Systemic sclerosis (scleroderma) trials in France

In France 57 Also abroad 213

57 trials · From ClinicalTrials.gov and EU CTIS (euclinicaltrials.eu), checked 11 November 2026. Ask the study team whether a trial fits you.

Phase 2Taking people
AlloNK®, an Allogeneic Non-genetically Modified, Cord Blood-derived NK Cell Therapy, in Combination With Rituximab, Studied in Relapsing Forms of B-cell Dependent Rheumatologic Diseases.
Where
Marseille, Montpellier, Toulouse Cedex 9
Age
18 years and over
People
90 worldwide
Run by
Artiva Biotherapeutics, Inc.
See details and how to joinNCT06991114 · EU 2025-520461-41-00
No phaseTaking people
Objective Assessment of Skin Damage Using ADHELASKIN in Patients With Systemic Sclerosis
Where
Saint-Priest-en-Jarez
Age
18 years and over
People
100
Run by
Centre Hospitalier Universitaire de Saint Etienne
See details and how to joinNCT07543679
Phase 2Not yet taking people in France
OBINUSS - A trial to evaluate a new drug in systemic sclerosis: obinutuzumab.
Where
Amiens Cedex 1, Angers, Angouleme Cedex 9, Avignon, Bobigny Cedex, Bordeaux, Caen, Clermont-Ferrand, Creteil Cedex, Dax, Dijon, Le Kremlin-Bicetre, Le Mans Cedex 9, Lille, Limoges, Marseille, Montivilliers, Nantes, Nice, Niort, Orleans Cedex 2, Paris, Paris Cedex 10, Perpignan Cedex, Reims Cedex, Rennes, Rouen, Saint-Priest-en-Jarez, Strasbourg Cedex, Strasbourg Cedex 2, Toulon Cedex 9, Toulouse, Tours, Valenciennes, Vandoeuvre Les Nancy, Vantoux
Age
18 years and over
People
74
Run by
Assistance Publique Hopitaux De Paris
See details and how to join2025-524003-68-00 · EU 2025-524003-68-00
Phase 1Taking people
A Study of Healthy Donor CD19-targeted Allogeneic CAR T Cells in Participants With Severe, Refractory Autoimmune Diseases
Where
Lille Cedex, Strasbourg Cedex 2
Age
18 years and over
People
125 worldwide
Run by
Juno Therapeutics, Inc., a Bristol-Myers Squibb Company
See details and how to joinNCT07115745 · EU 2024-517681-41-00
Phase 2/3Taking people
Preventive Effect of Clopidogrel on the Systemic Sclerosis Development Risk
Where
Bayonne, Bordeaux, Brest, Grenoble, Libourne, Mont-de-Marsan, Paris, Pau, Rennes, Toulouse
Age
18 years to 85 years
People
90
Run by
University Hospital, Bordeaux
See details and how to joinNCT05098704 · EU 2024-511005-39-00
No phaseTaking people
Immun4Cure Cohort of Autoimmune Diseases
Where
Montpellier
Age
18 years and over
People
500
Run by
University Hospital, Montpellier
See details and how to joinNCT07515638
No phaseTaking people
Prospective Cohort of Patients With Systemic Sclerosis at Brest University Hospital With Biobanking
Where
Brest
Age
18 years and over
People
100
Run by
University Hospital, Brest
See details and how to joinNCT05532865
Phase 3Taking people
Evaluation of Efficacy and Safety of Rituximab and Mycophenolate Mofetil Combination in Patients With Interstitial Lung Disease Related to Systemic Sclerosis
Where
Tours
Age
18 years to 100 years
People
102
Run by
University Hospital, Tours
See details and how to joinNCT06549231
No phaseTaking people
Identification of Cutaneous and Blood Biomarkers Predictive of Response to Systemic Treatments During Chronic Inflammatory Skin Diseases
Where
Paris
Age
18 years and over
People
830
Run by
Assistance Publique - Hôpitaux de Paris
See details and how to joinNCT06599411
No phaseTaking people
Efficacy of a Personalized Rehabilitation Program of Facial Involvement in Systemic Sclerosis
Where
Strasbourg
Age
18 years and over
People
60
Run by
University Hospital, Strasbourg, France
See details and how to joinNCT05177380
No phaseTaking people
EACVI Study on Multimodality Cardiovascular Imaging of Inflammatory Cardiovascular Diseases
Where
Paris
Age
18 years and over
People
5,000
Run by
Assistance Publique - Hôpitaux de Paris
See details and how to joinNCT07077304
Phase 1Taking people
A Phase 1 Study of FT819 in B-cell Mediated Autoimmune Disease
Where
Paris
