Sickle cell disease trials in United Kingdom

In United Kingdom 12 Also abroad 204

12 trials · From ClinicalTrials.gov, checked 11 November 2026. Ask the study team whether a trial fits you.

Phase 2Taking people
Safety of Anumigilimab (CSL324) in Adults With Sickle Cell Disease (SCD)
Where
Liverpool, London, Manchester
Age
18 years and over
People
63 worldwide
Run by
CSL Behring
See details and how to joinNCT07224360 · EU 2025-521154-42-00
Phase 4Enrolling by invitation
A Study to Provide Access to Mitapivat for Participants Who Previously Participated in an Agios-Sponsored Mitapivat Study
Where
Manchester
Age
18 years and over
People
55 worldwide
Run by
Agios Pharmaceuticals, Inc.
See details and how to joinNCT05777993 · EU 2026-526243-35-00
Phase 3Taking people
The Efficacy and Safety of Rilzabrutinib in Participants Aged 10 to 65 Years With Sickle-cell Disease
Where
London, Manchester
Age
10 years to 65 years
People
192 worldwide
Run by
Sanofi
See details and how to joinNCT06975865
Phase 2Taking people
Safety, Efficacy, and Pharmacokinetics of CSL889 in Adults and Adolescents With Sickle Cell Disease During Vaso-Occlusive Crisis
Where
Liverpool, London
Age
12 years and over
People
70 worldwide
Run by
CSL Behring
See details and how to joinNCT06699849 · EU 2024-513440-29-00
Phase 2Taking people
A Study to Evaluate the Pharmacokinetics and Safety of Etavopivat in Pediatric Patients With Sickle Cell Disease
Where
London, Manchester
Age
6 months to 18 years
People
95 worldwide
Run by
Forma Therapeutics, Inc.
See details and how to joinNCT06198712 · EU 2024-519881-32-00
Phase 3Taking people
A Research Study Looking at Long-term Treatment With Etavopivat in People With Sickle Cell Disease or Thalassaemia
Where
London, Manchester, Sheffield
Age
2 years and over
People
480 worldwide
Run by
Novo Nordisk A/S
See details and how to joinNCT06609226 · EU 2024-510805-27-00
Phase 3Taking people
A Study to Evaluate How Well Etavopivat Works in People With Sickle Cell Disease
Where
Cambridge, London
Age
12 years and over
People
510 worldwide
Run by
Novo Nordisk A/S
See details and how to joinNCT06612268 · EU 2023-509175-16-00
Phase 2/3Taking people
A Phase 2/3 Study of Osivelotor in Adult and Adolescent Participants With SCD
Where
Bristol, London
Age
12 years to 64 years
People
389 worldwide
Run by
Pfizer
See details and how to joinNCT05431088 · EU 2023-508766-14-00
Phase 1/2Taking people
A Study to Evaluate BMS-986470 in Healthy Volunteers and Participants With Sickle Cell Disease
Where
East Sussex, Leeds, London
Age
18 years and over
People
224 worldwide
Run by
Bristol-Myers Squibb
See details and how to joinNCT06481306 · EU 2023-510283-12-00
Phase 3Enrolling by invitation
A Long-term Follow-up Study in Participants Who Received CTX001
Where
London
Age
2 years to 64 years
People
160 worldwide
Run by
Vertex Pharmaceuticals Incorporated
See details and how to joinNCT04208529 · EU 2024-512654-19-00
No phaseTaking people
PASS of Xromi Comparing Safety and Effectiveness in Children Under 2 Years With Sickle Cell Disease [PRECISE PASS]
Where
Basildon, Cardiff, London, Manchester, Oxford
Age
9 months to 23 months
People
180 worldwide
Run by
Nova Laboratories Limited
See details and how to joinNCT06923111
Phase 3Taking people
RElated Haplo-DonoR Haematopoietic stEm Cell Transplantation for Adults With Severe Sickle Cell Disease
Where
London
Age
18 years and over
People
120
Run by
King's College Hospital NHS Trust
See details and how to joinNCT05392894