Sarcoma trials in United Kingdom

In United Kingdom 33 Also abroad 605

33 trials · From ClinicalTrials.gov, checked 10 November 2026. Ask the study team whether a trial fits you.

Phase 3Taking people
A Study to Evaluate the Efficacy and Safety of Divarasib Compared With Investigator's Choice of Immunotherapy or Observation in Participants With Resected Stage II-III KRAS G12C-Positive Non-Small Cell Lung Cancer (NSCLC)
Where
London
Age
18 years and over
People
400 worldwide
Run by
Hoffmann-La Roche
See details and how to joinNCT07541170 · EU 2025-524263-21-01
Phase 1Taking people
Anti-GD2 ADC M3554 in Advanced Solid Tumors
Where
Sutton
Age
18 years and over
People
65 worldwide
Run by
EMD Serono Research & Development Institute, Inc.
See details and how to joinNCT06641908 · EU 2024-513687-26-00
Phase 1/2Taking people
Substudy 01A: Zilovertamab Vedotin in Pediatric and Young Adult Participants With Hematologic Malignancies or Solid Tumors (MK-9999-01A/LIGHTBEAM-U01)
Where
Birmingham, Cardiff, London, Newcastle upon Tyne, Sutton
Age
6 months to 25 years
People
90 worldwide
Run by
Merck Sharp & Dohme LLC
See details and how to joinNCT06395103 · EU 2023-507178-41-00
Phase 1/2Taking people
Study to Test the Safety and Tolerability of PF-07220060 in Participants With Advance Solid Tumors
Where
Edinburgh, London, Manchester
Age
18 years and over
People
430 worldwide
Run by
Pfizer
See details and how to joinNCT04557449 · EU 2024-512120-11-00
Phase 1Taking people
A Study of MGC026 in Participants With Advanced Solid Tumors
Where
Oxford, Sutton
Age
18 years and over
People
394 worldwide
Run by
MacroGenics
See details and how to joinNCT06242470
Phase 3Taking people
A Study of Calderasib (MK-1084) Plus Pembrolizumab (MK-3475) in Participants With KRAS G12C Mutant Non-small Cell Lung Cancer (NSCLC) With Programmed Cell Death Ligand 1 (PD-L1) Tumor Proportion Score (TPS) ≥50% (MK-1084-004/KANDLELIT-004)
Where
Exeter, Milton Keynes
Age
18 years and over
People
348 worldwide
Run by
Merck Sharp & Dohme LLC
See details and how to joinNCT06345729 · EU 2023-507776-42-00
Phase 2Taking people
A Phase II Trial of Tebentafusp in HLA-A*02:01 Positive Patients With Advanced Clear Cell Sarcoma
Where
London
Age
18 years and over
People
47 worldwide
Run by
Sarcoma Alliance for Research through Collaboration
See details and how to joinNCT06942442
Phase 3Taking people
Surgery With or Without Neoadjuvant Chemotherapy in High Risk RetroPeritoneal Sarcoma
Where
Birmingham, Glasgow, Leeds, London, Metropolitan Borough of Wirral, Newcastle, Nottingham, Oxford
Age
18 years and over
People
250 worldwide
Run by
European Organisation for Research and Treatment of Cancer - EORTC
See details and how to joinNCT04031677
Phase 1/2Taking people
HTL0039732 in Participants With Advanced Solid Tumours
Where
Cambridge, Cardiff, Dundee, Liverpool, London, Manchester
Age
18 years and over
People
150
Run by
Cancer Research UK
See details and how to joinNCT05944237
Phase 1/2Taking people
A Study Evaluating the Efficacy and Safety of Risvutatug Rezetecan in Participants With Advanced Sarcomas (EMBOLD Sarcoma-202)
Where
London, Manchester
People
64 worldwide
Run by
GlaxoSmithKline
See details and how to joinNCT07602777
Phase 3Taking people
A Phase 3 Study of Ersodetug in Patients With Tumor Hyperinsulinism
Where
Saint Johns Wood, Withington
Age
18 years and over
People
16 worldwide
Run by
Rezolute
See details and how to joinNCT06881992
Phase 1Taking people
A Study to Evaluate the Safety, Tolerability, Pharmacokinetics (PK) and Preliminary Clinical Activity of RO7673396 in Participants With Advanced Solid Tumors Harboring Rat Sarcoma Viral Oncogene Homolog (RAS) Mutation(s)
Where
Birmingham, London
