Lung cancer trials in United States

In United States 900 Also abroad 2746

900 trials · From ClinicalTrials.gov, checked 14 November 2026. Ask the study team whether a trial fits you.

Phase 3Taking people
This is a Study to Learn About How the Combination of the Study Medicines Sigvotatug Vedotin Plus Pembrolizumab Works in People With Non-small Cell Lung Cancer With High Levels of PD-L1.
Where
Avon, Billings, Burnsville, Canton, Cleveland, Conroe, Coon Rapids, Edina, Elmhurst, El Paso, Fairbanks, Fairhaven, Fall River, Fremont, Fullerton, Golden, Grafton, Grand Island, Grand Junction, Grand Rapids, Green Bay, Greenville, Hinsdale, Houston, Jackson, Kansas City, Kearney, Kingwood, League City, Lee's Summit, Libertyville, Lincoln, Maple Grove, Maplewood, Mentor, Milwaukee, Minneapolis, Naperville, New Lenox, Nyack, Oak Lawn, Olympia, Omaha, Orange, Orange City, Overland Park, Park Ridge, Plantation, Portland, Robbinsdale, Saint Louis Park, Saint Paul, Scarborough, South Portland, Sugar Land, The Woodlands, Washington D.C., Wheat Ridge, Wilson, Woodbury
Age
18 years and over
People
714 worldwide
Run by
Pfizer
See details and how to joinNCT06758401 · EU 2024-517968-36-00
No phaseTaking people
Hyperpolarized Xenon-129 Magnetic Resonance Imaging in Lung Cancer Patients Receiving Radiation Therapy for Investigating Radiation-response and Toxicity
Where
Houston
Age
18 years and over
People
70
Run by
M.D. Anderson Cancer Center
See details and how to joinNCT06909201
Phase 1/2Taking people
A Study of PRMT5 Inhibitor BAY 3713372 in Participants With MTAP-deleted Solid Tumors
Where
Aurora, Birmingham, Boston, Denver, Duarte, Grand Rapids, Irving, Los Angeles, Milwaukee, Nashville, New York, Orlando, San Antonio, San Francisco, Stanford
Age
18 years and over
People
450 worldwide
Run by
Bayer
See details and how to joinNCT06914128 · EU 2025-520623-24-00
Phase 1Taking people
Evaluating BL-M14D1 in Subjects With Locally Advanced or Metastatic Small Cell Lung Cancer and Neuroendocrine Tumors
Where
Atlanta, Aurora, Columbus, Dallas, East Brunswick, Fairfax, Glendale, Greenville, Hackensack, Houston, Huntsville, Lakewood, Long Beach, Los Angeles, New Brunswick, New Haven, New Orleans, New York, Portland, San Antonio, San Francisco, Seattle
Age
18 years and over
People
120 worldwide
Run by
SystImmune Inc.
See details and how to joinNCT07080242
Phase 2/3Taking people
Study of Izalontamab Brengitecan (BMS-986507) Versus Platinum-based Chemotherapy With or Without Amivantamab for EGFR-mutated Non-small Cell Lung Cancer After Failure of EGFR TKI Therapy (IZABRIGHT-Lung01)
Where
Atlanta, Boston, Charlottesville, Chattanooga, Chicago, Cleveland, Columbus, Edwards, Gainesville, Houston, Irvine, Mineola, Nashville, New York, Orange, Pembroke Pines, Philadelphia, Pittsburgh, Portland, Reno, Richmond, Rochester, San Antonio, St Louis
Age
18 years and over
People
661 worldwide
Run by
Bristol-Myers Squibb
See details and how to joinNCT07100080
Phase 2Taking people
A Phase 2 Platform Study of Immunomodulatory Compounds in ICI-refractory Non-small Cell Lung Cancer
Where
Houston
Age
18 years and over
People
29
Run by
M.D. Anderson Cancer Center
See details and how to joinNCT07133425
No phaseTaking people
Evaluate the Clinical Performance of the Flow Cytometry - FlowPath Lung Test as a Sensitive and Specific Non-invasive Diagnostic of Sputum Samples to Identify/Detect the Presence of Lung Cancer in High-risk Individuals Who Have Existing Lung Nodules, 6 to <30 mm in Diameter, Determined by LDCT.
