Sarcoma trials in Italy

In Italy 52 Also abroad 605

52 trials · From ClinicalTrials.gov and EU CTIS (euclinicaltrials.eu), checked 10 November 2026. Ask the study team whether a trial fits you.

Phase 1Taking people
START: Safety and Anti-Tumor Activity of PeptiCRAd-1 in Treatment of Cancer
Where
Candiolo, Milan, Naples, Rozzano
Age
18 years and over
People
15 worldwide
Run by
Valo Therapeutics Oy
See details and how to joinNCT05492682 · EU 2024-517580-23-00
Phase 3Taking people
A Study to Evaluate the Efficacy and Safety of Divarasib Compared With Investigator's Choice of Immunotherapy or Observation in Participants With Resected Stage II-III KRAS G12C-Positive Non-Small Cell Lung Cancer (NSCLC)
Where
Bergamo, Florence, Milan, Modena, Monza, Perugia, Peschiera del Garda, Rome, Turin
Age
18 years and over
People
400 worldwide
Run by
Hoffmann-La Roche
See details and how to joinNCT07541170 · EU 2025-524263-21-01
Phase 2Taking people
A Study to Learn More About How Well Treatment With Sevabertinib (BAY 2927088) Tablets Works and How Safe it is in Participants Who Have a Solid Tumor With Mutations of the Human Epidermal Growth Factor Receptor 2 (HER2)
Where
Milan, Reggio Emilia, Rome
Age
18 years and over
People
111 worldwide
Run by
Bayer
See details and how to joinNCT06760819 · EU 2024-517419-62-00
No phaseTaking people
Observational Study in Localized Osteosarcoma
Where
Aviano, Bari, Bologna, Candiolo, Catania, Florence, Genova, Milan, Padova, Palermo, Pisa, Roma, Trieste
Age
Up to 40 years
People
120
Run by
Italian Sarcoma Group
See details and how to joinNCT04890067
Phase 2Taking people
Clinical Study in Adult and Young Adult Patients With Advanced Desmoplastic Small Round Cell Tumor (DSRCT) ISG-TULIPS
Where
Candiolo, Milan, Padova, Prato, Rome
Age
15 years and over
People
20 worldwide
Run by
Italian Sarcoma Group
See details and how to joinNCT07328425 · EU 2024-519261-21-00
Phase 1/2Taking people
Substudy 01A: Zilovertamab Vedotin in Pediatric and Young Adult Participants With Hematologic Malignancies or Solid Tumors (MK-9999-01A/LIGHTBEAM-U01)
Where
Milan, Rome, Turin
Age
6 months to 25 years
People
90 worldwide
Run by
Merck Sharp & Dohme LLC
See details and how to joinNCT06395103 · EU 2023-507178-41-00
Phase 1Taking people
Phase I Trial to Determine the Dose and Evaluate the PK and Safety of Lutetium Lu 177 Edotreotide Therapy in Pediatric Participants With SSTR-positive Tumors
Where
Milan
Age
24 months to 18 years
People
20 worldwide
Run by
ITM Solucin GmbH
See details and how to joinNCT06441331 · EU 2024-512831-66-00
Phase 3Taking people
A Study of Calderasib (MK-1084) Plus Pembrolizumab (MK-3475) in Participants With KRAS G12C Mutant Non-small Cell Lung Cancer (NSCLC) With Programmed Cell Death Ligand 1 (PD-L1) Tumor Proportion Score (TPS) ≥50% (MK-1084-004/KANDLELIT-004)
Where
Aviano, Leghorn, Milan, Naples, Padova, Ravenna, Rome
Age
18 years and over
People
348 worldwide
Run by
Merck Sharp & Dohme LLC
See details and how to joinNCT06345729 · EU 2023-507776-42-00
Phase 3Taking people
Fight Osteosarcoma Through European Research Evolving Study Platform From Diagnosis to Relapse
Where
Bologna, Genova, Milan, Padova, Pisa, Roma, Torino
Age
4 years and over
People
530 worldwide
Run by
Gustave Roussy, Cancer Campus, Grand Paris
See details and how to joinNCT07871864
Phase 3Taking people
Surgery With or Without Neoadjuvant Chemotherapy in High Risk RetroPeritoneal Sarcoma
Where
Aviano, Candiolo, Meldola, Milan, Padova, Roma
Age
18 years and over
People
250 worldwide
Run by
European Organisation for Research and Treatment of Cancer - EORTC
See details and how to joinNCT04031677
Phase 1/2Taking people
A Study of Repotrectinib in Pediatric and Young Adult Subjects Harboring ALK, ROS1, OR NTRK1-3 Alterations
Where
Milan
Age
Up to 25 years
People
75 worldwide
Run by
Turning Point Therapeutics, Inc.
See details and how to joinNCT04094610 · EU 2023-506464-14-00
Phase 1Taking people
Phase 1 Study of INBRX-109 in Subjects With Locally Advanced or Metastatic Solid Tumors Including Sarcomas
Where
Candiolo, Milan
Age
12 years to 85 years
People
411 worldwide
Run by
Inhibrx Biosciences, Inc
See details and how to joinNCT03715933 · EU 2023-508139-29-00
