Narcolepsy trials in United States

In United States 23 Also abroad 43

23 trials · From ClinicalTrials.gov, checked 13 November 2026. Ask the study team whether a trial fits you.

Phase 2/3Taking people
A Study of TAK-360 in People With Narcolepsy or Idiopathic Hypersomnia
Where
Atlanta, Austin, Bowie, Brandon, Chula Vista, Cincinnati, Colorado Springs, Columbia, Denver, Huntersville, Lansing, Miami, Middletown, Norfolk, San Antonio, Santa Ana, Southfield, St Louis, Winston-Salem, Winter Park
Age
18 years to 71 years
People
500 worldwide
Run by
Takeda
See details and how to joinNCT07646678 · EU 2025-522833-68-01
Phase 2/3Taking people
A Study to Investigate the Effects of Cleminorexton Compared With Placebo in the Treatment of Participants With Central Disorders of Hypersomnolence
Where
Atlanta, Austin, Birmingham, Brandon, Cincinnati, Colorado Springs, Columbia, Dallas, Denver, Dublin, Flowood, Frisco, Houston, Huntersville, Lansing, Miami, Miami Lakes, Orlando, Rincon, San Antonio, Stockbridge, St. Petersburg, Sugar Land
Age
18 years to 70 years
People
222
Run by
Centessa Pharmaceuticals (UK) Limited
See details and how to joinNCT07598708
No phaseTaking people
Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford
Where
Sioux Falls
People
20,000
Run by
Sanford Health
See details and how to joinNCT01793168
Phase 2/3Taking people
A Long-Term Study of ALKS 2680 in Subjects With Narcolepsy and Idiopathic Hypersomnia
Where
Abington, Atlanta, Austin, Boulder, Brandon, Canton, Cincinnati, Colorado Springs, Columbia, Cullman, Dallas, Denver, Dublin, Huntersville, Kansas City, Lansing, Lincoln, Little Rock, Los Angeles, Macon, Madison, Miami, Middletown, Peoria, Phoenix, San Antonio, San Francisco, Stanford, Sterling Heights, Stockbridge, Sugar Land, Winter Park, Wyomissing
Age
18 years to 70 years
People
786 worldwide
Run by
Alkermes, Inc.
See details and how to joinNCT06767683 · EU 2024-519822-18-00
Phase 2Taking people
A Study of TAK-360 in Adults With Narcolepsy Without Cataplexy (NT2)
Where
Atlanta, Auburn, Austin, Bowie, Bradenton, Brandon, Chandler, Chula Vista, Cincinnati, Cleveland, Colorado Springs, Columbia, Dallas, Denver, El Paso, Huntersville, Jacksonville, Lansing, Lathrup Village, Mansfield, Miami, Middletown, Norfolk, Orlando, Redwood City, San Antonio, Santa Ana, St Louis, Winston-Salem
Age
18 years to 70 years
People
88 worldwide
Run by
Takeda
See details and how to joinNCT06952699 · EU 2024-517711-70-01
Phase 3Taking people
A Study Evaluating the Efficacy and Safety of Xywav Expanded Dosing vs Placebo in Participants With Narcolepsy or IH
Where
Austin, Birmingham, Cincinnati, Colorado Springs, Dallas, Denver, Dublin, Irvine, Long Beach, Los Angeles, Miami, Morrisville, Nashville, Rincon, Sugar Land
Age
18 years to 75 years
People
120
Run by
Jazz Pharmaceuticals
See details and how to joinNCT07625280
Phase 3Taking people
A Study to Evaluate the Efficacy and Safety of ALKS 2680 in Adults With Narcolepsy Type 1
Where
Austin, Boulder, Brandon, Charlotte, Cincinnati, Columbia, Cullman, Kansas City, Lansing, Los Angeles, Macon, Madison, Miami, Middletown, Newton, Novi, Phoenix, San Antonio, St Louis, Sugar Land, Winter Park, Wyomissing
Age
18 years to 70 years
People
150 worldwide
Run by
Alkermes, Inc.
See details and how to joinNCT07455383
Phase 3Taking people
A Study to Evaluate the Efficacy and Safety of ALKS 2680 in Adults With Narcolepsy Type 2
Where
Austin, Boulder, Brandon, Charlotte, Cincinnati, Columbia, Cullman, Frisco, Huntersville, Kansas City, Lansing, Los Angeles, Macon, Maimi, Newton, Novi, Phoenix, Rochester, San Antonio, Stockbridge, Sugar Land, Winter Park, Wyomissing
Age
18 years to 70 years
People
176 worldwide
Run by
Alkermes, Inc.
See details and how to joinNCT07502443
Phase 3Taking people
A Study to Evaluate the Efficacy, Safety and Tolerability of ALKS 2680 in Adults With Narcolepsy Type 1 (Brilliance NT1 - 304)
Where
Atlanta, Brandon, Charlotte, Cincinnati, Colombia, Dallas, Frisco, Lansing, Macon, Miami, San Antonio, Spokane, St Louis, Sugar Land, Winter Park
Age
18 years to 70 years
People
150 worldwide
Run by
Alkermes, Inc.
See details and how to joinNCT07540897
No phaseTaking people
SUNOSI® (Solriamfetol) Pregnancy Registry
Where
Morrisville, Wilmington
People
1,731
Run by
Axsome Therapeutics, Inc.
See details and how to joinNCT06413420
