Prostate cancer trials in United States

In United States 655 Also abroad 1490

655 trials · From ClinicalTrials.gov, checked 15 November 2026. Ask the study team whether a trial fits you.

Phase 1/2Taking people
A Pilot Presurgical Trial of REGN5678 (Anti-PSMA x CD28) in Patients With High-risk, Localized Prostate Cancer Followed by Radical Prostatectomy
Where
Houston
Age
18 years and over
People
42
Run by
M.D. Anderson Cancer Center
See details and how to joinNCT06085664
Phase 2Not yet taking people in United States
Sacituzumab Tirumotecan in Pts w/ NEPC After Progression on Prior Chemotherapy
Where
Richmond
Age
18 years and over
People
20
Run by
Virginia Commonwealth University
See details and how to joinNCT07639086
Early phase 1Not yet taking people in United States
Response With Interim PSMA PET in Metastatic Castration-sensitive Prostate Cancer for Optimization of Adaptive Metastasis-directed Radiotherapy Delivery
Where
Dallas
Age
18 years and over
People
30
Run by
University of Texas Southwestern Medical Center
See details and how to joinNCT07674771
Phase 2Taking people
PRORAD-5 PROstate RADiation in 5 Fractions: Phase II Five Fraction Radiotherapy for Patients With Advanced Prostate Cancer.
Where
Houston
Age
18 years and over
People
100
Run by
M.D. Anderson Cancer Center
See details and how to joinNCT06369246
Phase 2Taking people
A Study of Talazoparib With or Without Enzalutamide in People With Prostate Cancer Who Have Previously Received Abiraterone Acetate or Darolutamide
Where
Boston, Duarte, La Jolla, Madison, Minneapolis, New York, Philadelphia, Seattle
Age
18 years and over
People
126
Run by
Prostate Cancer Clinical Trials Consortium
See details and how to joinNCT06844383
No phaseTaking people
A Single-arm, Multicenter Prospective Study to Evaluate the Diagnostic Performance of PROSTest in Men With PSA ≥ 3ng/ml Using Biopsy as the Sole Ground Truth
Where
Branford
Age
45 years to 80 years
People
1,500
Run by
Wren Laboratories LLC
See details and how to joinNCT07454603
No phaseTaking people
High Dose-Rate Brachytherapy and Stereotactic Body Radiotherapy for the Treatment of Prostate Adenocarcinoma
Where
Los Angeles
Age
18 years and over
People
52
Run by
Jonsson Comprehensive Cancer Center
See details and how to joinNCT04945642
Phase 1/2Taking people
A Phase 1b/2a Study of Pocenbrodib as Monotherapy and in Combination With Darolutamide in Participants With mCRPC
Where
Atlanta, Aurora, Baltimore, Chicago, Columbus, Dallas, Detroit, Durham, Fairfax, Fountain Valley, Houston, Indianapolis, Jefferson, Los Alamitos, Maumee, Miami, New York, Omaha, St Louis
Age
18 years and over
People
120
Run by
Pathos AI, Inc.
See details and how to joinNCT06785636
No phaseTaking people
Prostate Cancer Postoperative Stereotactic Body Radiotherapy With Adaptive Technology for Minimizing Toxicity
Where
Los Angeles
Age
18 years and over
People
200
Run by
Jonsson Comprehensive Cancer Center
See details and how to joinNCT07077239
No phaseTaking people
Dosing Physical Activity Among Older Cancer Survivors Who Experience Chronic Pain: a Micro-randomized Trial
Where
Milwaukee
Age
65 years and over
People
50
Run by
Medical College of Wisconsin
See details and how to joinNCT07227077
Phase 2Taking people
MRI-based Focal Intraprostatic Simultaneous Integrated Boost (SIB) Intensification With De-escalated Adaptive-risk SBRT for Patients With Low to Intermediate Risk Prostate Cancer
Where
Washington D.C.
Age
18 years and over
People
58
Run by
Georgetown University
See details and how to joinNCT07644598
Phase 1/2Taking people
A Study of Tulmimetostat DZR123 (CPI-0209) in Patients With Advanced Solid Tumors and Lymphomas
Where
Ann Arbor, Atlanta, Baltimore, Boston, Buffalo, Charlottesville, Chicago, Cincinnati, Grand Rapids, Hackensack, Maywood, New York, Philadelphia, Rochester, San Antonio, Seattle, Tampa, The Bronx
