HIV trials in South Africa

In South Africa 57 Also abroad 795

57 trials · From ClinicalTrials.gov, checked 15 November 2026. Ask the study team whether a trial fits you.

Phase 2Not yet taking people in South Africa
Evaluating the Safety and Immunogenicity of Polyvalent DNA and Recombinant gp120 Protein HIV Vaccine (PDPHV) in Healthy, HIV-uninfected Adults
Where
Cape Town
Age
18 years to 55 years
People
126 worldwide
Run by
Worcester HIV Vaccine
See details and how to joinNCT07675629
No phaseNot yet taking people in South Africa
The 'Comprehensive Adherence Resource and Empowerment Support' (CARES) Study
Where
Cape Town
Age
16 years to 24 years
People
2,100 worldwide
Run by
RTI International
See details and how to joinNCT07666139
Phase 4Taking people
Post-Injectable Cabotegravir Antiretroviral Salvage Strategy Options Trial
Where
Cape Town, Durban, Johannesburg
Age
15 years and over
People
100
Run by
University of Witwatersrand, South Africa
See details and how to joinNCT06485154
No phaseTaking people
Structured Peer-delivered ART and Reentry Community Strategy
Where
Johannesburg
Age
18 years and over
People
400
Run by
Johns Hopkins University
See details and how to joinNCT06027671
No phaseTaking people
Testing the WeCare Intervention to Address Mental Health and Medication Adherence Challenges Among MSM in South Africa
Where
Johannesburg
Age
18 years and over
People
60
Run by
Emory University
See details and how to joinNCT07226323
No phaseTaking people
An Adaptive Randomized Controlled Trial
Where
Durban
Age
18 years and over
People
360
Run by
Columbia University
See details and how to joinNCT05633056
Phase 1/2Taking people
A Study to Investigate Cabotegravir for Neonates Exposed to HIV-1
Where
Parow Valley
Age
Up to 10 days
People
44
Run by
ViiV Healthcare
See details and how to joinNCT07275606
No phaseNot yet taking people in South Africa
The Coach Mpilo Study: Evaluation of a Peer-led Intervention to Promote Engagement in HIV Care for Men Living With HIV
Where
Durban
Age
18 years and over
People
800
Run by
University of Cape Town
See details and how to joinNCT07564193
No phaseTaking people
Pre- and Post-treatment Lung Microbiota, Metabolome and Immune Signatures at the Site of Disease in Patients With Active Pulmonary Tuberculosis
Where
Cape Town
Age
18 years to 60 years
People
150
Run by
University of Stellenbosch
See details and how to joinNCT04700579
No phaseTaking people
Expanded Social Network Recruitment to HIV Testing (E-SNRHT) Intervention to Locate Undiagnosed Cases and Reduce HIV-related Stigma
Where
Pietermaritzburg
Age
18 years and over
People
2,480
Run by
University of Illinois Chicago
See details and how to joinNCT06857071
No phaseTaking people
Evaluation of Long-Acting Injectable (LAI) and Teen Clubs in Adolescents (ATTUNE).
Where
Cape Town, Durban, Johannesburg, Mtubatuba, Pretoria
Age
12 years to 19 years
People
720
Run by
Africa Health Research Institute
See details and how to joinNCT06721078
No phaseTaking people
Behavioral Risk Identification and Decision Guidance for HIV Engagement
Where
Johannesburg
Age
18 years and over
People
15,270
Run by
Boston University
See details and how to joinNCT07439003
No phaseTaking people
Tracking and Continuity of Care in Advanced HIV Disease
Where
Johannesburg
Age
18 years and over
People
150
Run by
Boston University
See details and how to joinNCT07428577
No phaseTaking people
HIV Self-testing for Partners of HIV-uninfected Postpartum Women
Where
Durban
Age
18 years and over
People
120
Run by
Massachusetts General Hospital
See details and how to joinNCT07194902
No phaseTaking people
A Randomized Clinical Trial to Evaluate Solutions for the Management of Virologic Failure on TLD in Sub-Saharan Africa
Where
Durban
Age
15 years and over
People
648 worldwide
Run by
Massachusetts General Hospital
See details and how to joinNCT05373758
No phaseNot yet taking people in South Africa
Choice-Based Support for Adults Starting or Restarting Antiretroviral Therapy in Cape Town, South Africa
Where
Cape Town
Age
18 years and over
People
140
Run by
University of Cape Town
See details and how to joinNCT07439562
Phase 4Taking people
Doravirine Dose Optimisation in Pregnancy
Where
Cape Town
Age
18 years and over
People
76
Run by
University of Liverpool
See details and how to joinNCT05630638
Phase 1Taking people
A Trial of a Gorilla Adenovirus Vectored Networked Epitopes Vaccine, Administered to Healthy Adults Living Without and With HIV.
Where
Cape Town, Mtubatuba
Age
18 years to 50 years
People
120 worldwide
Run by
International AIDS Vaccine Initiative
See details and how to joinNCT06617091
No phaseNot yet taking people in South Africa
ALIGN: A Non-randomised Study Delivering Injectable Lenacapavir for HIV Prevention Within a Pre-exposure Prophylaxis (PrEP) Choice Context in Cape Town, South Africa.
Where
Cape Town
Age
15 years to 35 years
People
3,700
Run by
Desmond Tutu HIV Foundation
See details and how to joinNCT07390409
No phaseTaking people
Universal Test and Connect for HIV Service Delivery in South Africa
Where
Cape Town
Age
12 years and over
People
2,000
Run by
Johns Hopkins University
See details and how to joinNCT06408142
No phaseTaking people
Pragmatic Use of Next-generation Sequencing for Management of Drug-resistant Tuberculosis
Where
Cape Town
People
2,500
Run by
University of California, San Francisco
See details and how to joinNCT05553236
No phaseTaking people
The SUSTAIN 2 Study - SUStained HIV Treatment for Adherence After Interruption in Care
Where
Cape Town
Age
18 years and over
People
310
Run by
Brigham and Women's Hospital
See details and how to joinNCT06554223
No phaseTaking people
Gathering Records to Evaluate Antiretroviral Treatment-South Africa
Where
Johannesburg
Age
15 years and over
People
7,000,000
Run by
Boston University
See details and how to joinNCT04149782
Phase 3Taking people
Reducing Mortality in Adults With Advanced HIV Disease (REVIVE)
Where
Cape Town, Hlabisa, Hluhluwe, Johannesburg, Klerksdorp, Mtubatuba, Port Elizabeth, Pretoria, Randburg, Rustenburg
Age
18 years and over
People
8,000 worldwide
Run by
Population Health Research Institute
See details and how to joinNCT05580666
No phaseTaking people
Assessing the Feasibility of Coach Mpilo for Men With TB and HIV
Where
East London
Age
18 years and over
People
240
Run by
Arizona State University
See details and how to joinNCT07117370