Written from the studies on PubMed, searched on 2026. nov. 11.. Every number below comes from a study listed under Sources.
What people read
Posts online say that Omega-3 fatty acids (fish oil) helps with Heart failure.
What has been studied
- 19In people18 randomised trials
- 14In animals
- 1Only in the lab
What the studies found
Omega-3 fatty acids (fish oil) has been tested in randomised trials in people with Heart failure.
We found 104 published papers on Omega-3 fatty acids (fish oil) and Heart failure. They were published between 1996 and 2026.
19 of them are studies in people (18 randomised trials), 31 are reviews, 14 are studies in animals and 1 are studies only in the lab.
The most important ones are listed under Sources.
What this means for you: A study in people is not proof that it helps you. Do not stop or change your medicines because of it. Ask your doctor before you start taking it.
Sources
- Metabolomic Lipid Profile Changes in Patients with Heart Failure Undergoing Oral Nutritional Supplements Enriched with the Omega-3 (n-3) Polyunsaturated Fatty Acids and Mediterranean Diet.2026 · Nutrients · Randomised trial
- Impact of Icosapent Ethyl on Cardiovascular Risk Reduction in Patients With Heart Failure in REDUCE-IT.2022 · J Am Heart Assoc · Randomised trial
- 1 Year HIIT and Omega-3 Fatty Acids to Improve Cardiometabolic Risk in Stage-A Heart Failure.2022 · JACC Heart Fail · Randomised trial
- [Influence of Omega-3 PUFA on Non-invasive factors determining the risk of arrhYthmias eXcess and sudden cardiac death in patients with HFpEF with ischemic etiology (ONYX)].2020 · Kardiologiia · Randomised trial
- The omega-3 index in patients with heart failure: A prospective cohort study.2019 · Prostaglandins Leukot Essent Fatty Acids · Randomised trial
- Effects of omega-3 polyunsaturated fatty acids on fibrosis, endothelial function and myocardial performance, in ischemic heart failure patients.2019 · Clin Nutr · Randomised trial
- Long-Chain Omega-3 Fatty Acid Supplements in Depressed Heart Failure Patients: Results of the OCEAN Trial.2018 · JACC Heart Fail · Randomised trial
- Red blood cell oleic acid levels reflect olive oil intake while omega-3 levels reflect fish intake and the use of omega-3 acid ethyl esters: The Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto Miocardico-Heart Failure trial.2016 · Nutr Res · Randomised trial
- Short term omega-3 polyunsaturated fatty acid supplementation induces favorable changes in right ventricle function and diastolic filling pressure in patients with chronic heart failure; A randomized clinical trial.2016 · Vascul Pharmacol · Study in people
- Supplementation of l-Alanyl-l-Glutamine and Fish Oil Improves Body Composition and Quality of Life in Patients With Chronic Heart Failure.2015 · Circ Heart Fail · Study in people
- Eicosapentaenoic Acid (EPA) and Docosahexaenoic Acid (DHA) Ameliorate Heart Failure through Reductions in Oxidative Stress: A Systematic Review and Meta-Analysis.2024 · Antioxidants (Basel) · Review
- Omega-3 fatty acids in the treatment of heart failure.2024 · Curr Probl Cardiol · Review
- The Effect of Omega-3 Supplementation on Heart Failure Outcome: A Meta-Analysis of Randomized Clinical Trial.2024 · J Lipid Atheroscler · Review
- Omega-3 supplementation and outcomes of heart failure: A systematic review of clinical trials.2024 · Medicine (Baltimore) · Review
- The Role of Omega-3 in Attenuating Cardiac Remodeling and Heart Failure through the Oxidative Stress and Inflammation Pathways.2023 · Antioxidants (Basel) · Review
- Does omega-3 supplementation improve the inflammatory profile of patients with heart failure? a systematic review and meta-analysis.2023 · Heart Fail Rev · Review
- Eicosapentaenoic acid attenuates heart failure with preserved ejection fraction via promoting TREM2-dependent efferocytosis.2026 · Phytomedicine · In animals
- Omega-3 fatty acid prevents the development of heart failure by changing fatty acid composition in the heart.2020 · Sci Rep · In animals
- The effects of dietary fish oil on exercising skeletal muscle vascular and metabolic control in chronic heart failure rats.2014 · Appl Physiol Nutr Metab · In animals
- Oral administration of eicosapentaenoic acid or docosahexaenoic acid modifies cardiac function and ameliorates congestive heart failure in male rats.2014 · J Nutr · In animals
- Docosahexaenoic acid supplementation alters key properties of cardiac mitochondria and modestly attenuates development of left ventricular dysfunction in pressure overload-induced heart failure.2013 · Cardiovasc Drugs Ther · In animals
- Fish oil selectively improves heart function in a mouse model of lipid-induced cardiomyopathy.2013 · J Cardiovasc Pharmacol · In animals
- Acute administration of fish oil inhibits triggered activity in isolated myocytes from rabbits and patients with heart failure.2008 · Circulation · In the lab
- Phenotypic age acceleration and omega-6/omega-3 PUFA ratio in dynamic atrial fibrillation-heart failure transitions: a multistate analysis.2026 · J Nutr Health Aging · Other paper
- Prevention of Heart Failure With Icosapent Ethyl Results in Cost-Savings in the Spanish Population With Established Cardiovascular Disease.2026 · Value Health Reg Issues · Other paper
- Association of Plasma Omega-3 Levels With Incident Heart Failure and Related Mortalities.2024 · Mayo Clin Proc · Other paper
- Omega-3 Fish Oils in Prevention and Management of Heart Failure.2024 · Mayo Clin Proc · Other paper