Prostate cancer trials in United States

In United States 655 Also abroad 1490

655 trials · From ClinicalTrials.gov, checked 15 November 2026. Ask the study team whether a trial fits you.

Phase 1/2Taking people
REGN15505 (PSMAx4-1BB) Alone or in Combination With Cemiplimab or REGN4336 (PSMAxCD3) in Adult Patients With Metastatic Castration-Resistant Prostate Cancer and Clear Cell Renal Cell Carcinoma
Where
Duarte, Goodyear, Houston, St Louis, Tampa, Zion
Age
18 years and over
People
265
Run by
Regeneron Pharmaceuticals
See details and how to joinNCT07594106
No phaseNot yet taking people in United States
Cancer Oriented Understanding and Navigation Via Supportive and Educational Language Models (COUNSEL)
Where
San Francisco
Age
18 years and over
People
50
Run by
University of California, San Francisco
See details and how to joinNCT07836933
No phaseEnrolling by invitation
MR-Guided Cryoablation of Prostate Bed Recurrences
Where
Rochester
Age
30 years to 100 years
People
200
Run by
Mayo Clinic
See details and how to joinNCT01727284
Phase 3Taking people
Screening for Prostate Cancer Using High Resolution Micro-ultrasound Versus Multiparametric Magnetic Resonance Imaging.
Where
Dallas, Los Angeles
Age
50 years to 70 years
People
1,284 worldwide
Run by
University of Alberta
See details and how to joinNCT06626022
Early phase 1Taking people
Pre-Surgical Tirzepatide-Assisted Weight Loss in Overweight and Obese Men With Intermediate Risk Prostate Cancer: A Pilot Feasibility Study
Where
Houston
Age
18 years and over
People
30
Run by
M.D. Anderson Cancer Center
See details and how to joinNCT06759701
Phase 1Taking people
Phase 1 Study of ACE-232 to Treat Patients With Metastatic Castration-Resistant Prostate Cancer
Where
Baltimore, Boston, La Jolla, Minneapolis, Myrtle Beach, Omaha, Seattle, Tampa
Age
18 years and over
People
88 worldwide
Run by
Acerand Therapeutics (Hong Kong) Limited
See details and how to joinNCT06801236
No phaseTaking people
DESTINY-PANTUMOUR04
Where
Birmingham, Boulder, Bullhead City, Canton, Casa Grande, Coral Springs, Dallas, Decatur, Durham, Farmington, Maumee, Nashville, Philadelphia, San Diego, St. Petersburg, Topeka, West Palm Beach, Wilson
Age
18 years to 130 years
People
100
Run by
AstraZeneca
See details and how to joinNCT07124000
No phaseTaking people
A Point of Prostate Cancer Diagnosis Virtual Reality Assistant Intervention in Supporting Newly Diagnosed Black Men
Where
Jacksonville
People
200
Run by
Mayo Clinic
See details and how to joinNCT07126548
Phase 1Taking people
A Study of GSK5764227 in Combination With Standard of Care (SoC) or Other Agents in Participants With Advanced Solid Tumors
Where
Dallas, Nashville, New Hyde Park, Philadelphia, Reunion
Age
18 years and over
People
83 worldwide
Run by
GlaxoSmithKline
See details and how to joinNCT07277270 · EU 2025-522274-37-00
No phaseTaking people
Decision Support Tool to Enhance Germline Genetic Testing for Patients With Prostate Cancer
Where
Houston
Age
18 years and over
People
108
Run by
M.D. Anderson Cancer Center
See details and how to joinNCT07377006
No phaseTaking people
Reduce HEAT: A Randomized Trial of Wearable Thermal Devices for ADT-Induced Hot Flashes
Where
Boston
Age
18 years and over
People
66
Run by
Dana-Farber Cancer Institute
See details and how to joinNCT07729150
Phase 1Taking people
A Phase 1 Study of BPX-601 CAR T-Cell Therapy in Adult Participants With Prostate Cancer That Has Returned, is Resistant to Treatment and Has Spread
Where
Atlanta, Hackensack, Portland
Age
18 years and over
People
36
Run by
Regeneron Pharmaceuticals
See details and how to joinNCT07543055
Phase 1Taking people
A Study in Patients With Metastatic Castration-Resistant Prostate Cancer
Where
Boston, East Brunswick, Fort Worth, Grand Rapids, Houston, Los Angeles, Myrtle Beach, Nashville, San Antonio
Age
18 years and over
People
60
Run by
Flare Therapeutics Inc.
