Sarcoma trials in United States

In United States 300 Also abroad 605

240 of 300 trials · From ClinicalTrials.gov, checked 12 November 2026. Ask the study team whether a trial fits you.

Phase 1Taking people
Study of Aerosol Gemcitabine in Patients With Solid Tumors and Pulmonary Metastases
Where
Houston
Age
12 years to 50 years
People
44
Run by
M.D. Anderson Cancer Center
See details and how to joinNCT03093909
Phase 2Taking people
Dexrazoxane Hydrochloride in Preventing Heart-Related Side Effects of Chemotherapy in Participants With Blood Cancers
Where
Houston
Age
12 years and over
People
100
Run by
M.D. Anderson Cancer Center
See details and how to joinNCT03589729
Phase 2Taking people
Study to Test the Safety and Tolerability of PF-07220060 in Participants With Advance Solid Tumors
Where
Boston, Grand Rapids, Houston, Los Angeles, Nashville, New Haven, Newton, Trumbull
Age
18 years and over
People
430 worldwide
Run by
Pfizer
See details and how to joinNCT04557449 · EU 2024-512120-11-00
No phaseTaking people
Patient-Specific Computational Walking Models in Improving Surgical and Rehabilitation Treatment in Patients With Pelvic Sarcomas
Where
Houston
Age
18 years and over
People
130
Run by
M.D. Anderson Cancer Center
See details and how to joinNCT05054335
Phase 1Taking people
A Study of Therapeutic Drug Monitoring-Based Atezolizumab Dosing
Where
Bethesda
Age
18 years to 120 years
People
30
Run by
National Cancer Institute (NCI)
See details and how to joinNCT06066138
Phase 3Taking people
A Study of Calderasib (MK-1084) Plus Pembrolizumab (MK-3475) in Participants With KRAS G12C Mutant Non-small Cell Lung Cancer (NSCLC) With Programmed Cell Death Ligand 1 (PD-L1) Tumor Proportion Score (TPS) ≥50% (MK-1084-004/KANDLELIT-004)
Where
Albany, Bakersfield, Beverly Hills, Billings, Cincinnati, Houston, Kansas City, Kettering, Lancaster, Madison, Miami Beach, Morristown, Skokie, Springfield, Stamford
Age
18 years and over
People
348 worldwide
Run by
Merck Sharp & Dohme LLC
See details and how to joinNCT06345729 · EU 2023-507776-42-00
Phase 2Taking people
KEYMAKER-U01 Substudy 01J: A Study of Pembrolizumab Plus MK-1084 in Participants With Non-Small Cell Lung Cancer (NSCLC) With Kirsten Rat Sarcoma Viral Oncogene Homolog (KRAS) G12C Mutations (MK-3475-01J/KEYMAKER-U01J)
Where
Clermont, Fargo, Sioux Falls
Age
18 years and over
People
140 worldwide
Run by
Merck Sharp & Dohme LLC
See details and how to joinNCT07252739 · EU 2025-521939-36-00
Phase 2Not yet taking people in United States
Phase 2 Study of Daraxonrasib in Recurrent KRAS-Mutant Biliary Tract Cancer
Where
Baltimore
Age
18 years and over
People
55
Run by
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
See details and how to joinNCT07793253
Phase 1Taking people
Metarrestin (ML-246) in Subjects With Metastatic Solid Tumors
Where
Bethesda, Fairway
Age
12 years to 120 years
People
116
Run by
National Cancer Institute (NCI)
See details and how to joinNCT04222413
Phase 1/2Taking people
Safety and Preliminary Efficacy of SA53-OS in Patients With Locally Advanced or Metastatic Solid Tumors
Where
Canton, Cleveland
Age
18 years and over
People
55
Run by
Lamassu Bio Inc
See details and how to joinNCT06578624
Phase 3Taking people
A Study to Evaluate the Efficacy and Safety of Divarasib Compared With Investigator's Choice of Immunotherapy or Observation in Participants With Resected Stage II-III KRAS G12C-Positive Non-Small Cell Lung Cancer (NSCLC)
Where
Atlanta, Bay Pines, Boston, Clovis, Columbus, Farmington, Farmington Hills, Memphis, Reno
Age
18 years and over
People
400 worldwide
Run by
Hoffmann-La Roche
See details and how to joinNCT07541170 · EU 2025-524263-21-01
Phase 3Taking people
