Ovarian cancer trials in United States

In United States 350 Also abroad 797

350 trials · From ClinicalTrials.gov, checked 12 November 2026. Ask the study team whether a trial fits you.

Phase 2Taking people
Immunotherapy Using Tumor Infiltrating Lymphocytes for Patients With Metastatic Cancer
Where
Bethesda
Age
18 years to 72 years
People
332
Run by
National Cancer Institute (NCI)
See details and how to joinNCT01174121
No phaseTaking people
DICER1-related Pleuropulmonary Blastoma Cancer Predisposition Syndrome: A Natural History Study
Where
Bethesda, Rockville
Age
1 month to 99 years
People
1,500
Run by
National Cancer Institute (NCI)
See details and how to joinNCT01247597
No phaseTaking people
Tissue Procurement and Natural History Study of Patients With Malignant Mesothelioma
Where
Bethesda
Age
2 years to 100 years
People
1,000
Run by
National Cancer Institute (NCI)
See details and how to joinNCT01950572
Phase 1Taking people
Testing the Combination of DS-8201a and Olaparib in HER2-Expressing Cancers With Expansion in Patients With Platinum Resistant Ovarian Cancer
Where
Atlanta, Boston, Coral Gables, Deerfield Beach, Doral, Jacksonville, Miami, Phoenix, Pittsburgh, Plantation, Rochester
Age
18 years and over
People
55
Run by
National Cancer Institute (NCI)
See details and how to joinNCT04585958
Phase 1Taking people
Individual Response to Hyperthermic Intraperitoneal Chemotherapy (HIPEC) Treatment of Peritoneal Carcinomatosis From Peritoneal Mesothelioma or Atypical Mesothelial Proliferation or From Ovarian, Colorectal, or Appendiceal Histologies
Where
Bethesda
Age
18 years to 120 years
People
60
Run by
National Cancer Institute (NCI)
See details and how to joinNCT04847063
Phase 2Taking people
Targeted Therapy Directed by Genetic Testing in Treating Patients With Locally Advanced or Advanced Solid Tumors, The ComboMATCH Screening Trial
Where
Abilene, ‘Aiea, Albuquerque, Allentown, Altoona, Anaconda, Anchorage, Ankeny, Ann Arbor, Appleton, Arroyo Grande, Asheboro, Ashland, Athens, Augusta, Aurora, Aventura, Avon, Baltimore, Barrington, Battle Creek, Beachwood, Bellevue, Belpre, Bemidji, Berlin, Bethesda, Bethlehem, Billings, Birmingham, Bismarck, Bloomington, Boiling Springs, Boise, Boston, Bozeman, Brewer, Brighton, Bristol, Bryn Mawr, Buffalo, Burlington, Caldwell, Canton, Cape Girardeau, Carmichael, Carterville, Carthage, Cedar Rapids, Centerville, Centralia, Charleston, Charlottesville, Chelsea, Chesterfield, Chicago, Chillicothe, Cincinnati, City of Saint Peters, Cleveland, Clinton, Coeur d'Alene, Collierville, Columbia, Columbus, Commack, Coon Rapids, Coral Gables, Creve Coeur, Crown Point, Crystal Lake, Cumberland, Dallas, Danville, Dayton, Dearborn, Decatur, Deerfield Beach, Deer River, DeKalb, Delaware, Des Moines, Dixon, Downers Grove, Dublin, Duluth, Durham, Easley, East Stroudsburg, Eau Claire, Edina, Edmonds, Effingham, Elgin, Elk Grove, Encinitas, Erie, Escanaba, Eureka, Evanston, ‘Ewa Beach, Fairfax, Falls Church, Fargo, Farmington, Farmington Hills, Findlay, Flemington, Flint, Fort Collins, Fort Lauderdale, Franklin, Fruitland, Gainesville, Galesburg, Geneva, Germantown, Glenview, Goldsboro, Goodyear, Grafton, Grand Rapids, Grayslake, Great Falls, Greeley, Green Bay, Greensboro, Greensburg, Greenville, Greer, Grenada, Grove City, Gulfport, Harrison, Harvey, Hazel Crest, Hazleton, Hibbing, Highland Park, High Point, Honolulu, Houston, Huntington, Issaquah, Jacksonville, Janesville, Johnson City, Jonesboro, Kalamazoo, Kalispell, Kenosha, Kettering, Kewanee, Kingman, Kingsport, Lacey, La Crosse, La Jolla, Lake Forest, Lakewood, Lancaster, Lansing, Las Vegas, Lexington, Libertyville, Livingston, Livonia, Long Branch, Los