Multiple sclerosis trials in Portugal

In Portugal 17 Also abroad 506

17 trials · From ClinicalTrials.gov and EU CTIS (euclinicaltrials.eu), checked 11 November 2026. Ask the study team whether a trial fits you.

Phase 3Taking people
A Study of Orelabrutinib in Patients With Primary Progressive Multiple Sclerosis
Where
Lisbon, Porto, Santa Maria Da Feira, Senhora Da Hora
Age
18 years to 60 years
People
705 worldwide
Run by
Zenas BioPharma (USA), LLC
See details and how to joinNCT07067463 · EU 2025-524316-11-00
Phase 2Taking people
A Pharmacokinetics (PK), Pharmacodynamics (PD), Safety and Tolerability Study of Fenebrutinib in Children and Adolescents With Relapsing Multiple Sclerosis (RMS)
Where
Braga, Coimbra
Age
10 years to 17 years
People
12 worldwide
Run by
Hoffmann-La Roche
See details and how to joinNCT07161258 · EU 2024-519800-28-00
Phase 3Taking people
A Study of Orelabrutinib in Patients With Secondary Progressive Multiple Sclerosis
Where
Lisbon, Porto, Santa Maria Da Feira, Senhora Da Hora
Age
18 years to 60 years
People
990 worldwide
Run by
Zenas BioPharma (USA), LLC
See details and how to joinNCT07299019 · EU 2025-524322-18-00
Phase 3Taking people
Efficacy and safety study of frexalimab (SAR441344) in adults with relapsing forms of multiple sclerosis
Where
Braga, Guimarães, Matosinhos
Age
18 years to 64 years
People
386 worldwide
Run by
Sanofi-Aventis Recherche & Developpement
See details and how to join2023-504358-36-00 · EU 2023-504358-36-00
Phase 3Taking people
Efficacy and Safety of Remibrutinib After Switching From Ocrelizumab in Participants Living With Relapsing Multiple Sclerosis.
Where
Braga, Coimbra, Lisbon
Age
40 years to 70 years
People
400 worldwide
Run by
Novartis Pharmaceuticals
See details and how to joinNCT06846281 · EU 2023-509275-17-00
Phase 3Taking people
A Study to Evaluate the Efficacy and Safety of Remibrutinib in Secondary Progressive Multiple Sclerosis
Where
Braga, Lisbon, Porto
Age
18 years to 65 years
People
1,275 worldwide
Run by
Novartis Pharmaceuticals
See details and how to joinNCT07225504
Phase 3Taking people
Non-inferiority Study of Frexalimab Subcutaneous Administration Compared to Intravenous Administration in Adult Participants With Multiple Sclerosis
Where
Braga, Coimbra, Guimaraes, Lisbon, Matosinhos
Age
18 years to 60 years
People
160 worldwide
Run by
Sanofi
See details and how to joinNCT07325292 · EU 2026-525688-41-00
Phase 2Taking people
A Study to Evaluate the Safety, Pharmacokinetics, Pharmacodynamics, and Efficacy of RO7268489 as Add-on Therapy to Ocrelizumab, in Participants With Progressive Forms of Multiple Sclerosis (MS)
Where
Braga, Coimbra, Lisbon, Santa Maria Da Feira
Age
18 years to 60 years
People
360 worldwide
Run by
Hoffmann-La Roche
See details and how to joinNCT07282574 · EU 2025-521636-10-00
Phase 3Taking people
Efficacy and safety of ofatumumab and siponimod compared to fingolimod in pediatric patients with multiple sclerosis
Where
Coimbra, Lisbon
Age
Up to 17 years
People
64 worldwide
Run by
Novartis Pharma AG
See details and how to join2024-511686-11-00 · EU 2024-511686-11-00
Phase 3Taking people
Study to Evaluate the Effectiveness and Safety of Ozanimod Compared to Fingolimod in Children and Adolescents With Relapsing Remitting Multiple Sclerosis
Where
Braga, Coimbra, Lisbon, Porto
Age
10 years to 17 years
People
194 worldwide
Run by
Bristol-Myers Squibb
See details and how to joinNCT06408259 · EU 2022-501332-42-00
Phase 3Taking people
A clinical trial to find out how well LOU064 (remibrutinib) works and how safe it is for people with secondary progressive multiple sclerosis
Where
Braga, Lisbon, Porto
Age
18 years and over
People
677 worldwide
Run by
Novartis Pharma AG
See details and how to join2025-521546-23-00 · EU 2025-521546-23-00
No phaseNot yet taking people in Portugal
Sociocognitive Intervention and Rehabilitation Program in Multiple Sclerosis
Where
Coimbra
Age
18 years to 55 years
People
130
Run by
Sonia Batista
See details and how to joinNCT07734675
No phaseTaking people
Ofatumumab in Portuguese Multiple Sclerosis Patients - an Observational Study
Where
Amadora, Guimarães, Leiria, Lisbon, Matosinhos Municipality, Ponte de Lima, Porto, Setúbal
Age
18 years to 99 years
People
174
Run by
Novartis Pharmaceuticals
See details and how to joinNCT05809986
Phase 2Taking people
Psilocybin Therapy for Psychological Distress in Palliative Patients
Where
Lisbon
Age
18 years and over
People
108 worldwide
Run by
University Medical Center Groningen
See details and how to joinNCT06782724 · EU 2023-510488-36-01
Phase 2Taking people
A phase II randomized, double-blind, placebo-controlled trial to evaluate the efficacy, safety, and tolerability of an oral solution of 9-Δ tetrahydrocannabinol/cannabidiol (THC/CBD) in multiple sclerosis patients with chronic neuropathic pain
Where
Braga
Age
18 years and over
People
68
Run by
Ferraz Lynce Especialidades Farmaceuticas S.A.
See details and how to join2024-520287-34-01 · EU 2024-520287-34-01
Phase 2Taking people
MODAFIMS: A Trial to Evaluate Predictors of Response to MODAFinil in Patients With Multiple Sclerosis
Where
Braga
Age
18 years to 64 years
People
64
Run by
Clinical Academic Center (2CA-Braga)
See details and how to joinNCT06592352 · EU 2022-501414-53-00
No phaseTaking people
Improving Learning and Memory in Portuguese Patients With Multiple Sclerosis
Where
Porto
Age
18 years to 70 years
People
80
Run by
Centro Hospitalar De São João, E.P.E.
See details and how to joinNCT06723444