Ulcerative colitis trials in France

In France 52 Also abroad 382

52 trials · From ClinicalTrials.gov and EU CTIS (euclinicaltrials.eu), checked 10 November 2026. Ask the study team whether a trial fits you.

Phase 2Taking people
An Adaptive, Dose-Ranging, Phase 2 Study of Eltrekibart Given Alone or in Combination with Mirikizumab for the Treatment of Adult Patients with Moderately to Severely Active Ulcerative Colitis
Where
Creteil Cedex, Grenoble Cedex 9, La Roche Sur Yon Cedex 9, Nice, Pierre-Bénite, Rouen Cedex
Age
18 years and over
People
593 worldwide
Run by
Eli Lilly & Co.
See details and how to join2023-507853-13-00 · EU 2023-507853-13-00
Phase 2Enrolling by invitation
Long-term Safety and Efficacy of Multiple Long-acting Antibodies Alone and in Combinations for IBD
Where
Marseille, Nantes, Nice, Pierre-Bénite, Saint-Priest-en-Jarez
Age
18 years and over
People
645 worldwide
Run by
Spyre Therapeutics, Inc.
See details and how to joinNCT07652294 · EU 2025-524640-35-00
No phaseTaking people
Ibd CAncer and seRious Infections in France (I-CARE 2)
Where
Amiens, Paris
Age
18 years to 75 years
People
6,000
Run by
Groupe d'Etude Therapeutique des Affections Inflammatoires Digestives
See details and how to joinNCT06089590
No phaseTaking people
Characterization of Colorectal Dysplasic Lesions and Stratification of Their Evolving Risk in Inflammatory Bowel Disease Patients: a Prospective, Observational and Multicenter Study
Where
Amiens, Besançon
Age
18 years and over
People
800
Run by
Groupe d'Etude Therapeutique des Affections Inflammatoires Digestives
See details and how to joinNCT07719426
Phase 3Taking people
Mirikizumab Administered at the Same Time as Tirzepatide in Adult Participants With Moderately to Severely Active Ulcerative Colitis and Obesity or Overweight: Phase 3b Study
Where
Échirolles, La Roche-sur-Yon, Le Kremlin-Bicêtre, Montpellier, Neuilly-sur-Seine, Nice, Paris, Saint-Priest-en-Jarez, Toulouse
Age
18 years to 70 years
People
350 worldwide
Run by
Eli Lilly and Company
See details and how to joinNCT06937086 · EU 2024-520209-38-00
Phase 2Taking people
LY4268989 in Adults With Moderately to Severely Active Ulcerative Colitis
Where
Neuilly-sur-Seine, Pessac, Pierre-Bénite, Toulouse
Age
18 years to 80 years
People
1,431 worldwide
Run by
Eli Lilly and Company
See details and how to joinNCT07415044
Phase 3Taking people
Extension Study of Long-term Safety and Efficacy of Tulisokibart in Participants With Crohn's Disease or Ulcerative Colitis (MK-7240-011)
Where
Lille Cedex, Neuilly-Sur-Seine, Nice, Vandoeuvre Les Nancy
Age
18 years and over
People
1,380 worldwide
Run by
Merck Sharp & Dohme LLC
See details and how to joinNCT06651281 · EU 2024-513533-20-00
Phase 3Taking people
A Long-term Extension (LTE) Study of Guselkumab in Pediatric Participants
Where
Lille Cedex
Age
3 years to 64 years
People
196 worldwide
Run by
Janssen Research & Development, LLC
See details and how to joinNCT06663332 · EU 2023-509560-16-00
Phase 3Taking people
A Study of JNJ-78934804 in Participants With Moderately to Severely Active Ulcerative Colitis
Where
Amiens Cedex 1, Besancon Cedex, Clichy, Creteil, Le Kremlin-Bicetre, Lille, Montpellier Cedex 5, Nancy Cedex, Nantes, Neuilly-Sur-Seine, Nice, Pessac, Pierre-Bénite, Reims Cedex, Saint-Priest-en-Jarez, Toulouse Cedex 9
Age
18 years and over
People
644 worldwide
Run by
Janssen Research & Development, LLC
See details and how to joinNCT07577856 · EU 2026-525923-26-00
Phase 4Not yet taking people in France
Efficacy of Upadacitinib Re-induction Therapy in Patients With Ulcerative Colitis Who Lost Response to 30 mg Maintenance Dose
Where
Amiens Cedex 1, Bayonne, Besançon, Chambray Les Tours, Clermont-Ferrand, Clichy, Colmar Cedex, Colombes, Grenoble Cedex 9, Lille Cedex, Marseille, Montpellier Cedex 5, Neuilly-Sur-Seine, Nice, Nimes Cedex 9, Paris, Pessac Cedex, Pierre-Bénite, Reims Cedex, Rennes Cedex 9, Saint-Priest-en-Jarez, Toulouse, Toulouse Cedex 9
Age
18 years to 64 years
People
100
Run by
Groupe d'Etude Therapeutique des Affections Inflammatoires Digestives
See details and how to joinNCT07700446 · EU 2026-526174-16-00
Phase 2Taking people
A Study to Evaluate the Efficacy, Safety, and Pharmacokinetics (PK) of RO7837195 in Participants With Moderately to Severely Active Ulcerative Colitis (UC)
Where
Clermont-Ferrand, Neuilly-Sur-Seine, Pierre-Bénite, Saint-Priest-en-Jarez
Age
18 years and over
People
224 worldwide
Run by
Genentech, Inc.
See details and how to joinNCT06979336 · EU 2025-520690-39-00
Phase 2Taking people
A Study of Long-acting Antibodies Alone and in Combinations for Moderate to Severe Ulcerative Colitis
Where
Marseille, Nantes, Nice, Pierre-Bénite, Saint-Priest-en-Jarez
Age
