Systemic sclerosis (scleroderma) trials in Italy

In Italy 14 Also abroad 213

14 trials · From ClinicalTrials.gov and EU CTIS (euclinicaltrials.eu), checked 11 November 2026. Ask the study team whether a trial fits you.

Phase 3Taking people
Rollover Study for Participants Who Have Completed a Previous Clinical Study With Anifrolumab (Saphnelo) and Clinically Benefited From Continued Treatment
Where
Brescia, Catania, Cona, Florence, Milan, Naples, Pavia, Roma
Age
5 years to 80 years
People
1,072 worldwide
Run by
AstraZeneca
See details and how to joinNCT07691970
Phase 3Not yet taking people in Italy
Rollover Study for Participants Who Have Completed a Previous Clinical Study with Anifrolumab (Saphnelo) and Clinically Beneﬁted from Continued Treatment.
Where
Brescia, Ferrara, Florence, Milan, Rome
People
340 worldwide
Run by
AstraZeneca AB
See details and how to join2026-526419-13-00 · EU 2026-526419-13-00
Phase 2Taking people
Evaluation of MTX-474 in Participants with Diffuse Cutaneous Systemic Sclerosis (dcSSc)
Where
Ancona, Catania, Genova, Milano, Modena, Rome
Age
18 years and over
People
36 worldwide
Run by
Mediar Therapeutics Inc.
See details and how to join2025-523288-39-00 · EU 2025-523288-39-00
Phase 3Taking people
A Study to Test Whether Nerandomilast Helps People With Systemic Sclerosis
Where
Ancona, Bari, Florence, Milan, Modena, Naples, Rome
Age
18 years and over
People
448 worldwide
Run by
Boehringer Ingelheim
See details and how to joinNCT07497087 · EU 2025-523884-39-00
Phase 2Taking people
EncompaSSc: Evaluation of MTX-474 in Participants With Diffuse Cutaneous Systemic Sclerosis (dcSSc)
Where
Ancona, Catania, Genoa, Milan, Modena, Roma
Age
18 years and over
People
85 worldwide
Run by
Mediar Therapeutics
See details and how to joinNCT07287670
Phase 1Not yet taking people in Italy
Basket trial for B-cEll driven severe auToimmunE and aLoimmune diseases (chronic Graft vErsUs host diseaSe) treated with anti-CD19 CAR T-cell thErapy
Where
Bologna, Rome
People
24
Run by
Azienda Ospedaliero-Universitaria Di Bologna IRCCS Istituto Di Ricerca E Di Cura A Carattere Scientifico
See details and how to join2025-522821-37-00 · EU 2025-522821-37-00
Phase 3Not yet taking people in Italy
A Study to Compare the Efficacy and Safety of BMS-986353 (Zolacabtagene- Autoleucel / Zola-cel), CD19-CAR T Cells, Versus Standard of Care in Participants With Active Systemic Sclerosis
Where
Milan, Pisa, Rome
Age
16 years and over
People
92 worldwide
Run by
Juno Therapeutics, Inc., a Bristol-Myers Squibb Company
See details and how to joinNCT07335562 · EU 2025-524337-11-00
Phase 2/3Taking people
A Study of the Efficacy and Safety of Belimumab in Adults With Systemic Sclerosis Associated Interstitial Lung Disease
Where
Ancona, Bari, Catania, Ferrara, Florence, Milan, Modena, Naples, Orbassano, Padova, Pavia, Rome, Verona
Age
18 years and over
People
300 worldwide
Run by
GlaxoSmithKline
See details and how to joinNCT05878717 · EU 2023-503219-14-01
Phase 2Taking people
Platform Clinical Study for Conquering Scleroderma
Where
Ancona, Brescia, Florence, Milan, Modena, Rome
Age
18 years and over
People
400 worldwide
Run by
Scleroderma Research Foundation, Inc.
See details and how to joinNCT06195072 · EU 2023-507129-40-00
Phase 2Taking people
AlloNK®, an Allogeneic Non-genetically Modified, Cord Blood-derived NK Cell Therapy, in Combination With Rituximab, Studied in Relapsing Forms of B-cell Dependent Rheumatologic Diseases.
Where
Brescia, Milan, Rome
Age
18 years and over
People
90 worldwide
Run by
Artiva Biotherapeutics, Inc.
See details and how to joinNCT06991114 · EU 2025-520461-41-00
No phaseNot yet taking people in Italy
TL1A Inhibition in Systemic Sclerosis-Related Skin Fibrosis and Immunological Alterations: A Proof-of-Concept In Vitro Study (FIBROSTOP)
Where
Rome
Age
18 years and over
People
20
Run by
Fondazione Policlinico Universitario Campus Bio-Medico
See details and how to joinNCT07642297
Phase 2Taking people
A Study of Nemolizumab for the Treatment of Adults With Systemic Sclerosis
Where
Legnano, Reggio Emilia, Rome
Age
18 years and over
People
162 worldwide
Run by
Galderma R&D
See details and how to joinNCT07047690 · EU 2025-522294-11-00
No phaseTaking people
EFESO: Study on Juvenile Onset Eosinophilic Fasciitis
Where
Florence, Genova, Udine
Age
Up to 18 years
People
20 worldwide
Run by
Meyer Children's Hospital IRCCS
See details and how to joinNCT07348263
No phaseEnrolling by invitation
Chest CT Biomarkers as Prognostic Predictors in SSc-ILD
Where
Ancona, Sassari, Siena
Age
18 years to 99 years
People
1,000 worldwide
Run by
Royal Brompton & Harefield NHS Foundation Trust
See details and how to joinNCT06472362