Phase 1/2Taking people
Phase I-II prospective trial, multicenter, open label, exploring the combination of Trabectedin plus RAdiotherapy in Soft Tissue Sarcoma patients
Where
Aviano, Candiolo, Milan
Age
18 years and over
People
163 worldwide
Run by
Asoc Grupo Espanol De Investigacion En Sarcomas
See details and how to join2024-518199-30-00 · EU 2024-518199-30-00
Phase 2Taking people
KEYMAKER-U01 Substudy 01J: A Study of Pembrolizumab Plus MK-1084 in Participants With Non-Small Cell Lung Cancer (NSCLC) With Kirsten Rat Sarcoma Viral Oncogene Homolog (KRAS) G12C Mutations (MK-3475-01J/KEYMAKER-U01J)
Where
Meldola, Milan, Rome
Age
18 years and over
People
140 worldwide
Run by
Merck Sharp & Dohme LLC
See details and how to joinNCT07252739 · EU 2025-521939-36-00
Phase 1Taking people
Long-Term Follow-Up (LTFU) of Participants Treated with Adoptive Cell Therapies
Where
Milan
People
7 worldwide
Run by
USWM Ct LLC
See details and how to join2024-513033-21-00 · EU 2024-513033-21-00
Phase 3Taking people
A Study to Investigate Efficacy & Safety of Intratumoral INT230-6 Compared to US Standard of Care in Adults With Soft Tissue Sarcomas (INVINCIBLE-3)
Where
Bergamo, Bologna, Candiolo, Milan, Padova, Palermo, Rome
Age
18 years and over
People
333 worldwide
Run by
Intensity Therapeutics, Inc.
See details and how to joinNCT06263231 · EU 2024-512423-36-00
No phaseTaking people
Identification of Circulating Biomarkers Associated With Extracellular Vesicles in Sarcomas
Where
Bologna
People
16
Run by
Istituto Ortopedico Rizzoli
See details and how to joinNCT07685405
Phase 1/2Taking people
A Study of Repotrectinib (TPX-0005) in Patients With Advanced Solid Tumors Harboring ALK, ROS1, or NTRK1-3 Rearrangements
Where
Aviano, Milan, Rome
Age
12 years and over
People
500 worldwide
Run by
Turning Point Therapeutics, Inc.
See details and how to joinNCT03093116 · EU 2024-512606-25-00
No phaseTaking people
Clinical Management and Outcomes of Primary Ovarian Leiomyosarcoma
Where
Avellino, Catania, Milan, Modena, Monza, Naples, Parma, Reggio Emilia, Verona
Age
18 years to 99 years
People
30
Run by
Azienda USL Reggio Emilia - IRCCS
See details and how to joinNCT06749600
No phaseTaking people
Electrochemotherapy (ECT) in Patients With Primary Visceral Tumors and/or Secondary Visceral Localizations, of Any Histotype
Where
Padova
Age
18 years to 99 years
People
24
Run by
Istituto Oncologico Veneto IRCCS
See details and how to joinNCT06753136
No phaseTaking people
The Epithelioid Hemangioendothelioma Registry of the European Reference Network on Rare Adult Solid Cancers (EURACAN)
Where
Bologna, Careggi, Milan, Orbassano, Padova, Palermo, Prato, Roma, Rozzano
Age
18 years and over
People
100 worldwide
Run by
Fondazione IRCCS Istituto Nazionale dei Tumori, Milano
See details and how to joinNCT06408441
Phase 2Taking people
Study on Trabectedin in Advanced Rearranged Mesenchymal Chondrosarcoma
Where
Bologna, Candiolo, Milan, Palermo, Prato, Rome
Age
16 years and over
People
16
Run by
Italian Sarcoma Group
See details and how to joinNCT04305548 · EU 2024-514319-85-00
Phase 2Taking people
Trial in Patients With Metastatic or Locally Advanced Leiomyosarcoma
Where
Aviano, Bologna, Candiolo, Genova, Meldola, Milan, Naples, Orbassano, Padova, Palermo, Prato, Roma, Rome, Rozzano, Torino
Age
18 years and over
People
100
Run by
Italian Sarcoma Group
See details and how to joinNCT04383119
Phase 3Taking people
Phase III Trial of Anlotinib, Catequentinib in Advanced Alveolar Soft Part Sarcoma, Leiomyosarcoma, Synovial Sarcoma (APROMISS)
Where
Milan, Palermo, Rome
Age
18 years and over
People
325 worldwide
Run by
Advenchen Laboratories, LLC
See details and how to joinNCT03016819
Phase 2Not yet taking people in Italy
Phase II Prospective Multicenter Study of High-Dose Treosulfan/Melphalan as Consolidation Treatment in Newly Diagnosed High-Risk and Very High-Risk Ewing Sarcoma
Where
Ancona, Bari, Naples, Pisa, Roma, Verona, Azienda Ospedaliero-Universitaria di Modena (AOU Modena) - Policlinico di Modena
Age
Up to 64 years
People
60
Run by
Fondazione Santobono Pausilipon Onlus
See details and how to join2024-518912-37-01 · EU 2024-518912-37-01