18 years to 75 years
People
645 worldwide
Run by
Spyre Therapeutics, Inc.
See details and how to joinNCT07012395 · EU 2025-521242-26-00
Phase 3Taking people
A study evaluating the effects of filgotinib in children and teenagers with ulcerative colitis
Where
Bron, Dijon, Lille Cedex, Montpellier Cedex 05, Rennes, Tours
Age
Up to 17 years
People
68 worldwide
Run by
Alfasigma S.p.A.
See details and how to join2024-511458-32-00 · EU 2024-511458-32-00
Phase 2Taking people
A Study of How the Medicine Called "Etrasimod" Works in Children With the Gut Disease Called Ulcerative Colitis
Where
Bron, Paris
Age
2 years to 11 years
People
24 worldwide
Run by
Pfizer
See details and how to joinNCT07470879 · EU 2025-523100-77-00
Phase 3Taking people
An Induction Study to Investigate the Efficacy and Safety of Duvakitug in Participants With Moderately to Severely Active Ulcerative Colitis
Where
Lille, Nice, Vandœuvre-lès-Nancy
Age
16 years to 80 years
People
980 worldwide
Run by
Sanofi
See details and how to joinNCT07184996
Phase 2Taking people
A Study to Evaluate Efficacy and Safety of MK-8690 in Participants With Moderately to Severely Active Ulcerative Colitis (MK-8690-002)
Where
Lens, Nantes
Age
18 years to 75 years
People
100 worldwide
Run by
Merck Sharp & Dohme LLC
See details and how to joinNCT07463183 · EU 2025-523479-49-00
Phase 2Taking people
A study of LY4268989 in participants with Moderately to Severely Active Ulcerative Colitis (EMERALD-3)
Where
Neuilly-Sur-Seine, Pessac, Pierre-Bénite, Toulouse Cedex 9
Age
18 years and over
People
104 worldwide
Run by
Eli Lilly & Co.
See details and how to join2025-524404-29-00 · EU 2025-524404-29-00
Phase 4Not yet taking people in France
FirST Lines of Biologics in pAtients With ulceRaTivE Colitis: a Randomised Controlled Trial
Where
Amiens, Avignon, Bayonne, Besançon, Chambray Les Tours, Clermont Ferrand Cedex 1, Clichy, Colmar Cedex, Créteil, Creteil Cedex, Grenoble Cedex 9, La Roche Sur Yon Cedex 9, Le Kremlin Bicetre Cedex, Lille, Limoges, Lyon Cedex 04, Marseille, Montpellier Cedex 5, Nantes, Nice, Nimes Cedex 9, Paris, Paris Cedex 12, Paris Cedex 18, Pessac Cedex, Poitiers, Rennes Cedex 9, Saint-Malo Cedex, Saint-Priest-en-Jarez, Toulon, Toulouse Cedex 9, Valence, Vandoeuvre Les Nancy
Age
18 years to 65 years
People
240
Run by
University Hospital, Clermont-Ferrand
See details and how to joinNCT07576452 · EU 2024-514964-24-00
Phase 2Taking people
A Trial to Investigate PALI-2108 Versus Placebo in Participants With Moderately to Severely Active Ulcerative Colitis
Where
Amiens, Clermont-Ferrand, Neuilly-sur-Seine, Nice, Saint-Priest-en-Jarez
Age
18 years to 75 years
People
204 worldwide
Run by
Palisade Bio
See details and how to joinNCT07845487
Phase 2/3Taking people
A Study Investigating Oral Ozanimod (RPC1063) in Pediatric Participants With Moderate to Severe Active Ulcerative Colitis
Where
Bron, Caen, Paris, Toulouse
Age
2 years to 17 years
People
120 worldwide
Run by
Bristol-Myers Squibb
See details and how to joinNCT05076175
Phase 3Taking people
A Study Evaluating the Effects of Filgotinib in Children and Teenagers With Ulcerative Colitis
Where
Bron, Dijon, Lille, Montpellier, Rennes, Tours
Age
8 years to 18 years
People
80 worldwide
Run by
Alfasigma S.p.A.
See details and how to joinNCT06865417
Phase 3Taking people
A Maintenance Study to Investigate the Efficacy and Safety of Duvakitug in Participants With Moderately to Severely Active Ulcerative Colitis
Where
Amiens, Besançon, Créteil, La Tronche, Lille, Marseille, Nantes, Nice, Paris, Saint-Priest-en-Jarez, Toulouse, Vandœuvre-lès-Nancy
Age
16 years to 80 years
People
751 worldwide
Run by
Sanofi
See details and how to joinNCT07185009
No phaseTaking people
Study of Tissue Repair in Inflammatory Bowel Disease Exploiting Organoid Technology
Where
Marseille
Age
18 years and over
People
60
Run by
Assistance Publique Hopitaux De Marseille
See details and how to joinNCT06805890
No phaseNot yet taking people in France
Adapted Physical Activity for Persistent Fatigue in Patients With Inflammatory Bowel Disease in Remission
Where
Grenoble
Age
18 years and over
People
120
Run by
University Hospital, Grenoble
See details and how to joinNCT07804511
Phase 2/3Taking people
A phase 2/3, multicenter, randomized, double-blind study to evaluate the efficacy, safety, pharmacokinetics and pharmacodynamics of oral ozanimod (RPC1063) in pediatric subjects with moderately to severely active ulcerative colitis with an inadequate response to conventional therapy.
Where
Bron, Caen Cedex 9, Paris, Toulouse Cedex 9
Age
Up to 17 years
People
62 worldwide
Run by
Bristol-Myers Squibb Services Unlimited Company
See details and how to join2023-509248-86-00 · EU 2023-509248-86-00