Liver and biliary tract cancer trials in Spain

In Spain 56 Also abroad 1314

56 trials · From ClinicalTrials.gov and EU CTIS (euclinicaltrials.eu), checked 11 November 2026. Ask the study team whether a trial fits you.

Phase 2Not yet taking people in Spain
A Phase 2 Study of Lirafugratinib in Non-CCA Solid Tumors With FGFR2 Fusion or Rearrangement
Where
Barcelona, Madrid
Age
18 years and over
People
14 worldwide
Run by
Elevar Therapeutics Inc.
See details and how to join2025-523923-22-00 · EU 2025-523923-22-00
Phase 1/2Taking people
A Phase 1/2 Study of VS-7375 in Patients With KRAS G12D-Mutated Solid Tumors
Where
Barcelona, Logroño, Madrid
Age
18 years and over
People
616 worldwide
Run by
Verastem, Inc.
See details and how to joinNCT07020221
Phase 2Taking people
Visugromab, Nivolumab and Lenvatinib Compared to Double Placebo and Lenvatinib in Unresectable or Metastatic Hepatocellular Carcinoma Post Anti-PD-(L)1 Failure
Where
Barcelona, L'Hospitalet de Llobregat, Madrid, Pamplona, Zaragoza
Age
18 years to 100 years
People
104 worldwide
Run by
CatalYm GmbH
See details and how to joinNCT07219459 · EU 2025-520675-86-00
Phase 2Taking people
A Study of Lirafugratinib in Non-CCA Solid Tumors With FGFR2 Fusion or Rearrangement
Where
Barcelona, Madrid
Age
18 years and over
People
30 worldwide
Run by
Elevar Therapeutics
See details and how to joinNCT07359820
No phaseTaking people
A Study to Evaluate Patient-Reported Satisfaction, Effectiveness, and Safety of Atezolizumab in Participants Treated in Routine Clinical Practice
Where
Albacete, Alcázar de San Juan, Alicante, Almería, Badajoz, Barakaldo, Barcelona, Bilbao, Ciudad Real, Granada, Guadalajara, Manresa, Murcia, Oviedo, Palma de Mallorca, Pontevedra, Puerto Real, Reus, Santa Cruz de Tenerife, Santiago de Compostela, Seville, Toledo, Valencia, Valladolid, Zaragoza
Age
18 years and over
People
700 worldwide
Run by
Hoffmann-La Roche
See details and how to joinNCT07284121
Phase 2Taking people
A Study to Learn More About How Well Treatment With Sevabertinib (BAY 2927088) Tablets Works and How Safe it is in Participants Who Have a Solid Tumor With Mutations of the Human Epidermal Growth Factor Receptor 2 (HER2)
Where
Barcelona, L'Hospitalet de Llobregat, Madrid
Age
18 years and over
People
111 worldwide
Run by
Bayer
See details and how to joinNCT06760819 · EU 2024-517419-62-00
Phase 1/2Taking people
A Clinical Study of MK-2870 Alone or With Other Treatments to Treat Gastrointestinal Cancers (MK-9999-02A)
Where
Barcelona, Madrid, Oviedo
Age
18 years and over
People
220 worldwide
Run by
Merck Sharp & Dohme LLC
See details and how to joinNCT06428409 · EU 2023-508703-21-00
Phase 2Taking people
DB-1311 in Combination With BNT327 or DB-1305 in Advanced/Metastatic Solid Tumors
Where
A Coruña, Barcelona, Girona, L'Hospitalet de Llobregat, Logrono
Age
18 years and over
People
750 worldwide
Run by
DualityBio Inc.
See details and how to joinNCT06953089 · EU 2025-523895-22-00
Phase 1/2Taking people
BOLD-100 in Combination With FOLFOX With or Without Bevacizumab for the Treatment of Advanced, Solid Tumours
Where
Barcelona, Madrid
Age
18 years and over
People
220 worldwide
Run by
Bold Therapeutics, Inc.
See details and how to joinNCT04421820 · EU 2024-517500-11-00
No phaseTaking people
Observational Study Protocol: LIVER-R
Where
Barcelona, Burgos, El Palmar, Madrid, Majadahonda, Ourense, Oviedo, Pamplona, Poniente Sur, Santa Cruz de Tenerife, Santander, Santiago de Compostela, Seville, Valencia, Zaragoza
Age
18 years to 130 years
People
4,000 worldwide
Run by
AstraZeneca
See details and how to joinNCT06252753
Phase 3Taking people
Efficacy and Safety of Zanidatamab With Standard-of-care Therapy Against Standard-of-care Therapy for Advanced HER2-positive Biliary Tract Cancer
Where
Barcelona, Córdoba, Madrid, Málaga, Pamplona, Santiago de Compostela, Sevilla, Valencia, Zaragoza
Age
18 years and over
People
286 worldwide
Run by
Jazz Pharmaceuticals
See details and how to joinNCT06282575 · EU 2023-508219-21-00
Phase 1/2Taking people
A Study to Evaluate the Efficacy and Safety of Ifinatamab Deruxtecan (I-DXd) in Subjects With Recurrent or Metastatic Solid Tumors (IDeate-PanTumor02)
Where
Barcelona, L'Hospitalet de Llobregat, Madrid, Sevilla
Age
18 years and over
People
680 worldwide
Run by
Daiichi Sankyo
See details and how to joinNCT06330064 · EU 2023-509632-26-00
