Sjögren's disease: open trials in United States

• NCT06297213

  R-2487 in Patients With Sjogren's Syndrome (SjD)

  Trial Treatment · Phase 1 · Rise Therapeutics LLC

  University of Michigan - Michigan Medicine, Ann Arbor · The Johns Hopkins Jerome L. Greene Sjögren's Syndrome Center Johns Hopkins University - Rheumatology Department, Baltimore

  Registry updated 2026-11-06

• NCT01425892

  The Pathogenesis and Natural History of Sjogren's Disease

  Research · National Institute of Dental and Craniofacial Research (NIDCR)

  National Institutes of Health Clinical Center, Bethesda

  Registry updated 2026-11-05

• NCT07829497

  Pain Phenotyping of Rheumatic Diseases - An Observational Study

  Research · National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)

  National Institutes of Health Clinical Center, Bethesda

  Registry updated 2026-11-05

• NCT07281456

  Safety of Tofacitinib, an Oral Janus Kinase Inhibitor, in Primary Sjogren Disease

  Trial Treatment · Phase 2 · National Institute of Dental and Craniofacial Research (NIDCR)

  National Institutes of Health Clinical Center, Bethesda

  Registry updated 2026-11-02

• NCT07737743

  A Phase 2a/b Study to Assess the Efficacy, Safety and Tolerability of DDY391 in Participants With Sjögren's Disease

  Trial Treatment · Phase 2 · Novartis Pharmaceuticals

  Stryde Research-Allen Arthritis, Allen · Novel Research LLC, Bellaire · Chicago Clinical Research Inst, Chicago · Clinical Res Of W Florida, Clearwater · Arthritis Care of Texas, Corpus Christi · Altoona Center for Clin Res, Duncansville · Shelby Research LLC, Memphis · RAO Research LLC, Oklahoma City · Clinical Research of West Florida Inc, Tampa · Willow Rheumatology Wellness, Willowbrook

  Registry updated 2026-10-28

• NCT02327884

  Characterization of Diseases With Salivary Gland Involvement

  Research · National Institute of Dental and Craniofacial Research (NIDCR)

  National Institutes of Health Clinical Center, Bethesda

  Registry updated 2026-10-27

• NCT07404865

  Phase 3 Study of Telitacicept in Active Primary Sjögren's Disease

  Trial Treatment · Phase 3 · Vor Biopharma

  Arthritis and Rheumatology Research Institute, PLLC, Allen · Allen Arthritis, Allen · Amarillo Premier Research, LLC, Amarillo · Accurate Clinical Research, Baytown · Novel Research LLC, Bellaire · Wallace Rheumatic Study Center, Beverly Hills · St. Luke's Clinic - Rheumatology, Boise · Tufts Medical Center, Boston · Arizona Arthritis & Rheumatology Associates P.C., Chandler · Arthritis and Osteoporosis Consultants of the Carolinas, Charlotte · Tidewater Clinical Research, Chesapeake · Chicago Clinical Research Institute INC, Chicago · Clinical Research of West Florida, Inc., Clearwater · Clinical Research of West Florida - Corporate, Clearwater · GNP Research, Cooper City · Helios CR Inc - Dallas, TX, Dallas · Denver Arthritis Clinic, Denver · Altoona Center for Clinical Research, P.C., Duncansville · Duke University Medical Center, Durham · Precision Comprehensive Clinical Research Solutions, Euless · Arizona Arthritis & Rheumatology Associates P.C., Flagstaff · Tekton Research, Fort Collins · Lone Star Arthritis & Rheumatology, Fort Worth · Arizona Arthritis & Rheumatology Associates, PLLC, Glendale · Finlay Medical Research Corp, Green Acres · Accurate Clinical Research, Inc, Houston · Precision Comprehensive Clinical Research Solution, Irving · Kansas City Physician Partners, Kansas City · R&H Clinical Research, Inc., Katy · Accurate Clinical Research, Inc, Lake Charles · Clever Medical Research, Miami · Suncoast Clinical Research, Inc., New Port Richey · Oklahoma Medical Research Foundation, Oklahoma City · Clinical Research of Philadelphia, LLC, Philadelphia · Arizona Arthritis & Rheumatology Associates P.C., Phoenix · Arthritis and Rheumatism Associates, Rockville · Clinical Research Institute of Michigan, LLC, Saint Clair Shores · Sarasota Arthritis Center, Sarasota · Clinical Investigation Specialist, Schaumburg · Bioresearch Partners, South Miami · Bioresearch Partner, South Miami · Clinical Research of West Florida Inc, Tampa · Arizona Arthritis & Rheumatology Associates, P.C., Tucson · Velocity Clinical Research, Waco, Waco · Willow Rheumatology Wellness, Willowbrook · Rheumatic Disease Associates, Ltd., Willow Grove · Conquest Research, Winter Park

