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Lupus (SLE): open trials in United States

49 open trials have a site in United States. Registry data; only the trial team decides who can take part.

  • NCT05039619

    A Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of Obinutuzumab in Adolescents With Active Class III or IV Lupus Nephritis and the Safety and PK of Obinutuzumab in Pediatric Participants

    Trial Treatment · Phase 2 · Hoffmann-La Roche

    Emory Children's Center, Atlanta · Children's Hospital Colorado, Anchutz Medical Campus, Aurora · Cincinnati Childrens Hospital, Cincinnati · Texas Arthritis Center, El Paso · Hackensack University Medical Center, Hackensack · Indiana University Health University Hospital, Indianapolis · Loma Linda University Health, Loma Linda · Chldren?s Hospital of Philadelphia, Philadelphia · Cohen Children's Medical Center of New York, Queens · UCSF Benioff Childrens Hospital, San Francisco · Louisiana State University, Shreveport

    Registry updated 2026-11-03

  • NCT06434363

    Phase I/II Study of AD-PluReceptor Plus Tafasitamab-cxix and Lymphodepleting Chemotherapy in Patients With Autoimmune Disorders

    Trial Treatment · Phase 1/2 · M.D. Anderson Cancer Center

    MD Anderson Cancer Center, Houston · The University of Texas Health Science Center at Houston, Houston

    Registry updated 2026-11-03

  • NCT07085104

    A Study to Investigate the Safety and Preliminary Efficacy of ALLO-329, an Allogeneic CAR T-cell Therapy, in Adults With Autoimmune Disease

    Trial Treatment · Phase 1 · Allogene Therapeutics

    University of Colorado Denver, Aurora · Johns Hopkins Hospital, Baltimore · Medical University of South Carolina, Charleston · Atrium Health Rheumatology-Southpark, Charlotte · The University of Chicago Medical Center, Chicago · Duke University Medical Center, Durham · Astera Cancer Care, East Brunswick · Prisma Health, Greenville · University of Iowa, Iowa City · Mayo Clinic, Jacksonville · University of Kansas Medical Center, Kansas City · Loma Linda University Medical Center, Loma Linda · Norton Cancer Institute, St. Matthews Campus, Louisville · Icahn School of Medicine at Mount Sinai, New York · Mayo Clinic, Phoenix · LDS Hospital - lntermountain Health, Salt Lake City · New York Medical College, Valhalla

    Registry updated 2026-11-02

  • NCT07175285

    A Study in Participants With Active Systemic Lupus Erythematosus With Inadequate Response to Glucocorticoids and ≥2 Immunosuppressants

    Research · Bristol-Myers Squibb

    University of Michigan, Ann Arbor · Atlanta · Kings County Hospital Center - Brooklyn, Brooklyn · DJL Clinical Research, PLLC, Charlotte · Arthritis Care of Texas - Corpus Christi, Corpus Christi · Lone Star Arthritis & Rheumatology Associates, P.C., Denton · Durham · El Paso Medical Research Institute (Medresearch Inc), El Paso · Centre for Rheumatology, Immunology and Arthritis, Fort Lauderdale · AA MRC, Grand Blanc · South Florida Rheumatology, Hollywood · Kalispell · La Jolla · La Palma · Los Angeles · Life Clinical Trials, Margate · Murfreesboro Medical Clinic, Murfreesboro · Oklahoma Medical Research Foundation, Oklahoma City · One- Rheumatology, Palm Beach Gardens · Philadelphia · Philadelphia · Arthritis & Rheumatism Associates, Rockville · Rheumatology Center of San Diego, San Diego · Van Vleck · Sahni Rheumatology & Therapy, West Long Branch · Willow Rheumatology Wellness, Willowbrook

    Registry updated 2026-11-02

  • NCT07053800

    Obe-cel in Severe, Refractory Systemic Lupus Erythematosus (SLE) With Active Lupus Nephritis (LN)

    Trial Treatment · Phase 2 · Autolus Limited

    Texas Children's Hospital, Houston · Icahn School of Medicine at Mount Sinai, New York · Texas Transplant Institute, San Antonio · State University of New York Upstate Medical Center (SUNY), Syracuse

    Registry updated 2026-10-30

  • NCT00001372

    Study of Systemic Lupus Erythematosus

    Research · National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)

    National Institutes of Health Clinical Center, Bethesda

    Registry updated 2026-10-29

  • NCT07201558

    Study Evaluating Safety, Tolerability, PK/PD of Surovatamig in Adult RA or SLE Participants

    Trial Treatment · Phase 1 · AstraZeneca

    Allen · Birmingham · Fullerton · Mesquite · Plantation · St Louis

    Registry updated 2026-10-28

  • NCT05567198

    Gonadotropin-releasing Hormone Agonist (GnRHa) in Ovarian Preservation in SLE Subjects Receiving Cyclophosphamide as Determined by Questionnaires

