi, Kitakyusyu-shi, Kobe, Kochi, Kure-shi, Maebashi, Matsumoto-shi, Meguro-ku, Mito, Moriyama-shi, Nagoya, Ōita, Osaka, Sagamihara-shi, Saitama-shi, Sakaishi, Sakata, Sanyoonoda-shi, Toshima-ku, Toyota, Tsuchiura-shi, Ueda-shi, Uji-shi, Uwajima-shi, Yanagawa-shi, Yokohama
Age
18 years to 130 years
People
3,850 worldwide
Run by
AstraZeneca
See details and how to joinNCT06307652 · EU 2023-508162-15-00
Phase 2Taking people
A Research Study Comparing Different Doses of CDR132L With Placebo on the Structure and Function of the Heart in People With Heart Failure With Preserved Ejection Fraction and Left Ventricular Hypertrophy
Where
Bunkyo-ku, Tokyo, Chikushino-shi, Fukuoka, Himeji-shi, Hyogo, Ibaraki, Kagawa, Kanagawa, Kita-gun, Kagawa, Kobe-shi, Hyogo, Ome-shi, Tokyo, Osaka-shi, Osaka, Osaka-Shi, Osaka, Sapporo-shi, Hokkaido, Yokohama-shi, Kanagawa
Age
40 years to 84 years
People
200 worldwide
Run by
Novo Nordisk A/S
See details and how to joinNCT06979362 · EU 2024-515796-35-00
Phase 3Taking people
A Study to Investigate CV Outcomes With Elecoglipron Compared With Placebo in Adult Participants With HFpEF or HFmrEF
Where
Aomori, Chikushino-shi, Chūōku, Fukui-shi, Fukushima, Higashiibaraki-gun, Higashiohmi-shi, Iwakuni-shi, Kagoshima, Kamakura-shi, Kanazawa, Kashihara-shi, Kasugai-shi, Kawagoe-shi, Kishiwada-shi, Kitakyusyu-shi, Kobe, Kure-shi, Kyoto, Maebashi, Matsusaka-shi, Minatoku, Mito, Morioka, Nagasaki, Nagoya, Ōmihachiman, Osaka, Sagamihara-shi, Sapporo, Sayama-shi,, Sendai, Shibuya-ku, Shizuoka, Suginami City, Suita, Suzuka-shi, Tachikawa-shi, Takaoka-shi, Takatsuki-shi, Tokushima, Toshima-ku, Toyama, Ueda-shi, Urasoe-Shi, Urayasu-shi, Uruma, Utsunomiya, Wakayama, Yakushi, Yokohama
Age
18 years and over
People
6,950 worldwide
Run by
AstraZeneca
See details and how to joinNCT07761117 · EU 2026-526304-79-00
No phaseTaking people
Novel Technologies to Improve Echocardiographic Estimates of Left Ventricular Filling Pressure in Heart Failure Combined With Atrial Fibrillation
Where
Nagoya, Tōon
Age
18 years and over
People
400 worldwide
Run by
Oslo University Hospital
See details and how to joinNCT07436299
Phase 3Taking people
A Research Study to Look at How Well NNC0487-0111 Works Compared to Placebo in People With Heart Failure and Obesity
Where
Bunkyo-ku, Tokyo, Chiba-shi,Chiba, Chikushino-shi, Fukuoka, Fuchu-shi,Tokyo, Fukuoka-shi, Fukuoka, Higashiosaka-shi, Osaka, Himeji-shi, Hyogo, Hyōgo, Ibaraki, Kanagawa, Kasugai-shi, Aichi, Kofu-shi, Yamanashi, Kyoto-shi, Kyoto, Maebashi-shi, Gunma, Matsumoto-shi, Nagano, Miura-gun, Kanagawa, Morioka-shi, Iwate, Nagasaki, Osaka, Osaka-Shi, Osaka, Ota-shi, Gunma, Sapporo-shi, Hokkaido, Shinjuku-ku, Tokyo, Shizuoka, Takamatsu-shi, Kagawa, Tokyo, Tomakomai-Shi, Hokkaido, Toshima-ku,Tokyo, Uwajima-shi, Wakayama-shi, Wakayama, Yokohama-shi，Kanagawa
Age
18 years and over
People
5,610 worldwide
Run by
Novo Nordisk A/S
See details and how to joinNCT07567001 · EU 2025-523717-29-00
Phase 4Taking people
Efficacy and Safety With Early Treatment of Finerenone in Hospitalized Patients With Heart Failure
Where
