Heart failure trials in United States

In United States 387 Also abroad 1266

387 trials · From ClinicalTrials.gov, checked 12 November 2026. Ask the study team whether a trial fits you.

Phase 3Taking people
A Study to Evaluate Finerenone on Clinical Efficacy and Safety in Patients With Heart Failure Who Are Intolerant or Not Eligible for Treatment With Steroidal Mineralocorticoid Receptor Antagonists
Where
Akron, Aurora, Austin, Baton Rouge, Bradenton, Burlington, Centerville, Charlotte, Chula Vista, Cincinnati, Cynthiana, Denison, Fairhope, Greenville, Hammond, Hialeah, Houston, Jacksonville, Kansas City, Layton, Lexington, Louisville, Merrillville, Miami, Milwaukee, Minneapolis, Miramar, Norfolk, Northridge, Orange, Orangeburg, Paducah, Peoria, Phoenix, Pomona, Richmond, Sacramento, Salem, San Diego, San Francisco, Sherman Oaks, Tarzana, Tyler, Van Nuys, West Covina, West Hills, West Monroe, Yuma
Age
18 years and over
People
2,600 worldwide
Run by
Colorado Prevention Center
See details and how to joinNCT06033950
No phaseTaking people
Care Transitions App for Patients With Multiple Chronic Conditions
Where
Boston
Age
55 years and over
People
798
Run by
Brigham and Women's Hospital
See details and how to joinNCT06051058
No phaseEnrolling by invitation
CardioMEMS HF System Real-World Evidence Post-Approval Study
Where
Atlanta
Age
18 years and over
People
2,500
Run by
Abbott Medical Devices
See details and how to joinNCT06306573
Phase 2Taking people
EXercise and Activin Inhibition to Modulate InflammatioN Effects on Heart Failure and Cognition (EXAMINE-HFC)
Where
Boston
Age
40 years and over
People
48
Run by
Massachusetts General Hospital
See details and how to joinNCT07202000
Phase 1/2Taking people
Treating Heart Dysfunction Related to Cancer Therapy With Sacubitril/Valsartan
Where
Richmond
Age
18 years to 120 years
People
70
Run by
Virginia Commonwealth University
See details and how to joinNCT05194111
Phase 2Taking people
A Study of 68Ga-Fibroblast Activation Protein Inhibitor (FAPI) Positron Emission Tomography in Heart Failure
Where
Rochester
Age
18 years and over
People
35
Run by
Mayo Clinic
See details and how to joinNCT07083011
No phaseNot yet taking people in United States
Self-directed Mobile Mindfulness to Address ICU Survivors' Psychological Distress
Where
Charleston, Durham, Los Angeles
Age
18 years and over
People
450
Run by
Duke University
See details and how to joinNCT07634419
Early phase 1Taking people
New MRI Methods Applied to Heart Failure With Preserved Ejection Fraction (HFpEF)
Where
Salt Lake City
Age
18 years and over
People
100
Run by
University of Utah
See details and how to joinNCT04600115
No phaseTaking people
Project 4: ACHIEVE PATHFINDER
Where
Detroit
Age
18 years and over
People
400
Run by
Henry Ford Health System
See details and how to joinNCT06070428
Phase 4Taking people
The STOP-MED CTRCD Trial
Where
Boston, Los Angeles
Age
18 years and over
People
335 worldwide
Run by
Dinesh Thavendiranathan
See details and how to joinNCT06183437
No phaseTaking people
UPBEAT: Using Polygenic Scores to Guide BB Therapy in HF With Mildly Reduced EF
Where
Detroit
Age
18 years to 89 years
People
10
Run by
David Lanfear
See details and how to joinNCT07054489
No phaseTaking people
Physical Rehabilitation for Older Patients With Acute Heart Failure With Preserved Ejection Fraction
Where
Winston-Salem
Age
60 years and over
People
880
Run by
Wake Forest University Health Sciences