Where
Bay Pines, Dayton, DuBois, Grand Junction, Miami, Milwaukee, Minneapolis, North Chicago, Palo Alto, San Antonio, Tampa
Age
50 years to 80 years
People
2,063
Run by
bioAffinity Technologies Inc.
See details and how to joinNCT07168993
Phase 3Taking people
A Clinical Study of Calderasib (MK-1084) and Other Treatments for Participants With Non-Small Cell Lung Cancer (MK-1084-007/KANDLELIT-007)
Where
Albany, Bend, Beverly Hills, Birmingham, Farmington, Fort Lauderdale, Fredericksburg, Hackensack, Lafayette, Lancaster, Miami Beach, Midlothian, Minneapolis, Morgantown, Roanoke, Rochester, Savannah, Stamford, Westbrook
Age
18 years and over
People
675 worldwide
Run by
Merck Sharp & Dohme LLC
See details and how to joinNCT07190248 · EU 2024-514500-14-00
Phase 2Taking people
A Study of Intismeran Autogene (V940)/Placebo + Pembrolizumab and Chemotherapy in Metastatic Squamous Non-Small Cell Lung Cancer (V940-013)
Where
Albany, Ann Arbor, Austin, Cleveland, Corvallis, Fairfax, Nashville, Paramus, Seattle, St Louis, Tampa
Age
18 years and over
People
180 worldwide
Run by
Merck Sharp & Dohme LLC
See details and how to joinNCT07221474 · EU 2025-520902-37-00
Phase 1Taking people
A Phase 1 Dose Escalation and Dose Expansion Trial of KST-6051 in Participants With Advanced Solid Tumors With Kirsten Rat Sarcoma Viral Oncogene Homolog (KRAS) Mutation
Where
Boston, Fairfax, Houston, Los Angeles, Philadelphia, Salt Lake City, San Antonio, Sarasota, Tampa
Age
18 years and over
People
545
Run by
Kestrel Therapeutics, Inc.
See details and how to joinNCT07458347
Phase 3Taking people
A Clinical Trial of Calderasib (MK-1084) and Durvalumab in People With Non-Small Cell Lung Cancer (MK-1084-015/KANDLELIT-015)
Where
Albany, Atlanta, Fairfax, Lincoln, Lisle, New Brunswick, Raleigh, Savannah
Age
18 years and over
People
310 worldwide
Run by
Merck Sharp & Dohme LLC
See details and how to joinNCT07554339 · EU 2025-522038-29-00
Phase 3Taking people
BL-M14D1 Plus Atezolizumab vs Standard of Care in First-Line Extensive-Stage Small Cell Lung Cancer (BrenDeLL-Lung01)
Where
East Brunswick, Fairfax, Glendale, Long Beach, Los Angeles, Miami, Springdale
Age
18 years and over
People
550 worldwide
Run by
SystImmune Inc.
See details and how to joinNCT07625644
Phase 1/2Taking people
DAREON®-36: A Study to Test Obrixtamig in Combination With ZL-1310 in People With Advanced Small Cell Lung Cancer or Other Neuroendocrine Cancers
Where
Lexington, Tampa, Washington D.C.
