Lung cancer trials in United States

In United States 900 Also abroad 2746

900 trials · From ClinicalTrials.gov, checked 15 November 2026. Ask the study team whether a trial fits you.

Phase 2Taking people
A Study to Assess the Efficacy of WSD0922-FU in Patients With C797S+ Advanced Non-small Cell Lung Cancer
Where
Austin, Cleveland, Fairfax, Manahawkin, Pittsburgh, Weston
Age
18 years and over
People
40 worldwide
Run by
Wayshine Biopharm, Inc.
See details and how to joinNCT06868485
Phase 1/2Taking people
A Phase 1/2 Study of VS-7375 in Patients With KRAS G12D-Mutated Solid Tumors
Where
Ann Arbor, Baltimore, Boston, Charlottesville, Fairfax, Houston, Los Angeles, Nashville, New York, Philadelphia, Salt Lake City, Seattle, St Louis
Age
18 years and over
People
616 worldwide
Run by
Verastem, Inc.
See details and how to joinNCT07020221
Phase 3Taking people
A Study of GSK5764227 in Participants With Relapsed Small Cell Lung Cancer (SCLC) [EMBOLD SCLC-301]
Where
Canton, East Syracuse, Fort Worth, Hialeah, Hinsdale, Los Angeles, Miami, Plantation, Tamarac, Wilson
Age
18 years and over
People
420 worldwide
Run by
GlaxoSmithKline
See details and how to joinNCT07099898
Phase 2Taking people
KEYMAKER-U01 Substudy 01J: A Study of Pembrolizumab Plus MK-1084 in Participants With Non-Small Cell Lung Cancer (NSCLC) With Kirsten Rat Sarcoma Viral Oncogene Homolog (KRAS) G12C Mutations (MK-3475-01J/KEYMAKER-U01J)
Where
Clermont, Fargo, Sioux Falls
Age
18 years and over
People
140 worldwide
Run by
Merck Sharp & Dohme LLC
See details and how to joinNCT07252739 · EU 2025-521939-36-00
Phase 3Taking people
Phase III Study of Datopotamab Deruxtecan Versus Docetaxel in Previously Treated TROP2-positive Advanced or Metastatic Non-squamous NSCLC Without Actionable Genomic Alterations
Where
Albuquerque, Austin, Baltimore, Boston, Brandywine, Bridgeton, Chandler, Charlottesville, Chicago, Columbia, Denton, Detroit, Duarte, East Syracuse, Eau Claire, Fairfax, Fort Myers, Gilbert, Goodyear, Grand Junction, Greenville, Hershey, Hinsdale, Irvine, Jacksonville, La Jolla, Lancaster, Lincoln, Loma Linda, Los Angeles, Louisville, Marietta, Memphis, Morgantown, Newark, Newnan, Niles, Plano, Portland, Rochester, San Diego, South Portland, St. Petersburg, Tacoma, Tampa, Washington D.C., West Palm Beach, Wheat Ridge, Williamsburg, Zion
Age
18 years and over
People
400 worldwide
Run by
AstraZeneca
See details and how to joinNCT07291037 · EU 2024-520101-39-00
No phaseTaking people
A Mobile Patient Health Technology Intervention for Improving Lung Cancer Screening Rates in Eligible High Risk Patients
Where
Winston-Salem
Age
50 years to 77 years
People
27,000
Run by
Wake Forest University Health Sciences
See details and how to joinNCT07322367
Phase 3Taking people
DAREON ® -Lung-1: A Study in People With Advanced Small Cell Lung Cancer to Compare Obrixtamig Plus Atezolizumab, Carboplatin, and Etoposide Treatment With Standard Chemoimmunotherapy
Where
Ann Arbor, Atlanta, Baltimore, Fayetteville, Hialeah, Kansas City, Little Rock, Louisville, Madison, Memphis, Mobile, Monroe, Omaha, Pikeville, Pittsburgh, Shreveport
Age
18 years and over
People
670 worldwide
Run by
Boehringer Ingelheim
See details and how to joinNCT07472517 · EU 2025-520565-51-00
Phase 1Taking people
A Study of IDE034 in Adult Participants With Locally Advanced/Metastatic Solid Tumors Types
Where
Austin, Celebration, Denver, Detroit, Duarte, East Brunswick, Fairfax, Fort Worth, Houston, Irvine, Irving, Lake Success, Nashville, New Haven, New York, Plantation, San Antonio, Sarasota, Spokane, West Valley City
Age
18 years and over
People
150 worldwide
Run by