    Research · National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)

    National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), Bethesda

    Registry updated 2026-10-27

  • NCT06975787

    Dose Escalation Study With Bispecific Antibodies in Adult Participants With Lupus Nephritis

    Trial Treatment · Phase 1 · Regeneron Pharmaceuticals

    University of Florida, Gainesville · Baylor College of Medicine, Houston · Mayo Clinic, Rochester · University of California San Francisco - Zuckerberg San Francisco General, San Francisco

    Registry updated 2026-10-27

  • NCT06613360

    A Study of CLN-978, a Subcutaneously Administered CD19-directed T Cell Engager, in Subjects With Systemic Lupus Erythematosus

    Trial Treatment · Phase 1 · Cullinan Therapeutics Inc.

    AARA Clinical Research, Avondale · Boston Children's Hospital, Boston · University of Iowa, Iowa City · Regional One Health, Memphis · Columbia University Medical Center, New York · NYU Grossman School of Medicine, New York · OMEGA Research Group, Orlando · Stryde Research, Plano · University of Rochester Medical Center, Rochester · Intermountain Health, Salt Lake City · AARA Clinical Research, Tucson · Tranquil Clinical Research, Webster

    Registry updated 2026-10-26

  • NCT06925542

    A Safety and Efficacy Study Evaluating CTX112 in Adult Subjects With Refractory Autoimmune Disease

    Trial Treatment · Phase 1 · CRISPR Therapeutics

    Boston Medical Center, Boston · University of North Carolina TraCS Institute - CTRC, Chapel Hill · Northwestern Medicine, Robert H. Lurie Comprehensive Cancer Center, Chicago · University of Iowa, Iowa City · UC San Diego Health, La Jolla · Tulane University Medical Center, New Orleans · Oregon Health Sciences University, Portland · Stanford University Medical Center, Redwood City · Washington University School of Medicine, St Louis

    Registry updated 2026-10-26

  • NCT07783152

    Lupus Nephritis Care Pathway

    Trial Treatment · Duke University

    Duke University, Durham

    Registry updated 2026-10-19

  • NCT07873931

    A Study of BMS-986553 in Participants With Refractory Autoimmune Diseases

    Trial Treatment · Phase 1 · Bristol-Myers Squibb

    Ann Arbor · Great Neck · Morristown · Newport Beach · Omaha · Philadelphia · Saint Paul · Salt Lake City · Seattle · Seattle · Worcester

    Registry updated 2026-10-14

  • NCT06711887

    Registry updated 2026-10-13

  • NCT06121297

    RESET-SLE: A Phase 1/2 Open-Label Study to Evaluate the Safety and Efficacy of CABA-201 in Subjects With Active Systemic Lupus Erythematosus

    Trial Treatment · Phase 1/2 · Cabaletta Bio

    Emory University, Atlanta · Massachusetts General Hospital, Boston · Boston Children's Hospital - Accepting Young Adult and Adolescent Patients, Boston · Tufts Medical Center, Boston · Brigham and Women's Hospital, Boston · UNC- Chapel Hill, Chapel Hill · Medical University of South Carolina, Charleston · Northwestern Memorial Hospital, Chicago · The University of Chicago Medical Center - Accepting Adult and Adolescent Patients, Chicago · University of Florida Health, Gainesville · University of Texas - MD Anderson Cancer Center, Houston · Mayo Clinic, Jacksonville · University of Kansas Medical Center, Kansas City · University of Minnesota, Minneapolis · Yale University, New Haven · Columbia University Irving Medical Center, New York · University of California Irvine, Orange · Children's Hospital of Philadelphia - Accepting Young Adult and Adolescent Patients, Philadelphia · University of Rochester, Rochester · UC Davis Health, Sacramento · UMASS Memorial Hospital, Worcester

    Registry updated 2026-10-06

  • NCT06419205

    A Phase 2 Study to Evaluate the Safety, PD, PK, and Clinical Activity of ADX-097 in Participants With IgAN, LN or C3G

    Trial Treatment · Phase 2 · Akebia Therapeutics

    Hollywood · Lawrenceville · Orangeburg

    Registry updated 2026-10-01

  • NCT07038447

    A Study of KITE-363 in Participants With Refractory Autoimmune Diseases

    Trial Treatment · Phase 1 · Kite, A Gilead Company

    City of Hope, Duarte · Icahn School of Medicine at Mount Sinai, New York · Stanford University, Stanford · Tampa General Hospital-Cancer Institute, Tampa