Phase 1/2Taking people
A Study to Evaluate the Safety and Tolerability of Pumitamig Alone or In Combination With Ipilimumab in Participants With First-Line Advanced or Unresectable Hepatocellular Carcinoma (HCC) (ROSETTA HCC-206)
Where
Barcelona, Madrid, Pamplona
Age
18 years and over
People
198 worldwide
Run by
Bristol-Myers Squibb
See details and how to joinNCT07291076 · EU 2025-523602-33-00
Phase 1Taking people
A First-in-human Study to Learn About the Safety of BAY 3547926 and How Well it Works in Participants With Advanced Liver Cancer
Where
L'Hospitalet de Llobregat, Madrid, Pamplona
Age
18 years and over
People
148 worldwide
Run by
Bayer
See details and how to joinNCT06764316 · EU 2024-516615-25-00
Phase 2Taking people
Evaluation of the Safety and Efficacy of Treatment w/High Dose Melphalan Given Directly Into the Liver Followed by Treatment w/Approved Cancer Treatment or Approved Cancer Treatment Alone in Patients w/ Metastatic Breast Cancer w/Liver Dominant Disease
Where
L'Hospitalet de Llobregat, Madrid
Age
18 years and over
People
90 worldwide
Run by
Delcath Systems Inc.
See details and how to joinNCT06875128 · EU 2025-521966-91-00
Phase 1/2Taking people
A Clinical Trial to Test if the Investigational Drug BNT329 is Safe and Potentially Beneficial for People With Advanced Solid Tumors Known to Express the Tumor Marker CA19-9
Where
Barcelona, Logroño, Madrid, Pozuelo de Alarcón
Age
18 years and over
People
245 worldwide
Run by
BioNTech SE
See details and how to joinNCT07186842 · EU 2025-522613-26-00
Phase 1Taking people
Study to Assess Adverse Events and Change in Disease Activity in Adult Participants With Select Advanced Solid Tumor Indications Receiving Intravenous (IV) ABBV-400
Where
Badalona, Barcelona, Madrid, Málaga, Pamplona, Zaragoza
Age
18 years and over
People
325 worldwide
Run by
AbbVie
See details and how to joinNCT06084481 · EU 2023-506227-29-00
Phase 1/2Taking people
First in Human Study to Evaluate AZD9793 in Participants With Advanced or Metastatic Solid Tumours
Where
Barcelona, Pamplona
Age
18 years and over
People
304 worldwide
Run by
AstraZeneca
See details and how to joinNCT06795022 · EU 2024-516698-56-00
Phase 3Taking people
Phase 3 Study of T-DXd and Rilvegostomig Versus SoC in Advanced HER2-expressing Biliary Tract Cancer
Where
Barcelona, Madrid, Málaga, Santander
Age
18 years to 99 years
People
620 worldwide
Run by
AstraZeneca
See details and how to joinNCT06467357 · EU 2023-508057-19-00
Phase 3Taking people
Phase III Study of Rilvegostomig in Combination With Bevacizumab With or Without Tremelimumab as First-line Treatment of Hepatocellular Carcinoma
Where
Barcelona, Madrid, Pamplona, Santander
Age
18 years and over
People
1,220 worldwide
Run by
AstraZeneca
See details and how to joinNCT06921785 · EU 2024-518210-81-00
Phase 1/2Taking people
Symbiotic-GI-13: A Study to Learn About Study Medicine Called PF-08634404 as a Single Treatment and Combination Treatment in Adult Participants With a Liver Cancer Called Hepatocellular Carcinoma, That is Too Advanced to be Removed by Surgery and May Have Spread to Other Parts of the Body.
Where
Barcelona, Madrid, Oviedo
Age
18 years and over
People
138 worldwide
Run by
Pfizer
See details and how to joinNCT07227012 · EU 2025-523525-17-00
Phase 1Taking people
A Study of ZW251 in Participants With Advanced Solid Tumors
Where
Barcelona, Logroño, Madrid, Málaga, Pamplona
Age
18 years and over
People
140 worldwide
Run by
Zymeworks BC Inc.
See details and how to joinNCT07164313
Phase 1/2Taking people
The Evaluation of PC14586 in Patients With Advanced Solid Tumors Harboring a TP53 Y220C Mutation (PYNNACLE)
Where
Barcelona, Madrid, Rioja, Valencia
Age
12 years and over
People
300 worldwide
Run by
PMV Pharmaceuticals, Inc
See details and how to joinNCT04585750
Phase 1Taking people
A Phase 1 Study of PLN-101095 in Adults With Advanced or Metastatic Solid Tumors
Where
Barcelona, Logroño, Madrid
Age
18 years and over
People
124 worldwide
Run by
Pliant Therapeutics, Inc.
See details and how to joinNCT06270706
Phase 3Taking people
A clinical trial of belzutifan and other treatments in people with solid tumors or von Hippel-Lindau (VHL)-related tumors (MK-6482-043)
Where
Barcelona, Madrid
Age
18 years and over
People
134 worldwide
Run by
Merck Sharp & Dohme LLC
See details and how to join2025-524160-38-00 · EU 2025-524160-38-00