What does science say about Metformin and Triple-negative breast cancer?
- We don’t say yes or no. We show what has been studied.
- Working in a lab or in animals does not mean it works in people.
- Don’t stop or change your treatment without talking to your doctor.
What has been studied
- Lab studies (cells)Tests on cells in a dish.Source: PubMed · as of 12 Nov 2026 · Open the search at PubMed37studies
- Animal studiesTests in mice, rats or other animals.Source: PubMed · as of 12 Nov 2026 · Open the search at PubMed22studies
- Studies in peoplePublished studies with human participants.Source: PubMed · as of 12 Nov 2026 · Open the search at PubMed9studies
- Registered trials in peopleTrials entered in a public registry, whatever their result.ClinicalTrials.gov: 3 · as of 12 Nov 2026 · Open the search at ClinicalTrials.govEU CTIS: 1 · as of 12 Nov 2026 · Open the search at EU CTISBy phase:Phase 2 (2)Phase 3 (1)Phase 1/2 (1)By status:Recruiting (2)Withdrawn before start (1)Running, not recruiting (1)Countries (10):United Kingdom (2)United States (2)Australia (1)Germany (1)Spain (1)France (1)Israel (1)Italy (1)South Korea (1)Taiwan (1)With a linked publication (results): 0 of 4The registries do not tell us here whether results were posted; a linked publication is shown instead.4trials
- Approved treatmentApproved by a medicines regulator for this disease.No
Examples of what we found
The trials
Phase 1/2
A Study Evaluating the Efficacy and Safety of Multiple Treatment Combinations in Patients With Metastatic or Locally Advanced Breast Cancer
Recruiting · Australia, Germany, Spain, France, United Kingdom, Israel, South Korea, Taiwan, United States
ClinicalTrials.gov · NCT03424005Phase 2
I-SPY TRIAL: Neoadjuvant and Personalized Adaptive Novel Agents to Treat Breast Cancer
Recruiting · United States
ClinicalTrials.gov · NCT01042379Phase 3
Study of the Safety, Tolerability and Efficacy of Metabolic Combination Treatments on Cancer
Withdrawn before start · United Kingdom
ClinicalTrials.gov · NCT02201381
Thinking of paying for it? Read this first
- Ask for published results. Stories, thank-you letters and "patients report" are not results. Ask where the results were published.
- Know what you pay for. Ask in writing: what exactly is included, who gets the money, and what happens if you stop.
- Ask your own doctor first. Some products interfere with chemotherapy, radiation or other medicines. Your treating doctor can check this.
- Do not stop standard treatment for it. Do not stop or delay your treatment without talking to your care team.
Other treatments people ask about
- Curcumin (turmeric)Step: Large trials
- MetforminStep: Large trials
- Mistletoe extractStep: Large trials
- Fasting and fasting-mimicking dietStep: Phase 2 trials
- StatinsStep: Phase 2 trials
- Vitamin DStep: Phase 2 trials
- IvermectinStep: First trials in people
- Ketogenic dietStep: First trials in people
- Cannabis and cannabinoids (CBD, THC)Step: Reports in people
- High-dose vitamin CStep: Reports in people
- HyperthermiaStep: Reports in people
- MelatoninStep: Reports in people
- Dichloroacetate (DCA)Step: Animal studies only
- MebendazoleStep: Animal studies only
- Amygdalin (laetrile, "vitamin B17")Step: Lab studies only
- FenbendazoleStep: Lab studies only
Not medical advice. Talk to the care team before changing treatment.