Liver and biliary tract cancer trials in Germany

In Germany 56 Also abroad 1314

56 trials · From ClinicalTrials.gov and EU CTIS (euclinicaltrials.eu), checked 11 November 2026. Ask the study team whether a trial fits you.

Phase 2Taking people
Visugromab, Nivolumab and Lenvatinib Compared to Double Placebo and Lenvatinib in Unresectable or Metastatic Hepatocellular Carcinoma Post Anti-PD-(L)1 Failure
Where
Berlin, Cologne, Frankfurt Am Main, Freiburg im Breisgau, Hamburg, Hanover, Mainz, Ulm
Age
18 years to 100 years
People
104 worldwide
Run by
CatalYm GmbH
See details and how to joinNCT07219459 · EU 2025-520675-86-00
No phaseTaking people
Transarterial Chemoembolization (TACE) and Stereotactic Body Radiation (SBRT) in Patients With Hepatocellular Carcinoma (HCC) Prior to Liver Transplantation
Where
München
Age
18 years and over
People
44
Run by
AIO-Studien-gGmbH
See details and how to joinNCT07924943
Phase 1Taking people
A Study of LY4337713 in Participants With FAP-Positive Solid Tumors
Where
Essen
Age
18 years and over
People
340 worldwide
Run by
Eli Lilly and Company
See details and how to joinNCT07213791 · EU 2025-521887-37-00
Phase 2Taking people
DB-1311 in Combination With BNT327 or DB-1305 in Advanced/Metastatic Solid Tumors
Where
Frankfurt am Main, Giessen
Age
18 years and over
People
750 worldwide
Run by
DualityBio Inc.
See details and how to joinNCT06953089 · EU 2025-523895-22-00
Phase 1/2Taking people
BOLD-100 in Combination With FOLFOX With or Without Bevacizumab for the Treatment of Advanced, Solid Tumours
Where
Bonn, Ulm
Age
18 years and over
People
220 worldwide
Run by
Bold Therapeutics, Inc.
See details and how to joinNCT04421820 · EU 2024-517500-11-00
No phaseTaking people
Observational Study Protocol: LIVER-R
Where
Aachen, Augsburg, Berlin, Bochum, Bremen, Bremenhaven, Cologne, Dortmund, Dresden, Göttingen, Halle, Hamburg, Hanover, Heidenheim, Kassel, Koblenz, Konstanz, Leipzig, Magdeburg, Mannheim, Marburg, Moers, Munich, Neumünster, Rostock, Schorndorf, Stolberg, Stuttgart, Wiesbaden, Zwickau
Age
18 years to 130 years
People
4,000 worldwide
Run by
AstraZeneca
See details and how to joinNCT06252753
Phase 3Taking people
Efficacy and Safety of Zanidatamab With Standard-of-care Therapy Against Standard-of-care Therapy for Advanced HER2-positive Biliary Tract Cancer
Where
Berlin, Dresden, Frankfurt am Main, Freiburg im Breisgau, Hamburg, Hanover, Heidelberg, Luebeck, Munich, Tuebingen
Age
18 years and over
People
286 worldwide
Run by
Jazz Pharmaceuticals
See details and how to joinNCT06282575 · EU 2023-508219-21-00
Phase 1/2Taking people
A Study to Evaluate the Efficacy and Safety of Ifinatamab Deruxtecan (I-DXd) in Subjects With Recurrent or Metastatic Solid Tumors (IDeate-PanTumor02)
Where
Berlin, Dresden, Heidelberg, Heilbronn, Leipzig, Mainz, Muenster
Age
18 years and over
People
680 worldwide
Run by
Daiichi Sankyo
See details and how to joinNCT06330064 · EU 2023-509632-26-00
Phase 2Taking people
Durvalumab + Intraductal Radiofrequency Ablation (ID-RFA) in Extra- and Intrahepatic Cholangiocarcinoma
Where
Aachen, Bonn, Cologne, Duesseldorf, Frankfurt am Main, Goettingen, Hanover, Luebeck, Mainz, Muenster
Age
18 years and over
People
42
Run by
Institut für Klinische Krebsforschung IKF GmbH at Krankenhaus Nordwest
See details and how to joinNCT06440993 · EU 2023-509165-21-00
Phase 1/2Taking people
A Study to Evaluate the Safety and Tolerability of Pumitamig Alone or In Combination With Ipilimumab in Participants With First-Line Advanced or Unresectable Hepatocellular Carcinoma (HCC) (ROSETTA HCC-206)
Where
Cologne, Frankfurt Am Main, Luebeck, Mainz
Age
18 years and over
People
198 worldwide
Run by
Bristol-Myers Squibb
See details and how to joinNCT07291076 · EU 2025-523602-33-00
No phaseTaking people
Ivosidenib in Locally Advanced or Metastatic Cholangiocarcinoma With IDH1 R132 Mutation After at Least One Prior Systemic Treatment - an Observational Study
Where
Augsburg, Bad Liebenwerda, Bad Mergentheim, Bamberg, Berlin, Dresden, Essen, Freiburg im Breisgau, Hanover, Hof, Mönchengladbach, München, Passau, Rheine, Rosenheim, Weinheim
Age
18 years and over
People
100
Run by
iOMEDICO AG
See details and how to joinNCT06607302
Phase 2Taking people
Evaluation of the Safety and Efficacy of Treatment w/High Dose Melphalan Given Directly Into the Liver Followed by Treatment w/Approved Cancer Treatment or Approved Cancer Treatment Alone in Patients w/ Metastatic Breast Cancer w/Liver Dominant Disease
Where
Leipzig
Age
18 years and over
People
90 worldwide
Run by
Delcath Systems Inc.
See details and how to joinNCT06875128 · EU 2025-521966-91-00
