Sarcoma: open trials in United States

301 open trials have a site in United States. Registry data; only the trial team decides who can take part.

NCT06263231
A Study to Investigate Efficacy & Safety of Intratumoral INT230-6 Compared to US Standard of Care in Adults With Soft Tissue Sarcomas (INVINCIBLE-3)
Trial Treatment · Phase 3 · Intensity Therapeutics, Inc.
The James Cancer Hospital and Solove Research Institute, Columbus · Duke Cancer Center, Durham · Profound Research, LLC, Farmington Hills · USC / Norris Comprehensive Cancer Center, Los Angeles · Yale School of Medicine - Smilow Cancer Hospital - Yale - New Haven Hospital Location, New Haven · Nebraska Methodist Hospital, Omaha · Temple University - Fox Chase Cancer Center, Philadelphia · University of Pennsylvania/Abramson Cancer Center, Philadelphia · Sarcoma Oncology Center, Santa Monica · University of California Los Angeles (UCLA) - Santa Monica Cancer Care, Santa Monica
Registry updated 2026-08-11
NCT07549022
Safety and Efficacy of BMS-986504 in Unresectable Malignant Peripheral Nerve Sheath Tumor
Trial Treatment · Phase 1/2 · Ankit Mangla, MD
University Hospitals Seidman Cancer Center, Case Comprehensive Cancer Center, Cleveland
Registry updated 2026-08-11
NCT03959800
Molecular Basis of Pediatric Liver Cancer
Research · University of Pittsburgh
UPMC Children's Hospital of Pittsburgh, Pittsburgh
Registry updated 2026-08-10
NCT05697874
International Rare Brain Tumor Registry
Research · Children's National Research Institute
Akron Children's Hospital, Akron · Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago · Cincinnati Children's Hospital Medical Center, Cincinnati · Children's Hospital Los Angeles, Los Angeles · University of California San Francisco, San Francisco · Children's National Hospital, Washington D.C.
Registry updated 2026-08-07
NCT04715191
Interleukin-15 and -21 Armored Glypican-3-specific Chimeric Antigen Receptor Expressed in T Cells for Pediatric Solid Tumors
Trial Treatment · Phase 1 · Baylor College of Medicine
Texas Children's Hospital, Houston
Registry updated 2026-08-06
NCT05210374
Disulfiram With Copper Gluconate and Liposomal Doxorubicin in Treatment-Refractory Sarcomas
Trial Treatment · Phase 1 · Case Comprehensive Cancer Center
Cleveland Clinic, Case Comprehensive Cancer Center, Cleveland
Registry updated 2026-08-06
NCT07129226
Musculoskeletal Cancers Remote Monitoring and Care
Trial Treatment · Case Comprehensive Cancer Center
Case Comprehensive Cancer Center, Cleveland Clinic Foundation, Cleveland
Registry updated 2026-08-06
NCT07444619
A Phase I Study of Pazopanib in Combination With Trabectedin, Ipilimumab and Nivolumab (TraPIN) in Pediatric and Young Adult Patients With Recurrent Soft Tissue Sarcomas
Trial Treatment · Phase 1 · M.D. Anderson Cancer Center
The University of Texas M. D. Anderson Cancer Center, Houston
Registry updated 2026-08-06
NCT06910657
IDOV-Immune for Advanced Solid Tumors
Trial Treatment · Phase 1 · ViroMissile, Inc.
MD Anderson Cancer Center, Houston · South Texas Accelerated Research Therapeutics, San Antonio · Washington University School of Medicine, St Louis
Registry updated 2026-08-05
NCT06113315
A Study Involving Collection of Samples and Data From Sarcoma Patients Receiving Immunotherapy
Research · Memorial Sloan Kettering Cancer Center
Memorial Sloan Kettering Cancer Center (All Protocol Activities), Basking Ridge · Memorial Sloan Kettering Cancer Center Suffolk - Commack (All Protocol Activities), Commack · Memorial Sloan Kettering Westchester (All Protocol Activities), East White Plains · Memorial Sloan Kettering Monmouth (All Protocol Activities), Middletown · Memorial Sloan Kettering Bergen (All Protocol Activities), Montvale · Memorial Sloan-Kettering Cancer Center, New York · Memorial Sloan Kettering Nassau (All Protocol Activities), Uniondale
Registry updated 2026-08-04
NCT06409013
Evaluation of Tumor Resection Guided by Intraoperative Indocyanine Green Dye Fluorescence Angiography in Patients With Sarcoma
Research · Mayo Clinic
Mayo Clinic in Rochester, Rochester
Registry updated 2026-08-04
NCT06239272
NRSTS2021, A Risk Adapted Study Evaluating Maintenance Pazopanib, Limited Margin, Dose-Escalated Radiation Therapy and Selinexor in Non-Rhabdomyosarcoma Soft Tissue Sarcoma (NRSTS)
Trial Treatment · Phase 1/2 · St. Jude Children's Research Hospital
Children's Healthcare of Atlanta, Atlanta · Our Lady of the Lake Children's Hospital, Baton Rouge · Dana-Farber Cancer Institute, Boston · Lurie Children's Hospital of Chicago, Chicago · Cincinnati Children's Hospital Medical Center, Cincinnati · St. Jude Children's Research Hospital, Memphis · Washington University Medical Center, St Louis
Registry updated 2026-08-03
NCT01659203
Proton or Photon RT for Retroperitoneal Sarcomas
Trial Treatment · Phase 1/2 · Massachusetts General Hospital