Age
18 years and over
People
300 worldwide
Run by
Novartis Pharmaceuticals
See details and how to joinNCT04104776 · EU 2023-508002-20-00
No phaseTaking people
Efficacy of Low-intensity Shockwave vs Radial Wave for Treatment of Erectile Dysfunction and Pelvic Pain
Where
Cleveland
Age
40 years and over
People
186
Run by
The Cleveland Clinic
See details and how to joinNCT05868668
No phaseTaking people
Impact of an Electronic Health Record Maintenance Alert on PSA Screening Rates in a 10-Hospital Integrated Health System
Where
St Louis
Age
40 years to 75 years
People
40,000
Run by
Washington University School of Medicine
See details and how to joinNCT07109427
No phaseTaking people
AI Algorithm-Informed Biopsy for Prostate Cancer Detection With Indeterminate and Low-Risk Prostate MRI Lesions
Where
Little Rock
Age
40 years and over
People
50
Run by
University of Arkansas
See details and how to joinNCT07231627
Phase 1Taking people
Study of DCC-2812 in Participants With Advanced Genitourinary Cancers
Where
Ann Arbor, Austin, Boston, Cleveland, Nashville, Philadelphia, San Antonio, St Louis
Age
18 years and over
People
60
Run by
Deciphera Pharmaceuticals, LLC
See details and how to joinNCT06966024
No phaseTaking people
Water Vapor Ablation for Prostate Cancer: Long-Term Registry
Where
Bossier City, San Antonio, Virginia Beach, Woodbury
People
2,500
Run by
Francis Medical Inc.
See details and how to joinNCT07455058
No phaseTaking people
Comparing Acupuncture vs. Sham Acupuncture for the Management of Hot Flashes in Prostate Cancer Patients Receiving Hormone Therapy
Where
Lexington
Age
18 years to 99 years
People
40
Run by
University of Kentucky
See details and how to joinNCT07594002
No phaseTaking people
EDRN Prostate MRI Biomarker Study
Where
Ann Arbor
Age
18 years and over
People
950
Run by
University of Michigan
See details and how to joinNCT03784924
Phase 2Taking people
A Study of FG-3246 in Participants With Metastatic Castration-Resistant Prostate Cancer (mCRPC)
Where
Albuquerque, Atlanta, Aventura, Charlottesville, Cleveland, Dallas, Durham, Goodyear, Hialeah, Houston, Los Angeles, Miami, Myrtle Beach, Nashville, New Haven, New Orleans, San Francisco, Scottsdale, Seattle, Tacoma, Tucson
Age
18 years and over
People
75
Run by
Kyntra Bio
See details and how to joinNCT06842498
Phase 2Taking people
Proof-of-Concept Trial to Assess the Efficacy and Safety of Fezolinetant in Improving Vasomotor Symptoms in Men With Prostate Cancer Undergoing Androgen Deprivation Therapy
Where
Boston
Age
40 years and over
People
60
Run by
Shehzad Basaria, M.D.
See details and how to joinNCT06957691
Phase 2Taking people
Metabolic Interventions (Time-Restricted Eating, GLP1 Receptor Agonist, and Heart Healthy Diet) to Improve Cardiometabolic Health in Prostate Cancer Patients During Androgen Deprivation Therapy, IMPACT-ADT Trial
Where
Duarte
Age
30 years to 79 years
People
60
Run by
City of Hope Medical Center
See details and how to joinNCT07202247
No phaseNot yet taking people in United States
Training on Systemic and Organ Spec. PM in PC
Where
Boston
Age
18 years and over
People
20
Run by
Massachusetts General Hospital
See details and how to joinNCT07768917
No phaseNot yet taking people in United States
Magnetic Resonance-Guided Stereotactic Body Radiation Therapy for the Treatment of Prostate Cancer
Where
Irvine
Age
18 years and over
People
20
Run by
City of Hope Medical Center
See details and how to joinNCT07769372
Phase 2Taking people
Genomic Biomarker-Selected Umbrella Neoadjuvant Study for High Risk Localized Prostate Cancer
Where
Ann Arbor, Boston, Houston, Sacramento, Seattle
Age
18 years and over
People
315 worldwide
Run by
University of British Columbia
See details and how to joinNCT04812366