Macular degeneration trials in United States

In United States 96 Also abroad 218

96 trials · From ClinicalTrials.gov, checked 11 November 2026. Ask the study team whether a trial fits you.

No phaseTaking people
Prescreening Study to Identify Potential Stargardt Participants for ACDN-01 Clinical Trials (STARPATH)
Where
Ann Arbor, Baltimore, Boston, Cincinnati, Dallas, Gainesville, Houston, San Francisco
Age
5 years and over
People
50
Run by
Ascidian Therapeutics, Inc
See details and how to joinNCT06445322
Phase 1/2Taking people
Phase 1b/2a Study of EYC-0305 in Patients With Neovascular Age-related Macular Degeneration
Where
Bellaire, Beverly Hills, Erie, McAllen, Modesto, The Woodlands, Wake Forest
Age
50 years and over
People
30
Run by
Eyconis INC.
See details and how to joinNCT07587515
Phase 2/3Taking people
A Clinical Trial of EYE201/MK-8748 in People With Macular Degeneration (MK-8748-002)
Where
Abilene, Aiken, Albuquerque, Altamonte Springs, Amarillo, Arlington, Austin, Bellaire, Bethlehem, Bluffton, Burlington, Carmel, Charleston, Cherry Hill, Cincinnati, Dallas, Edmond, Fayetteville, Fort Lauderdale, Gainesville, Germantown, Glendale, Grand Rapids, Greensboro, Greenville, Hagerstown, Hattiesburg, Hauppauge, Jacksonville, Lakeland, Liverpool, Lynchburg, Madison, Miami, Modesto, Mt. Pleasant, Oak Park, Palm Beach Gardens, Pasadena, Plano, Plantation, Portland, Redlands, Sacramento, Saint Louis Park, Salt Lake City, Scottsdale, Southlake, Spokane, Springdale, Springfield, St. Petersburg, Tallahassee, Tampa, The Woodlands, Tulsa, Tyler, Wausau, Weatherford, Wildwood, Winston-Salem
Age
50 years and over
People
960 worldwide
Run by
EyeBiotech Ltd.
See details and how to joinNCT07440225
Phase 2Enrolling by invitation
ORACLE: A Long-term Follow-up Study to Evaluate the Safety of GT005 in Participants With Geographic Atrophy Secondary to Age-related Macular Degeneration Treated in a Gyroscope-sponsored Antecedent Study
Where
Austin, Baltimore, Boston, Chesterfield, Cincinnati, Dallas, Durango, Eugene, Gainesville, Houston, Indianapolis, Lemont, New York, Philadelphia, Pompano Beach, Poway, Reno, Rochester, San Antonio, St. Petersburg, West Des Moines
Age
55 years and over
People
225 worldwide
Run by
Gyroscope Therapeutics Limited
See details and how to joinNCT05481827 · EU 2024-510946-15-00
Phase 3Taking people
Efficacy and Safety Study of Ixoberogene Soroparvovec (Ixo-vec) in Participants With Neovascular Age-related Macular Degeneration (AQUARIUS)
Where
Arlington, Asheville, Augusta, Austin, Bakersfield, Beachwood, Beverly Hills, Bloomfield, Bluffton, Campbell, Carmel, Cary, Chicago, Cleveland, Conroe, Dallas, Deerfield Beach, Denver, Edmond, Encino, Erie, Fort Lauderdale, Fort Myers, Fullerton, Gainesville, Greensboro, Hagerstown, Hickory, Huntington Beach, Jackson, Ladson, Lakeland, Liverpool, Lynchburg, McAllen, Mesa, Miami Springs, Nashville, Oak Forest, Oak Park, Orlando, Philadelphia, Phoenix, Plantation, Portland, Poway, Redlands, Rochester, Sacramento, San Antonio, San Marcos, Santa Barbara, Schertz, Scottsdale, Silverdale, South Miami, Springdale, St. Petersburg, Sun City, Tampa, Teaneck, The Woodlands, Torrance, Tyler, Wake Forest, Walnut Creek, Waterford, Winter Haven
Age
50 years and over
People
534
Run by
Adverum Biotechnologies, Inc.