Impact of Sentinel Lymph Node Mapping on Patient Reported Lower Extremity Limb Dysfunction in Stage I Endometrial Cancer
Where
Augusta, Baltimore, Bel Air, Billings, Bryn Mawr, Butte, Carmel, Charlottesville, Chicago, Coral Gables, Dallas, Deerfield Beach, Detroit, Doral, Edina, Farmington Hills, Flint, Fort Worth, Houston, Indianapolis, Kearney, Las Vegas, Maple Grove, Maplewood, Marrero, Metairie, Miami, New Orleans, North Miami, Oklahoma City, Omaha, Paoli, Plantation, Princeton, Providence, Richardson, Saint Paul, Springfield, Sugar Land, The Woodlands, Warrenville, Washington D.C., Wynnewood, Wyoming
Age
18 years and over
People
428 worldwide
Run by
NRG Oncology
See details and how to joinNCT05646316
Phase 2Taking people
At-Home Cancer Directed Therapy Versus in Clinic for the Treatment of Patients With Advanced Cancer
Where
Grand Forks, Jacksonville
Age
18 years and over
People
220
Run by
Mayo Clinic
See details and how to joinNCT05969860
Phase 3Taking people
Measuring if Immunotherapy Plus Chemotherapy is Better Than Chemotherapy Alone for Patients With Aggressive Poorly Differentiated Sarcomas
Where
Albuquerque, Anaconda, Ankeny, Ann Arbor, Appleton, Ashland, Atlanta, Aurora, Avon, Barrington, Basking Ridge, Baton Rouge, Beachwood, Bellevue, Bemidji, Billings, Bismarck, Bloomington, Boise, Boston, Bozeman, Brownstown, Buffalo, Burlington, Caldwell, Canton, Carroll, Carthage, Centerville, Centralia, Charleston, Charlottesville, Chicago, Cleveland, Clinton Township, Clive, Coeur d'Alene, Columbus, Coon Rapids, Coral Gables, Coral Springs, Creve Coeur, Crown Point, Crystal Lake, Cudahy, Danville, Dayton, Dearborn, Decatur, Deerfield Beach, Deer River, DeKalb, Derby, Des Moines, Detroit, Dixon, Downers Grove, Dublin, Duluth, Durham, Eau Claire, Edina, Effingham, Elgin, Elmhurst, Erie, Eureka, Fairfield, Fargo, Fort Collins, Fort Dodge, Franklin, Fremont, Fresno, Gainesville, Galesburg, Geneva, Germantown, Glenview, Grafton, Grayslake, Great Falls, Greeley, Green Bay, Greenville, Greenwich, Guilford, Harvey, Hazel Crest, Hibbing, Hollywood, Honolulu, Houston, Indianapolis, Iowa City, Jackson, Jacksonville, Jefferson Hills, Kalispell, Kenosha, Kewanee, La Jolla, Lake Forest, Lake Success, Lebanon, Libertyville, Los Angeles, Louisville, Loveland, Macomb, Maplewood, Marinette, Marshfield, Mattoon, Miami, Millville, Milwaukee, Minneapolis, Missoula, Modesto, Monroeville, Montvale, Mukwonago, Nampa, Naperville, Nashville, Newark, New Haven, New Lenox, Newport Beach, New York, North Miami, Novi, Oakland, Oak Lawn, Oconomowoc, O'Fallon, Oklahoma City, Omaha, Ontario, Orlando, Orland Park, Oshkosh, Oswego, Ottawa, Palo Alto, Park Ridge, Pasadena, Pekin, Peoria, Peru, Philadelphia, Phoenix, Pittsburgh, Plainfield, Plantation, Portland, Post Falls, Princeton, Racine, Rehoboth Beach, Rice Lake, Richmond, Rochester, Roseville, Sacramento, Saint Louis Park, Saint Paul, Sandpoint, Sandstone, San Francisco, San Jose, San Leandro, San Rafael, Santa Clara, Santa Rosa, Sheboygan, Sioux Falls, South San Francisco, Springfield, Stamford, Stevens Point, St Louis, Summit, Syracuse, Tampa, The Bronx, Torrington, Troy, Trumbull, Tucson, Two Rivers, Uniondale, Urbana, Vallejo, Verona, Virginia, Walnut Creek, Warrenville, Washington, Waterbury, Waterford, Waukee, Waukesha, Wauwatosa, West Allis, West Bloomfield, Weston, Wexford, Wyandotte
Age
18 years and over
People
365 worldwide
Run by
National Cancer Institute (NCI)
See details and how to joinNCT06422806
Phase 2Taking people
Testing Atezolizumab With Selinexor in People ≥ 12 Years Old With Alveolar Soft Part Sarcoma, AXIOM Trial
Where
Bethesda, Columbus, Hartford, Houston, Los Angeles, New Haven, Oklahoma City, Pittsburgh, Trumbull, Washington D.C.