Phase 1/2Taking people
A Clinical Trial to Test if the Investigational Drug BNT329 is Safe and Potentially Beneficial for People With Advanced Solid Tumors Known to Express the Tumor Marker CA19-9
Where
Bochum, München, Ulm
Age
18 years and over
People
245 worldwide
Run by
BioNTech SE
See details and how to joinNCT07186842 · EU 2025-522613-26-00
Phase 3Taking people
Phase 3 Study of T-DXd and Rilvegostomig Versus SoC in Advanced HER2-expressing Biliary Tract Cancer
Where
Berlin, Bonn, Cologne, Dresden, Frankfurt am Main, Freiburg im Breisgau, Goettingen, Hamburg, Leipzig, Luebeck, Munich, Ulm, Wuerzburg
Age
18 years to 99 years
People
620 worldwide
Run by
AstraZeneca
See details and how to joinNCT06467357 · EU 2023-508057-19-00
Phase 3Taking people
Phase III Study of Rilvegostomig in Combination With Bevacizumab With or Without Tremelimumab as First-line Treatment of Hepatocellular Carcinoma
Where
Aachen, Berlin, Bonn, Chemnitz, Cologne, Dortmund, Dresden, Erlangen, Essen, Frankfurt am Main, Frankfurt Am Main, Hamburg, Hanover, Leipzig, Luebeck, Magdeburg, Moers, Munich, Ulm
Age
18 years and over
People
1,220 worldwide
Run by
AstraZeneca
See details and how to joinNCT06921785 · EU 2024-518210-81-00
Phase 1/2Taking people
Symbiotic-GI-13: A Study to Learn About Study Medicine Called PF-08634404 as a Single Treatment and Combination Treatment in Adult Participants With a Liver Cancer Called Hepatocellular Carcinoma, That is Too Advanced to be Removed by Surgery and May Have Spread to Other Parts of the Body.
Where
Berlin, Bonn, Duesseldorf, Erlangen, Hanover, Mainz
Age
18 years and over
People
138 worldwide
Run by
Pfizer
See details and how to joinNCT07227012 · EU 2025-523525-17-00
Phase 1/2Taking people
The Evaluation of PC14586 in Patients With Advanced Solid Tumors Harboring a TP53 Y220C Mutation (PYNNACLE)
Where
Augsburg, Essen, Frankfurt am Main, Hamburg, Heidelberg
Age
12 years and over
People
300 worldwide
Run by
PMV Pharmaceuticals, Inc
See details and how to joinNCT04585750
Phase 3Taking people
A clinical trial of belzutifan and other treatments in people with solid tumors or von Hippel-Lindau (VHL)-related tumors (MK-6482-043)
Where
Magdeburg
Age
18 years and over
People
134 worldwide
Run by
Merck Sharp & Dohme LLC
See details and how to join2025-524160-38-00 · EU 2025-524160-38-00
Phase 1Taking people
Study of Zanzalintinib in Combination With Immuno-Oncology or Other Agents in Participants With Solid Tumors
Where
Essen, Heidelberg, Herne, Jena, Nuertingen, Tuebingen
Age
18 years and over
People
1,394 worldwide
Run by
Exelixis
See details and how to joinNCT05176483 · EU 2023-510061-10-00
Phase 1Not yet taking people in Germany
A phase I, open-label, dose-escalation, safety, pharmacokinetic/-dynamic and clinical activity study of p38α inhibitor Skepinone-L to enhance therapeutic efficacy of Sorafenib in advanced hepatocellular carcinomas of non-viral origin
Where
Tuebingen
Age
18 years and over
People
20
Run by
Universitaetsklinikum Tuebingen AöR
See details and how to join2024-511516-24-00 · EU 2024-511516-24-00
Phase 3Taking people
A Study of Rilvegostomig or Durvalumab Plus Chemotherapy for First-Line Treatment of Biliary Tract Cancer (ARTEMIDE-Biliary02)
Where
Aachen, Berlin, Bonn, Duesseldorf, Essen, Frankfurt am Main, Frankfurt Am Main, Freiburg im Breisgau, Hamburg, Heidelberg, Heilbronn, Karlsruhe, Magdeburg, Munich, Ulm
Age
18 years and over
People
1,100 worldwide
Run by
AstraZeneca
See details and how to joinNCT07221253 · EU 2025-523085-24-00
Phase 2Taking people
Study of Dato-DXd as Monotherapy and in Combination With Anti-cancer Agents in Patients With Advanced Solid Tumours (TROPION-PanTumor03)
Where
Berlin, Essen, Hanover, München, Regensburg
Age
18 years to 130 years
People
454 worldwide
Run by
AstraZeneca
See details and how to joinNCT05489211 · EU 2023-509436-26-00
Phase 1/2Taking people
Safety of HRX215 in Patients After Minor and Major Liver Resection
Where
Essen, Tübingen
Age
18 years to 75 years
People
80 worldwide
Run by
HepaRegeniX GmbH
See details and how to joinNCT06638502
Phase 1Taking people
Peptide Vaccine for Fibrolamellar Hepatocellular Carcinoma Patients and Other Tumor Entities Carrying the Driver Fusion DNAJB1-PRKACA
Where
Tübingen
Age
12 years and over
People
20
Run by
University Hospital Tuebingen
See details and how to joinNCT06789198 · EU 2024-519387-41-00
No phaseNot yet taking people in Germany
Liver Transplantation for Non-Resectable Colorectal Liver Metastases Without Local Treatment Options
Where
Berlin
Age
18 years to 65 years
People
260
Run by
Charite University, Berlin, Germany
See details and how to joinNCT07811453