Liver and biliary tract cancer trials in United States

In United States 302 Also abroad 1314

302 trials · From ClinicalTrials.gov, checked 11 November 2026. Ask the study team whether a trial fits you.

Phase 1Taking people
A Study of Therapeutic Drug Monitoring-Based Atezolizumab Dosing
Where
Bethesda
Age
18 years to 120 years
People
30
Run by
National Cancer Institute (NCI)
See details and how to joinNCT06066138
Phase 1/2Taking people
A Phase 1/2 Study of VS-7375 in Patients With KRAS G12D-Mutated Solid Tumors
Where
Ann Arbor, Baltimore, Boston, Charlottesville, Fairfax, Houston, Los Angeles, Nashville, New York, Philadelphia, Salt Lake City, Seattle, St Louis
Age
18 years and over
People
616 worldwide
Run by
Verastem, Inc.
See details and how to joinNCT07020221
Phase 2Taking people
Visugromab, Nivolumab and Lenvatinib Compared to Double Placebo and Lenvatinib in Unresectable or Metastatic Hepatocellular Carcinoma Post Anti-PD-(L)1 Failure
Where
Atlanta, Boston, Irvine, Los Angeles, Orange, Peoria, Santa Monica
Age
18 years to 100 years
People
104 worldwide
Run by
CatalYm GmbH
See details and how to joinNCT07219459 · EU 2025-520675-86-00
No phaseNot yet taking people in United States
Scheduled Meditation for Improving Postoperative Outcomes in Patients Undergoing Pancreatectomy
Where
Duarte
Age
18 years and over
People
70
Run by
City of Hope Medical Center
See details and how to joinNCT07608458
Phase 1Not yet taking people in United States
Hepatic Artery Infusion of Carfilzomib in Participants With Liver Metastatic Disease Previously Treated With Hepatic Artery Infusion Pump Therapy
Where
Bethesda
Age
18 years to 120 years
People
20
Run by
National Cancer Institute (NCI)
See details and how to joinNCT07715903
Phase 2Not yet taking people in United States
Phase 2 Study of Daraxonrasib in Recurrent KRAS-Mutant Biliary Tract Cancer
Where
Baltimore
Age
18 years and over
People
55
Run by
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
See details and how to joinNCT07793253
No phaseTaking people
Collection of Blood From Patients With Cancer
Where
Bethesda
Age
18 years and over
People
1,750
Run by
National Cancer Institute (NCI)
See details and how to joinNCT00034216
No phaseTaking people
Follow-Up Study of Subjects Previously Enrolled in Poxviral Vector Gene Transfer Studies
Where
Bethesda
Age
18 years and over
People
750
Run by
National Cancer Institute (NCI)
See details and how to joinNCT00451022
Phase 2Taking people
A Study of Lirafugratinib in Non-CCA Solid Tumors With FGFR2 Fusion or Rearrangement
Where
Boston, Chicago, Houston, Jacksonville, New York, Phoenix, Rochester, Tampa
Age
18 years and over
People
30 worldwide
Run by
Elevar Therapeutics
See details and how to joinNCT07359820
Phase 2Taking people
At-Home Cancer Directed Therapy Versus in Clinic for the Treatment of Patients With Advanced Cancer
Where
Grand Forks, Jacksonville
Age
18 years and over
People
220
Run by
Mayo Clinic
See details and how to joinNCT05969860
No phaseTaking people
Real-world Evaluation of the HistoSonics Edison System for Treatment of Liver Tumors Across Multidisciplinary Users (BOOMBOX: Master Study)
Where
Allentown, Altamonte Springs, Austin, Baltimore, Boston, Celebration, Centerville, Chicago, Cleveland, Columbus, Detroit, Fort Myers, Fullerton, Gainesville, Los Angeles, Madison, Manhasset, Miami, Mission Viejo, Mobile, Newport Beach, New York, Reno, Richmond, Rochester, San Francisco, Santa Monica, Seattle, Shreveport, Winston-Salem, Wyoming
Age
22 years and over
People
5,000
Run by
HistoSonics, Inc.
See details and how to joinNCT06486454
No phaseTaking people
The Vanguard Study: Testing a New Way to Screen for Cancer
Where
Bethesda, Brownstown, Chapel Hill, Charlottesville, Chesterfield, Cheyenne Wells, Cleveland, Clinton Township, Dearborn, Denver, Detroit, Durham, Fairfax, Fort Collins, Greeley, Grosse Pointe Farms, Honolulu, Kansas City, Lafayette, Livonia, Lone Tree, Loveland, Milwaukee, Minneapolis, Norfolk, Novi, Oklahoma City, Pleasanton, Plymouth, Portsmouth, Richmond, Royal Oak, San Diego, South Hill, Springfield, Sterling Heights, St Louis, Tacoma, Troy, West Bloomfield, Wyandotte
