Lung cancer trials in United States

In United States 900 Also abroad 2746

900 trials · From ClinicalTrials.gov, checked 15 November 2026. Ask the study team whether a trial fits you.

Phase 1/2Taking people
Study of INBRX-106 and INBRX-106 in Combination With Pembrolizumab (Keytruda®) in Subjects With Locally Advanced or Metastatic Solid Tumors (Hexavalent OX40 Agonist)
Where
Allentown, Atlanta, Billings, Camden, Chicago, Clermont, Cleveland, Dallas, Detroit, Duarte, El Paso, Fairfax, Glendale, Grand Island, Grand Rapids, Iowa City, Knoxville, La Jolla, Lakewood, Los Angeles, Louisville, Milwaukee, Murrieta, Nashville, Omaha, Orange City, Portland, Saint Louis Park, Saint Paul, San Antonio, Santa Rosa, St Louis, The Bronx, The Woodlands, Tyler
Age
18 years and over
People
340 worldwide
Run by
Inhibrx Biosciences, Inc
See details and how to joinNCT04198766
Phase 1/2Taking people
A Study of Neladalkib (NVL-655) in Patients With Advanced NSCLC and Other Solid Tumors Harboring ALK Rearrangement or Activating ALK Mutation (ALKOVE-1)
Where
Atlanta, Aurora, Baltimore, Boston, Chicago, Columbus, Detroit, Durham, Houston, Miami, Nashville, New York, Orange, Philadelphia, Sacramento, Seattle, Stanford, St Louis, Washington D.C.
Age
12 years and over
People
840 worldwide
Run by
Nuvalent Inc.
See details and how to joinNCT05384626 · EU 2024-514266-39-00
Phase 2Taking people
At-Home Cancer Directed Therapy Versus in Clinic for the Treatment of Patients With Advanced Cancer
Where
Grand Forks, Jacksonville
Age
18 years and over
People
220
Run by
Mayo Clinic
See details and how to joinNCT05969860
No phaseNot yet taking people in United States
Lung Cancer and Aging: Improving Well-being for Older Adults With Lung Cancer
Where
Durham
Age
60 years and over
People
16
Run by
Duke University
See details and how to joinNCT06636721
Phase 3Taking people
Study of Daraxonrasib (RMC-6236) in Patients With RAS Mutated NSCLC (RASolve 301)
Where
Aberdeen, Ann Arbor, Athens, Atlanta, Austin, Baltimore, Bettendorf, Billings, Birmingham, Buffalo, Chapel Hill, Chicago, Cincinnati, Colorado Springs, Dallas, Detroit, Eugene, Fairfax, Fort Myers, Hackensack, Henderson, Hershey, Houston, Indianapolis, Iowa City, Irving, Lebanon, Loma Linda, Long Beach, Maumee, Morristown, Nashville, New Haven, New York, Orange, Plantation, Salt Lake City, Sioux Falls, St Louis, St. Petersburg, Stuart, The Bronx, The Woodlands, Waukee, West Palm Beach, Westwood
Age
18 years and over
People
590 worldwide
Run by
Revolution Medicines, Inc.
See details and how to joinNCT06881784 · EU 2024-518154-16-00
Phase 1Taking people
A Study of ERAS-0015 in Patients With Advanced or Metastatic Solid Tumors
Where
Atlanta, Aurora, Boston, Fairfax, Houston, New York, Santa Rosa, Sarasota, Tampa, Tyler
Age
18 years to 99 years
People
600 worldwide
Run by
Erasca, Inc.