See details and how to joinNCT07719361
Phase 2Taking people
Study of Dato-DXd as Monotherapy and in Combination With Anti-cancer Agents in Patients With Advanced Solid Tumours (TROPION-PanTumor03)
Where
Albuquerque, Boston, Cincinnati, Columbus, Commack, East Brunswick, Grand Rapids, Houston, Kansas City, Los Angeles, Madison, Muncie, Nashville, Portland, San Diego, Santa Rosa
Age
18 years to 130 years
People
454 worldwide
Run by
AstraZeneca
See details and how to joinNCT05489211 · EU 2023-509436-26-00
No phaseTaking people
Precise Oncology Interventions in Nutrition and Training (OnPoint)
Where
Miami
Age
18 years and over
People
306
Run by
University of Miami
See details and how to joinNCT06534918
Phase 2Taking people
Androgen Deprivation Therapy (Relugolix) for the Improvement of Diagnostic Imaging (PSMA PET/CT Scan) in Patients With High Risk or Very High Risk Prostate Cancer, The EnrichPSMA Trial
Where
Scottsdale
Age
18 years and over
People
30
Run by
Mayo Clinic
See details and how to joinNCT07025369
No phaseTaking people
CV CARE: CardioVascular Care in PC Patients
Where
Boston
Age
18 years and over
People
180
Run by
Dana-Farber Cancer Institute
See details and how to joinNCT06202820
Phase 2/3Taking people
Open-label Study Comparing AAA817 Versus Standard of Care in the Treatment of Previously Treated PSMA-positive mCRPC Adults Who Have Disease Progressed on or After [177Lu]Lu-PSMA Targeted Therapy
Where
Athens, Atlanta, Boston, Chicago, Dallas, Denver, Fairfax, Gahanna, Hartford, Indianapolis, Kansas City, Los Angeles, Metairie, Miami, Milwaukee, Murray, Myrtle Beach, New York, Omaha, Orlando, Palo Alto, Philadelphia, Roanoke, San Antonio, Santa Barbara, Santa Monica, Scottsdale, Seattle, Springfield, St Louis, Syracuse, The Bronx, Voorhees Township
Age
18 years to 100 years
People
443 worldwide
Run by
Novartis Pharmaceuticals
See details and how to joinNCT06780670 · EU 2024-512342-42-00
Phase 1Taking people
Phase I Study of [225Ac]Ac-ETN029 in Patients With Advanced DLL3-expressing Solid Tumors
Where
Boston, Iowa City, Royal Oak, Seattle
Age
18 years to 100 years
People
116 worldwide
Run by
Novartis Pharmaceuticals
See details and how to joinNCT07006727 · EU 2024-519111-34-00
Phase 2Taking people
PSMA-High: EBRT/ PSMA617/ ADT vs. EBRT/ ADT
Where
Baltimore
Age
18 years and over
People
60
Run by
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
See details and how to joinNCT07550517
No phaseTaking people
Protoacoustic Imaging For 3D Mapping
Where
Oklahoma City
Age
18 years and over
People
24
Run by
University of Oklahoma
See details and how to joinNCT07832617
Phase 1Taking people
Evaluate BL-B01D1 in Patients With Metastatic or Unresectable Non-Small Cell Lung Cancer (NSCLC) and Other Solid Tumors
Where
Aurora, Beverly Hills, Boston, Chicago, Duarte, Fairfax, Greenville, Houston, Iowa City, Louisville, Miami, Nashville, New Haven, New York, Orange, Orlando, Port Saint Lucie, Santa Monica, Seattle, Washington D.C.
Age
18 years and over
People
540 worldwide
Run by
SystImmune Inc.
See details and how to joinNCT05983432
Phase 2Taking people
PSMA-PET Guided De-escalation of Salvage Radiation Treatment in Recurrent Prostate Cancer
Where
Omaha
Age
30 years and over
People
54
Run by
University of Nebraska
See details and how to joinNCT07234981
Phase 2/3Taking people
Dose Optimization and Diagnostic Performance in Prostate Cancer (SPARROW [Staging Prostate Cancer With Advanced RM2 Radiotracer Oncologic Workup])
Where
Grand Rapids
Age
18 years and over
People
408
Run by
Lantheus Medical Imaging
See details and how to joinNCT07831824
Phase 1/2Taking people
Phase I/II Study of PEGylated Arginine Deiminase (ADI-PEG20) With Carboplatin and Cabazitaxel in Men With Aggressive Variant Prostate Cancers (AVPC)
Where
Houston
Age
18 years and over
People
30
Run by
M.D. Anderson Cancer Center
See details and how to joinNCT06085729