Mantle cell lymphoma trials in United States

In United States 82 Also abroad 150

82 trials · From ClinicalTrials.gov, checked 11 November 2026. Ask the study team whether a trial fits you.

Phase 1Taking people
BAFFR-targeting CAR T Cells for Patients With Relapsed or Refractory B-NHL
Where
Duarte, Kansas City, Minneapolis, Seattle, Stanford
Age
18 years and over
People
36
Run by
PeproMene Bio, Inc.
See details and how to joinNCT05370430
Phase 2Taking people
Phase II Study of Pirtobrutinib, Rituximab (PR) in Previously Untreated Low and Intermediate Risk MCL (Mantle Cell Lymphoma) Patients
Where
Houston
Age
18 years and over
People
50
Run by
M.D. Anderson Cancer Center
See details and how to joinNCT06263491
Phase 3Taking people
A Study to Evaluate Glofitamab as a Single Agent vs. Investigator's Choice in Participants With Relapsed/Refractory Mantle Cell Lymphoma
Where
Ann Arbor, Berkeley, Charleston, Charlottesville, Chesterfield, Coral Gables, Duarte, East Syracuse, El Paso, Indianapolis, Iowa City, Los Angeles, Morgantown, New Brunswick, New Haven, Reno, Rochester, Santa Monica, Seattle, Sioux Falls, Stony Brook, Tampa, The Woodlands, Washington D.C., Waukee
Age
18 years and over
People
182 worldwide
Run by
Hoffmann-La Roche
See details and how to joinNCT06084936
Phase 2Taking people
Auto Stem Cell Transplant for Lymphoma Patients
Where
Minneapolis
Age
Up to 75 years
People
150
Run by
Masonic Cancer Center, University of Minnesota
See details and how to joinNCT03125642
Phase 1Taking people
A Study of LY4152199 in Participants With Previously Treated B-cell Malignancies (BAF_FRontier-1 )
Where
Ann Arbor, Aurora, Boston, Chicago, Cleveland, Dallas, Denver, Duarte, Houston, Iowa City, Kansas City, Milwaukee, Nashville, New Brunswick, New Haven, New York, Philadelphia, Rochester, Salt Lake City, Seattle
Age
18 years and over
People
215 worldwide
Run by
Eli Lilly and Company
See details and how to joinNCT07101328 · EU 2025-524180-20-00
Phase 2Not yet taking people in United States
A Study of Zanubrutinib, Obinutuzumab, and Sonrotoclax in People With Mantle Cell Lymphoma
Where
Basking Ridge, Commack, Harrison, Middletown, Montvale, New York, Uniondale
Age
18 years and over
People
45
Run by
Memorial Sloan Kettering Cancer Center
See details and how to joinNCT07799220
Phase 1Taking people
IKS03 in Patients With Advanced B Cell Non-Hodgkin Lymphomas
Where
Baltimore
Age
18 years and over
People
140 worldwide
Run by
Iksuda Therapeutics Ltd.