See details and how to joinNCT06983743 · EU 2026-525794-39-00
No phaseTaking people
The Vanguard Study: Testing a New Way to Screen for Cancer
Where
Bethesda, Brownstown, Chapel Hill, Charlottesville, Chesterfield, Cheyenne Wells, Cleveland, Clinton Township, Dearborn, Denver, Detroit, Durham, Fairfax, Fort Collins, Greeley, Grosse Pointe Farms, Honolulu, Kansas City, Lafayette, Livonia, Lone Tree, Loveland, Milwaukee, Minneapolis, Norfolk, Novi, Oklahoma City, Pleasanton, Plymouth, Portsmouth, Richmond, Royal Oak, San Diego, South Hill, Springfield, Sterling Heights, St Louis, Tacoma, Troy, West Bloomfield, Wyandotte
Age
45 years to 75 years
People
24,000
Run by
National Cancer Institute (NCI)
See details and how to joinNCT06995898
Phase 2Taking people
A Study of Lurbinectedin in Combination With Durvalumab for the Treatment of Participants With ES-SCLC
Where
Atlanta, Jacksonville, Kansas City, Lexington, Los Angeles, Rock Hill
Age
18 years and over
People
50
Run by
Jazz Pharmaceuticals
See details and how to joinNCT07459634 · EU 2025-524566-13-00
No phaseNot yet taking people in United States
Home-Based Respiratory Muscle Training and Aerobic Exercise Programs to Improve Lung Health in Current and Former Cigarette Smokers
Where
Buffalo
Age
50 years and over
People
200
Run by
Roswell Park Cancer Institute
See details and how to joinNCT07553819
No phaseTaking people
A Multilevel Approach to Connecting Underrepresented Populations to Clinical Trials
Where
Gainesville, Jacksonville, Miami
Age
18 years to 100 years
People
350
Run by
University of Florida
See details and how to joinNCT05655494
Phase 1/2Taking people
A Study Evaluating the Safety, Activity, and Pharmacokinetics of Divarasib as a Single Agent or in Combination With Other Anti-Cancer Therapies in Participants With Previously Untreated Advanced or Metastatic Non-Small Cell Lung Cancer With a KRAS G12C Mutation
Where
Blacksburg, Duarte, Fort Myers, Houston, Huntington Beach, Irvine, La Jolla, Long Beach, Mineola, New Haven, New York, Norfolk, St. Petersburg, The Bronx, West Palm Beach
Age
18 years and over
People
320 worldwide
Run by
Hoffmann-La Roche
See details and how to joinNCT05789082 · EU 2023-507171-22-00
Phase 2Taking people
MOnaliZumab in Combination With durvAlumab (MEDI4736) for tRreatmenT of Small Cell Lung Cancer
Where
Charlottesville, Detroit, Indianapolis, Iowa City
Age
18 years and over
People
84
Run by
Khalil Choucair
See details and how to joinNCT05903092
Phase 1Taking people
A Study With NKT3964 for Adults With Advanced/Metastatic Solid Tumors
Where
Atlanta, Augusta, Austin, Boston, Charlottesville, Dallas, Denver, Fairfax, Fairway, Hackensack, Lake Mary, Little Rock, Los Angeles, Nashville, Orlando, Philadelphia, Pittsburgh, Salt Lake City, San Francisco
Age
19 years and over
People
238 worldwide
Run by
NiKang Therapeutics, Inc.
See details and how to joinNCT06586957
No phaseTaking people
Multi-site Trial of a Brief Behavioral Intervention for Dyspnea in Patients With Advanced Lung Cancer
Where
Boston, Coral Gables
Age
18 years and over
People
420
Run by
Massachusetts General Hospital
See details and how to joinNCT06791057
Phase 3Taking people
A Study Evaluating the Efficacy and Safety of Divarasib and Pembrolizumab Versus Pembrolizumab and Pemetrexed and Carboplatin or Cisplatin in Participants With Previously Untreated, KRAS G12C-Mutated, Advanced or Metastatic Non-Squamous Non-Small Cell Lung Cancer
Where