Dana-Farber Cancer Institute, Boston · Massachusetts General Hospital, Boston · Roswell Park Cancer Institute, Buffalo · Rush University Medical Center, Chicago · Washington University School of Medicine Siteman Cancer Center West County, Creve Coeur · Duke University, Durham · MD Anderson Cancer Center, Houston · Mayo Clinic, Rochester · University of Utah, Salt Lake City · Washington University School of Medicine Siteman Cancer Center South County, St Louis
Registry updated 2026-07-31
NCT07628634
Feasibility Study on the Effect of a Methionine-Reduced Diet on Serum Levels in Pts w/ Solid Tumors
Trial Treatment · Early phase 1 · University of California, Irvine
Chao Family Comprehensive Cancer Center, University of California, Irvine, Orange
Registry updated 2026-07-31
NCT07633756
A Phase 1b, Open-Label Study Of REC-617, A Selective CDK7 Inhibitor, In Patients With Metastatic Or Unresectable RB1-Negative Leiomyosarcoma After Prior Systemic Therapy
Trial Treatment · Phase 1 · M.D. Anderson Cancer Center
MD Anderson Cancer Center, Houston
Registry updated 2026-07-31
NCT00579566
Novel Biochemical and Molecular Determinants for Soft Tissue Sarcoma
Research · Memorial Sloan Kettering Cancer Center
Memorial Sloan Kettering Basking Ridge (Consent and Follow-Up), Basking Ridge · Memorial Sloan Kettering Commack (Consent and Follow-Up), Commack · Memorial Sloan Kettering Westchester (Consent and Followup), Harrison · Memorial Sloan Kettering Monmouth (Consent and Followup), Middletown · Memorial Sloan Kettering Bergen (Consent and Follow-Up), Montvale · Memorial Sloan Kettering Cancer Center (All Protocol Activities), New York · Memorial Sloan Kettering Nassau (Consent and Followup), Rockville Centre
Registry updated 2026-07-30
NCT06083883
Phase I/Ib Study of NK Expressing an Affinity-enhanced T-cell Receptor (TCR) Against the NY-ESO-1
Trial Treatment · Phase 1 · M.D. Anderson Cancer Center
MD Anderson Cancer Center, Houston
Registry updated 2026-07-29
NCT04040205
Abemaciclib for Bone and Soft Tissue Sarcoma With Cyclin-Dependent Kinase (CDK) Pathway Alteration
Trial Treatment · Phase 2 · Medical College of Wisconsin
University of Iowa Hospitals and Clinics, Iowa City · Mayo Clinic, Jacksonville · Froedtert Hospital & the Medical College of Wisconsin, Milwaukee · Washington University in St. Louis, St Louis
Registry updated 2026-07-28
NCT07089992
A Study of Pembrolizumab in People With Ultra-Rare Sarcomas
Trial Treatment · Phase 2 · Memorial Sloan Kettering Cancer Center
Memorial Sloan Kettering at Basking Ridge (All Protocol Activities), Basking Ridge · Memorial Sloan Kettering Cancer Center @ Suffolk-Commack (Limited Protocol Activities), Commack · Memorial Sloan Kettering at Westchester (Limited Protocol Activities), Harrison · Memorial Sloan Kettering Monmouth (Limited Protocol Activities), Middletown · Memorial Sloan Kettering Bergen (Limited Protocol Activities), Montvale · Memorial Sloan Kettering Cancer Center (All Protocol Activities), New York · Memorial Sloan Kettering Nassau (All Protocol Activities), Uniondale
Registry updated 2026-07-28
NCT06735820
Early Phase Study Evaluating MEK and MDM2 Inhibition in Patients With NF1 and MPNST
Trial Treatment · Phase 1/2 · AeRang Kim
UT Southwestern Medical Center, Dallas · Children's National Hospital, Washington D.C.
Registry updated 2026-07-27
NCT07291297
Metformin Hydrochloride in Combination With Standard of Care Systemic Therapy in Previously Untreated Advanced Unresectable or Metastatic Soft Tissue Sarcoma
Trial Treatment · Phase 2 · Wake Forest University Health Sciences
Levine Cancer Institute, Charlotte · Atrium Health Wake Forest Baptist Comprehensive Cancer Center, Winston-Salem
Registry updated 2026-07-23
NCT07374848
Phase 1a/b Study of ZL-6201 Safety, PK, and Preliminary Efficacy in Sarcoma and Selected Tumors
Trial Treatment · Phase 1 · Zai Lab (Shanghai) Co., Ltd.
Fairfax · Los Angeles · New Haven · New York · Sarasota · St Louis
Registry updated 2026-07-23
NCT07723235
Web-based Lifestyle Program, mHealth and EMA Intervention, to Improve Weight Loss in Rural Stage I-III Postmenopausal Breast and Endometrial Cancer Survivors, HERO-C Trial
Trial Treatment · Ohio State University Comprehensive Cancer Center
Ohio State University Comprehensive Cancer Center, Columbus
Registry updated 2026-07-23
NCT07038278
5-AminoLevulinic Acid Aided Resection Margins in Sarcoma
Trial Treatment · Early phase 1 · University of Colorado, Denver
University of Colorado Hospital, Aurora
Registry updated 2026-07-22
NCT07211737
NKG2D.Zeta-NK Cell Conditioning With C7R.GD2.CAR-T Cells for Patients With Relapsed or Refractory Osteosarcoma or Neuroblastoma
Trial Treatment · Phase 1 · Baylor College of Medicine
Texas Children's Hospital, Houston
Registry updated 2026-07-21

All Sarcoma trials and the map

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