Ulcerative colitis trials in United States

In United States 112 Also abroad 384

86 of 112 trials · From ClinicalTrials.gov, checked 13 November 2026. Ask the study team whether a trial fits you.

Phase 1Taking people
Testing an Immunotherapy Anti-cancer Drug, Nivolumab, for Advanced Cancers in Patients With Autoimmune Disorders, AIM-NIVO
Where
Atlanta, Baltimore, Bethesda, Birmingham, Boston, Chicago, City of Saint Peters, Columbus, Creve Coeur, Dallas, Detroit, Fairway, Fort Worth, Hays, Houston, Kansas City, Lawrence, Lee's Summit, Lexington, Mineola, New Brunswick, New Haven, New York, North Kansas City, Olathe, Overland Park, Palo Alto, Philadelphia, Pittsburg, Pittsburgh, Richardson, Richmond, Sacramento, Salina, Salt Lake City, St Louis, Topeka, Washington D.C., Westwood
Age
18 years and over
People
300 worldwide
Run by
National Cancer Institute (NCI)
See details and how to joinNCT03816345
Phase 2Taking people
A Study to Test Whether BI 3032950 Helps People With Ulcerative Colitis
Where
Cedar Park, Charlotte, Colorado Springs, Gurnee, Houston, Kansas City, Kissimmee, Lakewood Rch, Miami, New York, Scottsdale, Seattle, Tacoma, Tyler
Age
18 years to 80 years
People
80 worldwide
Run by
Boehringer Ingelheim
See details and how to joinNCT06636656 · EU 2023-509544-10-00
Phase 2Taking people
A Study to Evaluate Efficacy and Safety of MK-8690 in Participants With Moderately to Severely Active Ulcerative Colitis (MK-8690-002)
Where
Anaheim, Colorado Springs, Coronado, Englewood, Inverness, Kansas City, Liberty, Macon, Miami, New Orleans, Orlando
Age
18 years to 75 years
People
100 worldwide
Run by
Merck Sharp & Dohme LLC
See details and how to joinNCT07463183 · EU 2025-523479-49-00
Phase 2Taking people
A Trial to Investigate PALI-2108 Versus Placebo in Participants With Moderately to Severely Active Ulcerative Colitis
Where
Albany, Baton Rouge, Bellevue, Bristol, Brunswick, Clifton, Cordova, Dayton, Des Plaines, Garland, Georgetown, Glenview, Gurnee, Houston, Lubbock, Mandeville, Mansfield, Milwaukee, Orlando, Providence, Richmond, Rochester, San Diego, Southlake, St Louis, Sun City, Tacoma, Tupelo, Tyler, Westlake
Age
18 years to 75 years
People
204 worldwide
Run by
Palisade Bio
See details and how to joinNCT07845487
Phase 3Taking people
Extension Study of Long-term Safety and Efficacy of Tulisokibart in Participants With Crohn's Disease or Ulcerative Colitis (MK-7240-011)
Where
Bristol, Charlottesville, Garland, Liberty, Lubbock, New York, San Antonio, Southlake, Tacoma, Tyler, Ypsilanti
Age
18 years and over
People
1,380 worldwide
Run by
Merck Sharp & Dohme LLC
See details and how to joinNCT06651281 · EU 2024-513533-20-00
No phaseTaking people
Microbiome-targeted Diet Therapy in Ulcerative Colitis
Where
Minneapolis
Age
18 years and over
People
40
Run by
University of Minnesota
See details and how to joinNCT07520461
Phase 2Enrolling by invitation
Long-term Safety and Efficacy of Multiple Long-acting Antibodies Alone and in Combinations for IBD
Where
Kissimmee, La Jolla, Lancaster, Marrero, Providence, Rochester, San Antonio, Southlake, Tacoma
Age
18 years and over
People
645 worldwide
Run by
Spyre Therapeutics, Inc.
