Heart failure trials in South Africa

In South Africa 9 Also abroad 1265

9 trials · From ClinicalTrials.gov, checked 11 November 2026. Ask the study team whether a trial fits you.

Phase 2/3Taking people
Efficacy, Safety, and Pharmacokinetics of Vericiguat in Pediatric Participants With Heart Failure Due to Left Ventricular Systolic Dysfunction (MK-1242-036)
Where
Cape Town
Age
29 days to 17 years
People
342 worldwide
Run by
Merck Sharp & Dohme LLC
See details and how to joinNCT05714085 · EU 2022-501238-52-00
Phase 3Taking people
A Study to Test Whether Vicadrostat in Combination With Empagliflozin Helps People With Heart Failure
Where
Bloemfontein, Cape Town, Centurion, Johannesburg, Somerset West, Worcester
Age
18 years and over
People
6,712 worldwide
Run by
Boehringer Ingelheim
See details and how to joinNCT06424288 · EU 2023-509706-30-00
Phase 3Taking people
Phase III Study Investigating Heart Failure and Cardiovascular Death With Baxdrostat in Combination With Dapagliflozin
Where
Bellville, Benoni, Brackenfell, Cape Town, Centurion, Claremont, Diepkloof, Soweto, Durban, East London, eMkhomazi, Johannesburg, Lenasia, Midrand, Paarl, Pretoria, Somerset West, Wentworth, Worcester
Age
40 years and over
People
11,300 worldwide
Run by
AstraZeneca
See details and how to joinNCT06677060 · EU 2024-514506-32-00
Phase 3Taking people
Study to Evaluate the Effect of Balcinrenone/Dapagliflozin in Patients With Heart Failure and Impaired Kidney Function
Where
Bloemfontein, Centurion, Durban, Johannesburg, KwaDukuza, Panorama, Parow, Pietermaritzburg, Somerset West, Soweto, Worcester
Age
18 years to 130 years
People
3,850 worldwide
Run by
AstraZeneca
See details and how to joinNCT06307652 · EU 2023-508162-15-00
No phaseTaking people
iCaReMe Global Registry: Multinational Real-world Evidence in Cardiorenal and Metabolic Diseases
Where
Florida, Parow, Umhlanga
Age
18 years and over
People
35,000 worldwide
Run by
AstraZeneca
See details and how to joinNCT03549754
Phase 3Taking people
A Research Study to Look at How Well NNC0487-0111 Works Compared to Placebo in People With Heart Failure and Obesity
Where
Benoni, Bloemfontein, Cape Town, Durban, East London, Johannesburg, Kempton Park, KwaDukuza, Midrand, Mossel Bay, Pietermaritzburg, Polokwane, Pretoria, Somerset West
Age
18 years and over
People
5,610 worldwide
Run by
Novo Nordisk A/S
See details and how to joinNCT07567001 · EU 2025-523717-29-00
Phase 3Taking people
Study to Evaluate Safety, Tolerability and Efficacy of Inclisiran in Children With Homozygous Familial Hypercholesterolemia
Where
Bloemfontein, Johannesburg
Age
2 years to 11 years
People
9 worldwide
Run by
Novartis Pharmaceuticals
See details and how to joinNCT06597006
Phase 3Taking people
Study to Evaluate Efficacy and Safety of Inclisiran in Children With Heterozygous Familial Hypercholesterolemia
Where
Bloemfontein
Age
6 years to 11 years
People
60 worldwide
Run by
Novartis Pharmaceuticals
See details and how to joinNCT06597019
No phaseTaking people
Remote Ischaemic Conditioning in STEMI Patients in AFRICA
Where
Cape Town, Durban, George, Johannesburg, Klerksdorp
Age
18 years and over
People
1,400 worldwide
Run by
University of Cape Town
See details and how to joinNCT04813159