See details and how to joinNCT05365659
Phase 3Taking people
Testing Continuous Versus Intermittent Treatment With the Study Drug Zanubrutinib for Older Patients With Previously Untreated Mantle Cell Lymphoma
Where
Albany, Ames, Anaconda, Ankeny, Ann Arbor, Appleton, Ashland, Atlanta, Augusta, Bay City, Bellevue, Bemidji, Beverly Hills, Billings, Bismarck, Bloomington, Boiling Springs, Boise, Boone, Bozeman, Brainerd, Brighton, Buffalo, Caldwell, Camillus, Canton, Cape Girardeau, Carroll, Carthage, Chapel Hill, Charleston, Chelsea, Chesterfield, Chicago, City of Saint Peters, Clarkston, Clive, Coeur d'Alene, Columbus, Coon Rapids, Creve Coeur, Crown Point, Danville, Decatur, Deer River, Derby, Des Moines, Detroit, Dixon, Duarte, Duluth, Durham, Dyer, Easley, East Syracuse, Eau Claire, Edina, Edmonds, Effingham, Eureka, Evanston, Fairfield, Fargo, Farmington Hills, Flint, Fort Dodge, Fruitland, Galesburg, Glastonbury, Glenview, Great Falls, Greenville, Greenwich, Greer, Guilford, Hartford, Hays, Hibbing, Highland Park, Hobart, Indianapolis, Iowa City, Irvine, Issaquah, Jefferson, Johns Creek, Johnson Creek, Kalispell, Kansas City, Kearney, Kewanee, La Crosse, Lansing, Lapeer, Lawrence, Lawton, Leavenworth, Lebanon, Lee's Summit, Little Rock, Livonia, Los Angeles, Louisville, Macomb, Madison, Maplewood, Marshalltown, Marshfield, Mattoon, Meridian, Milwaukee, Mineola, Minneapolis, Minocqua, Missoula, Mount Pleasant, Mount Vernon, Mukwonago, Munster, Nampa, Newark, Newberg, New Berlin, New Haven, New York, North Haven, North Kansas City, Oconomowoc, O'Fallon, Oklahoma City, Olathe, Omaha, Ontario, Oregon City, Ottawa, Overland Park, Pekin, Peoria, Peru, Petoskey, Pittsburg, Pontiac, Portland, Post Falls, Princeton, Providence, Rice Lake, Richmond, Rochester, Royal Oak, Saginaw, Saint Cloud, Saint Johnsbury, Saint Louis Park, Saint Paul, Salina, Salt Lake City, Sandpoint, Sandstone, Seattle, Seneca, Shiloh, Sioux Falls, Springfield, Stamford, Stevens Point, St Louis, Tawas City, Topeka, Torrington, Troy, Trumbull, Tulsa, Urbana, Valparaiso, Virginia, Washington, Waterbury, Waterford, Waukee, Waukesha, Webster, West Branch, Westerly, Weston, Westwood, Woodbury, Ypsilanti
Age
60 years and over
People
421
Run by
Alliance for Clinical Trials in Oncology
See details and how to joinNCT05976763
Phase 2Taking people
Acalabrutinib, Obinutuzumab, and Glofitamab for the Treatment of Relapsed or Refractory Mantle Cell Lymphoma
Where
Duarte
Age
18 years and over
People
40
Run by
City of Hope Medical Center
See details and how to joinNCT06054776
Phase 2Taking people
Testing the Anti-cancer Drug, Glofitamab, in Patients With Mantle Cell Lymphoma (A Type of Blood Cancer) Whose Disease Returned After CAR-T Cell Therapy
Where
Atlanta, Baltimore, Charlottesville, Cleveland, Columbus, Duarte, Lexington, Nashville, Pittsburgh
Age
18 years and over
People
20
Run by
National Cancer Institute (NCI)
See details and how to joinNCT07003295
Phase 1Taking people
A Study of ARC-02 in B-cell NHL
Where
Charlotte, Los Angeles, Louisville, Milwaukee, Richmond, Spokane
Age
18 years and over
People
140 worldwide
Run by
Taiho Oncology, Inc.
See details and how to joinNCT07691606 · EU 2026-525606-35-00
Phase 2Not yet taking people in United States
Polatuzumab Vedotin, Mosunetuzumab, and Acalabrutinib for the Treatment of Mantle Cell Lymphoma, PAcMan Trial
Where
Seattle
Age
18 years and over
People
27
Run by
University of Washington
See details and how to joinNCT07910435
Phase 2Taking people
Sonrotoclax, Rituximab, and Zanubrutinib in Treating Participants With Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma, and Mantle Cell Lymphoma
Where
Seattle
Age
18 years and over
People
30
Run by
Fred Hutchinson Cancer Center
See details and how to joinNCT06839053
No phaseTaking people
Observational Study of Cardiac Arrhythmias During Treatment With BTK Inhibitors or Venetoclax
Where