IDEAYA Biosciences
See details and how to joinNCT07503808 · EU 2026-526299-21-00
Phase 3Taking people
Study of Izalontamab Brengitecan (BMS-986507) in Combination With Osimertinib Versus Osimertinib Monotherapy or Osimertinib in Combination With Platinum-based Chemotherapy for EGFRmt Non-small Cell Lung Cancer (IZABRIGHT-Lung02)
Where
Baltimore, Beaumont, Beverly Hills, Boulder, Charlotte, Chicago, Dallas, Easton, Edina, Fairfax, Fort Myers, Fullerton, La Jolla, Lebanon, Memphis, Morgantown, New Brunswick, New York, Omaha, Orlando, Ottawa, Palm Bay, Portland, Saint Paul, Salt Lake City, San Antonio, Sandusky, Seattle, Silver Spring, Sioux Falls, St Louis, St. Petersburg, The Bronx, Washington D.C., West Palm Beach, Winchester
Age
18 years and over
People
850 worldwide
Run by
Bristol-Myers Squibb
See details and how to joinNCT07680790 · EU 2026-526486-21-00
Phase 2Not yet taking people in United States
Cemiplimab for Clinical Stage I, 2-3.9cm, Non-Small Cell Lung Cancer
Where
Charleston
Age
18 years to 80 years
People
38
Run by
Medical University of South Carolina
See details and how to joinNCT07720167
Phase 1/2Taking people
A Study of DS-3939a in Participants With Solid Tumors
Where
Fairfax, Fayetteville, Houston, Los Angeles, Portland, Providence, Tampa
Age
18 years and over
People
400 worldwide
Run by
Daiichi Sankyo
See details and how to joinNCT07739966 · EU 2026-525218-75-00
Phase 2Taking people
Prospective Study on Radiation Induced Cardiotoxicity Assessed By PET-CT for Locally Advanced Non-Small Cell Lung Cancer (NSCLC)
Where
Indianapolis
Age
18 years and over
People
10
Run by
Indiana University
See details and how to joinNCT07761910
Phase 1/2Taking people
A Study to Test Obrixtamig in Combination With Pumitamig in People With Advanced Small Cell Lung Cancer (Dareon®-Rosetta35)
Where
Boston, East Brunswick, Miami, Nashville, New York
Age
18 years and over
People
55 worldwide
Run by
Boehringer Ingelheim
See details and how to joinNCT07843940 · EU 2026-525459-99-00
No phaseNot yet taking people in United States
MyPatientPal+: A Smartphone App and a Provider Dashboard to Manage Patient Care While on Treatment
Where
Detroit
Age
18 years to 70 years
People
100
Run by
Barbara Ann Karmanos Cancer Institute
See details and how to joinNCT07928154
Phase 1Not yet taking people in United States
A Study of LY4336619 in Adult Participants With Advanced Solid Tumors
Where
Boston, Chicago, Columbus, Duarte, Houston, La Jolla, Lake Success, New York, Scottsdale, West Valley City
Age
18 years and over
People
370 worldwide
Run by
Eli Lilly and Company
See details and how to joinNCT07928258 · EU 2026-526553-33-00
No phaseTaking people
Collection of Blood From Patients With Cancer
Where
Bethesda
Age
18 years and over
People
1,750
Run by
National Cancer Institute (NCI)
See details and how to joinNCT00034216
No phaseTaking people
Follow-Up Study of Subjects Previously Enrolled in Poxviral Vector Gene Transfer Studies
Where
Bethesda
Age
18 years and over
People
750
Run by
National Cancer Institute (NCI)
See details and how to joinNCT00451022
No phaseTaking people
Health Opportunities and Promoters of Equitable Screening for Lung Cancer
Where
Boston
Age
50 years to 80 years
People
2,000
Run by
Massachusetts General Hospital
See details and how to joinNCT05784922
Phase 3Taking people
A Study to Compare the Efficacy of Nivolumab and Relatlimab Plus Chemotherapy vs Pembrolizumab Plus Chemotherapy for Stage IV/Recurrent Non-squamous Non-small Cell Lung Cancer With PD-L1 Expression ≥ 1%
Where
