Systemic sclerosis (scleroderma): open trials in France

24 open trials have a site in France. Registry data; only the trial team decides who can take part.

NCT07888842
A Clinical Study on Systemic Sclerosis and the Validation of French-language Questionnaires Assessing Disability, Quality of Life, and Disease Status.
Research · Assistance Publique - Hôpitaux de Paris
Department of Internal Medicine - Cochin hospital, Paris
Registry updated 2026-10-22
2023-508432-53-00
SUBCUTANEOUS INJECTIONS OF AUTOLOGOUS CULTURED ADIPOSE-DERIVED STROMA/ STEM CELLS TO HEAL REFRACTORY ISCHEMIC DIGITAL ULCERS IN PATIENTS WITH SCLERODERMA
Trial Treatment · Phase 2 · Centre Hospitalier Universitaire De Toulouse
Centre Hospitalier Universitaire De Caen Normandie, Caen Cedex 9 · Centre Hospitalier Universitaire de Dijon, Dijon · Centre Hospitalier Universitaire Grenoble Alpes, Grenoble Cedex 9 · Centre Hospitalier Universitaire de Lille, Lille · Centre Hospitalier Universitaire De Montpellier, Montpellier Cedex 5 · Centre Hospitalier Universitaire de Nantes, Nantes · Centre Hospitalier Universitaire De Toulouse, Toulouse Cedex 9
Registry updated 2026-10-20
NCT07493395
Phase IIa Trial of Anti-CD19 CAR T-Cells in Systemic Sclerosis Resistant to Immunosuppressive Therapy
Trial Treatment · Phase 2 · University Hospital, Montpellier
CHRU Lille, Lille · Montpellier University Hospital, Montpellier · APHP Necker, Paris · CHU Rouen, Rouen
Registry updated 2026-10-14
NCT07873931
A Study of BMS-986553 in Participants With Refractory Autoimmune Diseases
Trial Treatment · Phase 1 · Bristol-Myers Squibb
Montpellier · Paris
Registry updated 2026-10-14
NCT06195072
A study of different investigational treatments in people with the interstitial lung disease that accompanies scleroderma (CONQUEST)
Trial Treatment · Phase 2 · Scleroderma Research Foundation
Assistance Publique Hopitaux De Paris, Bobigny · Hospices Civils de Lyon, Bron · Centre Hospitalier Universitaire Grenoble Alpes, Grenoble Cedex 9 · Centre Hospitalier Universitaire De Lille, Lille Cedex · Centre Hospitalier Universitaire De Bordeaux, Pessac Cedex · Centre Hospitalier Universitaire de Rennes, Rennes · Les Hopitaux Universitaires De Strasbourg, Strasbourg Cedex · Centre Hospitalier Universitaire de Toulouse, Toulouse
Registry updated 2026-10-08
NCT06470048
A randomized, double-blind, parallel group, placebo-controlled multicenter study to evaluate efficacy, safety and tolerability of ianalumab in participants with diffuse cutaneous systemic sclerosis
Trial Treatment · Phase 2 · Novartis Pharma AG
Centre Hospitalier Universitaire de Dijon, Dijon · Centre Hospitalier Le Mans, Le Mans Cedex 9 · Centre Hospitalier Universitaire de Lille, Lille · Centre Hospitalier Universitaire de Montpellier, Montpellier · Assistance Publique Hopitaux de Paris, Paris · Centre Hospitalier Universitaire de Rennes, Rennes · Les Hopitaux Universitaires De Strasbourg, Strasbourg Cedex 2 · Centre Hospitalier Universitaire De Toulouse, Toulouse Cedex 9
Registry updated 2026-10-06
NCT06954597
Safety and tolerability of TOP-N53 applied on digital ulcers in patients with systemic sclerosis
Trial Treatment · Phase 1/2 · Topadur Pharma Deutschland GmbH
Centre hospitalier Universitaire de Bordeaux, Bordeaux · Centre Hospitalier Universitaire Grenoble Alpes, Grenoble Cedex 9 · Centre Hospitalier Universitaire de Lille, Lille · Assistance Publique Hopitaux de Paris, Paris
Registry updated 2026-08-31
NCT07251179
Characterization of Autoreactive b Lymphocytes in Autoimmune Diseases and Immune Deficiencies
Research · University Hospital, Strasbourg, France
Hopitaux Universitaires de Strasbourg, Strasbourg
Registry updated 2026-08-20
NCT06182293
Periodontal Microbiota in Systemic Sclerosis
Trial Treatment · University Hospital, Strasbourg, France
Clinique Dentaire, Strasbourg
Registry updated 2026-08-19
NCT07335562
Study of BMS-986353, CD19-CAR T Cells, versus SoC in Participants with Active SSc (Breakfree-SSc)
Trial Treatment · Phase 3 · Celgene Corp.
Pellegrin Hospital, Bordeaux · Hospices Civils de Lyon, Bron · Assistance Publique Hopitaux de Paris, Paris · Centre Hospitalier Universitaire de Rennes, Rennes · Les Hopitaux Universitaires De Strasbourg, Strasbourg Cedex 2 · Centre Hospitalier Universitaire De Toulouse, Toulouse Cedex 9
Registry updated 2026-08-18
NCT06991114
