What does science say about Vitamin D and Osteoporosis?
- We don’t say yes or no. We show what has been studied.
- Working in a lab or in animals does not mean it works in people.
- Don’t stop or change your treatment without talking to your doctor.
What has been studied
- Lab studies (cells)Tests on cells in a dish.Source: PubMed · as of 11 Nov 2026 · Open the search at PubMed35studies
- Animal studiesTests in mice, rats or other animals.Source: PubMed · as of 11 Nov 2026 · Open the search at PubMed211studies
- Studies in peoplePublished studies with human participants.Source: PubMed · as of 11 Nov 2026 · Open the search at PubMed1934studies
- Registered trials in peopleTrials entered in a public registry, whatever their result.ClinicalTrials.gov: 26 · as of 11 Nov 2026 · Open the search at ClinicalTrials.govEU CTIS: 0 · as of 11 Nov 2026 · Open the search at EU CTISBy phase:No phase (20)Phase 4 (5)Phase 3 (1)By status:Completed (13)Recruiting (6)Running, not recruiting (5)Not yet recruiting (2)Countries (20):United States (5)China (3)Egypt (3)Greece (3)Italy (2)Norway (2)Poland (2)Bulgaria (1)Estonia (1)Spain (1)France (1)Georgia (1)Hungary (1)South Korea (1)Latvia (1)Mexico (1)Serbia (1)Russia (1)Sweden (1)Taiwan (1)With a linked publication (results): 2 of 26The registries do not tell us here whether results were posted; a linked publication is shown instead.26trials
- Approved treatmentApproved by a medicines regulator for this disease.No
Examples of what we found
The trials
Phase 4
Sequential Treatment With Romosozumab Followed by Denosumab vs. Zoledronic Acid for Gains in HIP BMD
Not yet recruiting · Sweden
ClinicalTrials.gov · NCT07772609No phase
Prunes Preventing Bone Loss in Perimenopause
Recruiting · United States
ClinicalTrials.gov · NCT07120997No phase
Vitamin D Status and Multi-Omics Profiles in Primary Osteoporosis
Recruiting · China
ClinicalTrials.gov · NCT07296471No phase
Vitamin k, D-chiro Inositol and α-lactalbumin in Bone Homeostasis
Recruiting · Italy
ClinicalTrials.gov · NCT07256769No phase
Strenght Training in Osteoporosis Prevention
Running, not recruiting · Poland
ClinicalTrials.gov · NCT06733064No phase
Single or Repeat Zoledronate Versus Alendronate Following Denosumab (EUROpean Denosumab Effects Consolidation Study)
Running, not recruiting · France, Greece, Italy
ClinicalTrials.gov · NCT05575167No phase
Profylactic Treatment for Patients in Risk Osteoporosis
Recruiting · Norway
ClinicalTrials.gov · NCT05787808Phase 4
Romosozumab Use to Build Skeletal Integrity
Running, not recruiting · United States
ClinicalTrials.gov · NCT05058976No phase
Beijing Osteoporosis With Neurological Disorders in Epigenetic Changes Study
Running, not recruiting · China
ClinicalTrials.gov · NCT03401619No phase
Dried Plums and Bone Health in Postmenopausal Women
Running, not recruiting · United States
ClinicalTrials.gov · NCT02822378Phase 3
A Study to Compare Efficacy, PK, PD, Safety and IMM of MB09 to Prolia® [EU-sourced] in Postmenopausal Osteoporosis.
Completed · Bulgaria, Estonia, Georgia, Hungary, Latvia, Mexico, Poland, Serbia
ClinicalTrials.gov · NCT05338086No phase
A Study of High-Dose Vit D Versus Standard of Care Vit D Supplementation
Completed · United States
ClinicalTrials.gov · NCT05016310Phase 4
Novel Combination Therapy for Osteoporosis in Men
Completed · United States
ClinicalTrials.gov · NCT03994172
Thinking of paying for it? Read this first
- Ask for published results. Stories, thank-you letters and "patients report" are not results. Ask where the results were published.
- Know what you pay for. Ask in writing: what exactly is included, who gets the money, and what happens if you stop.
- Ask your own doctor first. Some products interfere with chemotherapy, radiation or other medicines. Your treating doctor can check this.
- Do not stop standard treatment for it. Do not stop or delay your treatment without talking to your care team.
Other treatments people ask about
- Cannabis and cannabinoids (CBD, THC)Step: Large trials
- Curcumin (turmeric)Step: Large trials
- Fasting and fasting-mimicking dietStep: Large trials
- High-dose vitamin CStep: Large trials
- MelatoninStep: Large trials
- MetforminStep: Large trials
- StatinsStep: Large trials
- Vitamin DStep: Large trials
- HyperthermiaStep: Reports in people
- Ketogenic dietStep: Reports in people
- Mistletoe extractStep: Reports in people
Not medical advice. Talk to the care team before changing treatment.