Abilene, Albuquerque, Annapolis, Asheville, Bozeman, Canton, Centerville, Chicago Ridge, Cincinnati, Cleveland, Coeur d'Alene, Edgewood, Edmonds, Elyria, Grand Junction, Greenville, Harlingen, Hattiesburg, Hawthorne, Houston, Issaquah, Kansas City, Lacey, Lancaster, Lexington, Los Angeles, Massillon, Miami, Mobile, Morristown, New York, Northport, Paducah, Paterson, Pembroke Pines, Philadelphia, Reno, Rochester, Royal Oak, Sacramento, Salt Lake City, San Francisco, Santa Monica, Schenectady, Seattle, St. Petersburg, Summit, Syracuse, Tamarac, The Bronx, Tucson, Tyler, Westminster, West Palm Beach, Wichita, Zanesville
Age
18 years and over
People
1,000 worldwide
Run by
Bristol-Myers Squibb
See details and how to joinNCT06561386 · EU 2024-513682-40-01
Phase 3Taking people
A Study of Pembrolizumab (MK-3475) With or Without Intismeran Autogene (V940) in Participants With Non-small Cell Lung Cancer (V940-009/INTerpath-009)
Where
Aurora, Bethlehem, Boston, Buffalo, Charlotte, Chattanooga, Chicago, Cincinnati, Colorado Springs, Columbia, Corvallis, Dallas, East Syracuse, Fairfax, Fort Lauderdale, Fullerton, Gilbert, Greeley, Houston, Indianapolis, Knoxville, Long Beach, Los Angeles, Memphis, Miami, Nashville, New Haven, New York, Norfolk, Norwich, Osage Beach, Peoria, Post Falls, Richmond, Rockville, San Francisco, Seattle, Silverdale, Syracuse, The Bronx, Tucson, Tyler, Valhalla, Westminster, Winston-Salem
Age
18 years and over
People
680 worldwide
Run by
Merck Sharp & Dohme LLC
See details and how to joinNCT06623422 · EU 2023-506327-29-00
Phase 1/2Taking people
A Clinical Study of Gocatamig (MK-6070) and Infinatamab Deruxtecan (MK-2400) in People With Small Cell Lung Cancer (MK-6070-003)
Where
Aurora, Charlottesville, Edgewood, Hackensack, Houston, Knoxville, Memphis, Nashville, Orlando, Portland, Santa Rosa, Sioux Falls, St Louis
Age
18 years to 64 years
People
170 worldwide
Run by
Merck Sharp & Dohme LLC
See details and how to joinNCT07227597 · EU 2025-521032-11-00
Phase 3Taking people
A Clinical Trial of Adjuvant Intismeran (V940) With or Without Pembrolizumab Coformulated With Berahyaluronidase Alfa (MK-3475A) in High-Risk Stage I Non-Small Cell Lung Cancer (V940-014)
Where
Albany, Asheville, Aurora, Billings, Chapel Hill, Fargo, Fredericksburg, Gainesville, Grand Forks, Houston, Knoxville, La Crosse, Lincoln, Morgantown, New Haven, Peoria, Philadelphia, Raleigh, Reno, Sacramento, Seattle, Sioux Falls, St Louis, Syracuse, White Plains
Age
18 years and over
People
876 worldwide
Run by
Merck Sharp & Dohme LLC
See details and how to joinNCT07513376 · EU 2025-522643-18-00
Phase 3Taking people
A Study to Evaluate the Efficacy and Safety of Divarasib Compared With Investigator's Choice of Immunotherapy or Observation in Participants With Resected Stage II-III KRAS G12C-Positive Non-Small Cell Lung Cancer (NSCLC)
Where
Atlanta, Bay Pines, Boston, Clovis, Columbus, Farmington, Farmington Hills, Memphis, Reno
Age
18 years and over
People
400 worldwide
Run by
Hoffmann-La Roche
See details and how to joinNCT07541170 · EU 2025-524263-21-01
Phase 3Taking people
A Study to Compare Setidegrasib (ASP3082) With Docetaxel, in People With Non-small Cell Lung Cancer With a KRAS G12D Mutation
Where
Arlington, Boca Raton, Edison, Glendale, Longview, Los Angeles, New Brunswick, San Francisco
Age
18 years and over
People
356 worldwide
Run by
Astellas Pharma Global Development, Inc.
See details and how to joinNCT07566052 · EU 2025-524079-22-00
No phaseTaking people
Investigating the Feasibility and Acceptability of an Innovative Interdisciplinary Supportive Care Program: Couples Coping Together Against Cancer
Where
Duarte
Age
18 years and over
People
160
Run by
City of Hope Medical Center
See details and how to joinNCT07664579