    Registry updated 2026-09-28

  • NCT06839976

    CD19-Directed Chimeric Antigen Receptor Autologous T Cells (CART19) for Lupus

    Trial Treatment · Phase 1/2 · Children's Hospital of Philadelphia

    Children's Hospital of Philadelphia, Philadelphia

    Registry updated 2026-09-24

  • NCT07049653

    Anifrolumab Pregnancy Study

    Research · AstraZeneca

    Cary

    Registry updated 2026-09-18

  • NCT06987565

    Transcutaneous Vagus Nerve Stimulation in SLE

    Trial Treatment · Phase 2 · Northwell Health

    Feinstein Institutes for Medical Research, Manhasset

    Registry updated 2026-09-17

  • NCT07328581

    A Phase IIa Study of ICG318 CAR-T in Refractory Systemic Lupus Erythematosus With or Without Lupus Nephritis

    Trial Treatment · Phase 2 · iCell Gene Therapeutics

    University of Chicago, Chicago · New York Medical College, Hawthorne · NorthWell, New Hyde Park · Fox Chase Cancer Center- Temple BMT, Philadelphia

    Registry updated 2026-09-17

  • NCT05201469

    VIBRANT: VIB4920 for Active Lupus Nephritis

    Trial Treatment · Phase 2 · National Institute of Allergy and Infectious Diseases (NIAID)

    University of Michigan, Ann Arbor · Emory University School of Medicine: Division of Rheumatology, Atlanta · University of Colorado School of Medicine: Division of Rheumatology, Aurora · University of South Carolina, Charleston · University of Chicago, Department of Medicine: Rheumatology, Chicago · Penn State Health Milton S. Hershey Medical Center: Division of Rheumatology, Hershey · University of California San Diego School of Medicine: Division of Rheumatology, Allergy and Immunology, La Jolla · UCLA Medical Center: Division of Rheumatology, Los Angeles · Feinstein Institute for Medical Research: Center for Autoimmune and Musculoskeletal Diseases, Manhasset · University of Miami Miller School of Medicine: Nephrology & Hypertension Division, Miami · Yale University School of Medicine: Section of Rheumatology, New Haven · Hospital for Special Surgery, New York: Division of Rheumatology, New York · Columbia University Medical Center: Department of Medicine, Division of Rheumatology, New York · of California, Irvine School of Medicine Division of Rheumatology, Orange · Temple University, Lewis Katz School of Medicine, Department of Medicine: Nephrology, Philadelphia · University of California San Francisco School of Medicine: Lupus Clinic and Rheumatology Clinical Research Center, San Francisco · Washington University School of Medicine in St. Louis: Division of Nephrology, St Louis

    Registry updated 2026-09-16

  • NCT07823478

    HEALTH Home Urinalysis Testing

    Trial Treatment · NYU Langone Health

    NYU Langone Health, New York

    Registry updated 2026-09-16

  • NCT05538208

    The Pediatric Lupus Nephritis Mycophenolate Mofetil (PLUMM) Study

    Trial Treatment · Phase 2 · Children's Hospital Medical Center, Cincinnati

    Akron Children's Hospital, Akron · Emory Children's Center, Atlanta · Children's Hospital Colorado, Aurora · University of North Carolina at Chapel Hill, Chapel Hill · Medical University of South Carolina, Charleston · Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago · University of Chicago Medicine- Comer Children's, Chicago · Cincinnati Children's Hospital Medical Center, Cincinnati · University Hospitals Cleveland Medical Center*, Cleveland · Nationwide Children's Hospital, Columbus · Hackensack University Medical Center, Hackensack · Baylor College of Medicine Pediatric Immunology Allergy Rheumatology, Houston · Children's Wisconsin & Medical College of Wisconsin, Milwaukee · Children's Hospital at Montefiore, New York · Hospital for Special Surgery, New York · University of Utah, Salt Lake City · University of California San Francisco, San Francisco · Seattle Children's Hospital; University of Washington, Seattle · Washington University in St. Louis, School of Medicine, St Louis

    Registry updated 2026-09-14

  • NCT07570862

    A Phase 2, Open-Label, Single-Arm Trial of FT819 in Participants With Lupus Nephritis

    Trial Treatment · Phase 2 · Fate Therapeutics

    Wallace Rheumatic Studies Center, Beverly Hills · GNP Research, Cooper City · The University of Texas Southwestern Medical Center, Dallas · Cross Creek Medical Clinic, Fayetteville · Kaiser Permanente-Fontana, Fontana · Providence Medical Foundation, Fullerton · University of Florida Clinical Research Center, Gainesville · University of California, Irvine, Irvine · Nicklaus Children's Hospital, Miami · Miami Dermatology and Laser Research, Miami · University of Nebraska Medical Center, Omaha · University of California San Francisco, San Francisco

    Registry updated 2026-09-14

All Lupus (SLE) trials and the map

This page is not medical advice. Talk to your doctor before contacting a trial.