Angeles, Loveland, Lubbock, Macomb, Madison, Manistique, Mansfield, Maple Grove, Maplewood, Marinette, Marion, Marshfield, Martinez, Marysville, Mattoon, Mayfield Heights, Maywood, Mechanicsburg, Media, Memphis, Mentor, Meridian, Metairie, Miami, Michigan City, Middleburg Heights, Middletown, Milwaukee, Mineola, Minneapolis, Minocqua, Missoula, Mobile, Monroeville, Morgantown, Mount Vernon, Mukwonago, Muskegon, Nampa, Nashville, Nassau Bay, Neenah, New Albany, Newark, Newberg, New Brunswick, New Lenox, New London, Newnan, New Orleans, New Richmond, New York, Niles, Normal, North Miami, Norton Shores, Oak Lawn, Oconomowoc, Oconto Falls, O'Fallon, Oklahoma City, Omaha, Ontario, Orange, Oregon City, Orland Park, Oshkosh, Ottawa, Oxford, Paducah, Palo Alto, Paoli, Park Ridge, Pekin, Pennington, Peoria, Perrysburg, Peru, Philadelphia, Phoenix, Pickerington, Pittsburgh, Plantation, Pontiac, Portland, Portsmouth, Post Falls, Princeton, Providence, Racine, Raleigh, Rapid City, Reed City, Reidsville, Reno, Renton, Rice Lake, Richmond, Roanoke, Rochester, Rockford, Rocklin, Rolla, Royal Oak, Sacramento, Saginaw, Sainte Genevieve, Saint Joseph, Saint Louis Park, Saint Paul, San Diego, Sandpoint, Sandstone, San Francisco, Santa Monica, Sayre, Scarborough, Seattle, Seneca, Sewell, Shawano, Sheboygan, Shiloh, Sioux Falls, Somerville, South Bend, Southhaven, South Hill, South Portland, Springfield, Stevens Point, St Louis, Stoneham, Sturgeon Bay, Sugar Land, Sullivan, Summit, Syracuse, Tawas City, Temple, The Bronx, The Woodlands, Toledo, Toms River, Traverse City, Troy, Twin Falls, Two Rivers, Urbana, Virginia, Walla Walla, Walnut Creek, Warrenville, Washington, Waukee, Waukesha, Waupaca, Wauwatosa, West Allis, West Branch, Westerville, Weston, Whittier, Willow Grove, Winston-Salem, Woodland, Wynnewood, Wyoming, Yakima, Youngstown, Ypsilanti, Zanesville, Zion
People
2,900 worldwide
Run by
National Cancer Institute (NCI)
See details and how to joinNCT05564377
No phaseTaking people
Identifying Underserved Individuals inTexas With Hereditary Cancer Risk Using Mobile Mammography Units and Telegenetics.
Where
Houston
Age
18 years and over
People
1,000
Run by
M.D. Anderson Cancer Center
See details and how to joinNCT05649072
Phase 1/2Taking people
Phase II IMNN-001 (Also Known as GEN-1) on SLL With BEV and NACT, Newly Diagnosed Advanced Ovarian, Fallopian Tube or Primary Peritoneal Cancer
Where
Baltimore, Houston, New York, Oklahoma City
Age
18 years and over
People
30
Run by
Imunon
See details and how to joinNCT05739981
Phase 1Taking people
Testing Different Amounts of the Combination of Drugs M1774 and ZEN-3694 for the Treatment of Recurrent Ovarian and Endometrial Cancer
Where
Albuquerque, Augusta, Chicago, Cleveland, Columbus, Detroit, Iowa City, Milwaukee, Oklahoma City, Philadelphia, Providence
Age
18 years and over
People
65
Run by
National Cancer Institute (NCI)
See details and how to joinNCT05950464
Phase 2Taking people
Phase II Investigation of Pembrolizumab in Combination With Bevacizumab and Oral Cyclophosphamide in Patients With High Grade Ovarian Cancer and Surgically Documented Minimal Residual Disease After Frontline Therapy
Where
Houston, New York
Age
18 years and over
People
20
Run by
M.D. Anderson Cancer Center
See details and how to joinNCT06083844
Phase 1Taking people
A Phase 1 Study of PLN-101095 in Adults With Advanced or Metastatic Solid Tumors
Where
Atlanta, Austin, East Brunswick, Edmonds, Fairfax, Fort Worth, Grand Rapids, Houston, Lake Success, Nashville, New Brunswick, New Haven, San Antonio, Sioux Falls, St Louis, Washington D.C., West Valley City, Wilson
Age
18 years and over
People
124 worldwide
Run by
Pliant Therapeutics, Inc.
