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Lupus (SLE): open trials in United States

100 open trials have a site in United States. Registry data; only the trial team decides who can take part.

  • NCT07873931

    A Study of BMS-986553 in Participants With Refractory Autoimmune Diseases

    Trial Treatment · Phase 1 · Bristol-Myers Squibb

    Ann Arbor · Great Neck · Morristown · Newport Beach · Omaha · Philadelphia · Saint Paul · Salt Lake City · Seattle · Seattle · Worcester

    Registry updated 2026-10-14

  • NCT06133972

    Phase 3 Extension Study to Evaluate Long-term Safety of Ianalumab in Participants With Systemic Lupus Erythematosus (SIRIUS-SLE Extension).

    Trial Treatment · Phase 3 · Novartis Pharmaceuticals

    Pinnacle Research Group, LLC, Anniston · University of Colorado Denver, Aurora · University of Maryland, Baltimore · Novel Research LLC, Bellaire · Providence Medical Center, Burbank · Clinical Res Of W Florida, Clearwater · GNP Research, Cooper City · Henry Ford Health, Detroit · Ahmed Arif Medical Research Center, Grand Blanc · Homestead Assoc In Research Inc, Homestead · West Tennessee Research Institute, Jackson · Accurate Clinical Research, Lake Charles · Advanced Medical Research, La Palma · Parris and Associates Rheumatology, Lawrenceville · Accurate Clinical Research, League City · Shelby Research LLC, Memphis · Paramount Med Rsrch and Consult LLC, Middleburg Heights · UMC New Orleans, New Orleans · University of Pittsburgh, Pittsburgh · IRIS Research and Development, Plantation · Epic Medical Research, Red Oak · Robert A Hozman MD SC, Skokie · Clinical Research of West Florida Inc, Tampa · Millennium Clinical Trials, Westlake Village · Willow Rheumatology Wellness, Willowbrook

    Registry updated 2026-10-13

  • NCT06711887

    Registry updated 2026-10-13

  • NCT07716462

    Home-Based High-Intensity Interval Training in Systemic Lupus Erythematosus

    Trial Treatment · University of Alabama at Birmingham

    The Kirklin Clinic of UAB Hospital, Birmingham

    Registry updated 2026-10-13

  • NCT06121297

    RESET-SLE: A Phase 1/2 Open-Label Study to Evaluate the Safety and Efficacy of CABA-201 in Subjects With Active Systemic Lupus Erythematosus

    Trial Treatment · Phase 1/2 · Cabaletta Bio

    Emory University, Atlanta · Brigham and Women's Hospital, Boston · Boston Children's Hospital - Accepting Young Adult and Adolescent Patients, Boston · Massachusetts General Hospital, Boston · Tufts Medical Center, Boston · UNC- Chapel Hill, Chapel Hill · Medical University of South Carolina, Charleston · Northwestern Memorial Hospital, Chicago · The University of Chicago Medical Center - Accepting Adult and Adolescent Patients, Chicago · University of Florida Health, Gainesville · University of Texas - MD Anderson Cancer Center, Houston · Mayo Clinic, Jacksonville · University of Kansas Medical Center, Kansas City · University of Minnesota, Minneapolis · Yale University, New Haven · Columbia University Irving Medical Center, New York · University of California Irvine, Orange · Children's Hospital of Philadelphia - Accepting Young Adult and Adolescent Patients, Philadelphia · University of Rochester, Rochester · UC Davis Health, Sacramento · UMASS Memorial Hospital, Worcester

    Registry updated 2026-10-06

  • NCT03816345

    Testing an Immunotherapy Anti-cancer Drug, Nivolumab, for Advanced Cancers in Patients With Autoimmune Disorders, AIM-NIVO

    Trial Treatment · Phase 1 · National Cancer Institute (NCI)