  Registry updated 2026-10-19

• NCT07873931

  A Study of BMS-986553 in Participants With Refractory Autoimmune Diseases

  Trial Treatment · Phase 1 · Bristol-Myers Squibb

  Ann Arbor · Great Neck · Morristown · Newport Beach · Omaha · Philadelphia · Saint Paul · Salt Lake City · Seattle · Seattle · Worcester

  Registry updated 2026-10-14

• NCT07621809

  Two Arm, Double-blind, Phase III Study Assessing Efficacy and Safety of Ianalumab Versus Placebo, in Participants With Sjögren's Disease With High Symptom Burden

  Trial Treatment · Phase 3 · Novartis Pharmaceuticals

  Novel Research LLC, Bellaire · Tufts Medical Center, Boston · On Site Clinical Solutions Llc, Charlotte · Clinical Res Of W Florida, Clearwater · Arthritis Care of Texas, Corpus Christi · Precision Comprehensive Clinical Research Solutions, Euless · Abigail Neiman MD PA, Houston · West Tennessee Research Institute, Jackson · Accurate Clinical Research, League City · TEKTON, Leander · Shelby Research LLC, Memphis · RAO Research LLC, Oklahoma City · Sun Valley Arthritis Center Ltd, Peoria · St Lawrence Health System, Potsdam · Clinical Research Inst of MI, Saint Clair Shores · Arthritis Northwest, PLLC, Spokane · Clinical Research of West Florida Inc, Tampa · Arthritis Rheumatology and Bone Disease Associates PA, Voorhees Township · Willow Rheumatology Wellness, Willowbrook · Carolina Arthritis Associates, Wilmington

  Registry updated 2026-10-13

• NCT03816345

  Testing an Immunotherapy Anti-cancer Drug, Nivolumab, for Advanced Cancers in Patients With Autoimmune Disorders, AIM-NIVO

  Trial Treatment · Phase 1 · National Cancer Institute (NCI)

  Emory University Hospital/Winship Cancer Institute, Atlanta · Johns Hopkins University/Sidney Kimmel Cancer Center, Baltimore · National Institutes of Health Clinical Center, Bethesda · National Cancer Institute Developmental Therapeutics Clinic, Bethesda · University of Alabama at Birmingham Cancer Center, Birmingham · Massachusetts General Hospital Cancer Center, Boston · Dana-Farber Cancer Institute, Boston · University of Chicago Comprehensive Cancer Center, Chicago · Northwestern University, Chicago · Siteman Cancer Center at Saint Peters Hospital, City of Saint Peters · Ohio State University Comprehensive Cancer Center, Columbus · Siteman Cancer Center at West County Hospital, Creve Coeur · UT Southwestern Simmons Cancer Center - RedBird, Dallas · UT Southwestern/Simmons Cancer Center-Dallas, Dallas · Wayne State University/Karmanos Cancer Institute, Detroit · University of Kansas Clinical Research Center, Fairway · UT Southwestern/Simmons Cancer Center-Fort Worth, Fort Worth · HaysMed, Hays · UT MD Anderson Cancer Center, Houston · University of Kansas Cancer Center, Kansas City · University Health Truman Medical Center, Kansas City · University of Kansas Cancer Center - North, Kansas City · Lawrence Memorial Hospital, Lawrence · University of Kansas Cancer Center - Lee's Summit, Lee's Summit · University of Kentucky/Markey Cancer Center, Lexington · NYU Langone Hospital - Long Island, Mineola · Rutgers Cancer Institute of New Jersey, New Brunswick · Smilow Cancer Center/Yale-New Haven Hospital, New Haven · Yale University, New Haven · Laura and Isaac Perlmutter Cancer Center at NYU Langone, New York · NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center, New York · NYP/Weill Cornell Medical Center, New York · University of Kansas Cancer Center at North Kansas City Hospital, North Kansas City · The University of Kansas Cancer Center - Olathe, Olathe · University of Kansas Cancer Center-Overland Park, Overland Park · University of Kansas Hospital-Indian Creek Campus, Overland Park · Stanford Cancer Institute Palo Alto, Palo Alto · Thomas Jefferson University Hospital, Philadelphia · Mercy Hospital Pittsburg, Pittsburg · UPMC Hillman Cancer Center, Pittsburgh · UT Southwestern Clinical Center at Richardson/Plano, Richardson · VCU Massey Comprehensive Cancer Center, Richmond · University of California Davis Comprehensive Cancer Center, Sacramento · Salina Regional Health Center, Salina · Huntsman Cancer Institute/University of Utah, Salt Lake City · Washington University School of Medicine, St Louis · Siteman Cancer Center at Christian Hospital, St Louis · Siteman Cancer Center-South County, St Louis · University of Kansas Health System Saint Francis Campus, Topeka · MedStar Georgetown University Hospital, Washington D.C. · University of Kansas Hospital-Westwood Cancer Center, Westwood