See details and how to joinNCT07482176
Phase 2Taking people
A Phase IIb Randomized, Multicenter Trial of Subretinal CPCB-RPE1 in Advanced Dry AMD (Geographic Atrophy)
Where
Austin, Huntington Beach, Lemont, Los Angeles, The Woodlands
Age
55 years to 90 years
People
24
Run by
Regenerative Patch Technologies, LLC
See details and how to joinNCT06557460
Phase 1/2Taking people
A Phase 1/2 Study of the Safety and Efficacy of BRX011 Oral Administration Once Daily in Subjects With Geographic Atrophy Secondary to Age-Related Macular Degeneration
Where
Abilene, Beachwood, Cleveland, Gilbert, Hattiesburg, McAllen, Middleburg Heights, Phoenix, Reno, Spokane, St. George
Age
55 years and over
People
152 worldwide
Run by
Biojiva LLC
See details and how to joinNCT07029945
No phaseTaking people
A Registry Study to Assess Photobiomodulation in Dry Age-Related Macular Degeneration (GLOBALIGHT)
Where
Beverly Hills, Charleston, Cincinnati, McAllen, Silverdale
People
500 worldwide
Run by
LumiThera, Inc.
See details and how to joinNCT06351605
Phase 2Taking people
A Study in Adults With Geographic Atrophy
Where
Appleton, Aurora, Bakersfield, Bellaire, Beverly Hills, Burleson, Erie, Hagerstown, Hauppauge, Lemont, Nashville, Schertz, Waltham, Waterford, Wausau
Age
60 years and over
People
300 worldwide
Run by
Sitala Bio LTD
See details and how to joinNCT07606365 · EU 2026-525738-40-00
Phase 3Taking people
Study of ALK-001 on the Progression of Stargardt Disease
Where
Aurora, Boston, Columbus, Dallas, Erie, Fairfax, Fort Worth, Gainesville, Grand Rapids, Norfolk, Philadelphia, Phoenix, Pittsburgh, San Antonio
Age
8 years to 45 years
People
230
Run by
Alkeus Pharmaceuticals, Inc.
See details and how to joinNCT07419334 · EU 2026-525296-60-00
Phase 1Taking people
The Effects of Disulfiram (Antabuse®) on Visual Acuity in Patients With Retinal Degeneration
Where
Rochester
Age
18 years and over
People
15
Run by
University of Rochester
See details and how to joinNCT06319872
Phase 2Taking people
A Phase 2 Study of NT-101 Topical in Patients With Wet AMD
Where
Bonita Springs, Erie, Tulsa
Age
50 years and over
People
66
Run by
NexThera Co., Ltd.
See details and how to joinNCT07811726
Phase 2Taking people
Study to Evaluate Efficacy and Safety of ONL1204 in Patients With GA Associated With AMD
Where
Ann Arbor, Austin, Bakersfield, Beaumont, Bellaire, Bellevue, Beverly Hills, Carmel, Cary, Chevy Chase, Chicago, Cleveland, Colorado Springs, Durham, Elmhurst, Erie, Gilbert, Glendale, Greenville, Hagerstown, Huntington Beach, Katy, Liverpool, Lynchburg, McAllen, Mt. Pleasant, Nashville, Oak Park, Oceanside, Orlando, Palm Desert, Pensacola, Phoenix, Reno, Rochester, Royal Oak, Sacramento, San Antonio, Sarasota, Silverdale, Southlake, Springfield, St Louis, Tampa, The Woodlands, Towson, Traverse City, Wake Forest, Walnut Creek, Waterford, Westbury, West Columbia
Age
55 years and over
People
324 worldwide
Run by
ONL Therapeutics
See details and how to joinNCT06659445 · EU 2024-513174-22-00
Phase 3Not yet taking people in United States
An Open-label Extension Study of the Long-Term Safety of Vonaprument (ANX007) in Participants With Dry Age-Related Macular Degeneration (AMD) With Geographic Atrophy (GA)
Where
Asheville, Eugene, Hagerstown, Sarasota, Springfield, St. Petersburg
Age
50 years and over
People
605
Run by
Annexon, Inc.