See details and how to joinNCT06270706
Phase 3Taking people
Phase 3 Trial Evaluating the Safety & Efficacy of IMNN-001 Administered in Combination w/ Standard NACT & Adjuvant Chemotherapy in Newly Diagnosed Patients w/ Advanced EOC, Fallopian Tube or Primary Peritoneal Cancer
Where
Chattanooga, Detroit, Milwaukee, Minneapolis, New Orleans, Orlando, Portland, Rochester, Sioux Falls, Spokane, St Louis
Age
18 years and over
People
500
Run by
Imunon
See details and how to joinNCT06915025
Phase 1Taking people
A Trial to Evaluate Ovarian Suppression Following Subcutaneous ZOLADEX 10.8 mg in Premenopausal Women With Early-stage and Advanced HR+ Breast Cancer
Where
Amsterdam, Athens, Bethlehem, Billings, Cary, Chicago, Cleveland, Columbus, Des Moines, Evanston, Farmington, Hershey, Hot Springs, Houston, Lisle, Miami, New Orleans, New York, Ocoee, Royal Oak, Savannah, Sayre, Skokie, Spokane, Springfield, The Bronx, Washington D.C., Westbury
Age
18 years to 55 years
People
176
Run by
TerSera Therapeutics LLC
See details and how to joinNCT07310420
Phase 1Taking people
A Study to Evaluate OPB-201 in Recurrent Endometrial and Platinum-resistant Ovarian Cancer.
Where
Atlanta, Detroit, Houston, Minneapolis, San Francisco
Age
18 years and over
People
30
Run by
Outpace Bio, Inc.
See details and how to joinNCT07664735
Phase 1/2Taking people
A Phase I/II, First-in-Human Study to Evaluate TJ102 in Participants With Advanced or Metastatic Ovarian Cancer and Other Solid Tumors.
Where
Fairfax, Houston, Irving, Lake Success, Los Angeles, Nashville, Orlando, Philadelphia
Age
18 years and over
People
150 worldwide
Run by
Phrontline Biopharma
See details and how to joinNCT07778498
Phase 1/2Taking people
A KRAS Inhibitor in Participants With Advanced Solid Tumors
Where
Fairfax
Age
18 years and over
People
320
Run by
Ensem Therapeutics
See details and how to joinNCT07912593
Phase 1Taking people
A Phase 1 Study of CTIM-76 in Patients With Recurring Ovarian Cancer and Other Advanced Solid Tumors
Where
Beverly Hills, Boston, Canton, Dallas, Denver, Durham, Hackensack, Little Rock, Nashville, New York, Omaha, Philadelphia, Portland, Providence
Age
18 years and over
People
156 worldwide
Run by
Context Therapeutics Inc.