See details and how to joinNCT07652294 · EU 2025-524640-35-00
Phase 3Taking people
A Study to Evaluate the Pharmacokinetics, Safety and Efficacy of Afimkibart (RO7790121) in Children With Moderately to Severely Active Ulcerative Colitis
Where
Atlanta, Aurora, Cleveland, Harlingen, Hartford, Lake Success, New York, Pittsburgh, St Louis, Tampa
Age
2 years to 17 years
People
100 worldwide
Run by
Hoffmann-La Roche
See details and how to joinNCT07158242 · EU 2025-522518-22-01
Phase 3Taking people
Mirikizumab Administered at the Same Time as Tirzepatide in Adult Participants With Moderately to Severely Active Ulcerative Colitis and Obesity or Overweight: Phase 3b Study
Where
Anaheim, Beverly Hills, Chevy Chase, Chicago, Cordova, Dothan, Fayetteville, Greenville, Idaho Falls, Indianapolis, Lebanon, Los Alamitos, Louisville, Miami, Milwaukee, New Albany, New Bedford, New Iberia, New York, Northridge, Orlando, Pensacola, Philadelphia, Providence, Roanoke, San Antonio, Shreveport, St Louis, Sunrise, Tacoma, Tyler, Westlake, Yonkers
Age
18 years to 70 years
People
350 worldwide
Run by
Eli Lilly and Company
See details and how to joinNCT06937086 · EU 2024-520209-38-00
Phase 2Taking people
LY4268989 (MORF-057) Co-Administered With Mirikizumab in Adults With Moderately to Severely Active Ulcerative Colitis:
Where
Anaheim, Belleville, Bellevue, Boston, Cedar Park, Chicago, Clinton Township, Colorado Springs, Cordova, Dallas, Dayton, Des Plaines, Flowood, Fort Worth, Garland, Glenview, Greenville, Gurnee, Hialeah, Jacksonville, Kissimmee, Lakewood Rch, Lancaster, Lighthouse PT, Los Angeles, Louisville, Lubbock, Margate, New Albany, Ogden, Orlando, Providence, Richmond, Roanoke, San Antonio, Scottsdale, Tyler, Utica, Webster
Age
18 years to 80 years
People
252 worldwide
Run by
Eli Lilly and Company
See details and how to joinNCT07186101
Phase 2Taking people
LY4268989 in Adults With Moderately to Severely Active Ulcerative Colitis
Where
Anaheim, Boise, Charleston, Chicago, Colorado Springs, Daytona Beach, Denver, Des Plaines, Folsom, Fort Worth, Garland, Greenville, Hamden, Hilliard, Houston, Idaho Falls, Jackson, Kissimmee, Lakewood, Lakewood Rch, Las Vegas, Louisville, Mandeville, Mansfield, Moorestown, New Albany, New Brunswick, Norfolk, Orlando, Phoenix, Portland, Rochester, San Antonio, San Marcos, Scottsdale, Seattle, Sioux Falls, Spokane, Springboro, Springfield, St Louis, Stony Brook, Tacoma, Temple City, Tyler, Victorville, Westlake, Wilmington, Wyoming
Age
18 years to 80 years
People
1,431 worldwide
Run by
Eli Lilly and Company
See details and how to joinNCT07415044
Phase 2Taking people
A Master Protocol (IIBD): A Study of Multiple Drugs in Adults With Ulcerative Colitis or Crohn's Disease
Where
Atlanta, Chicago, Englewood, Kingwood, Las Vegas, Los Angeles, Miami, Miami Lakes, Oxnard, San Antonio, Scottsdale, St Louis, Topeka, Wyoming
Age
18 years to 80 years
People
60 worldwide
Run by
Eli Lilly and Company
See details and how to joinNCT07483073 · EU 2025-524112-11-00
Phase 3Taking people
A Long-term Extension (LTE) Study of Guselkumab in Pediatric Participants
Where
Atlanta, Cincinnati, Fort Worth, Indianapolis, Salt Lake City
Age
3 years to 64 years
People
196 worldwide
Run by
Janssen Research & Development, LLC
See details and how to joinNCT06663332 · EU 2023-509560-16-00
Phase 3Taking people
A Study of JNJ-78934804 in Participants With Moderately to Severely Active Ulcerative Colitis
Where
Anaheim, Chapel Hill, Chula Vista, Colorado Springs, Cordova, Crestview Hills, Farmington Hill, Lafayette, Lakewood Rch, Lee's Summit, Los Alamitos, Mentor, Metairie, Miami, New York, Oklahoma City, Orlando, Portland, Richmond, San Antonio, San Diego, Scottsdale, Summerville, Sun City, Suwanee, Tacoma, Tampa, Tyler, Uniontown, Webster
Age
18 years and over
People
644 worldwide
Run by
Janssen Research & Development, LLC
See details and how to joinNCT07577856 · EU 2026-525923-26-00
Phase 4Taking people
A Remotely Conducted Study to Assess Concentration of TREMFYA in Breast Milk of Lactating Women Who Are Receiving TREMFYA Therapeutically
Where
Chapel Hill
Age
18 years and over
People
10
Run by
Janssen Research & Development, LLC
See details and how to joinNCT07654751
Phase 1/2Taking people
Safety, Dosage, and Microbiome Engraftment Study of MGT-006 for Ulcerative Colitis (ROOT Study)
Where
Boston, Naples, New York
Age
18 years to 75 years
People
54 worldwide
Run by
Metagen Therapeutics, Inc.