Age
12 years and over
People
27
Run by
National Cancer Institute (NCI)
See details and how to joinNCT05333458
Phase 1/2Taking people
Study of Lurbinectedin Monotherapy in Pediatric and Young Adult Participants With Relapsed/Refractory Ewing Sarcoma
Where
Atlanta, Baltimore, Cincinnati, Columbus, Dallas, Durham, Grand Rapids, Houston, Los Angeles, Memphis, New York, Palo Alto, Philadelphia, St. Petersburg, Washington D.C.
Age
2 years to 30 years
People
60 worldwide
Run by
Jazz Pharmaceuticals
See details and how to joinNCT05734066
Phase 2Taking people
Enasidenib in IDH2-Mutated Malignant Sinonasal and Skull Base Tumors
Where
Bethesda
Age
18 years to 120 years
People
40
Run by
National Cancer Institute (NCI)
See details and how to joinNCT06176989
Phase 1Taking people
Anti-GD2 ADC M3554 in Advanced Solid Tumors
Where
Boston, Houston, New York
Age
18 years and over
People
65 worldwide
Run by
EMD Serono Research & Development Institute, Inc.
See details and how to joinNCT06641908 · EU 2024-513687-26-00
Phase 1Taking people
Testing Low-Dose Common Chemotherapy (Liposomal Doxorubicin) in Combination With an Anti-Cancer Drug, Peposertib, in Advanced Sarcoma
Where
Ann Arbor, Aurora, Baltimore, Bethesda, Boston, Charlottesville, Chicago, Houston, Los Angeles, Miami, New Lenox, Orland Park, Pittsburgh, St Louis
Age
18 years and over
People
30
Run by
National Cancer Institute (NCI)
See details and how to joinNCT05711615
Phase 2Taking people
Iscador® P (Mistletoe) Immunotherapy for Recurrent Resectable Osteogenic Sarcoma
Where
Hackensack, Houston
Age
8 years to 30 years
People
32
Run by
Hackensack Meridian Health
See details and how to joinNCT05726383
Phase 2Taking people
A Study to Learn More About How Well Treatment With Sevabertinib (BAY 2927088) Tablets Works and How Safe it is in Participants Who Have a Solid Tumor With Mutations of the Human Epidermal Growth Factor Receptor 2 (HER2)
Where
Birmingham, Boston, Cleveland, Detroit, Duarte, Farmington Hills, Fort Myers, Houston, Madison, Nashville, Seattle
Age
18 years and over
People
111 worldwide
Run by
Bayer
See details and how to joinNCT06760819 · EU 2024-517419-62-00
No phaseTaking people
Distance-Based Exercise to Preserve Function and Prevent Disability
Where
Boston, Butler, Cranberry Township, Dublin, Fremont, Fresno, Indiana, Kernersville, Mechanicsville, Midlothian, Modesto, Mount Airy, New Castle, Oakland, Pittsburgh, Richmond, Sacramento, San Francisco, San Jose, San Rafael, Santa Clara, Santa Rosa, Seneca, Vallejo, Walnut Creek, Winston-Salem
Age
18 years and over
People
104
Run by
Alliance for Clinical Trials in Oncology
See details and how to joinNCT07059884
Phase 2Taking people
The CATSINDO Trial - Clinical and Translational Study in Newly Diagnosed Osteosarcoma
Where
Chapel Hill, Charleston, Charlotte, Columbia, Durham, Greenville, Winston-Salem
Age
7 years to 22 years
People
46
Run by
Wake Forest University Health Sciences
See details and how to joinNCT07560826
Phase 1Taking people
Phase I Trial of TURALIO(R) (Pexidartinib, PLX3397) in Children and Young Adults With Refractory Leukemias and Refractory Solid Tumors Including Neurofibromatosis Type 1 (NF1) Associated Plexiform Neurofibromas (PN) and Tenosynovial Giant Cell Tumor ...
Where
Bethesda
Age
3 years to 35 years
People
54
Run by
National Cancer Institute (NCI)
See details and how to joinNCT02390752
Phase 1Taking people
T Cell Membrane-Anchored Tumor-Targeted IL12 -Modified TIL Cell Therapy (attIL12-TIL) for Advanced/Metastatic Soft Tissue and Bone Sarcoma Patients.
Where
Houston
Age
12 years and over
People
40
Run by
M.D. Anderson Cancer Center
See details and how to joinNCT06474676