See details and how to joinNCT07807969 · EU 2026-527023-96-00
Phase 1Taking people
A Study of the Safety and Tolerability of ASP7317 in Senior Adults Who Are Losing Their Clear, Sharp Central Vision Due to Geographic Atrophy Secondary to Dry Age-related Macular Degeneration
Where
Ann Arbor, Atlanta, Boston, Dallas, Fort Myers, Los Angeles, McAllen, Nashville, New Brunswick, Oak Forest, Palo Alto, Pensacola, Philadelphia, Phoenix, Portland, Riverside, Seattle, Southaven, Spokane
Age
50 years and over
People
42
Run by
Astellas Institute for Regenerative Medicine
See details and how to joinNCT03178149
Phase 2Taking people
Phase 2 Study of ADX-038 in Participants With Geographic Atrophy
Where
Austin, Bakersfield, Bellaire, Beverly Hills, Dallas, Erie, Gilbert, Hagerstown, Huntington Beach, McAllen, Orlando, Phoenix, Poway, Reno, Riverside, Round Rock, San Antonio, St. George, The Woodlands, Walnut Creek, Wildwood
Age
60 years and over
People
240 worldwide
Run by
ADARx Pharmaceuticals, Inc.
See details and how to joinNCT06990269 · EU 2025-521779-30-00
No phaseTaking people
Noninvasive Imaging Biomarkers of Treatable Macrovascular Disease in Age-related Macular Degeneration.
Where
Cleveland
Age
50 years to 80 years
People
30
Run by
Scott Raymond
See details and how to joinNCT07798323
No phaseTaking people
A Long-term Follow-up Study to Evaluate SKG0106 in the Treatment of Patients With nAMD
Where
Boston, Katy, Norfolk
Age
50 years and over
People
83 worldwide
Run by
Skyline Therapeutics
See details and how to joinNCT06346600
No phaseTaking people
Effect of Lutein, Zeaxanthin, and Meso-Zeaxanthin Supplementation on Skin Carotenoid Concentration: A Six-Month, Placebo-Controlled Crossover Study
Where
Kansas City
Age
18 years and over
People
60
Run by
Insight Eyecare Specialties, Inc. dba Vision Source Eyecare,
See details and how to joinNCT06965426
Phase 1/2Taking people
Phase I/II Study of SKG0106 Intravitreal Injection in Patients With Neovascular Age-related Macular Degeneration (nAMD)
Where
Boston, Katy, Norfolk, St. Petersburg
Age
50 years and over
People
68 worldwide
Run by
Skyline Therapeutics (US) Inc.
See details and how to joinNCT05986864
No phaseTaking people
(CIRRUS-2023-1) CLINICAL CLIN Assessment of PathFinder 1.0 on the CIRRUS 6000 and the CIRRUS 5000
Where
Fort Lauderdale, Kansas City, Mountain View, Portland, San Francisco, Tucson
Age
18 years and over
People
400
Run by
Carl Zeiss Meditec-Dublin CoCe
See details and how to joinNCT07680244
No phaseTaking people
Microcurrent Stimulation Therapy for Intermediate to Advanced Nonexudative Age-related Macular Degeneration
Where
Beachwood, Fort Worth, Lemont, Manchester, Poway, Reno, Tyler
Age
60 years and over
People
100 worldwide
Run by
i-Lumen Scientific AUS PTY LTD
See details and how to joinNCT06662162
Phase 2Taking people
SGLT2 Inhibitors in Geographic Atrophy
Where
St Louis
Age
50 years and over
People
70
Run by
Washington University School of Medicine
See details and how to joinNCT07174687
Phase 1/2Taking people
4D-150 in Patients With Neovascular (Wet) Age-Related Macular Degeneration
Where
Asheville, Austin, Bellevue, Bethlehem, Boston, Carmel, Deerfield Beach, Eugene, Fort Lauderdale, Gainesville, Hagerstown, Lakewood, McAllen, Melbourne, Nashville, Oak Forest, Oxnard, Pensacola, Phoenix, Reno, Sacramento, Tampa, The Woodlands, West Columbia
Age
50 years and over
People
215 worldwide
Run by
4D Molecular Therapeutics
See details and how to joinNCT05197270
Phase 3Taking people
Phase 3 Study to Assess Efficacy, Safety & Tolerability of OCU410 For Geographic Atrophy Secondary to Dry AMD
Where
Erie, McAllen, Phoenix
Age
55 years and over
People
237
Run by
Ocugen
See details and how to joinNCT07770828