See details and how to joinNCT07913347
Phase 1/2Taking people
An Open-Label, Proof of Consent Study of Vorinostat for the Treatment of Mdoerate-to-Severe Crohn s Disease and Maintenance Therapy With Ustekinumab
Where
Bethesda
Age
18 years to 65 years
People
35
Run by
National Institute of Allergy and Infectious Diseases (NIAID)
See details and how to joinNCT03167437
Phase 2Taking people
Aquamin® for Prevention of Ulcerative Colitis J-Pouch-associate Intestinal Inflammation
Where
Ann Arbor
Age
18 years to 80 years
People
52
Run by
Muhammad N Aslam, MD
See details and how to joinNCT07501078
Phase 1/2Taking people
Study of XmAb942 in Healthy Participants and Participants With Ulcerative Colitis
Where
Albany, Beavercreek, Bradenton, Brandon, Cedar Park, Cordova, Denton, Garland, Georgetown, Houston, Jacksonville, Kingwood, Kissimmee, Louisville, Lubbock, Margate, Oxford, Palmetto Bay, Palo Alto, Raleigh, Richmond, Rochester, San Antonio, Scottsdale, Tampa, Tupelo, Tyler, Webster
Age
18 years to 75 years
People
270 worldwide
Run by
Xencor, Inc.
See details and how to joinNCT06619990
Phase 4Enrolling by invitation
INSIGHT-IBD Pragmatic Study
Where
Cedar Park, Fort Worth, Glenview, Gurnee, Houston, Indianapolis, Plano, Richmond, Rochester, San Antonio, San Marcos, Sun City, Tucson
Age
21 years and over
People
400
Run by
Specialty Networks Research.
See details and how to joinNCT07686757
Phase 4Taking people
A Study of Vedolizumab in Adults With Ulcerative Colitis (UC) or Crohn's Disease (CD) in the Community Setting
Where
Albuquerque, Atlanta, Baton Rouge, Bellevue, Birmingham, Bridgeton, Brooksville, Carmel, Cedarhurst, Chandler, Charlotte, Chevy Chase, Cincinnati, Clearwater, Colorado Springs, Columbia, Crestview Hills, Dayton, Decatur, Downers Grove, Elmhurst, El Paso, Escondido, Framingham, Fresh Meadows, Georgetown, Gilbert, Glen Burnie, Glenview, Greenville, Hialeah, Houston, Hutchinson, Kansas City, Katy, Kingsport, Kingwood, Kissimmee, Lafayette, Lake Barrington, Lake Success, Liberty Township, Little Rock, Littleton, Lubbock, Mentor, Metairie, Miami, Mobile, Murrieta, Naperville, New Bedford, Newport Beach, New York, Oak Lawn, Ogden, Orange, Orlando, Pensacola, Pinehurst, Pinellas Park, Plymouth, Portland, Providence, Reno, Roanoke, Rochester, Rockford, San Diego, Seaford, Sioux Falls, Southaven, Springboro, Springfield, Statesville, Suffolk, Summerville, Sun City, Syracuse, Tomball, Utica, Waco, Webster, Weldon Spring, Westfield, Westlake, West Nyack, Williamsburg, Wilmington, Wyoming, Ypsilanti
Age
18 years to 80 years
People
200
Run by
Takeda
See details and how to joinNCT06581328
Phase 2Taking people
A Study to Evaluate Etrasimod Treatment in Adolescents With Ulcerative Colitis
Where
Abilene, Boston, Chicago, Cleveland, Fort Worth, Garden Grove, Little Rock, Loma Linda, Orlando, Royal Oak, San Bernardino, San Francisco
Age
12 years to 17 years
People
36 worldwide
Run by
Pfizer
See details and how to joinNCT05287126 · EU 2022-500345-25-00
Phase 2Taking people
A Study to Evaluate the Efficacy, Safety, and Pharmacokinetics (PK) of RO7837195 in Participants With Moderately to Severely Active Ulcerative Colitis (UC)
Where
Chicago, Colorado Springs, Fresh Meadows, Kissimmee, Lancaster, Monroe, Rochester, Salt Lake City, San Diego
Age
18 years and over
People
224 worldwide
Run by
Genentech, Inc.
See details and how to joinNCT06979336 · EU 2025-520690-39-00
Phase 2Taking people
A Study of Long-acting Antibodies Alone and in Combinations for Moderate to Severe Ulcerative Colitis
Where
Boston, Canoga Park, Cedar Park, Chapel Hill, Chicago, Colorado Springs, Durham, Garland, Glen Burnie, Kansas City, Kingsport, Kissimmee, La Jolla, Lancaster, Louisville, Marrero, Miami, New York, Providence, Rochester, San Antonio, Seattle, Southlake, St Louis, Tacoma, Webster, Winston-Salem
Age
18 years to 75 years
People
645 worldwide
Run by
Spyre Therapeutics, Inc.
See details and how to joinNCT07012395 · EU 2025-521242-26-00
Phase 3Taking people
A Study to Learn More About How Risankizumab Works in Young Participants With Ulcerative Colitis
Where
Atlanta, Chicago, Cleveland, Dallas, Greenville, Miami, Morristown, Philadelphia, Phoenix, Pittsburgh, San Diego, San Francisco
Age
2 years to 17 years
People
120 worldwide
Run by
AbbVie
See details and how to joinNCT07071519 · EU 2024-514695-41-00