    Emory University Hospital/Winship Cancer Institute, Atlanta · Johns Hopkins University/Sidney Kimmel Cancer Center, Baltimore · National Institutes of Health Clinical Center, Bethesda · National Cancer Institute Developmental Therapeutics Clinic, Bethesda · University of Alabama at Birmingham Cancer Center, Birmingham · Massachusetts General Hospital Cancer Center, Boston · Dana-Farber Cancer Institute, Boston · University of Chicago Comprehensive Cancer Center, Chicago · Northwestern University, Chicago · Siteman Cancer Center at Saint Peters Hospital, City of Saint Peters · Ohio State University Comprehensive Cancer Center, Columbus · Siteman Cancer Center at West County Hospital, Creve Coeur · UT Southwestern Simmons Cancer Center - RedBird, Dallas · UT Southwestern/Simmons Cancer Center-Dallas, Dallas · Wayne State University/Karmanos Cancer Institute, Detroit · University of Kansas Clinical Research Center, Fairway · UT Southwestern/Simmons Cancer Center-Fort Worth, Fort Worth · HaysMed, Hays · UT MD Anderson Cancer Center, Houston · University of Kansas Cancer Center, Kansas City · University Health Truman Medical Center, Kansas City · University of Kansas Cancer Center - North, Kansas City · Lawrence Memorial Hospital, Lawrence · University of Kansas Cancer Center - Lee's Summit, Lee's Summit · University of Kentucky/Markey Cancer Center, Lexington · NYU Langone Hospital - Long Island, Mineola · Rutgers Cancer Institute of New Jersey, New Brunswick · Smilow Cancer Center/Yale-New Haven Hospital, New Haven · Yale University, New Haven · Laura and Isaac Perlmutter Cancer Center at NYU Langone, New York · NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center, New York · NYP/Weill Cornell Medical Center, New York · University of Kansas Cancer Center at North Kansas City Hospital, North Kansas City · The University of Kansas Cancer Center - Olathe, Olathe · University of Kansas Cancer Center-Overland Park, Overland Park · University of Kansas Hospital-Indian Creek Campus, Overland Park · Stanford Cancer Institute Palo Alto, Palo Alto · Thomas Jefferson University Hospital, Philadelphia · Mercy Hospital Pittsburg, Pittsburg · UPMC Hillman Cancer Center, Pittsburgh · UT Southwestern Clinical Center at Richardson/Plano, Richardson · VCU Massey Comprehensive Cancer Center, Richmond · University of California Davis Comprehensive Cancer Center, Sacramento · Salina Regional Health Center, Salina · Huntsman Cancer Institute/University of Utah, Salt Lake City · Washington University School of Medicine, St Louis · Siteman Cancer Center at Christian Hospital, St Louis · Siteman Cancer Center-South County, St Louis · University of Kansas Health System Saint Francis Campus, Topeka · MedStar Georgetown University Hospital, Washington D.C. · University of Kansas Hospital-Westwood Cancer Center, Westwood

    Registry updated 2026-10-05

  • NCT05352919

    A Study to Learn More About the Long-Term Safety of Litifilimab (BIIB059) Injections and it's Effects on Symptoms in Adults With Systemic Lupus Erythematosus (SLE)

    Trial Treatment · Phase 3 · Biogen

    Arthritis & Rheumatology Research Institute, Allen · University of Colorado Denver, Aurora · Tekton Research - PARENT, Austin · Arthritis & Rheumatic Disease Specialties, Aventura · Highlands Research Institute, Avon Park · Accurate Clinical Research, Baytown · Wallace Rheumatic Study Center, Beverly Hills · NYU Langone Brooklyn, Brooklyn · DJL Clinical Research, PLLC, Charlotte · University of Cincinnati, Cincinnati · Clinical Research of West Florida - Corporate, Clearwater · Precision Comprehensive Clinical Research Solution, Colleyville · GNP Research at Mark Jaffe, MD, Cooper City · Omega Research Consultants, DeBary · AA MRC LLC Ahmed Arif Medical Research Center, Flint · Arthritis Center of North Georgia, Gainesville · Prolato Clinical Research Center, Houston · Accurate Clinical Research, Inc, Humble · Care Access Research - Huntington Beach, Huntington Beach · West Tennessee Research Institute, Jackson · R and H Clinical Research, Katy · Life Clinical Trials, Margate · Ramesh C Gupta, MD, Memphis · Paramount Medical Research & Consulting, LLC, Middleburg Heights · Providence Facey Medical Foundation, Mission Hills · HMD Research, LLC, Orlando · Arizona Arthritis & Rheumatology Associates P.C., Phoenix · Precision Comprehensive Clinical Research Solutions, Rochester Hills · Onyx Clinical Research, LLC, Salisbury · Sun Research Institute, LLC, San Antonio · Swedish Medical Center, Seattle · Saint Louis Rheumatology, St Louis · AdventHealth Medical Group, Tampa · Clinical Research of West Florida Inc, Tampa · Advanced Rheumatology of Houston, The Woodlands · Inland Rheumatology Clinical Trials Inc., Upland · Georgetown University Hospital-Medstar, Washington D.C. · University of Massachusetts Chan Medical School, Worcester

    Registry updated 2026-10-05

  • NCT06570798

    A Phase 2 Master Protocol Assessing Inebilizumab and Blinatumomab in Autoimmune Diseases