Bethesda
Age
18 years to 110 years
People
135
Run by
National Heart, Lung, and Blood Institute (NHLBI)
See details and how to joinNCT05724121
Phase 3Taking people
A Study to Investigate the Efficacy and Safety of Sonrotoclax Plus Zanubrutinib Compared With Placebo Plus Zanubrutinib in Adults With Relapsed/Refractory Mantle Cell Lymphoma (CELESTIAL-RRMCL)
Where
Ann Arbor, Baltimore, Baton Rouge, Birmingham, Boston, Charlotte, Charlottesville, Chicago, Cleveland, Columbus, Durham, Fort Wayne, Fresno, Gainesville, Grand Island, Grand Rapids, Hattiesburg, Hershey, Houston, Irvine, Madison, Nashville, New Haven, New York, Omaha, Paramus, Pembroke Pines, Richmond, Rochester, Round Rock, St Louis, Tucson, Vancouver, Waukee, Weston, West Reading, Winston-Salem
Age
18 years and over
People
300 worldwide
Run by
BeOne Medicines
See details and how to joinNCT06742996 · EU 2024-515593-27-00
No phaseTaking people
Tissue, Blood, and Body Fluid Sample Collection From Patients With Hematologic Cancer
Where
Chapel Hill
Age
18 years to 120 years
People
15,000
Run by
UNC Lineberger Comprehensive Cancer Center
See details and how to joinNCT01137643
Phase 1/2Taking people
A Study of AZD0486 Monotherapy or in Combination With Other Anti-Cancer Agents for Mature B-Cell Malignancies
Where
Boston, Charlotte, Columbus, Hackensack, Houston, New Brunswick, New York, Philadelphia, Pittsburgh, Portland, Providence, Winston-Salem
Age
18 years and over
People
408 worldwide
Run by
AstraZeneca
See details and how to joinNCT06564038 · EU 2024-515034-33-00
Phase 1Taking people
Anti-CD19 Chimeric Antigen Receptor T Cells for Treatment of Relapsed or Refractory Non-Hodgkin Lymphoma
Where
San Francisco
Age
18 years and over
People
36
Run by
C. Babis Andreadis
See details and how to joinNCT04545762
Phase 1/2Taking people
Glofitamab With Obinutuzumab, Venetoclax, and Lenalidomide for the Treatment of Patients With Newly Diagnosed High Risk Mantle Cell Lymphoma
Where
Duarte, New York, Salt Lake City
Age
18 years to 80 years
People
50
Run by
City of Hope Medical Center
See details and how to joinNCT05861050
Phase 1/2Taking people
Gene Therapy for CD19-Positive Hematologic Malignancies (SENTRY-CD19)
Where
Chapel Hill, Columbus, Denver, Duarte, Houston, Jacksonville, Los Angeles, Nashville, Portland, Rochester, Valhalla
Age
13 years to 90 years
People
32
Run by
Vironexis Biotherapeutics Inc.
See details and how to joinNCT06533579
Phase 1/2Taking people
A Study to Investigate the Safety of Novel Dose Ramp-up Schedule(s) When Initiating Sonrotoclax in Participants Treated for Blood Cancers.
Where
Boston, Fort Wayne, Seattle, St Louis, Tampa, Westwood
Age
18 years and over
People
258 worldwide
Run by
BeOne Medicines
See details and how to joinNCT06697184 · EU 2024-518829-15-00
Phase 2Taking people
Natalizumab for the Prevention of ICANS in Patients With Recurrent or Refractory Diffuse Large B-Cell Lymphoma or Mantle Cell Lymphoma Receiving CAR T-Cell Therapy
Where
Ann Arbor
Age
18 years and over
People
26
Run by
University of Michigan Rogel Cancer Center
See details and how to joinNCT07892027
Phase 1/2Taking people
Golcadomide in Combination With Rituximab for the Treatment of Patients With Relapsed or Refractory Mantle Cell Lymphoma
Where
Duarte
Age
18 years and over
People
58
Run by
City of Hope Medical Center
See details and how to joinNCT07578077
Phase 1Taking people
A Study of APG-3288 in Relapsed/Refractory Blood Cancers
Where
East Brunswick, Grand Rapids, Houston, Jacksonville, Los Angeles
Age
18 years and over
People
180 worldwide
Run by
Ascentage Pharma Group Inc.
See details and how to joinNCT07424833
Phase 1/2Taking people
Venetoclax, Lenalidomide and Rituximab in Patients With Previously Untreated Mantle Cell Lymphoma
Where
Ann Arbor, Charlottesville, Columbus, Duarte
Age
18 years and over
People
28
Run by
City of Hope Medical Center
See details and how to joinNCT03523975