Systemic sclerosis (scleroderma) trials in Netherlands

In Netherlands 13 Also abroad 213

13 trials · From ClinicalTrials.gov and EU CTIS (euclinicaltrials.eu), checked 11 November 2026. Ask the study team whether a trial fits you.

Phase 3Taking people
Rollover Study for Participants Who Have Completed a Previous Clinical Study With Anifrolumab (Saphnelo) and Clinically Benefited From Continued Treatment
Where
Rotterdam
Age
5 years to 80 years
People
1,072 worldwide
Run by
AstraZeneca
See details and how to joinNCT07691970
Phase 3Not yet taking people in Netherlands
Rollover Study for Participants Who Have Completed a Previous Clinical Study with Anifrolumab (Saphnelo) and Clinically Beneﬁted from Continued Treatment.
Where
Rotterdam
People
340 worldwide
Run by
AstraZeneca AB
See details and how to join2026-526419-13-00 · EU 2026-526419-13-00
Phase 2Taking people
Evaluation of MTX-474 in Participants with Diffuse Cutaneous Systemic Sclerosis (dcSSc)
Where
Groningen
Age
18 years and over
People
36 worldwide
Run by
Mediar Therapeutics Inc.
See details and how to join2025-523288-39-00 · EU 2025-523288-39-00
Phase 3Taking people
A Study to Test Whether Nerandomilast Helps People With Systemic Sclerosis
Where
Groningen, Nijmegen, Rotterdam
Age
18 years and over
People
448 worldwide
Run by
Boehringer Ingelheim
See details and how to joinNCT07497087 · EU 2025-523884-39-00
Phase 1Not yet taking people in Netherlands
A Study of BMS-986553 in Participants With Refractory Autoimmune Diseases
Where
Amsterdam, Leiden
Age
18 years and over
People
60 worldwide
Run by
Bristol-Myers Squibb
See details and how to joinNCT07873931
Phase 2Taking people
EncompaSSc: Evaluation of MTX-474 in Participants With Diffuse Cutaneous Systemic Sclerosis (dcSSc)
Where
Groningen
Age
18 years and over
People
85 worldwide
Run by
Mediar Therapeutics
See details and how to joinNCT07287670
Phase 1/2Taking people
T-Guard in dcSSc
Where
Nijmegen
Age
18 years and over
People
13
Run by
Philikos B.V.
See details and how to join2024-517283-28-00 · EU 2024-517283-28-00
Phase 2Taking people
Platform Clinical Study for Conquering Scleroderma
Where
Groningen, Leiden, Utrecht
Age
18 years and over
People
400 worldwide
Run by
Scleroderma Research Foundation, Inc.
See details and how to joinNCT06195072 · EU 2023-507129-40-00
Phase 2Taking people
Fibroblast markers to tackle fibrosis in immune-mediated inflammatory diseases
Where
Amsterdam
Age
18 years and over
People
60
Run by
Amsterdam UMC Stichting
See details and how to join2025-522834-30-01 · EU 2025-522834-30-01
Phase 4Taking people
Efficacy and safety of repeated Rituximab infusions in patients with Active Systemic SClerosis and background medication, a one year randomized blinded placebo-controlled trial, the RASSc study.
Where
Leiden, Nijmegen, Utrecht
Age
18 years and over
People
105
Run by
Radboud universitair medisch centrum Stichting
See details and how to join2025-520483-17-01 · EU 2025-520483-17-01
Phase 1/2Taking people
Mesenchymal Stromal Cells as Treatment for Digital Ulcers in Systemic Sclerosis
Where
Utrecht
Age
18 years and over
People
20
Run by
UMC Utrecht
See details and how to joinNCT03211793 · EU 2024-515387-31-00
Phase 4Not yet taking people in Netherlands
Investigating the (autoreactive) B cell compartment in antibody-mediated autoimmune diseases in comparison with the recall Tetanus Toxoid response
Where
Leiden
Age
18 years and over
People
96
Run by
Leids Universitair Medisch Centrum (LUMC)
See details and how to join2024-515312-50-00 · EU 2024-515312-50-00
No phaseTaking people
Hand Function Impairment in Systemic Sclerosis: Outcomes, Mechanisms and Experience (HANDSOME)
Where
Utrecht
Age
18 years and over
People
300
Run by
UMC Utrecht
See details and how to joinNCT06133244