    Trial Treatment · Phase 2 · Amgen

    University of Colorado, Aurora · Massachusetts General Hospital, Boston · MetroHealth Medical Center, Cleveland · Cleveland Clinic Foundation, Cleveland · The Metro Health System Main Campus, Cleveland · Northwell Health, Great Neck · Westchester Medical Center, Hawthorne · Vida Research Center, Hialeah · Homestead Associates in Research Inc, Homestead · Prolato Clinical Research Center, Houston · Vitaly Clinical Research, Miami · University Medical Center New Orleans, New Orleans · Columbia University Medical Center, New York · University of Rochester Medical Center, Rochester · Mayo Clinic, Rochester · HonorHealth Research and Innovation Institute, Scottsdale · Seattle Rheumatology Associates, Seattle · Bioresearch Partner Coral Terrace, South Miami

    Registry updated 2026-10-05

  • NCT06419205

    A Phase 2 Study to Evaluate the Safety, PD, PK, and Clinical Activity of ADX-097 in Participants With IgAN, LN or C3G

    Trial Treatment · Phase 2 · Akebia Therapeutics

    Hollywood · Lawrenceville · Orangeburg

    Registry updated 2026-10-01

  • NCT05835310

    An Efficacy and Safety Study of Intravenous Anifrolumab to Treat Systemic Lupus Erythematosus in Pediatric Participants

    Trial Treatment · Phase 3 · AstraZeneca

    Bethesda · Chicago · Cincinnati · Cleveland · Columbus · Durham · El Paso · Greenville · Houston · Los Angeles · New Hyde Park · New Orleans · New York · Philadelphia · Phoenix · Portland · Saint Paul · Salt Lake City · The Bronx · Valhalla · Washington D.C.

    Registry updated 2026-09-30

  • NCT07038447

    A Study of KITE-363 in Participants With Refractory Autoimmune Diseases

    Trial Treatment · Phase 1 · Kite, A Gilead Company

    City of Hope, Duarte · Icahn School of Medicine at Mount Sinai, New York · Stanford University, Stanford · Tampa General Hospital-Cancer Institute, Tampa

    Registry updated 2026-09-28

  • NCT07430306

    A Study to Evaluate the Treatment Outcomes of Subcutaneous Anifrolumab in Immunosuppressant-naïve and Biologic-naïve Systemic Lupus Erythematosus

    Trial Treatment · Phase 3 · AstraZeneca

    Anniston · Austin · Baytown · Birmingham · Brandon · Colleyville · Edinburg · Fontana · Houston · Kansas City · La Jolla · Lake Charles · La Palma · Memphis · Menifee · Miami · New Albany · Oklahoma City · Phoenix · San Leandro · Silver Spring · Spokane · Sugar Land · Temecula · Tucson · West Long Branch · Willowbrook

    Registry updated 2026-09-25

  • NCT07840287

    A Long-Term Extension (LTE) Study Of Enpatoran In Cutaneous Manifestations Of Lupus With Or Without Systemic Disease [Elowen-LTE]

    Trial Treatment · Phase 3 · EMD Serono Research & Development Institute, Inc.

    Billerica

    Registry updated 2026-09-25

  • NCT06839976

    CD19-Directed Chimeric Antigen Receptor Autologous T Cells (CART19) for Lupus

    Trial Treatment · Phase 1/2 · Children's Hospital of Philadelphia

    Children's Hospital of Philadelphia, Philadelphia

    Registry updated 2026-09-24

  • NCT05440422

    The Role of Anifrolumab in Improving Markers of Vascular Risk in Patients With Systemic Lupus Erythematosus (SLE) - IFN-CVD

    Trial Treatment · Phase 2 · National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)

    National Institutes of Health Clinical Center, Bethesda

    Registry updated 2026-09-18

  • NCT07049653

    Anifrolumab Pregnancy Study

    Research · AstraZeneca

    Cary

    Registry updated 2026-09-18

  • NCT06987565

    Transcutaneous Vagus Nerve Stimulation in SLE

    Trial Treatment · Phase 2 · Northwell Health

    Feinstein Institutes for Medical Research, Manhasset

    Registry updated 2026-09-17

  • NCT07328581

    A Phase IIa Study of ICG318 CAR-T in Refractory Systemic Lupus Erythematosus With or Without Lupus Nephritis

    Trial Treatment · Phase 2 · iCell Gene Therapeutics

    University of Chicago, Chicago · New York Medical College, Hawthorne · NorthWell, New Hyde Park · Fox Chase Cancer Center- Temple BMT, Philadelphia

    Registry updated 2026-09-17

  • NCT05201469

    VIBRANT: VIB4920 for Active Lupus Nephritis

    Trial Treatment · Phase 2 · National Institute of Allergy and Infectious Diseases (NIAID)