Age
18 years and over
People
60 worldwide
Run by
Boehringer Ingelheim
See details and how to joinNCT07707895 · EU 2026-525634-27-00
Phase 1Taking people
A Study of Armored CAR T Cells in People With Cancer
Where
Basking Ridge, Commack, Harrison, Middletown, Montvale, New York, Uniondale
Age
18 years and over
People
16
Run by
Memorial Sloan Kettering Cancer Center
See details and how to joinNCT07783477
Phase 2Taking people
Zanzalintinib and Pembrolizumab in First-Line Maintenance for Metastatic Squamous Non-Small Cell Lung Cancer (NSCLC)
Where
Omaha
Age
18 years and over
People
60
Run by
Exelixis
See details and how to joinNCT07845786
Phase 1/2Not yet taking people in United States
Tocilizumab Combined With First-Line Chemo-Immunotherapy in Metastatic Non-Small Cell Lung Cancer
Where
Ann Arbor, Cleveland, Indianapolis, Pittsburgh
Age
18 years and over
People
43
Run by
VA Office of Research and Development
See details and how to joinNCT07889232
Phase 1/2Taking people
A KRAS Inhibitor in Participants With Advanced Solid Tumors
Where
Fairfax
Age
18 years and over
People
320
Run by
Ensem Therapeutics
See details and how to joinNCT07912593
No phaseTaking people
Detection of Genetic Markers of Lung Cancer
Where
Pittsburgh
Age
18 years and over
People
6,000
Run by
University of Pittsburgh
See details and how to joinNCT00280202
Phase 1Taking people
Study of Aerosol Gemcitabine in Patients With Solid Tumors and Pulmonary Metastases
Where
Houston
Age
12 years to 50 years
People
44
Run by
M.D. Anderson Cancer Center
See details and how to joinNCT03093909
Phase 4Taking people
Dabrafenib and/or Trametinib Rollover Study
Where
Bethesda, Columbus, Dallas, Scottsdale
Age
18 years to 100 years
People
100 worldwide
Run by
Novartis Pharmaceuticals
See details and how to joinNCT03340506 · EU 2023-509318-13-00
Phase 2Taking people
Study to Test the Safety and Tolerability of PF-07220060 in Participants With Advance Solid Tumors
Where
Boston, Grand Rapids, Houston, Los Angeles, Nashville, New Haven, Newton, Trumbull
Age
18 years and over
People
430 worldwide
Run by
Pfizer
See details and how to joinNCT04557449 · EU 2024-512120-11-00
Phase 1Taking people
A Study of Therapeutic Drug Monitoring-Based Atezolizumab Dosing
Where
Bethesda
Age
18 years to 120 years
People
30
Run by
National Cancer Institute (NCI)
See details and how to joinNCT06066138
Phase 3Taking people
LUNAR-2: TTFields With Pembrolizumab + Platinum-based Chemotherapy for Metastatic NSCLC
Where
Annapolis, Auburn, Barrington, Birmingham, Cary, Dallas, Edinburg, Elmhurst, Fort Wayne, Fullerton, Gig Harbor, Goodyear, Houston, Indianapolis, Jacksonville, Kansas City, Lee's Summit, Naperville, New Hyde Park, Newport Beach, New York, Ocala, Overland, Philadelphia, Pittsburgh, Puyallup, Richardson, Rochester, Sacramento, San Antonio, Shirley, Spokane, Tacoma, Tampa, The Bronx, Westwood, Zion
Age
18 years and over
People
734 worldwide
Run by
NovoCure GmbH
See details and how to joinNCT06216301
Phase 3Taking people
A Study to Assess Efficacy and Safety of Pembrolizumab With or Without Sacituzumab Tirumotecan (MK- 2870) in Adult Participants With Resectable Non Small Cell Lung Cancer (NSCLC) Not Achieving Pathological Complete Response (pCR) (MK-2870-019)
Where
Albany, Atlanta, Baton Rouge, Beverly Hills, Bluffton, Charleston, Columbus, Edgewood, Elmhurst, Evanston, Fargo, Fort Wayne, Hershey, Houston, Ithaca, Jacksonville, Knoxville, Lafayette, Lancaster, Lisle, Little Rock, Los Angeles, Miami Beach, Minneapolis, Morristown, Naperville, Newnan, Newport Beach, Oklahoma City, Orange, Orange City, Portland, Reno, Rochester, Salt Lake City, San Francisco, Savannah, Sioux Falls, Springdale, Stamford, St Louis, Stony Brook, Thomasville, Westbrook, White Plains
Age
18 years and over
People
780 worldwide
Run by
Merck Sharp & Dohme LLC
See details and how to joinNCT06312137 · EU 2023-508012-35-00
Phase 3Taking people
A Study to Compare the Efficacy and Safety of BMS-986489 (Atigotatug+ Nivolumab Fixed Dose Combination) in Combination With Carboplatin Plus Etoposide to That of Atezolizumab With Carboplatin Plus Etoposide as First-Line Therapy in Participants With Extensive-Stage Small Cell Lung Cancer (TIGOS).
Where
Albuquerque, Austin, Bismarck, Cincinnati, Daphne, Durham, Edmonds, Fargo, Fort Myers, Hot Springs, Marietta, Minneapolis, Nashville, Orange City, Peoria, Roanoke, Seattle, Sioux Falls, St. Petersburg, Tyler
Age
18 years and over
People
530 worldwide
Run by
Bristol-Myers Squibb
See details and how to joinNCT06646276 · EU 2024-515740-23-00