Anchorage, Appleton, Atlanta, Baltimore, Bethesda, Bethlehem, Boise, Boston, Chicago Ridge, Clovis, Colorado Springs, Columbus, Dallas, Des Moines, East Brunswick, El Paso, Farmington, Farmington Hills, Fort Collins, Fort Myers, Fort Worth, Gainesville, Goodyear, Grand Junction, Greenbrae, Greer, Hartford, Hialeah, Hinsdale, Hollywood, Houston, Iowa City, Irvine, Jackson, Kingwood, Lincoln, Los Angeles, Lubbock, Memphis, Miami, Milwaukee, Newnan, Newport Beach, Norfolk, Orange, Orlando, Palo Alto, Pensacola, Pinehurst, Pittsburgh, Portland, Raleigh, Reno, Roseville, Saint Louis Park, San Francisco, Savannah, Spartanburg, St Louis, St. Petersburg, Syracuse, The Bronx, The Woodlands, Tyler, Westbury, West Palm Beach, West Reading, Worcester, Zion
Age
18 years and over
People
600 worldwide
Run by
Hoffmann-La Roche
See details and how to joinNCT06793215
Phase 1Taking people
Anti-Mesothelin TNaive/SCM hYP218 (TNhYP218) CAR T Cells in Participants With Mesothelin-Expressing Solid Tumors Including Mesothelioma
Where
Bethesda
Age
18 years to 120 years
People
120
Run by
National Cancer Institute (NCI)
See details and how to joinNCT06885697
Phase 1Taking people
A Study to Learn About the Study Medicine Called PF-08046876 in People With Advanced Solid Tumors
Where
Boston, Conroe, Duarte, Houston, Irvine, League City, Los Angeles, Nashville, New Haven, Newton, San Antonio, Santa Monica, Sugar Land, Trumbull
Age
18 years and over
People
540 worldwide
Run by
Pfizer
See details and how to joinNCT07090499 · EU 2025-521729-33-00
Phase 3Taking people
A Study to Learn About the Study Medicine Called PF-08046054/SGN-PDL1V Versus Docetaxel in Adult Participants With Previously-Treated Programmed Cell Death Ligand 1 (PD-L1) Positive Non-Small-Cell Lung Cancer (NSCLC)
Where
Abilene, Alabaster, Alhambra, Allen, Amarillo, Anchorage, Annapolis, Arlington, Arlington Heights, Atascadero, Aurora, Austin, Avon, Bartlett, Baton Rouge, Beaumont, Beaverton, Bedford, Belleville, Bellevue, Bensalem, Berkeley, Bessemer, Bethesda, Billings, Birmingham, Blacksburg, Bloomington, Boulder, Bozeman, Brandywine, Broomall, Burbank, Burleson, Burnsville, Centennial, Chattanooga, Chicago, Cincinnati, Cleveland, Collierville, Colorado Springs, Columbia, Concord, Conroe, Coon Rapids, Dallas, Dalton, Daphne, Denison, Denton, Denver, Doylestown, Edina, El Paso, Encinitas, Encino, Englewood, Eugene, Fairfield, Fayetteville, Flower Mound, Foley, Fort Worth, Fullerton, Galesburg, Germantown, Grapevine, Gresham, Harlingen, Horsham, Houston, Humble, Irvine, Irving, Jonesboro, Knoxville, Laguna Hills, La Jolla, Lakewood, Langhorne, Largo, League City, Lebanon, Lewisville, Lisle, Littleton, Lone Tree, Longmont, Longview, Los Angeles, Louisville, Low Moor, Lubbock, Maple Grove, Maplewood, Marina del Rey, McAllen, McKinney, Media, Memphis, Mentor, Midland, Minneapolis, Mount Juliet, Murfreesboro, Nashville, Newark, Odessa, Olympia, Omaha, Orange, Ottawa, Palestine, Palm Bay, Panama City, Paragould, Paris, Pasadena, Pearland, Pekin, Peoria, Peru, Plano, Porter Ranch, Portland, Pueblo, Quinton, Reno, Richmond, Ringgold, Roanoke, Rockville, Rogers, Roseville, Round Rock, Sacramento, Saint Paul, Salem, San Diego, San Luis Obispo, Santa Barbara, Santa Fe, Santa Monica, Sellersville, Shelbyville, Silver Spring, Smyrna, Southaven, South Hill, Springdale, Sugar Land, Tappahannock, The Bronx, The Woodlands, Thornton, Torrance, Tualatin, Tyler, Valencia, Ventura, Vista, Waco, Walnut Creek, Washington, Weatherford, Webster, Weslaco, Westlake Village, White Plains, Wichita Falls, Winchester, Woodbury, Worcester, Wynnewood, Wytheville
Age
18 years and over
People
680 worldwide
Run by
Pfizer
See details and how to joinNCT07144280 · EU 2025-521281-97-00
Early phase 1Taking people
Testing the Safety of Dapagliflozin Prior to Surgery for the Treatment of Patients With Stage IA Lung Adenocarcinoma