    University of Michigan, Ann Arbor · Emory University School of Medicine: Division of Rheumatology, Atlanta · University of Colorado School of Medicine: Division of Rheumatology, Aurora · University of South Carolina, Charleston · University of Chicago, Department of Medicine: Rheumatology, Chicago · Penn State Health Milton S. Hershey Medical Center: Division of Rheumatology, Hershey · University of California San Diego School of Medicine: Division of Rheumatology, Allergy and Immunology, La Jolla · UCLA Medical Center: Division of Rheumatology, Los Angeles · Feinstein Institute for Medical Research: Center for Autoimmune and Musculoskeletal Diseases, Manhasset · University of Miami Miller School of Medicine: Nephrology & Hypertension Division, Miami · Yale University School of Medicine: Section of Rheumatology, New Haven · Hospital for Special Surgery, New York: Division of Rheumatology, New York · Columbia University Medical Center: Department of Medicine, Division of Rheumatology, New York · of California, Irvine School of Medicine Division of Rheumatology, Orange · Temple University, Lewis Katz School of Medicine, Department of Medicine: Nephrology, Philadelphia · University of California San Francisco School of Medicine: Lupus Clinic and Rheumatology Clinical Research Center, San Francisco · Washington University School of Medicine in St. Louis: Division of Nephrology, St Louis

    Registry updated 2026-09-16

  • NCT06594068

    Registry updated 2026-09-16

  • NCT07823478

    HEALTH Home Urinalysis Testing

    Trial Treatment · NYU Langone Health

    NYU Langone Health, New York

    Registry updated 2026-09-16

  • NCT05538208

    The Pediatric Lupus Nephritis Mycophenolate Mofetil (PLUMM) Study

    Trial Treatment · Phase 2 · Children's Hospital Medical Center, Cincinnati

    Akron Children's Hospital, Akron · Emory Children's Center, Atlanta · Children's Hospital Colorado, Aurora · University of North Carolina at Chapel Hill, Chapel Hill · Medical University of South Carolina, Charleston · Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago · University of Chicago Medicine- Comer Children's, Chicago · Cincinnati Children's Hospital Medical Center, Cincinnati · University Hospitals Cleveland Medical Center*, Cleveland · Nationwide Children's Hospital, Columbus · Hackensack University Medical Center, Hackensack · Baylor College of Medicine Pediatric Immunology Allergy Rheumatology, Houston · Children's Wisconsin & Medical College of Wisconsin, Milwaukee · Children's Hospital at Montefiore, New York · Hospital for Special Surgery, New York · University of Utah, Salt Lake City · University of California San Francisco, San Francisco · Seattle Children's Hospital; University of Washington, Seattle · Washington University in St. Louis, School of Medicine, St Louis

    Registry updated 2026-09-14

  • NCT07570862

    A Phase 2, Open-Label, Single-Arm Trial of FT819 in Participants With Lupus Nephritis

    Trial Treatment · Phase 2 · Fate Therapeutics

    Wallace Rheumatic Studies Center, Beverly Hills · GNP Research, Cooper City · The University of Texas Southwestern Medical Center, Dallas · Cross Creek Medical Clinic, Fayetteville · Kaiser Permanente-Fontana, Fontana · Providence Medical Foundation, Fullerton · University of Florida Clinical Research Center, Gainesville · University of California, Irvine, Irvine · Nicklaus Children's Hospital, Miami · Miami Dermatology and Laser Research, Miami · University of Nebraska Medical Center, Omaha · University of California San Francisco, San Francisco

    Registry updated 2026-09-14

  • NCT06475742

    Long-term Safety and Tolerability of Cenerimod in Adults With Systemic Lupus Erythematosus

    Trial Treatment · Phase 3 · Viatris Innovation GmbH

    University of Colorado Denver, Aurora · Accurate Clinical Research Inc - (Najam), Baytown · Novel Research LLC, Bellaire · Clinical Research of West Florida, Inc., Clearwater · Omega Research MetroWest, LLC, DeBary · Accurate Clinical Research, Inc, Houston · Accurate Clinical Research Inc. - Lake Charles, Lake Charles · RB Wellness Clinic, Las Vegas · Professional Research Center, Inc., Miami · Allied Biomedical Research Institute, Miami · SouthCoast Research Center, Inc., Miami · D&H National Research Centers, Inc, Miami · San Marcus Res Clin Inc., Miami Lakes · Sun Research, San Antonio

    Registry updated 2026-09-11

  • NCT06897930

    A Study to Investigate the Safety, Tolerability, and Efficacy of AZD0120 in Adults With Refractory SLE

    Trial Treatment · Phase 1/2 · AstraZeneca

    Atlanta · Baltimore · Bethesda · Boston · Chapel Hill · Charlotte · Chicago · New York · Richmond · San Francisco · Seattle · Stanford · St Louis · Syracuse · Tampa

    Registry updated 2026-09-10

All Lupus (SLE) trials and the map

This page is not medical advice. Talk to your doctor before contacting a trial.

Under construction, not live – Lupus (SLE) trials in United States – Frontlight Research