  Registry updated 2026-10-05

• NCT02422875

  Comparative Autoantibody and Immunologic Cell Marker Study

  Research · Emory University

  Emory University/Winship Cancer Institute, Atlanta · Grady Health System, Atlanta · Emory University Hospital, Atlanta

  Registry updated 2026-10-01

• NCT06392711

  Dose-Escalation Trial of Mesenchymal Stromal Cells in Patients With Medical Xerostomia

  Trial Treatment · Phase 1 · University of Wisconsin, Madison

  University of Wisconsin, Madison

  Registry updated 2026-08-19

• NCT07041099

  A Study of CLN-978, a Subcutaneously Administered CD19-directed T Cell Engager, in Subjects With Sjogren's Disease

  Trial Treatment · Phase 1 · Cullinan Therapeutics Inc.

  New York University, Brooklyn · Regional One, Memphis · Omega Research, Orlando · Stryde Research, Plano · Intermountain, Salt Lake City · Tranquil Research, Webster

  Registry updated 2026-08-11

• NCT06977724

  A Study to Assess Adverse Events, How the Drug Moves Through the Body and Effectiveness of Intravenous Infusions of ABBV-319 in Adult Participants With Systemic Lupus Erythematosus (SLE), Sjogren's Disease (SjD) and Rheumatoid Arthritis (RA)

  Trial Treatment · Phase 1 · AbbVie

  Highlands Advanced Rheumatology And Arthritis Center - Avon Park /ID# 278239, Avon Park · Clinical Research Of West Florida - Phase I Unit /ID# 275834, Clearwater · Integrative Rheumatology of South Texas - Harlingen /ID# 276458, Harlingen · Life Clinical Trials - Colonial Drive - Margate /ID# 276050, Margate · Private Practice - Dr. Ramesh C. Gupta /ID# 275826, Memphis · Advanced Quality Medical Research /ID# 278462, Orland Park · Clinical Research Of West Florida - Tampa - North Howard Avenue /ID# 275836, Tampa

  Registry updated 2026-08-10

• NCT07180537

  Creating Health Course Study for People With Rheumatological Conditions and Mood Disorders

  Trial Treatment · Terry L. Wahls

  Univeristy of Iowa, Iowa City

  Registry updated 2026-08-10

• NCT06991114

  AlloNK®, an Allogeneic Non-genetically Modified, Cord Blood-derived NK Cell Therapy, in Combination With Rituximab, Studied in Relapsing Forms of B-cell Dependent Rheumatologic Diseases.

  Trial Treatment · Phase 2 · Artiva Biotherapeutics, Inc.

  Artiva Investigational Site Arlington, Arlington · Artiva Investigational Site Bellaire, Bellaire · Artiva Investigational Site Charleston, Charleston · Artiva Investigational Site Charlotte, Charlotte · Artiva Investigational Site Chula Vista, Chula Vista · Artiva Investigational Site Covina, Covina · Artiva Investigational Site Gainesville, Gainesville · Artiva Investigational Site Iowa Great Falls, Great Falls · Artiva Investigational Site Hixson, Hixson · Artiva Investigational Site Iowa, Iowa City · Artiva Investigational Site Irving, Irving · Artiva Investigational Site Jackson, Jackson · Artiva Investigational Site Jupiter, Jupiter · Artiva Investigational Site Katy, Katy · Artiva Investigational Site Los Alamitos, Los Alamitos · Artiva Investigational Site Los Angeles, Los Angeles · Artiva Investigational Site Mesquite, Mesquite · Artiva Investigational Site Miami, Miami · Artiva Investigational Site Norcross, Norcross · Artiva Investigational Site Phoenix, Phoenix · Artiva Investigational Site Plantation, Plantation · Artiva Investigational Site Red Oak, Red Oak · Artiva Investigational Site Roanoke, Roanoke · Artiva Investigational Site Santa Ana, Santa Ana · Artiva Investigational Site Statesville, Statesville · Artiva Investigational Site Tucson, Tucson · Artiva Investigational Site Tuscaloosa, Tuscaloosa · Artiva Investigational Site Tustin, Tustin · Artiva Investigational Site Willowbrook, Willowbrook · Artiva Investigational Site Woodland, Woodland

