Written from the studies on PubMed, searched on 2026. nov. 11.. Every number below comes from a study listed under Sources.
The claim
Posts online say that CBD (cannabidiol) helps with melanoma.
Where research stands
We found 13 published papers on CBD (cannabidiol) and melanoma. They were published between 2021 and 2026. None of them is a study in people. 3 were studies in animals, and 5 were only in cells in the lab. 3 papers are reviews that sum up other studies.
- 0In people
- 3In animals
- 5Only in the lab
What the studies found
We have not summed up these studies in words yet. The most important papers are listed under Sources.
Verdict
CBD (cannabidiol) has been studied for melanoma in animals, not yet in people.
Unproven means: it was only tested in animals or cells, or there is too little or mixed data from people. How we rate claims
What this means for you: Results in animals or in cells often do not hold in people. Do not stop or change your medicines because of it. Ask your doctor before you start taking it.
Sources
- Cannabidiol inhibits melanoma progression by regulating PPARγ-TET1 complex-dependent LRSAM1 demethylation.2026 · Phytomedicine · Review
- Combinatorial approach of cannabidiol and active-targeted-mediated photodynamic therapy in malignant melanoma treatment.2024 · J Biophotonics · Review
- Advanced multifunctional nano-lipid carrier loaded gel for targeted delivery of 5-flurouracil and cannabidiol against non-melanoma skin cancer.2023 · Environ Res · Review
- Bipiperidinyl Derivatives of Cannabidiol Enhance Its Antiproliferative Effects in Melanoma Cells.2024 · Antioxidants (Basel) · In animals
- Effervescent cannabidiol solid dispersion-doped dissolving microneedles for boosted melanoma therapy via the "TRPV1-NFATc1-ATF3" pathway and tumor microenvironment engineering.2023 · Biomater Res · In animals
- Effects of cannabidiol (CBD) on the inhibition of melanoma cells in vitro.2021 · J Immunoassay Immunochem · In animals
- Cannabidiol Activates Integrated Stress Response Signaling and Immune Trafficking Programs in an A375 Melanoma-Jurkat T Cell Coculture Model: A Multi-Omics Analysis.2026 · ACS Omega · In the lab
- Codelivery of Paclitaxel and Cannabidiol in Lipid Nanoparticles Enhances Cytotoxicity against Melanoma Cells.2025 · ACS Omega · In the lab
- Cannabidiol and Minor Phytocannabinoids: A Preliminary Study to Assess Their Anti-Melanoma, Anti-Melanogenic, and Anti-Tyrosinase Properties.2023 · Pharmaceuticals (Basel) · In the lab
- Photodynamic Therapy Efficacy of Novel Zinc Phthalocyanine Tetra Sodium 2-Mercaptoacetate Combined with Cannabidiol on Metastatic Melanoma.2022 · Pharmaceutics · In the lab
- THC and CBD Induce Heme Oxygenase-1-Dependent Cell Death and Trigger Mitochondrial Dysfunction in Human Melanoma and Cutaneous Squamous Cell Carcinoma Cells.2026 · Antioxidants (Basel) · Other paper
- Differences in the phospholipid profile of melanocytes and melanoma cells irradiated with UVA and treated with cannabigerol and cannabidiol.2023 · Sci Rep · Other paper