Fukuoka, Handa, Iizuka, Izunokuni, Kakegawa, Kawagoe, Maebashi, Nagoya, Ōbu, Osaka, Sagamihara, Sakai, Sapporo, Suita, Takasaki, Tokyo, Tōon, Toyota
Age
18 years and over
People
550
Run by
Juntendo University
See details and how to joinNCT07397650
Phase 3Taking people
A Study to Evaluate Finerenone on Clinical Efficacy and Safety in Patients With Heart Failure Who Are Intolerant or Not Eligible for Treatment With Steroidal Mineralocorticoid Receptor Antagonists
Where
Isehara, Iwakuni, Kyoto, Osaka, Ōta-ku, Sagamihara, Sapporo, Sendai, Suita
Age
18 years and over
People
2,600 worldwide
Run by
Colorado Prevention Center
See details and how to joinNCT06033950
No phaseTaking people
A Study to Learn More About the Safety of the Drug Vericiguat in Japanese People With Chronic Heart Failure Who Will be Receiving Vericiguat Under Real-world Conditions
Where
Multiple Locations
People
1,400
Run by
Bayer
See details and how to joinNCT05666518
Phase 2Taking people
Exploratory Study of ADR-002K for Heart Failure Patients With Ischemic Heart Disease Who Undergo CABG
Where
Osaka
Age
18 years to 80 years
People
50
Run by
Rohto Pharmaceutical Co., Ltd.
See details and how to joinNCT07192211
No phaseTaking people
Entresto Tablets and Granules for Pediatric Specified Drug-use Survey (Pediatric Chronic Heart Failure)
Where
Akita, Bunkyo Ku, Fuchū, Fukuoka, Hamamatsu, Hidaka, Kawasaki, Kumamoto, Kurume, Nagasaki, Ōbu, Okayama, Ōmura, Ōta-ku, Saitama, Sapporo, Setagaya-ku, Shinagawa Ku, Shinjuku Ku, Toyama, Toyoake, Tsu, Tsukuba, Yokohama
Age
1 year to 17 years
People
30
Run by
Novartis Pharmaceuticals
See details and how to joinNCT06659393
Phase 2Taking people
A Research Study Comparing CDR132L With Placebo on the Structure and Function of the Heart in People With Heart Failure With Reduced/Mildly Reduced Ejection Fraction and Left Ventricular Hypertrophy
Where
Bunkyo-ku, Tokyo, Hamamatsu-shi, Shizuoka, Himeji-shi, Hyogo, Ibaraki, Kanagawa, Kita-gun, Kagawa, Kobe-shi, Hyogo, Osaka, Osaka-shi, Osaka, Osaka-Shi, Osaka, Sapporo-shi, Hokkaido, Yokohama-shi, Kanagawa
Age
40 years to 84 years
People
200 worldwide
Run by
Novo Nordisk A/S
See details and how to joinNCT06979375 · EU 2024-515797-27-00
Phase 3Taking people
Early Treatment With a Sodium-glucose Co-transporter 2 Inhibitor in High-risk Patients With Acute Heart Failure
Where
Adachi City, Anjo, Chikushino-shi, Chiyoda City, Fuchū, Fukuoka, Funabashi, Gifu, Hachiōji, Hamamatsu, Hirosaki, Hiroshima, Hokkaido, Isehara, Izunokuni, Kamakura, Kamogawa, Kanagawa, Kashihara, Kasukabe, Kawagoe, Kawaguchi, Kawasaki, Kochi, Kurume, Kushiro, Maebashi, Minato, Morioka, Nagakute, Nagoya, Nankoku, Nara, Ōgaki, Okayama, Okinawa, Osaka, Saitama, Sapporo, Sayama, Shinjuku, Sōka, Suita, Sumoto, Tachikawa, Tokushima, Tokyo, Tsuchiura, Urasoe, Urayasu, Utsunomiya, Yokohama
Age
20 years and over
People
444
Run by
Juntendo University
See details and how to joinNCT05392764
No phaseEnrolling by invitation
A Prognostic Study for Patients With Cardiovascular Disease in Niigata
Where
Niigata
Age
18 years and over
People
8,500
Run by
Niigata University Medical & Dental Hospital
See details and how to joinNCT06992284