Age
12 years to 70 years
People
244 worldwide
Run by
Fate Therapeutics
See details and how to joinNCT06308978
No phaseTaking people
Deployment o the Multidisciplinary Prospective Cohort Imminent
Where
Lille
Age
18 years and over
People
2,200
Run by
University Hospital, Lille
See details and how to joinNCT04334031
No phaseTaking people
Trichoscopy and Systemic Scleroderma
Where
Lille
Age
18 years and over
People
200
Run by
University Hospital, Lille
See details and how to joinNCT04804930
Phase 2Taking people
Phase I/II randomized clinical trial of allogeneic adipose tissue-derived mesenchymal stromal cells systemic infusion in severe systemic sclerosis MSC-AT-SSc
Where
Paris, Rennes, Toulouse Cedex 9
Age
18 years and over
People
18
Run by
Assistance Publique Hopitaux De Paris
See details and how to join2023-505977-34-00 · EU 2023-505977-34-00
Phase 2Taking people
A Study of Nemolizumab for the Treatment of Adults With Systemic Sclerosis
Where
Angers, Le Mans Cedex 9, Lille, Nice, Rennes, Saint-Priest-en-Jarez, Toulon Cedex 9, Toulouse Cedex 9, Tours
Age
18 years and over
People
162 worldwide
Run by
Galderma R&D
See details and how to joinNCT07047690 · EU 2025-522294-11-00
No phaseTaking people
Clinico-biological Collection to Investigate the Physiopathology of Systemic Autoimmune Diseases
Where
Toulouse
Age
6 years to 99 years
People
3,000
Run by
University Hospital, Toulouse
See details and how to joinNCT05251415
No phaseTaking people
Clinico-biological Collection of Autoimmune, Dysimmune or Auto-inflammatory Dermatological Diseases
Where
Toulouse
Age
6 years to 99 years
People
800
Run by
University Hospital, Toulouse
See details and how to joinNCT06387654
No phaseTaking people
Transcriptomic Study of Cutaneous Fibroblasts in Scleroderma
Where
Dijon
Age
18 years and over
People
60
Run by
Centre Hospitalier Universitaire Dijon
See details and how to joinNCT07256418
No phaseTaking people
Familial Systemic Scleroderma
Where
Strasbourg
Age
18 years and over
People
20
Run by
University Hospital, Strasbourg, France
See details and how to joinNCT07343115
Phase 2Not yet taking people in France
Efficacy and Safety of Allogenic Cultured Adipose-derived Mesenchymal Stromal Cell Injections on MoUth Fibrosis and Handicap in Patients With Systemic sclEroderma
Where
Bordeaux, Dijon, Montpellier Cedex 5, Nantes, Toulouse Cedex 9
Age
18 years and over
People
50
Run by
University Hospital, Toulouse
See details and how to joinNCT07326033 · EU 2024-518516-39-00
Phase 2Taking people
Subcutaneous Injections of ASC to Heal Digital Ulcers in Patients With Scleroderma.
Where
Grenoble, Lille, Marseille, Montpellier, Nantes, Poitiers, Toulouse
Age
18 years and over
People
32
Run by
University Hospital, Toulouse
See details and how to joinNCT04356755
No phaseTaking people
Analysis of Dermal Fibroblasts and Immune Cells During Systemic Sclerosis
Where
Lille
Age
18 years and over
People
40
Run by
University Hospital, Lille
See details and how to joinNCT05273138
Phase 2Taking people
Safety and Efficacy of Itacitinib in Adults With Systemic Sclerosis
Where
Amiens, Angers, Besancon Cedex, Bobigny Cedex, Bordeaux, Boulogne-Billancourt, Brest, Caen Cedex 9, Clermont Ferrand Cedex 1, Creteil, Dax, Dijon, La Tronche, Le Mans Cedex 9, Lille, Limoges Cedex 1, Marseille, Montpellier Cedex 5, Nantes, Nice, Paris, Pierre-Bénite, Poitiers, Pringy Cedex, Quimper Cedex, Reims Cedex, Rennes, Rouen Cedex, Saint-Priest-en-Jarez, Strasbourg Cedex, Toulouse Cedex 9, Tours, Valenciennes, Vandoeuvre Les Nancy Cedex, Vantoux
Age
18 years and over
People
74
Run by
Assistance Publique - Hôpitaux de Paris
See details and how to joinNCT04789850 · EU 2024-513648-27-00
No phaseTaking people
Longitudinal Characterization of Microbial Signature in Systemic Sclerosis Patients
Where
Marseille
Age
18 years and over
People
60
Run by
Hôpital Européen Marseille
See details and how to joinNCT04132206