AlloNK®, an Allogeneic Non-genetically Modified, Cord Blood-derived NK Cell Therapy, in Combination With Rituximab, Studied in Relapsing Forms of B-cell Dependent Rheumatologic Diseases.
Trial Treatment · Phase 2 · Artiva Biotherapeutics, Inc.
Artiva Investigational Site Marseille, Marseille · Artiva Investigational Site Montpellier, Montpellier · Artiva Investigational Site Toulouse, Toulouse
Registry updated 2026-07-31
NCT05098704
Preventive Effect of Clopidogrel on the Systemic Sclerosis Development Risk
Trial Treatment · Phase 2/3 · University Hospital, Bordeaux
CH de la Côte Basque - service de rhumatologie, Bayonne · CHU de Bordeaux - service de Médecine Interne et Maladies Infectieuses, Bordeaux · CHU de Bordeaux - service de rhumatologie, Bordeaux · CHU de Brest - Service de rhumatologie, Brest · CHU de Grenoble Alpes - service de médecine vasculaire, Grenoble · CH de Libourne - service de rhumatologie, Libourne · CH de Mont-de-Marsan - service de rhumatologie, Mont-de-Marsan · AP-HP - Hôpital Cochin - service de Médecine Interne, Paris · CH de Pau - service de médecine interne, Pau · Service de Médecine Interne et Immunologie Clinique, Rennes · CHU de Toulouse - service de médecine interne, Toulouse
Registry updated 2026-07-07
NCT06599411
Identification of Cutaneous and Blood Biomarkers Predictive of Response to Systemic Treatments During Chronic Inflammatory Skin Diseases
Research · Assistance Publique - Hôpitaux de Paris
Hopital Saint Louis, Paris
Registry updated 2026-06-12
NCT04804930
Trichoscopy and Systemic Scleroderma
Research · University Hospital, Lille
Hop Claude Huriez Chu Lille, Lille
Registry updated 2026-04-22
NCT05251415
Clinico-biological Collection to Investigate the Physiopathology of Systemic Autoimmune Diseases
Research · University Hospital, Toulouse
Purpan University Hospital, Toulouse
Registry updated 2026-03-17
NCT06387654
Clinico-biological Collection of Autoimmune, Dysimmune or Auto-inflammatory Dermatological Diseases
Research · University Hospital, Toulouse
University Hospital, Toulouse
Registry updated 2026-03-17
NCT07256418
Transcriptomic Study of Cutaneous Fibroblasts in Scleroderma
Research · Centre Hospitalier Universitaire Dijon
Chu Dijon Bourgogne, Dijon
Registry updated 2026-01-29
NCT07343115
Familial Systemic Scleroderma
Research · University Hospital, Strasbourg, France
Service de Médecine interne et Immunologie clinique - CHU de Strasbourg - France, Strasbourg
Registry updated 2026-01-15
NCT04356755
Subcutaneous Injections of ASC to Heal Digital Ulcers in Patients With Scleroderma.
Trial Treatment · Phase 2 · University Hospital, Toulouse
Grenoble Hospital, Grenoble · Lille Hopsital, Lille · Marseille Hospital, Marseille · Montpellier Hospital, Montpellier · Nantes Hospital, Nantes · Poitiers Hospital, Poitiers · CHU de Toulouse - Hôpital PURPAN-TSA, Toulouse
Registry updated 2025-12-31
NCT04265144
Cohort of Patients With Systemic Sclerosis Within the Framework of the RESO Reference Centre
Trial Treatment · University Hospital, Bordeaux
CHU de Bordeaux - service de rhumatologie, Bordeaux
Registry updated 2025-09-04
NCT07326033
Efficacy and safety of allogenic cultured Adipose-derived mesenchymal stromal cell injections on MoUth fibrosis and handicap in patients with Systemic sclEroderma
Trial Treatment · Phase 2 · Centre Hospitalier Universitaire De Toulouse
Centre hospitalier Universitaire de Bordeaux, Bordeaux · Centre Hospitalier Universitaire de Dijon, Dijon · Centre Hospitalier Universitaire De Montpellier, Montpellier Cedex 5 · Centre Hospitalier Universitaire de Nantes, Nantes · Centre Hospitalier Universitaire De Toulouse, Toulouse Cedex 9
Registry updated 2025-08-01
NCT06680310
Ultrasonic COmparison of Salivary Glands in Autoimmune Diseases (COUGAR)
Research · University Hospital, Brest
Chu Brest, Brest
Registry updated 2024-11-08
NCT06593041
ROLE of PLATELETS in the PATHOPHYSIOLOGY of SYSTEMIC LUPUS
Research · University Hospital, Strasbourg, France
Hopitaux Universitaires de Strasbourg - Hopital de Hautepierre - Service de rhumatologie, Strasbourg
Registry updated 2024-09-19
NCT04917705
Search for Diagnostic and Prognostic Biomarkers in Systemic Sclerosis and Inflammatory Myopathies
Trial Treatment · University Hospital, Strasbourg, France
University Hospital of Hautepierre, Strasbourg
Registry updated 2021-12-15

All Systemic sclerosis (scleroderma) trials and the map

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