What does science say about Probiotics and Obesity?
- We don’t say yes or no. We show what has been studied.
- Working in a lab or in animals does not mean it works in people.
- Don’t stop or change your treatment without talking to your doctor.
What has been studied
- Lab studies (cells)Tests on cells in a dish.Source: PubMed · as of 9 Nov 2026 · Open the search at PubMed16studies
- Animal studiesTests in mice, rats or other animals.Source: PubMed · as of 9 Nov 2026 · Open the search at PubMed553studies
- Studies in peoplePublished studies with human participants.Source: PubMed · as of 9 Nov 2026 · Open the search at PubMed331studies
- Registered trials in peopleTrials entered in a public registry, whatever their result.ClinicalTrials.gov: 39 · as of 9 Nov 2026 · Open the search at ClinicalTrials.govEU CTIS: 0 · as of 9 Nov 2026 · Open the search at EU CTISBy phase:No phase (36)Phase 2 (2)Early Phase 1 (1)By status:Completed (20)Recruiting (10)Running, not recruiting (4)Not yet recruiting (3)Stopped early (1)By invitation only (1)Countries (15):China (15)United States (4)Spain (3)Italy (3)France (2)Poland (2)Ukraine (2)United Kingdom (1)Croatia (1)Indonesia (1)Ireland (1)Mexico (1)Malaysia (1)Netherlands (1)Taiwan (1)With a linked publication (results): 6 of 39The registries do not tell us here whether results were posted; a linked publication is shown instead.39trials
- Approved treatmentApproved by a medicines regulator for this disease.No
Examples of what we found
The trials
No phase
Lactobacillus Acidophilus and Inulin for Cognitive Impairment in Obesity
Recruiting · Mexico
ClinicalTrials.gov · NCT07810517No phase
Effects of Gallotannins on the Gut Microbiome and How it Affects Inflammatory Markers Among Obese Individuals.
Running, not recruiting · United States
ClinicalTrials.gov · NCT07505212No phase
Oral Lactobacillus Reuteri for Skin Barrier Dysfunction in Obesity
Not yet recruiting
ClinicalTrials.gov · NCT07512050No phase
Probiotic for Weight Management in Overweight and Obese Adults
Not yet recruiting · China
ClinicalTrials.gov · NCT07507929No phase
Effect of Probiotics on Appetite Regulation in Adults With Overweight/Obesity
Recruiting · Netherlands
ClinicalTrials.gov · NCT07715955No phase
Probiotics Use and Preventing Gastrointestinal Symptoms in People Living With Overweight and Obesity.
By invitation only · United Kingdom
ClinicalTrials.gov · NCT07253155No phase
The Impact of Probiotics on Bariatric Treatment Outcomes
Running, not recruiting · Poland
ClinicalTrials.gov · NCT07258732Early Phase 1
L. Acidophilus (Strain TW01) on Gut Health, Body Composition, and Inflammation
Running, not recruiting · United States
ClinicalTrials.gov · NCT06912100No phase
Lactobacillus Plantarum and Hormonal Regulation in Obese Women
Recruiting · China
ClinicalTrials.gov · NCT06987279No phase
Study on the Weight Loss Effects and Mechanisms of Probiotic Preparation Intervention in Weight Cyclers
Not yet recruiting · China
ClinicalTrials.gov · NCT07031596Phase 2
EXploratory Study on Postprandial Energy Metabolism
Recruiting · France
ClinicalTrials.gov · NCT06786052Phase 2
Study on the Efficacy of Probiotics in the Treatment of Childhood Obesity and Their Effects on Gut Microbiota
Running, not recruiting · China, Malaysia
ClinicalTrials.gov · NCT07448220No phase
Oral Bifidobacterium Longum for Skin Barrier Dysfunction in Obesity
Completed · China
ClinicalTrials.gov · NCT07184905No phase
Probiotics in Obese Patients Treated With Semaglutide
Completed · Poland
ClinicalTrials.gov · NCT07847593No phase
Probiotics' Effects on Hormones, Body and Mood in Obese Women
Completed · China
ClinicalTrials.gov · NCT07013409No phase
Lactobacillus Gasseri and Hormonal Regulation in Obese Women
Completed · China
ClinicalTrials.gov · NCT07502404No phase
Research on Probiotics in Improving Obesity
Completed · China
ClinicalTrials.gov · NCT06964919No phase
Weight Loss Effect of Akkermansia Muciniphila in Obese Patients
Completed · China
ClinicalTrials.gov · NCT06780007No phase
Probiotics and Insulin Resistance in Obese Asthmatics
Stopped early · United States
ClinicalTrials.gov · NCT05949255No phase
Probiotic Influence on Obesity-Related Lipidemia
Completed · China
ClinicalTrials.gov · NCT06305650
Thinking of paying for it? Read this first
- Ask for published results. Stories, thank-you letters and "patients report" are not results. Ask where the results were published.
- Know what you pay for. Ask in writing: what exactly is included, who gets the money, and what happens if you stop.
- Ask your own doctor first. Some products interfere with chemotherapy, radiation or other medicines. Your treating doctor can check this.
- Do not stop standard treatment for it. Do not stop or delay your treatment without talking to your care team.
Other treatments people ask about
- Cannabis and cannabinoids (CBD, THC)Step: Large trials
- Curcumin (turmeric)Step: Large trials
- Fasting and fasting-mimicking dietStep: Large trials
- High-dose vitamin CStep: Large trials
- HyperthermiaStep: Large trials
- IvermectinStep: Large trials
- Ketogenic dietStep: Large trials
- MelatoninStep: Large trials
- MetforminStep: Large trials
- StatinsStep: Large trials
- Vitamin DStep: Large trials
- Dichloroacetate (DCA)Step: Animal studies only
- FenbendazoleStep: Animal studies only
- Mistletoe extractStep: Animal studies only
Not medical advice. Talk to the care team before changing treatment.