What does science say about Metformin and Endometrial cancer?
- We don’t say yes or no. We show what has been studied.
- Working in a lab or in animals does not mean it works in people.
- Don’t stop or change your treatment without talking to your doctor.
What has been studied
- Lab studies (cells)Tests on cells in a dish.Source: PubMed · as of 12 Nov 2026 · Open the search at PubMed43studies
- Animal studiesTests in mice, rats or other animals.Source: PubMed · as of 12 Nov 2026 · Open the search at PubMed16studies
- Studies in peoplePublished studies with human participants.Source: PubMed · as of 12 Nov 2026 · Open the search at PubMed88studies
- Registered trials in peopleTrials entered in a public registry, whatever their result.ClinicalTrials.gov: 10 · as of 11 Nov 2026 · Open the search at ClinicalTrials.govEU CTIS: 0 · as of 11 Nov 2026 · Open the search at EU CTISBy phase:Phase 2 (7)Phase 1/2 (1)Phase 3 (1)No phase (1)By status:Completed (4)Recruiting (3)Running, not recruiting (2)Not yet recruiting (1)Countries (13):United States (7)Australia (1)Belgium (1)China (1)Germany (1)Spain (1)France (1)Ireland (1)Iraq (1)Italy (1)Japan (1)Netherlands (1)New Zealand (1)With a linked publication (results): 2 of 10The registries do not tell us here whether results were posted; a linked publication is shown instead.10trials
- Approved treatmentApproved by a medicines regulator for this disease.No
Examples of what we found
The trials
Phase 2
Canagliflozin Plus Progestin for Atypical Endometrial Hyperplasia and Early-Stage Endometrial Cancer
Not yet recruiting · China
ClinicalTrials.gov · NCT07890064Phase 2
HPV Vaccine, Imiquimod, and Metformin Combination Trial
Recruiting · United States
ClinicalTrials.gov · NCT06686043Phase 1/2
First-in-Human Study of Tersolisib (STX-478) as Monotherapy and in Combination With Other Antineoplastic Agents in Participants With Advanced Solid Tumors
Recruiting · Belgium, Germany, Spain, France, Ireland, Italy, Japan, Netherlands, United States
ClinicalTrials.gov · NCT05768139Phase 2
Megestrol Acetate Compared With Megestrol Acetate and Metformin to Prevent Endometrial Cancer
Running, not recruiting · United States
ClinicalTrials.gov · NCT04576104Phase 2
RESOLVE: Abemaciclib + Letrozole +/- Metformin or Gedatolisib in Endometrial Cancer
Recruiting · United States
ClinicalTrials.gov · NCT03675893Phase 2
Improving the Treatment for Women With Early Stage Cancer of the Uterus
Running, not recruiting · Australia, New Zealand
ClinicalTrials.gov · NCT01686126Phase 3
An Endometrial Cancer Chemoprevention Study of Metformin
Completed · United States
ClinicalTrials.gov · NCT01697566
Thinking of paying for it? Read this first
- Ask for published results. Stories, thank-you letters and "patients report" are not results. Ask where the results were published.
- Know what you pay for. Ask in writing: what exactly is included, who gets the money, and what happens if you stop.
- Ask your own doctor first. Some products interfere with chemotherapy, radiation or other medicines. Your treating doctor can check this.
- Do not stop standard treatment for it. Do not stop or delay your treatment without talking to your care team.
Other treatments people ask about
- Ketogenic dietStep: Large trials
- MetforminStep: Large trials
- StatinsStep: Phase 2 trials
- HyperthermiaStep: First trials in people
- Cannabis and cannabinoids (CBD, THC)Step: Reports in people
- Curcumin (turmeric)Step: Reports in people
- Fasting and fasting-mimicking dietStep: Reports in people
- High-dose vitamin CStep: Reports in people
- MelatoninStep: Reports in people
- Vitamin DStep: Reports in people
- Mistletoe extractStep: Animal studies only
- Dichloroacetate (DCA)Step: Lab studies only
Not medical advice. Talk to the care team before changing treatment.