See details and how to joinNCT05525663
No phaseNot yet taking people in United States
Health Coaching for Patients With Cardiovascular Disease
Where
Columbus
Age
18 years and over
People
70
Run by
Ohio State University
See details and how to joinNCT06904144
Phase 2Taking people
18F-mFBG Imaging for Myocardial Sympathetic Innervation
Where
Houston
Age
18 years and over
People
20
Run by
Innervate Radiopharmaceuticals LLC (Formerly: Illumina Radiopharmaceuticals LLC)
See details and how to joinNCT06965621
No phaseTaking people
PROACTIVE-HF-2 Trial Heart Failure NYHA Class II and III
Where
Atlanta, Austin, Baltimore, Boston, Burlington, Charleston, Cincinnati, Cleveland, Dallas, Downers Grove, Durham, Everett, Greenville, Hershey, Houston, Howell, Indianapolis, Kansas City, Los Angeles, Madison, Miami, Milwaukee, Minneapolis, Morgantown, Nashville, New York, Palos Park, Pensacola, Phoenix, Pittsburgh, Portland, Saint Cloud, San Antonio, San Francisco, Sioux Falls, Stony Brook, Temple
Age
18 years and over
People
1,750 worldwide
Run by
Endotronix, Inc.
See details and how to joinNCT05934487
No phaseTaking people
The CardioClip Study
Where
New York
Age
18 years to 90 years
People
60
Run by
Columbia University
See details and how to joinNCT06241430
No phaseTaking people
Impact of Barostimulation on Hemodynamics in Adults With Heart Failure
Where
Charleston, Chicago, New York, San Francisco, Washington D.C.
Age
18 years and over
People
58
Run by
Columbia University
See details and how to joinNCT07335510
No phaseTaking people
Paced Heart Rate Acceleration for Cardiac Conditioning
Where
Iowa City
Age
18 years to 120 years
People
52
Run by
Denice Hodgson-Zingman, MD
See details and how to joinNCT06332391
No phaseTaking people
Pediatric Cardiomyopathy Mutation Analysis
Where
Indianapolis
People
300
Run by
Indiana University
See details and how to joinNCT02432092
No phaseEnrolling by invitation
Improving Risk Stratification of Emergency Department Patients With Acute Heart Failure
Where
Antioch, Fremont, Fresno, Manteca, Modesto, Oakland, Redwood City, Richmond, Roseville, Sacramento, San Francisco, San Jose, San Leandro, San Rafael, Santa Clara, Santa Rosa, South San Francisco, Vacaville, Vallejo, Walnut Creek
Age
18 years and over
People
17,459
Run by
Kaiser Permanente
See details and how to joinNCT06065761
No phaseTaking people
Deep Learning Detection of Pulmonary Hypertension and Low Ejection Fraction Via Digital Stethoscope and 3-Lead ECG
Where
Norfolk, O'Fallon, Springfield
Age
18 years and over
People
3,850
Run by
Eko Devices, Inc.
See details and how to joinNCT07087613
No phaseTaking people
Palliative Care for People With HF
Where
Indianapolis
Age
18 years and over
People
20
Run by
Indiana University
See details and how to joinNCT07356843
No phaseTaking people
Quantifying New Heart Muscle Cells
Where
New York, Philadelphia, Pittsburgh
Age
30 days to 1 year
People
30
Run by
Weill Medical College of Cornell University
See details and how to joinNCT06587165
Early phase 1Taking people
Hearts on Fire: Targeting Inflammation in Heart Failure With Preserved Ejection Fraction
Where
Gainesville
Age
18 years to 85 years
People
70
Run by
University of Florida
See details and how to joinNCT07634640
Phase 4Taking people
Gator SCALES-WHF: SubCutaneous Administration of Lasix to Eliminate Symptoms of Worsening Heart Failure
Where
Gainesville
Age
18 years to 80 years
People
100
Run by
University of Florida
See details and how to joinNCT06979726