Age
18 years and over
People
405 worldwide
Run by
Hoffmann-La Roche
See details and how to joinNCT06884618 · EU 2024-519622-20-00
Phase 1/2Taking people
A Study of Repotrectinib in Pediatric and Young Adult Subjects Harboring ALK, ROS1, OR NTRK1-3 Alterations
Where
Birmingham, Cardiff, Glasgow, Liverpool, London
Age
Up to 25 years
People
75 worldwide
Run by
Turning Point Therapeutics, Inc.
See details and how to joinNCT04094610 · EU 2023-506464-14-00
Phase 1/2Taking people
First-in-Human Study of ADCE-D01 in Soft Tissue Sarcoma
Where
London
Age
18 years and over
People
270 worldwide
Run by
Adcendo ApS
See details and how to joinNCT06797999 · EU 2024-516900-41-00
Phase 1Taking people
Phase 1 Study of INBRX-109 in Subjects With Locally Advanced or Metastatic Solid Tumors Including Sarcomas
Where
London, Manchester
Age
12 years to 85 years
People
411 worldwide
Run by
Inhibrx Biosciences, Inc
See details and how to joinNCT03715933 · EU 2023-508139-29-00
Phase 1Taking people
A Study to Test the Safety, Tolerability and Effect of ZI-MA4-1 for Patients With Locally Advanced or Metastatic Solid Malignancies
Where
London, Manchester
Age
18 years to 75 years
People
9
Run by
Zelluna Immunotherapy AS
See details and how to joinNCT07613723
Phase 1Taking people
Multi-modular Chimeric Antigen Receptor T Cells tarGeting B7-H3 in Children, Teenage & Young Adult Sarcoma
Where
London
Age
1 year to 24 years
People
12
Run by
University College, London
See details and how to joinNCT07751380
Phase 1Taking people
A Phase 1, First-in-human Study of OKN4395 and Pembrolizumab in Patients With Solid Tumors
Where
Glasgow, Leicester, London, Manchester, Oxford
Age
18 years and over
People
146 worldwide
Run by
Epkin
See details and how to joinNCT06789172
Phase 1/2Taking people
A Study of Repotrectinib (TPX-0005) in Patients With Advanced Solid Tumors Harboring ALK, ROS1, or NTRK1-3 Rearrangements
Where
London, Manchester, Sutton
Age
12 years and over
People
500 worldwide
Run by
Turning Point Therapeutics, Inc.
See details and how to joinNCT03093116 · EU 2024-512606-25-00
No phaseTaking people
The Epithelioid Hemangioendothelioma Registry of the European Reference Network on Rare Adult Solid Cancers (EURACAN)
Where
London
Age
18 years and over
People
100 worldwide
Run by
Fondazione IRCCS Istituto Nazionale dei Tumori, Milano
See details and how to joinNCT06408441
No phaseTaking people
Multi-Institutional Registry for Malignant Peripheral Nerve Sheath Tumors
Where
London
People
1,050 worldwide
Run by
Washington University School of Medicine
See details and how to joinNCT03141021
Phase 3Taking people
Phase III Trial of Anlotinib, Catequentinib in Advanced Alveolar Soft Part Sarcoma, Leiomyosarcoma, Synovial Sarcoma (APROMISS)
Where
London
Age
18 years and over
People
325 worldwide
Run by
Advenchen Laboratories, LLC
See details and how to joinNCT03016819
No phaseTaking people
Precision Medicine Approaches for Neoadjuvant Therapy in High-risk Sarcoma Patients
Where
London
Age
18 years and over
People
800
Run by
Royal Marsden NHS Foundation Trust
See details and how to joinNCT07432932
No phaseTaking people
HIFU Ablation of Soft Tissue Sarcoma
Where
Oxford
Age
18 years and over
People
10
Run by
Oxford University Hospitals NHS Trust
See details and how to joinNCT05111964
Phase 2/3Taking people
DETERMINE Trial Treatment Arm 06: Capmatinib in Adult Patients With Cancers Harbouring MET Dysregulations
Where
Belfast, Birmingham, Bristol, Cambridge, Cardiff, Edinburgh, Glasgow, Leicester, London, Manchester, Metropolitan Borough of Wirral, Newcastle, Oxford, Sheffield, Southampton, Sutton
Age
18 years and over
People
30
Run by
Cancer Research UK
See details and how to joinNCT06988475