Age
45 years to 75 years
People
24,000
Run by
National Cancer Institute (NCI)
See details and how to joinNCT06995898
No phaseTaking people
CREO - Microwave Ablation Feasibility Study
Where
Chicago, Gilbert, Houston, Knoxville, Los Angeles, Morgantown
Age
18 years and over
People
75
Run by
Banner Health
See details and how to joinNCT07817147
Phase 3Taking people
D07001 Softgel-Capsules and Capecitabine Combination Therapy in Patients With Advanced Biliary Tract Cancer
Where
Cleveland, Dallas, Miami Beach, Tucson
Age
18 years and over
People
240 worldwide
Run by
InnoPharmax Inc.
See details and how to joinNCT06622057
Phase 2Taking people
A Study to Learn More About How Well Treatment With Sevabertinib (BAY 2927088) Tablets Works and How Safe it is in Participants Who Have a Solid Tumor With Mutations of the Human Epidermal Growth Factor Receptor 2 (HER2)
Where
Birmingham, Boston, Cleveland, Detroit, Duarte, Farmington Hills, Fort Myers, Houston, Madison, Nashville, Seattle
Age
18 years and over
People
111 worldwide
Run by
Bayer
See details and how to joinNCT06760819 · EU 2024-517419-62-00
Phase 2Not yet taking people in United States
A Phase II Study of Single Tremelimumab With Regular Interval Durvalumab Plus Gemcitabine and Cisplatin in Locally Advanced Unresectable/Metastatic Combined Hepatocellular-cholangiocarcinoma
Where
Birmingham
Age
18 years and over
People
29
Run by
Mehmet Akce
See details and how to joinNCT06855225
No phaseTaking people
Distance-Based Exercise to Preserve Function and Prevent Disability
Where
Boston, Butler, Cranberry Township, Dublin, Fremont, Fresno, Indiana, Kernersville, Mechanicsville, Midlothian, Modesto, Mount Airy, New Castle, Oakland, Pittsburgh, Richmond, Sacramento, San Francisco, San Jose, San Rafael, Santa Clara, Santa Rosa, Seneca, Vallejo, Walnut Creek, Winston-Salem
Age
18 years and over
People
104
Run by
Alliance for Clinical Trials in Oncology
See details and how to joinNCT07059884
Phase 1Taking people
A Study of LY4337713 in Participants With FAP-Positive Solid Tumors
Where
Boston, Dallas, Detroit, Durham, Glen Burnie, Grand Rapids, Houston, Indianapolis, Madison, Miami, Newport Beach, New York, Philadelphia, Rochester, Stanford, St Louis, Tampa
Age
18 years and over
People
340 worldwide
Run by
Eli Lilly and Company
See details and how to joinNCT07213791 · EU 2025-521887-37-00
Phase 2Taking people
Gemcitabine, Cisplatin, Nab-paclitaxel (GAP) and Cemiplimab for Locally Advanced Biliary Tract Cancer (BTC)
Where
New York
Age
18 years and over
People
20
Run by
Columbia University
See details and how to joinNCT07433673
No phaseNot yet taking people in United States
Characterizing Tumor Hypoxia With BOLD-MRI to Predict Y-90 Treatment Response
Where
Chapel Hill
Age
18 years and over
People
12
Run by
UNC Lineberger Comprehensive Cancer Center
See details and how to joinNCT07916376
Phase 1/2Taking people
A Phase 1 and 2 Study of VMD-102 in Hepatocellular Carcinoma and Other Solid Tumors
Where
Los Angeles, Scottsdale
Age
18 years to 75 years
People
111
Run by
VM Discovery, Inc.
See details and how to joinNCT07636785
No phaseTaking people
Targeted Navigation in Hepatocellular Carcinoma (HCC)
Where
Miami
Age
18 years and over
People
210
Run by
University of Miami
See details and how to joinNCT06260943
Phase 2Not yet taking people in United States
Zolbetuximab With mFOLFOX6 or CAPOX in Claudin 18.2 Overexpressed Advanced or Metastatic Biliary Tract Cancers
Where
Birmingham
Age
18 years and over
People
32
Run by
Midhun Malla
See details and how to joinNCT07723534
No phaseTaking people
DNP-MRSI of HCC Metabolism to Predict Therapeutic Response
Where
Philadelphia
Age
18 years and over
People
232
Run by
Abramson Cancer Center at Penn Medicine
See details and how to joinNCT07807475
Phase 1/2Taking people
CR-002 in Adult Participants With Locally Advanced or Metastatic Solid Tumors
Where
Austin, Dallas, Fairfax
Age
18 years and over
People
219
Run by
Crescent Biopharma, Inc.
See details and how to joinNCT07909031 · EU 2026-527289-54-00