What does science say about Statins and Coronary artery disease?
- We don’t say yes or no. We show what has been studied.
- Working in a lab or in animals does not mean it works in people.
- Don’t stop or change your treatment without talking to your doctor.
What has been studied
- Lab studies (cells)Tests on cells in a dish.Source: PubMed · as of 11 Nov 2026 · Open the search at PubMed26studies
- Animal studiesTests in mice, rats or other animals.Source: PubMed · as of 11 Nov 2026 · Open the search at PubMed96studies
- Studies in peoplePublished studies with human participants.Source: PubMed · as of 11 Nov 2026 · Open the search at PubMed2572studies
- Registered trials in peopleTrials entered in a public registry, whatever their result.ClinicalTrials.gov: 44 · as of 11 Nov 2026 · Open the search at ClinicalTrials.govEU CTIS: 1 · as of 11 Nov 2026 · Open the search at EU CTISBy phase:Phase 4 (23)No phase (14)Phase 3 (3)Phase 2 (3)Phase 1/2 (1)Phase 2/3 (1)By status:Recruiting (15)Not yet recruiting (9)Completed (9)Running, not recruiting (8)Stopped early (2)Withdrawn before start (2)Countries (15):South Korea (12)China (9)United States (5)Pakistan (4)Spain (2)Hungary (2)Italy (2)Russia (2)Germany (1)Estonia (1)Egypt (1)United Kingdom (1)Indonesia (1)Puerto Rico (1)Taiwan (1)With a linked publication (results): 7 of 45The registries do not tell us here whether results were posted; a linked publication is shown instead.45trials
- Approved treatmentApproved by a medicines regulator for this disease.No
Examples of what we found
The trials
No phase
Aggressive Lipid Lowering Therapy in ICI-Treated Melanoma
Recruiting · United States
ClinicalTrials.gov · NCT07704918Phase 3
A Study of Bempedoic Acid/Ezetimibe/High-intensity Statin in Patients Without Cardiovascular Events
Not yet recruiting · Germany, Spain, Italy
ClinicalTrials.gov · NCT07474649Phase 4
Early Intensive Lipid-Lowering With Inclisiran for Plaque Stabilization in Acute Coronary Syndrome
Not yet recruiting · South Korea
ClinicalTrials.gov · NCT07799779Phase 3
PRE-EMPT: Prospective RandomizEd Evaluation and Management of Premature aTherosclerosis
Recruiting · United States
ClinicalTrials.gov · NCT07232069Phase 4
Triple vs Dual Lipid-Lowering Therapy for LDL-C Reduction in Acute Coronary Syndrome
Not yet recruiting · Pakistan
ClinicalTrials.gov · NCT07508254No phase
Optimal Antiplatelet and Lipid Therapy in ACS With DES: OPACT Trial
Not yet recruiting · South Korea
ClinicalTrials.gov · NCT07432516Phase 2/3
Changes in plaque characteristics after short-term statin therapy assessed with coronary CT (INTENSE)
Not yet recruiting · Hungary
EU CTIS · 2025-522868-32-00Phase 4
Comparison of Moderate-Intensity Statin Plus Ezetimibe vs. High-Intensity Statin for Coronary Plaque Stabilization
Running, not recruiting · South Korea
ClinicalTrials.gov · NCT06767345Phase 4
Polygenic Risk Driven Pragmatic Statin Trial for Heart Disease Prevention
Running, not recruiting · Estonia
ClinicalTrials.gov · NCT06820086Phase 2
High-Dose Rosuvastatin Preloading for Enhanced Outcomes in STEMI Patients Undergoing Primary PCI
Running, not recruiting · Pakistan
ClinicalTrials.gov · NCT06924684Phase 4
Polygenic Risk-based Detection of Subclinical Coronary Atherosclerosis and Intervention With Statin and Colchicine
Running, not recruiting · United States
ClinicalTrials.gov · NCT05850091Phase 4
Comparative Study of Rosuvastatin/Ezetimib 20/10 mg and Atovastatin/Ezetimib 40/10 mg (TOLERANT Trial)
Running, not recruiting · South Korea
ClinicalTrials.gov · NCT05910476No phase
PCSK 9 Inhibitor Added to High-Intensity Statin Therapy to Prevent Cardiovascular Events in Patients With ACS After PCI
Running, not recruiting · China
ClinicalTrials.gov · NCT05457582Phase 4
Cross-over Study of Coronary Risk Factors With a Polypill
Recruiting · Spain
ClinicalTrials.gov · NCT05030818Phase 4
Low Dose Rosuvastatin Plus Ezetimibe Versus High-dose Rosuvastatin in AMI
Recruiting · South Korea
ClinicalTrials.gov · NCT04499859Phase 4
Women's IschemiA TRial to Reduce Events In Non-ObstRuctive CAD
Running, not recruiting · Puerto Rico, United States
ClinicalTrials.gov · NCT03417388Phase 4
Aggressive Risk-Prevention Therapies for Coronary Atherosclerotic Plaque (ART-CAP)
Withdrawn before start · United States
ClinicalTrials.gov · NCT06280976Phase 1/2
YN001 in Healthy Subjects and Patients With Coronary Atherosclerosis
Completed · China
ClinicalTrials.gov · NCT06048588No phase
Weak Pulse at Yang and Wiry Pulse at Yin Theory
Completed · China
ClinicalTrials.gov · NCT07378228No phase
Targeting Investigation and Treatment in Patients With Type 2 Myocardial Infarction
Completed · United Kingdom
ClinicalTrials.gov · NCT05419583Phase 4
Statin Therapy In Patients With Vasospastic Angina
Withdrawn before start · South Korea
ClinicalTrials.gov · NCT02790528Phase 4
ANti-Oxidant in Variant Angina (ANOVA) Trial
Stopped early · South Korea
ClinicalTrials.gov · NCT03228238
Thinking of paying for it? Read this first
- Ask for published results. Stories, thank-you letters and "patients report" are not results. Ask where the results were published.
- Know what you pay for. Ask in writing: what exactly is included, who gets the money, and what happens if you stop.
- Ask your own doctor first. Some products interfere with chemotherapy, radiation or other medicines. Your treating doctor can check this.
- Do not stop standard treatment for it. Do not stop or delay your treatment without talking to your care team.
Other treatments people ask about
- Curcumin (turmeric)Step: Large trials
- Fasting and fasting-mimicking dietStep: Large trials
- High-dose vitamin CStep: Large trials
- MelatoninStep: Large trials
- MetforminStep: Large trials
- StatinsStep: Large trials
- Vitamin DStep: Large trials
- Cannabis and cannabinoids (CBD, THC)Step: Reports in people
- Dichloroacetate (DCA)Step: Reports in people
- HyperthermiaStep: Reports in people
- Ketogenic dietStep: Reports in people
- Mistletoe extractStep: Reports in people
- IvermectinStep: Animal studies only
Not medical advice. Talk to the care team before changing treatment.