Phase 3Taking people
A Phase 3 Study to Evaluate the Efficacy and Safety of Samelisant in Patients With Narcolepsy (AWAKE)
Where
Columbia
Age
18 years and over
People
240
Run by
Suven Life Sciences Limited
See details and how to joinNCT07540364
Phase 3Taking people
A Phase 3 Efficacy and Safety Study of HBS-301 in Participants With Narcolepsy
Where
Abington, Ardmore, Atlanta, Austin, Birmingham, Boulder, Charleston, Chesterfield, Cincinnati, Cleveland, Colorado Springs, Columbia, Dallas, Danville, Denver, East Providence, Fort Wayne, Gastonia, Glenview, Huntersville, Kansas City, Lancaster, Los Angeles, Macon, Madison, McKinney, Miami, Middletown, Mobile, Morgantown, Nashville, New Hyde Park, Novi, Peoria, Pittsburgh, Redwood City, Rincon, San Antonio, San Francisco, San Ramon, Southfield, Spokane, Sterling Heights, Stockbridge, Sugar Land, Williamsburg, Winter Park, Wyomissing
Age
18 years and over
People
258 worldwide
Run by
Harmony Biosciences Management, Inc.
See details and how to joinNCT07675135 · EU 2025-523821-17-00
No phaseTaking people
Decreasing Nightmares in Adults With Narcolepsy
Where
Salt Lake City
Age
18 years and over
People
80
Run by
University of Utah
See details and how to joinNCT06383806
Phase 2Taking people
A Study of TAK-360 in Adults With Narcolepsy Type 1 (Narcolepsy With Cataplexy)
Where
Cincinnati, Miami, Redwood City
Age
18 years to 70 years
People
92 worldwide
Run by
Takeda
See details and how to joinNCT07633301 · EU 2025-522587-33-00
No phaseTaking people
WAKIX® (Pitolisant) Pregnancy Registry
Where
Morrisville
People
1,329
Run by
Harmony Biosciences Management, Inc.
See details and how to joinNCT05536011
No phaseEnrolling by invitation
Cardiovascular and Cognitive Implications of Central Disorders of Hypersomnolence and Their Treatments
Where
Scottsdale
Age
18 years to 75 years
People
100
Run by
Mayo Clinic
See details and how to joinNCT05371483
Phase 1Taking people
A Phase 1, First-in-human Study of VX-433
Where
Salt Lake City
Age
18 years to 55 years
People
118
Run by
Vertex Pharmaceuticals Incorporated
See details and how to joinNCT07584434
Phase 2Taking people
A Study to Evaluate the Efficacy and Safety of E2086 in Adults With Narcolepsy
Where
Atlanta, Austin, Baltimore, Brandon, Columbia, Denver, Lansing, Macon, Medley, Miami, Novi, San Antonio, Santa Ana, Southfield, Stockbridge
Age
18 years and over
People
64 worldwide
Run by
Eisai Inc.
See details and how to joinNCT07493265
Phase 2Taking people
A Study of ORX750 in Participants With Narcolepsy and Idiopathic Hypersomnia
Where
Atlanta, Auburn, Austin, Brandon, Chandler, Cincinnati, Cleveland, Columbia, Denver, Dublin, El Paso, Henderson, Huntersville, Long Beach, Miami, New Orleans, Newton, North Charleston, Orlando, Riverdale, San Antonio, Santa Ana, Scottsdale, Southfield, Sterling Heights, Willow Grove, Winter Park
Age
18 years to 65 years
People
248 worldwide
Run by
Centessa Pharmaceuticals (UK) Limited
See details and how to joinNCT06752668 · EU 2024-518929-15-00
Phase 2Taking people
A Long-term Extension Study of ORX750 in Participants With Narcolepsy and Idiopathic Hypersomnia
Where
Abington, Atlanta, Auburn, Austin, Cincinnati, Denver, Dublin, El Paso, Henderson, Huntersville, Miami, North Charleston, Orlando, Santa Ana, Sterling Heights, Willow Grove, Winter Park
Age
18 years to 65 years
People
90 worldwide
Run by
Centessa Pharmaceuticals (UK) Limited
See details and how to joinNCT07096674 · EU 2025-522987-34-00
Phase 2/3Taking people
A Study of TAK-861 for the Treatment of Selected Central Hypersomnia Conditions
Where
Atlanta, Birmingham, Charleston, Cincinnati, Cleveland, Colorado Springs, Columbia, Denver, Dublin, Gainesville, Huntersville, Newton, Norfolk, Novi, Orlando, Redwood City, San Antonio, Santa Ana
Age
16 years to 70 years
People
500 worldwide
Run by
Takeda
See details and how to joinNCT05816382 · EU 2023-508462-15-00
No phaseTaking people
Unhide® Project: A Digital Health Platform to Collect Lifestyle Data for Brain Inflammation Research
Where
Delafield
Age
2 years and over
People
10,000
Run by
Brain Inflammation Collaborative
See details and how to joinNCT04806620
Phase 2Taking people
Extended-release Sodium Oxybate in Children
Where
Redwood City
Age
7 years to 17 years
People
36
Run by
Stanford University
See details and how to joinNCT06809803