  Registry updated 2026-07-31

• NCT07732582

  Sjogren's Mini-Pill Oral and Gut Microbiome Study

  Trial Treatment · Tufts University

  Tufts University School of Dental Medicine, Boston

  Registry updated 2026-07-29

• NCT06747949

  A Long-term Extension Study of Dazodalibep in Participants With Sjögren's Syndrome (SS)

  Trial Treatment · Phase 3 · Amgen

  Arizona Arthritis & Rheumatology Associates - Avondale, Avondale · Accurate Clinical Management-Baytown, Baytown · Rheumatology and Pulmonary Clinic, Beckley · Tufts University School of Dental Medicine, Boston · Western Washington Medical Group, Bothell - Rheumatology, Bothell · Bradenton Research Center, Inc., Bradenton · Arthritis and Osteoporosis Consultants of The Carolinas - Charlotte - 1918 Randolph Rd, Charlotte · Clinical Research of West Florida, Inc. (Clearwater), Clearwater · Precision Comprehensive Clinical Research Solutions, Colleyville · Samy Metyas MD Inc, Covina · Duke Early Phase Clinical Research Unit - PPDS, Durham · Arizona Arthritis and Rheumatology Associates - Flagstaff - 399 S Malpais Ln, Flagstaff · Tekton Research, LLC - 2121 E Harmony Rd - PPDS, Fort Collins · Arizona Arthritis and Rheumatology Associates - Gilbert - 3645 S Rome St, Gilbert · Arizona Arthritis and Rheumatology Associates - Glendale - 5681 W Beverly Ln, Glendale · Kansas City Physician Partners-8350 N Saint Clair Ave, Kansas City · R & H Clinical Research-777 S Fry Rd, Katy · Houston Rheumatology & Arthritis Specialists - PLLC - PPDS, Katy · UCSD Altman Clinical and Translational Research Institute Building, La Jolla · Biopharma Informatic - Ridge Road - PPDS, McAllen · Arthritis & Osteoporosis Center of Southwest Ohio - Miamisburg, Miamisburg · Murfreesboro Medical Clinic Westlawn, Murfreesboro · Shores Rheumatology, Saint Clair Shores · Onsite Clinical Solutions, LLC - Salisbury, Salisbury · BayCare Medical Group Primary Care and Rheumatology - Tampa, Tampa · Advanced Rheumatology of Houston, The Woodlands · University of Toledo Medical Center, Toledo · DM Clinical Research - Migraine and COPD - PPDS, Tomball · Arizona Arthritis and Rheumatology Associates - Tucson - 2001 W Orange Grove Rd, Tucson · STAT Research-600 Aviator Ct, Vandalia · Arthritis, Rheumatic & Bone Disease Associates - Voorhees, Voorhees Township

  Registry updated 2026-04-28

• NCT05056012

  Penn SICCA Follow-up Study

  Research · University of Pennsylvania

  Scheie Eye Institute, Philadelphia

  Registry updated 2026-03-02

• NCT04402086

  Rheumatology Patient Registry and Biorepository

  Research · Yale University

  Yale New Haven Hospital, New Haven

  Registry updated 2026-02-13

• NCT03276923

  Maternal Autoimmune Disease Research Alliance (MADRA) Registry

  Research · Duke University

  Duke University, Durham

  Registry updated 2026-01-08

• NCT03047369

  The Myelin Disorders Biorepository Project

  Research · Children's Hospital of Philadelphia

  Akron Children's Hospital, Akron · Emory University, Children's Healthcare of Atlanta, Atlanta · Kennedy Krieger Institute, Baltimore · Massachusetts General Hospital (MGH), Boston · Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago · Nationwide Children's Hospital, Columbus · Baylor College of Medicine/ Texas Children's Hospital, Houston · UT Health Houston, Houston · Children's Hospital of Los Angeles, Los Angeles · University of Minnesota, Minneapolis · Children's Hospital of Orange County, Orange · Stanford University (Lucile Packard Children's Hospital), Palo Alto · University of Pennsylvania, Philadelphia · The Children's Hospital Of Philadelphia, Philadelphia · University of Pittsburgh Medical Center, Pittsburgh · Mayo Clinic, Rochester · University of California, Davis (UC Davis Health), Sacramento · University of Utah, Primary Children's Hospital, Salt Lake City · University of California, San Diego Rady Children's Hospital, San Diego · UCSF Benioff Children's Hospital, San Francisco · Seattle Children's Hospital, Seattle · Children's National Medical Center, Washington D.C. · Atrium Health Wake Forest Baptist, Winston-Salem

  Registry updated 2025-10-23

• NCT06339957

  Rheumatology Diet Study

  Research · University of Central Florida

  UCF Health Clinics, Orlando

  Registry updated 2024-12-06

All Sjögren's disease trials and the map

This page is not medical advice. Talk to your doctor before contacting a trial.

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