See details and how to joinNCT06515613 · EU 2025-523968-20-00
Phase 3Taking people
A Study to Evaluate the Efficacy and Safety of Sacituzumab Tirumotecan (MK-2870) Maintenance Treatment Versus Standard of Care in Participants With Platinum-sensitive Recurrent Ovarian Cancer (MK-2870-022/TroFuse-022/ENGOT-ov84/GOG-3103)
Where
Albuquerque, Anchorage, Atlanta, Augusta, Austin, Birmingham, Cincinnati, Columbus, Covington, Duarte, Eugene, Fairfax, Fort Wayne, Fort Worth, Hackensack, Irvine, Jackson, Maplewood, Miami Beach, Milwaukee, Mineola, Nashville, New Brunswick, New Haven, New York, Omaha, Pinehurst, Pittsburgh, Providence, San Antonio, San Francisco, Sarasota, Scarborough, St Louis, Tulsa, Walnut Creek, Webster, West Palm Beach, Westwood
Age
18 years and over
People
770 worldwide
Run by
Merck Sharp & Dohme LLC
See details and how to joinNCT06824467 · EU 2023-508015-23-00
Phase 1/2Taking people
A Clinical Study of Raludotatug Deruxtecan in People With Ovarian Cancer (MK-5909-003).
Where
Boston, Charlottesville, Fort Worth, Houston, Louisville, New Haven, New York, Oklahoma City, Shreveport, West Valley City
Age
18 years and over
People
605 worldwide
Run by
Merck Sharp & Dohme LLC
See details and how to joinNCT06843447 · EU 2024-514674-47-00
Phase 3Taking people
A Clinical Trial of Sac-TMT in People With Non-HRD Positive Advanced Ovarian Cancer (MK-2870-021)
Where
Albany, Arlington Heights, Atlanta, Aurora, Birmingham, Cincinnati, Columbia, Covington, Durham, Fairfax, Fort Wayne, Fort Worth, Germantown, Highlands Ranch, Hilliard, Indianapolis, Knoxville, La Jolla, Miami Beach, Nashville, New York, Norfolk, Omaha, Orlando, Philadelphia, Pittsburgh, Portland, Providence, Reno, Scarborough, Tulsa, Walnut Creek
Age
18 years and over
People
900 worldwide
Run by
Merck Sharp & Dohme LLC
See details and how to joinNCT07318558 · EU 2023-508047-40-00
Phase 1Taking people
A Study of IDE034 in Adult Participants With Locally Advanced/Metastatic Solid Tumors Types
Where
Austin, Celebration, Denver, Detroit, Duarte, East Brunswick, Fairfax, Fort Worth, Houston, Irvine, Irving, Lake Success, Nashville, New Haven, New York, Plantation, San Antonio, Sarasota, Spokane, West Valley City
Age
18 years and over
People
150 worldwide
Run by
IDEAYA Biosciences
See details and how to joinNCT07503808 · EU 2026-526299-21-00
Phase 2Taking people
Sacituzumab Tirumotecan +/- Pembrolizumab in I/O Exposed Metastatic or Recurrent Ovarian Clear Cell Cancer
Where
Boston
Age
18 years and over
People
50
Run by
Tufts Medical Center
See details and how to joinNCT07718854
Phase 3Taking people
A Clinical Trial of Raludotatug Deruxtecan (R-DXd) With or Without Bevacizumab in Participants With Ovarian Cancer Who Have Progressed During Treatment With PARP-inhibitors Treatment on First Line Maintenance (MK-5909-008/ENGOT-ov107/GOG-3142 / REJOICE-Ovarian05)
Where
Burlington, Fort Worth, Fountain Valley, Orlando
Age
18 years and over
People
646 worldwide
Run by
Merck Sharp & Dohme LLC
See details and how to joinNCT07743164 · EU 2025-525130-59-00
Phase 1Not yet taking people in United States
A Study of LY4336619 in Adult Participants With Advanced Solid Tumors
Where
Boston, Chicago, Columbus, Duarte, Houston, La Jolla, Lake Success, New York, Scottsdale, West Valley City
Age
18 years and over
People
370 worldwide
Run by
Eli Lilly and Company
See details and how to joinNCT07928258 · EU 2026-526553-33-00
Phase 1Taking people
A Study of Azenosertib (ZN-c3) in Patients With Ovarian Cancer
Where
Aurora, Boston, Durham, Houston, Nashville, New York, Providence, St Louis
Age
18 years and over
People
172 worldwide
Run by
K-Group, Beta, Inc., a wholly owned subsidiary of Zentalis Pharmaceuticals, Inc
See details and how to joinNCT04516447 · EU 2025-524868-38-00