Where
Los Angeles
Age
22 years and over
People
48
Run by
Jonsson Comprehensive Cancer Center
See details and how to joinNCT07235280
Phase 3Taking people
A Study to Evaluate Pumitamig Versus Durvalumab Following Concurrent Chemoradiation Therapy in Participants With Unresectable Stage III Non-small Cell Lung Cancer (NSCLC) (ROSETTA Lung-201)
Where
Akron, Amarillo, Austin, Boston, Chicago, Christiansburg, Cincinnati, Cleveland, Columbia, Daphne, Denton, Detroit, Eugene, Evanston, Fort Wayne, Fort Worth, Golden, Happy Valley, Houston, Lexington, Maple Grove, Marietta, Mayfield Heights, Minneapolis, Nashville, Newark, New York, Norfolk, Ocala, Peoria, San Antonio, Tamarac, Tyler, Westbury, Winston-Salem
Age
18 years and over
People
850 worldwide
Run by
Bristol-Myers Squibb
See details and how to joinNCT07361497 · EU 2025-523576-23-00
Phase 3Taking people
Testing the Impact of an Anti-Cancer Drug, Atezolizumab, After Surgery to Prevent Early Stage Non-small Cell Lung Cancer From Returning, AASI-NSCLC Trial
Where
Ames, Anaconda, Anaheim, Ashland, Baldwin Park, Battle Creek, Bay Shore, Bellflower, Beverly Hills, Billings, Bloomington, Bozeman, Brainerd, Brick, Buffalo, Camillus, Canton, Cape Girardeau, Carthage, Cedar Rapids, Chicago, Coeur d'Alene, Coon Rapids, Crown Point, Danville, Decatur, Deer River, Detroit Lakes, Duluth, Dyer, East Syracuse, Edina, Edmonds, Effingham, Eureka, Fairway, Fargo, Fontana, Fort Dodge, Galesburg, Grand Rapids, Great Falls, Green Bay, Greenlawn, Harbor City, Hibbing, Hobart, Indianapolis, Irvine, Issaquah, Kalamazoo, Kalispell, Kansas City, Kewanee, Lake Success, Lee's Summit, Lexington, Liberty, Los Angeles, Macomb, Manahawkin, Marshalltown, Mattoon, Menomonee Falls, Millville, Milwaukee, Minneapolis, Missoula, Mount Kisco, Mukwonago, Munster, Neptune City, Newark, New Berlin, New York, Niles, Normal, Oak Creek, Oconomowoc, O'Fallon, Oklahoma City, Olathe, Ontario, Ottawa, Overland Park, Owensboro, Panorama City, Pekin, Peoria, Peru, Pinehurst, Post Falls, Princeton, Red Bank, Reed City, Rego Park, Rehoboth Beach, Riverside, Saint Joseph, Saint Louis Park, Saint Paul, San Diego, Sandpoint, Sandstone, San Marcos, Seattle, Sleepy Hollow, Springfield, Stony Brook, Superior, Sylvania, Tarzana, Torrance, Traverse City, Urbana, Valparaiso, Virginia, Washington, Waukesha, West Bend, Westwood, Woodland Hills, Wyoming
Age
18 years and over
People
336
Run by
National Cancer Institute (NCI)
See details and how to joinNCT07388524
Phase 1/2Taking people
A Phase 1/2 Study of TRI-611 in ALK-Positive NSCLC
Where
Aurora, Boston, Cincinnati, Durham, Fairfax, Houston, Maumee, Nashville, New York, Pittsburgh, San Francisco, St Louis, West Valley City
Age
18 years and over
People
160 worldwide
Run by
TRIANA Biomedicines, Inc.
See details and how to joinNCT07491497 · EU 2025-524418-27-00
Phase 1Taking people
Phase 1 Study of PF-08046033 in Advanced Solid Tumors
Where
Denver, Fairfax, Nashville, New Haven, Trumbull
Age
18 years and over
People
250 worldwide
Run by
Pfizer
See details and how to joinNCT07519655
Phase 1/2Taking people
A 2-part Phase 1/2 Open-label Trial on ODM-212
Where
Fairfax, Fort Worth, Irving, Los Angeles, Orange
Age
18 years and over
People
229 worldwide
Run by
Orion Corporation, Orion Pharma
See details and how to joinNCT07563738
Phase 2Taking people
Hotspot Stereotactic Ablative Radiotherapy Versus Traditional Stereotactic Ablative Radiotherapy for the Treatment of Early-Stage Non-Small Cell Lung Cancer
Where
Buffalo
Age
18 years and over
People
200
Run by
Roswell Park Cancer Institute
See details and how to joinNCT07718672